The dominant paradigm in turbulent wall flows is that the mean velocity near the wall, when scaled on wall variables, is independent of the friction Reynolds number $Re_\tau$. This paradigm faces challenges when applied to fluctuations but has received serious attention only recently. Here, by extending our earlier work (Chen & Sreenivasan, J. Fluid Mech., vol. 908, 2021, p. R3) we present a promising perspective, and support it with data, that fluctuations displaying non-zero wall values, or near-wall peaks, are bounded for large values of $Re_\tau$, owing to the natural constraint that the dissipation rate is bounded. Specifically, $\varPhi _\infty - \varPhi = C_\varPhi \,Re_\tau ^{-1/4},$ where $\varPhi$ represents the maximum value of any of the following quantities: energy dissipation rate, turbulent diffusion, fluctuations of pressure, streamwise and spanwise velocities, squares of vorticity components, and the wall values of pressure and shear stresses; the subscript $\infty$ denotes the bounded asymptotic value of $\varPhi$, and the coefficient $C_\varPhi$ depends on $\varPhi$ but not on $Re_\tau$. Moreover, there exists a scaling law for the maximum value in the wall-normal direction of high-order moments, of the form $\langle \varphi ^{2q}\rangle ^{{1}/{q}}_{max}= \alpha _q-\beta _q\,Re^{-1/4}_\tau$, where $\varphi$ represents the streamwise or spanwise velocity fluctuation, and $\alpha _q$ and $\beta _q$ are independent of $Re_\tau$. Excellent agreement with available data is observed. A stochastic process for which the random variable has the form just mentioned, referred to here as the ‘linear $q$-norm Gaussian’, is proposed to explain the observed linear dependence of $\alpha _q$ on $q$.

This study investigated associations of adherence to the Australian Dietary Guidelines (ADG) with cognitive performance and cognitive decline over 6 years. We used longitudinal data from the Sydney Memory and Aging Study comprising 1037 community-dwelling non-demented participants aged 70–90 years. Dietary intake was assessed at baseline using the Dietary Questionnaire for Epidemiological Studies Version 2. Adherence to the ADG was scored using the Dietary Guideline Index 2013 (DGI-2013). Cognition was assessed using neuropsychological tests in six cognitive domains and global cognition at baseline and 2, 4 and 6 years later. Linear mixed models analysed the association between adherence to the ADG and cognitive function and cognitive decline over 6 years. Results indicated that overall adherence to the ADG was suboptimal (DGI-2013 mean score 43⋅8 with a standard deviation of 10⋅1; median score 44, range 12–73 with an interquartile range of 7). The percent of participants attaining recommended serves for the five food groups were 30⋅2 % for fruits, 11⋅2 % for vegetables, 54⋅6 % for cereals, 28⋅9 % for meat and alternatives and 2⋅1 % for dairy consumption. Adherence to the ADG was not associated with overall global cognition over 6 years (β = 0⋅000; 95 % CI: −0⋅007, 0⋅007; P = 0⋅95). Neither were DGI-2013 scores associated with change in global cognitive performance over 6 years (β = 0⋅002; 95 % CI: −0⋅002, 0⋅005; P = 0⋅41) nor in any individual cognitive domains. In conclusion, adherence to the ADG was not associated with cognitive health over time in this longitudinal analysis of older Australians. Future research is needed to provide evidence to support specific dietary guidelines for neurocognitive health among Australian older adults.

Chronic inflammation exerts pleiotropic effects in the aetiology and progression of chronic obstructive pulmonary disease (COPD). Glucosamine is widely used in many countries and may have anti-inflammatory properties. We aimed to prospectively evaluate the association of regular glucosamine use with incident COPD risk and explore whether such association could be modified by smoking in the UK Biobank cohort, which recruited more than half a million participants aged 40–69 years from across the UK between 2006 and 2010. Cox proportional hazards models with adjustment for potential confounding factors were used to calculate hazard ratios (HR) as well as 95 % CI for the risk of incident COPD. During a median follow-up of 8·96 years (interquartile range 8·29–9·53 years), 9016 new-onset events of COPD were documented. We found that the regular use of glucosamine was associated with a significantly lower risk of incident COPD with multivariable adjusted HR of 0·80 (95 % CI, 0·75, 0·85; P < 0·001). When subgroup analyses were performed by smoking status, the adjusted HR for the association of regular glucosamine use with incident COPD were 0·84 (0·73, 0·96), 0·84 (0·77, 0·92) and 0·71 (0·62, 0·80) among never smokers, former smokers and current smokers, respectively. No significant interaction was observed between glucosamine use and smoking status (P for interaction = 0·078). Incident COPD could be reduced by 14 % to 84 % through a combination of regular glucosamine use and smoking cessation.

Cytochrome P450 monooxygenases play a key role in pest resistance to insecticides by detoxification. Four new P450 genes, CYP6AS160, CYP6AS161, CYP4AB73 and CYP4G232 were identified from Solenopsis invicta. CYP6AS160 was highly expressed in the abdomen and its expression could be induced significantly with exposure to fipronil, whereas CYP4AB73 was not highly expressed in the abdomen and its expression could not be significantly induced following exposure to fipronil. Expression levels of CYP6AS160 and CYP4AB73 in workers were significantly higher than that in queens. RNA interference-mediated gene silencing by feeding on double-stranded RNA (dsRNA) found that the levels of this transcript decreased (by maximum to 64.6%) when they fed on CYP6AS160-specific dsRNA. Workers fed dsCYP6AS160 had significantly higher mortality after 24 h of exposure to fipronil compared to controls. Workers fed dsCYP6AS160 had reduced total P450 activity of microsomal preparations toward model substrates p-nitroanisole. However, the knockdown of a non-overexpressed P450 gene, CYP4AB73 did not lead to an increase of mortality or a decrease of total P450 activity. The knockdown effects of CYP6AS160 on worker susceptibility to fipronil, combined with our other findings, indicate that CYP6AS160 is responsible for detoxification of fipronil. Feeding insects dsRNA may be a general strategy to trigger RNA interference and may find applications in entomological research and in the control of insect pests in the field.

In this paper, we designed two different configurations with locally isothermal sidewalls, where the temperature is set to be the bulk temperature, to control the large-scale circulation in turbulent Rayleigh–Bénard convection, namely two-point control and four-point control. At fixed Rayleigh number $Ra=10^8$ and Prandtl number $Pr=2$, a series of direct numerical simulations are performed on both two-dimensional (2-D) and quasi-two-dimensional (quasi-2-D) cavities with both types of control, where the width of the control area is fixed at $\delta _c=0.05$ and the vertical distance from the cavity centre $h_c$ varies from 0 to 0.45 with an interval of 0.05. Our results show that the control effect depends on $h_c$, the control configurations as well as the flow dimensions. For 2-D cavities, both two-point control and four-point control suppress the flow reversal when $h_c \geq 0.05$, accompanied by the enhancement of vertical heat transfer and the strength of the large-scale circulation. For quasi-2-D cavities, the suppression of the flow reversals is obvious with two-point control and $h_c\geq 0.05$, while the effect is rather limited with four-point control. Further experiments with $Pr=5.7$ and $Ra$ up to $7.36\times10^8$ show that two-point control with $h_c=0.15$ can effectively suppress the flow reversal, while two-point control with $h_c=0$ can suppress the reversals at low $Ra=1.93\times 10^8$ and activate them at higher $Ra=7.36\times 10^8$, which agrees well with our numerical simulations.

The high overall plant-based diet index (PDI) is considered to protect against type 2 diabetes in the general population. However, whether the PDI affects gestational diabetes mellitus (GDM) risk among pregnant women is still unclear. We evaluated the association between PDI and GDM risk based on a Chinese large prospective cohort – the Tongji Maternal and Child Health Cohort. Dietary data were collected at 13–28 weeks of pregnancy by a validated semi-quantitative FFQ. The PDI was obtained by assigning plant food groups positive scores while assigning animal food groups reverse scores. GDM was diagnosed by a 75 g 2-h oral glucose tolerance test at 24–28 weeks of gestation. Logistic regression models were fitted to estimate OR of GDM, with associated 95 % CI, comparing women in different PDI quartiles. Among the total 2099 participants, 169 (8·1 %) were diagnosed with GDM. The PDI ranged from 21·0 to 52·0 with a median of 36·0 (interquartile range (IQR) 33·0–39·0). After adjusting for social-demographic characteristics and lifestyle factors etc., the participants with the highest quartile of PDI were associated with 57 % reduced odds of GDM compared with women in the lowest quartile of PDI (adjusted OR 0·43; 95 % CI 0·24, 0·77; P for trend = 0·005). An IQR increment in PDI was associated with 29 % decreased odds of GDM (adjusted OR 0·71; 95 % CI 0·56, 0·90). Findings suggest that adopting a plant-based diet during pregnancy could reduce GDM risk among Chinese women, which may be valuable for dietary counselling during pregnancy.

We present a numerical study of the flow states and reversals of the large-scale circulation (LSC) in a two-dimensional circular Rayleigh–Bénard cell. Long-time direct numerical simulations are carried out in the Rayleigh number ($Ra$) range $10^{7} \leqslant Ra \leqslant 10^{8}$ and Prandtl number ($Pr$) range $2.0 \leqslant Pr \leqslant 20.0$. We found that a new, long-lived, chaotic flow state exists, in addition to the commonly observed circulation states (the LSC in the clockwise and counterclockwise directions). The circulation states consist of one primary roll in the middle and two secondary rolls near the top and bottom circular walls. The primary roll becomes stronger and larger, while the two secondary rolls diminish, with increasing $Ra$. Our results suggest that the reversal of the LSC is accompanied by the secondary rolls growing, breaking the primary roll and then connecting to form a new primary roll with reversed direction. We mapped out the phase diagram of the existence of the LSC and the reversal in the $Ra\text{--}Pr$ space, which reveals that the flow is in the circulation states when $Ra$ is large and $Pr$ is small. The reversal of the LSC can only occur in a limited $Pr$ range. The phase diagram can be understood in terms of competition between the thermal and viscous diffusions. We also found that the internal flow states manifested themselves into global properties such as Nusselt and Reynolds numbers.

Power scaling based on traditional ytterbium-doped fibers (YDFs) is limited by optical nonlinear effects and transverse mode instability (TMI) in high-power fiber lasers. Here, we propose a novel long tapered fiber with a constant cladding and tapered core (CCTC) along its axis direction. The tapered-core region of the fiber is designed to enhance the stimulated Raman scattering (SRS) threshold and suppress higher-order mode resonance in the laser cavity. The CCTC YDF was fabricated successfully with a modified chemical vapor deposition (MCVD) method combined with solution doping technology, which has a cladding diameter of 400 μm and a varying core with a diameter of ~24 μm at both ends and ~31 μm in the middle. To test the performance of the CCTC fiber during high-power operation, an all-fiber laser oscillator based on a CCTC YDF was investigated experimentally. As a result, a maximum output power of 3.42 kW was achieved with an optical-to-optical efficiency of 55.2%, although the TMI effect was observed at an output power of ~3.12 kW. The measured beam quality (M2 factor) was ~1.7, and no sign of the Raman component was observed in the spectrum. We believe that CCTC YDF has great potential to simultaneously mitigate the SRS and TMI effects, and further power scaling is promising by optimizing the structure of the YDF.

In passive seismic and microseismic monitoring, identifying and characterizing events in a strong noisy background is a challenging task. Most of the established methods for geophysical inversion are likely to yield many false event detections. The most advanced of these schemes require thousands of computationally demanding forward elastic-wave propagation simulations. Here we train and use an ensemble of Gaussian process surrogate meta-models, or proxy emulators, to accelerate the generation of accurate template seismograms from random microseismic event locations. In the presence of multiple microseismic events occurring at different spatial locations with arbitrary amplitude and origin time, and in the presence of noise, an inference algorithm needs to navigate an objective function or likelihood landscape of highly complex shape, perhaps with multiple modes and narrow curving degeneracies. This is a challenging computational task even for state-of-the-art Bayesian sampling algorithms. In this paper, we propose a novel method for detecting multiple microseismic events in a strong noise background using Bayesian inference, in particular, the Multimodal Nested Sampling (MultiNest) algorithm. The method not only provides the posterior samples for the 5D spatio-temporal-amplitude inference for the real microseismic events, by inverting the seismic traces in multiple surface receivers, but also computes the Bayesian evidence or the marginal likelihood that permits hypothesis testing for discriminating true vs. false event detection.

The celebrated wall-scaling works for many statistical averages in turbulent flows near smooth walls, but the streamwise velocity fluctuation, $u^{\prime }$, is thought to be among the few exceptions. In particular, the near-wall mean-square peak, $\overline {u'u'}^+_p$ – where the superscript $+$ indicates normalization by the friction velocity $u_\tau$, the subscript $p$ indicates the peak value and the overbar indicates time averaging – is known to increase with increasing Reynolds number. The existing explanations suggest a logarithmic growth with respect to $Re$, where $Re$ is the Reynolds number based on $u_\tau$ and the thickness of the wall flow. We show that this boundless growth calls into question the veracity of wall-scaling and so cannot be sustained, and we establish an alternative formula for the peak magnitude that approaches a finite limit $\overline {u'u'}^+_\infty$ owing to the natural constraint of boundedness on the dissipation rate at the wall. This new formula agrees well with the existing data and, in contrast to the logarithmic growth, supports the classical wall-scaling for turbulent intensity at asymptotically high Reynolds numbers.

Na0.5Bi0.5TiO3-based ceramics have been paid great attention as Pb-free piezoelectric and electrical energy storage materials. Here, adding 10 mol% BiFeO3 in Na0.5Bi0.5TiO3–SrTiO3 binary system, 0.5Na0.5Bi0.5TiO3–0.4SrTiO3–0.1BiFeO3 ceramics were prepared by a conventional solid-state reaction method. Dielectric measurements reflected a near-plateau dielectric response at high temperature, e.g., the mid-dielectric permittivity of 2052 with the variation within ±10% from 57 to 371 °C and within ±15% from 54 to 371 °C for the ceramic sintered at 1100 °C. At a moderate electric field of 70 kV/cm, a capacitor made by the ceramic has an electrical energy storage density of 0.95 J/cm3, while the polarization has yet saturated at the moderate electric field. These results suggest that 0.5Na0.5Bi0.5TiO3–0.4SrTiO3–0.1BiFeO3 ceramic is a promising novel material with thermally stable dielectric permittivity and high electrical energy storage property for applications in high-temperature electronics.

In this paper, we show that the numbers of t-stack sortable n-permutations with k − 1 descents satisfy central and local limit theorems for t = 1, 2, n − 1 and n − 2. This result, in particular, gives an affirmative answer to Shapiro's question about the asymptotic normality of the Narayana numbers.

The objective of our study was to investigate the acculturation experiences of Syrian refugee families in two contexts (Toronto, Canada, and Munich, Germany) 2 years postresettlement. Specifically, using qualitative methodologies, we examined acculturation orientation through the lens of parent and child minority and majority language use and preferences within multiple contexts. The interview data related to parent and child minority and majority language practices in Canada suggested an integration orientation. Those of families living in Germany were less indicative of a clear orientation; contextual factors restricted parents’ participation in the majority culture, while the youngest of their children tended toward assimilation. Our study revealed similarities and differences in the acculturation experiences of Syrian refugees in Canada and Germany and unveiled specific factors that influenced acculturation orientation in each country.

While most research focuses on the clinical treatment of COVID-19, fewer studies have investigated individuals' responses towards this novel infectious disease. This study aims to report the temporal changes in individuals' psychological wellbeing, perceived discrimination, sociopolitical perceptions and information-seeking behaviours among the general public in Hubei, China. Data were obtained from a two-wave survey of 1902 respondents aged 18–80 in Hubei province during the peak and mitigation stages of the outbreak. The results showed that the prevalence of psychological distress dropped from over 75% to around 15% throughout the study period, but perceived discrimination remained stable. Female, middle-aged, well-educated respondents and those employed in government/public institutions/state-owned enterprises tended to report more distress. While respondents' attention on COVID-19 information kept high and stable, their sources of information diversified across different sociodemographic groups. Over time, people obtained more social support from neighbourhoods than from their friends and relatives or non-government organisations. Over 80% of respondents were satisfied with the performance of the central government, which was notably higher than their ratings on the local government and neighbourhood/village committees. The findings of this research are informative for formulating effective intervention strategies to tackle various psychosocial problems during COVID-19.

Drawing on an ethnographic study in two counties in Hunan province, this article explores how political brokerage has contributed to political order in China by facilitating contentious and non-contentious bargaining between the government and ordinary people. To account for the changing role of village leaders in rural politics, the article develops a concept of dual brokerage. This concept not only recognizes formal and informal linkages between village leaders and the two principals – the government and the community of villagers – but also underscores the interactivity between the linkages. We contend that despite the tensions between village leaders’ roles as state agents and as village representatives, these two roles in the reform era tend to be mutually beneficial. Under such an institutional configuration, village leaders in China in the reform era have strong incentives to act as dual agents and can make policy implementation more flexible and the use of state force more moderate. A comparison between the trilateral interactions before and after the tax reform in 2005 confirms that whether village leaders can effectively act as dual agents has a significant impact on the quality of rural governance in China.

We report an approach to expand the effective number of pixels available to small, two-dimensional electron detectors. To do so, we acquire subsections of a diffraction pattern that are then accurately stitched together in post-processing. Using an electron microscopy pixel array detector (EMPAD) that has only 128 × 128 pixels, we show that the field of view can be expanded while achieving high reciprocal-space sampling. Further, we highlight the need to properly account for the detector position (rotation) and the non-orthonormal diffraction shift axes to achieve an accurate reconstruction. Applying the method, we provide examples of spot and convergent beam diffraction patterns acquired with a pixelated detector.