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Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40–49 years without CVD during 2002–2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.
Norms for cognitive measures used to assess dementia are scant for
minority groups, in particular for older Japanese Americans. Using the
Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
Neuropsychology Battery, we compared the baseline performance of demented
and nondemented Japanese Americans. Participants came from two harmonized
epidemiological studies of dementia which were examined separately: the
Kame Project, Seattle (350 men and women; 201 nondemented), age 65 and
older; Honolulu-Asia Aging Study (HAAS), Hawaii (418 men; 120
nondemented), age 71 and older. The measures examined were Verbal Fluency;
abbreviated Boston Naming; constructional praxis; and Word List Learning,
Recall, and Recognition. Within each study, the CERAD measures
distinguished between nondemented participants and those with mild
cognitive impairment. Among persons with dementia, average level of
performance decreased as severity of dementia increased. Determinants of
score (age, education, language of administration, stage of dementia)
varied between the two studies. Among Japanese Americans, the CERAD
Neuropsychology Battery distinguished nondemented persons from those with
dementia, but was less consistent in distinguishing levels of severity of
dementia. This battery is useful for comparative epidemiological studies
of dementia in minority populations. (JINS, 2005, 11,
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