Experiments were conducted during 1999, 2002, and 2003 to evaluate sicklepod control by 2,4-DB applied alone or in mixture with selected fungicides and insecticides registered for use in peanut. The fungicides boscalid, chlorothalonil, fluazinam, propiconazole plus trifloxystrobin, pyraclostrobin, or tebuconazole and the insecticides acephate, carbaryl, esfenvalerate, fenpropathrin, lambda-cyhalothrin, methomyl, or indoxacarb applied in mixtures with 2,4-DB did not reduce sicklepod control by 2,4-DB compared with 2,4-DB alone. The fungicide azoxystrobin reduced control in some but not all experiments. Sicklepod control was highest when 2,4-DB was applied before flowering regardless of fungicide treatment. Seed production and germination were reduced when 2,4-DB was applied 81 to 85 d after emergence when sicklepod was flowering. Applying 2,4-DB before flowering and at pod set and pod fill did not affect seed production.