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22 results

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  • Pilot Study of Postexposure Prophylaxis for Hepatitis C Virus in Healthcare Workers

  • Kathleen E. Corey, Julie C. Servoss, Deborah R. Casson, Arthur Y. Kim, Gregory K. Robbins, Jean Franzini, Katherine Twitchell, Susan C. Loomis, Diane R. Abraczinskas, Adam M. Terella, Jules L. Dienstag, Raymond T. Chung
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 30 / Issue 10 / October 2009
    Published online by Cambridge University Press:
    02 January 2015, pp. 1000-1005
    Print publication:
    October 2009
  • Background and Objective.

    Hepatitis C virus (HCV) transmission occurs in 0.2%-10% of people after accidental needlestick exposures. However, postexposure prophylaxis is not currently recommended. We sought to determine the safety, tolerability, and acceptance of postexposure prophylaxis with peginterferon alfa-2b in healthcare workers (HCWs) exposed to blood from HCV-infected patients.

    Design.

    Open-label pilot trial of peginterferon alfa-2b for HCV postexposure prophylaxis.

    Setting.

    TWO academic tertiary-referral centers.

    Methods.

    HCWs exposed to blood from HCV-infected patients were informed of the availability of postexposure prophylaxis. Persons who elected postexposure prophylaxis were given weekly doses of peginterferon alfa-2b for 4 weeks.

    Results.

    Among 2,702 HCWs identified with potential exposures to bloodborne pathogens, 213 (7.9%) were exposed to an HCV antibody-positive source. Of 51 HCWs who enrolled in the study, 44 (86%) elected to undergo postexposure prophylaxis (treated group). Seven subjects elected not to undergo postexposure prophylaxis (untreated group). No cases of HCV transmission were observed in either the treated or untreated group, and no cases occurred in the remaining 162 HCWs who did not enroll in this study. No serious adverse events related to a peginterferon alfa-2b regimen were recorded, but minor adverse events were frequent.

    Conclusion.

    In this pilot study, there was a lower than expected frequency of HCV transmission after accidental occupational exposure. Although peginterferon alfa-2b was safe, because of the lack of HCV transmission in either the treated or untreated groups there is little evidence to support routine postexposure prophylaxis against HCV in HCWs.

  • Bolshevik Administration in the Ukraine—1918

  • Arthur E. Adams
  • Journal:
    The Review of Politics / Volume 20 / Issue 3 / July 1958
    Published online by Cambridge University Press:
    05 August 2009, pp. 289-306

  • Through 1918 Russia's new Bolshevik rulers, amateurs at the business of governing, were exposed to bureaucratic lessons much faster than they could assimilate them. Administrative techniques and organizational models essential for the direction of an empire had to be hurriedly invented or borrowed and rushed into operation; numerous special arrangements had to be devised for those areas where military crises or nationalist and separatist movements demanded immediate attention. During the process of simultaneously ruling and learning, the Moscow center sometimes received sharp lessons from the peripheries of the empire. Leading figures of the Russian Communist Party were often compelled by circumstances and by the hot tempers and loud voices of their colleagues out in the hustings to listen and learn and adapt themselves to the pressures of facts as others saw them. Passionate theoretical debates gave way to quarrels about the most expedient, most efficient method of getting the work accomplished; and the reciprocal adjustments resulting from this conflict between the center and the men working in the peripheral areas established patterns of thought and habits of action that were to become permanent features of the Soviet administrative system.

  • An analysis of seed development in Pisum sativum. XV. The influence of seed size on protein content

  • A. E. Arthur, H. Adams, K. Strouts, D. A. Jones, T. L. Wang, C. L. Hedley
  • Journal:
    Seed Science Research / Volume 1 / Issue 4 / December 1991
    Published online by Cambridge University Press:
    19 September 2008, pp. 203-208

  • The variation for protein content has been assessed in a series of pea (Pisum sativum L.) lines differing in mean seed size. The range of seed size within each genotype was manipulated by growing the plants in different environments and by altering the structure of the plant. The response of the lines in terms of seed weight to the environments and treatments was inconsistent, but 90% of the total variation was accounted for by differences between genotypes. In contrast, for percentage protein, the genetic component was much weaker with nearly half the variation being accounted for by within (residual) variation. The correlations between seed weight and percentage protein were highly genotype specific. For the largerseeded genotype, percentage protein increased with increasing seed size (r= +0.9, P < 0.01), while for the small-seeded genotype there was mid-range negative value (r = −0.5, P <0.01). It is suggested that any assessment of percentage protein in pea genotypes must take account of seed size.

  • [no title]

  • Arthur E. Adams
  • Journal:
    Slavic Review / Volume 22 / Issue 3 / September 1963
    Published online by Cambridge University Press:
    27 January 2017, pp. 615-616
    Print publication:
    September 1963
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