OBJECTIVES/GOALS: Early diagnosis of congenital sensorineural hearing loss (SNHL) is of paramount importance in preventing speech and language impairment.Diffusion tensor imaging (DTI) MRI can identify brain microstructural changes that may potentially contribute towards prognosticating rehabilitation. METHODS/STUDY POPULATION: We retrospectively reviewed pediatric patients with SNHL who obtained DTI MRI between 2011 and 2019, identifying 16 pediatric patients (age <18 years) with at least moderate asymmetric/bilateral SNHL., and gender-matched controlswithout neurological, developmental, or MRI-based brain macrostructural abnormalities. The following brainstem regions and tracts of the auditory pathway were assessed: superior olivary nucleus (SON), inferior colliculus (IC), ipsilateral tracts between the inferior colliculus and superior olivary nucleus (IC-SON). Diffusion values for bilateral regions and tracts were generated, then averaged to calculate a mean value for fractional anisotropy (FA) and mean diffusivity (MD) for each subject. RESULTS/ANTICIPATED RESULTS: Significant differences were identified in FA values of the SON between the SNHL cohort and controls (0.377±0.056 vs 0.422±0.052; p=0.009). No other FA or MD values were significantly different. In children £5 years, MD was significantly decreased in the SNHL cohort compared to controls in the IC (0.918±0.051 vs 1.120±0.142; p<0.001). In children >5 years, there were no significant differences in MD (1.124±0.198 vs 0.997±0.103; p = 0.119). There were no significant differences in MD or FA in the white matter fibers of the IC-SON tract [applewebdata%3A//720AAF0C-C4CF-459C-A42A-6BAA56C4E4CA#_msocom_2]. DISCUSSION/SIGNIFICANCE: This is the first study to assess microstructural changes in brainstem auditory pathway regions among children with SNHL. Longitudinal studies are warranted to assess the predictive value of DTI imaging for long-term outcomes and prognosticating intervention.

OBJECTIVES/GOALS: Diffusion MRI can identify microstructural brain changes and can provide insight into neural development and to potentially prognosticate speech and language outcomes in children with SNHL. The goal of our study was to investigate MRI-based microstructural changes along the brainstem regions of the auditory pathway in pediatric patients with SNHL. METHODS/STUDY POPULATION: We reviewed cohort of pediatric patients with SNHL who obtained MRI at 3T between 2011 and 2019. We identified 16 pediatric patients (age RESULTS/ANTICIPATED RESULTS: We identified significant differences in FA values of the SON between the SNHL cohort and controls (0.377 ± 0.056 vs 0.422 ± 0.052; p=0.009). No other FA or MD values were significantly different between the two groups. Among younger children (ï‚£5 years), MD was significantly decreased in the SNHL cohort compared to controls in the IC (0.918 ± 0.051 vs 1.120 ± 0.142; p5 years), there were no significant differences in MD (1.124 ± 0.198 vs 0.997 ± 0.103; p = 0.119). There were no significant differences in MD or FA in the white matter fibers of the IC-SON tract. DISCUSSION/SIGNIFICANCE: This study is the first to assess microstructural changes in brainstem auditory pathway regions among children with SNHL. Longitudinal studies are warranted to assess the predictive value of these MRI-based findings for long-term outcomes and the efficacy of intervention.

The Very High Frequency (VHF) Data Exchange System (VDES) is a new radio communication system being developed by the international maritime community, with the principal objectives to safeguard existing Automatic Identification System (AIS) core functions and enhance maritime communication applications, based on robust, efficient and secure data transmission with wider bandwidth than the AIS. VDES is also being considered as a potential component of the R-mode concept, where the same signals used for communication are also used for ranging, thus mitigating the impact of disruptions to satellite positioning services. This paper establishes statistical performance bounds on the ranging precision of VDES R-mode, assuming an additive white Gaussian noise propagation channel. Modified Cramér-Rao bounds on the pseudorange estimation error are provided for all waveforms currently proposed for use in terrestrial VDES communications. These are then used to estimate the maximum usable ranges for AIS/VDES R-mode stations. The results show that, under the assumed channel conditions, all of the new VDES waveforms provide better ranging performance than the AIS waveform, with the best performance being achieved using the 100 kHz bandwidth terrestrial VDE waveforms.

Integrated pest management (IPM) initially focused on insect pest control. More recently, IPM encompasses a broader concept of management, one which crosses several disciplinary boundaries. This article reports results of research dealing with four integrated management decisions for alfalfa (cultivar selection, inset control, weed control, and end-of-season harvest options).

We have begun a series of laboratory experiments focused on understanding how coronal mass ejections (CME) interact and evolve in the solar wind. The experiments make use of the Helicon-Cathode (HelCat) plasma facility, and the Plasma Bubble eXperiment (PBeX). PBeX can generate CME-like structures (sphereomak geometry) that propagate into the high-density, magnetized background plasma of the HelCat device. The goal of the current research is to compare CME evolution under conditions where there is sheared flow in the background plasma, versus without flow; observations suggest that CME evolution is strongly influenced by such sheared flow regions. Results of these studies will be used to validate numerical simulations of CME evolution, in particular the 3D BATS-R-US MHD code of the University of Michigan. Initial studies have characterized the plasma bubble as it evolves into the background field with and without plasma (no shear).

The purpose of the present research was to examine the perceptions of risk regarding falling held by older adults and their adult children. Using a focused ethnographic approach, older adults and adult children were interviewed in depth. Thematic analysis was conducted to identify themes within groups and to compare the perspectives of older adults and adult children. Findings highlighted differences in perceptions and approaches to action between older adults and their adult children. There were three approaches to action adopted by these families, which focused around whose actions were dominant: parents' actions, shared actions, and children's secret actions. The results emphasize the value placed on independence by older adults and the impact of multiple family relations taking action to prevent falls. The present study points to the importance of including multiple family perspectives in research concerning injury prevention for older adults.

Versions of this paper were first presented at the Royal Institute of Navigation GNSS Vulnerabilities and Solutions Conference held at Baska, Croatia in September 2008 and the Royal Institute of Navigation NAV 08 Conference held at Church House, Westminster, London in October 2008.

The US Global Positioning System (GPS) is currently the primary source of Position, Navigation and Timing (PNT) information in maritime applications, whether stand-alone or augmented with additional systems. This situation will continue in the future with GPS, possibly together with other Global Navigation Satellite Systems (GNSS) e.g. Galileo, being the core PNT technology for e-Navigation – the future digital maritime architecture. GPS signals, measured at the surface on the Earth, are very weak. As such, the system is vulnerable to unintentional interference and jamming, resulting in possible denial of service over large geographical areas. The result of such interference could be the complete failure of the mariner's GPS receiver or, possibly worse, the presentation to the mariner of hazardously misleading information (HMI) for navigation and situational awareness, depending on how the GPS receiver reacts to the jamming incident. Recognising this, the General Lighthouse Authorities of the United Kingdom and Ireland (GLA), in collaboration with the UK Ministry of Defence (MOD) Defence Science and Technology Laboratory (DSTL), have conducted a series of sea-trials with the aim of identifying the full effects of GPS jamming on safe navigation at sea.

This paper presents the key findings of these trials and provides important information on the effect of GPS denial. The GLA are playing a pivotal role in the establishment of eLoran as an independent source of PNT, taking advantage of eLoran's complementary nature, having dissimilar failure modes to GPS and the future GNSS. This paper provides information on the performance of an eLoran receiver in an area of GPS service denial. The paper presents the rationale for the work, details the system architecture employed, the data gathering efforts and finally the data analysis procedures, results and conclusions.

This paper examines a town in northwest England and a particular set of conditions that inhibited the growth of working-class politics during the twentieth century. The paradox of class politics in Lancaster is that despite a proletarian population, the labour movement locally remained extremely weak. Ironically, it was only upon the deindustrialisation of the town in the later 1960s that labour showed any collective strength. Explanation of quiescence in terms of paternalism and deference is rejected. Rather an account is given in terms of powerlessness. Local structural conditions rendered Lancaster workers so highly dependent that resistance to political domination was precluded.

The maritime radiobeacon differential GNSS service in Europe has recently been reorganised with the aim of having at least two of the 162 stations serve each critical coastal location. Maritime administrations have now set specifications for the availability and continuity of the service. The paper analyses these requirements, noting incompatibilities between them. It proposes a method of predicting the performance of beacons, employing IALA standards. This takes into account each beacon's own availability, and propagation factors that include groundwave signal attenuation, interference, and skywave fading at night. Availability, continuity and coverage maps produced by the new programs are presented in the paper.

This Note uses the British Household Panel Study (BHPS) to consider the changing volume and distribution of voluntary association membership (and hence social capital) in Great Britain. We aim to supplement Hall's study of trends in social capital published in this Journal with more recent and longitudinal data. This allows us to show that whilst the volume of social capital is not declining, it is becoming increasingly class specific, and that its relative aggregate stability masks considerable turnover at the individual level. These findings are significant for current debates on social capital.

Objectives: Calculations of healthcare costs rarely disclose the specific approach used to allocate the cost of hospitalizations by diagnosis. However, the type of approach used can have a major impact on the findings in the case of significant comorbidities. The present analyses compared three approaches for attributing Medicare DRG reimbursements (which were used as surrogates for average costs) for hospitalization by diagnosis.

Methods: Medical resource utilization data from the National Hospital Discharge Survey were analyzed using each of three allocation approaches: a) attributing 100% of the cost of hospitalization to the disease when it was the first-listed diagnosis; b) attributing a portion of the cost of hospitalization to the disease, depending on its position in the list of diagnoses and the relevance of any comorbidities; and c) an incremental analysis of cost based upon the hospitalization experiences of an age and gender matched cohort. These three approaches were applied to the cost of hospitalization for chronic obstructive pulmonary disease (COPD).

Results: The first approach projected 206,098 hospitalizations at $3,449 per hospitalization for a projected U.S. annual total of $711 million. The second approach projected 681,547 hospitalizations at $3,205 per hospitalization for a projected U.S. annual total of $2.2 billion. The third approach also projected 681,547 hospitalizations, but at $2,361 per hospitalization, for a projected U.S. annual total of $1.6 billion.

Conclusions: Expanding from the example on COPD, the limitations of each approach are described and their applications to other conditions are presented.