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Exploitative mining in the deep seas is coming, and with it will arrive a new wave of international disputes. Numerous stakeholders will be interested in these disputes, such as those seeking to profit from exploitative mining activity; developing states seeking to benefit from equitable sharing of wealth and lessons learned; and environmentalists all over the world worried about environmental catastrophes that could result from such activity. Stakeholders include the mining contractor, the sponsoring state of the contractor, the International Seabed Authority (ISA) created by the UN Convention on the Law of the Sea (UNCLOS) to control mining activity in the deep seas, states (both states parties to UNCLOS and those that are not) and affected communities, which includes Indigenous peoples and climate activists. However, the dispute settlement system of UNCLOS treats these different stakeholders unequally in terms of whether they may be parties to a dispute proceeding and, if so, what claims they may bring. Unsurprisingly, the system excludes non-states parties and non-state entities (apart from the International Seabed Authority and the contractor), such as Indigenous peoples and climate activists, from serving as parties (claimant or respondent) to a dispute. This essay explores the limited ways in which excluded stakeholders nonetheless may be able to participate in a dispute initiated under UNCLOS. Specifically, they may serve as witnesses, experts, or amicus curiae in proceedings before the International Tribunal for the Law of the Sea (ITLOS), the Seabed Disputes Chamber, or a commercial arbitral tribunal. This essay also advocates for the ISA to establish administrative processes for ongoing monitoring and whistleblower complaints. Such processes would allow excluded stakeholders to submit relevant evidence and information that could—and should—be used in any formal dispute settlement processes initiated by those stakeholders who enjoy direct participatory rights.
Cetyltrimethylammonium- and tetradecyltrimethylammonium-intercalated magadiites were prepared by direct syntheses, starting from sodium metasilicate (Na2O/SiO2 = 1.0) and nitric acid. Total substitution of sodium by cetyltrimethylammonium or tetradecyltrimethylammonium cations was not achieved in the range of surfactant: silicon molar ratios used in this study. When a phosphoniun-based surfactant replaces the ammonium surfactants in the same procedure, the result of the synthesis is a mixture of quartz and unmodified surfactant. If dodecylammonium bromide is used, an MCM-41 molecular sieve is obtained. The substitution of the silicon source by tetramethylammonium silicate or of nitric acid by hydrochloric, hydrofluoric, or acetic acids also yields MCM-41 molecular sieves, indicating that the formation of magadiite is greatly dependent on the presence of sodium cations and nitrate anions.
Despite associations between hypoglycemia and cognitive performance using cross-sectional and experimental methods (e.g., Insulin clamp studies), few studies have evaluated this relationship in a naturalistic setting. This pilot study utilizes an EMA study design in adults with T1D to examine the impact of hypoglycemia and hyperglycemia, measured using CGM, on cognitive performance, measured via ambulatory assessment.
Participants and Methods:
Twenty adults with T1D (mean age 38.9 years, range 26-67; 55% female; 55% bachelor’s degree or higher; mean HbA1c = 8.3%, range 5.4% - 12.5%), were recruited from the Joslin Diabetes Center at SUNY Upstate Medical University. A blinded Dexcom G6 CGM was worn during everyday activities while completing 3-6 daily EMAs using personal smartphones. EMAs were delivered between 9 am and 9 pm, for 15 days. EMAs included 3 brief cognitive tests developed by testmybrain.org and validated for brief mobile administration (Gradual Onset CPT d-prime, Digit Symbol Matching median reaction time, Multiple Object Tracking percent accuracy) and self-reported momentary negative affect. Day-level average scores were calculated for the cognitive and negative affect measures. Hypoglycemia and hyperglycemia were defined as the percentage of time spent with a sensor glucose value <70 mg/dL or > 180 mg/dL, respectively. Daytime (8 am to 9 pm) and nighttime (9 pm to 8 am) glycemic excursions were calculated separately. Multilevel models estimated the between- and within-person association between the night prior to, or the same day, time spent in hypoglycemia or hyperglycemia and cognitive performance (each cognitive test was modeled separately). To evaluate the effect of between-person differences, person-level variables were calculated as the mean across the study and grand-mean centered. To evaluate the effect of within-person fluctuations, day-level variables were calculated as deviations from these person-level means.
Results:
Within-person fluctuations in nighttime hypoglycemia were associated with daytime processing speed. Specifically, participants who spent a higher percentage of time in hypoglycemia than their average percentage the night prior to assessment performed slower than their average performance on the processing speed test (Digit Symbol Matching median reaction time, b = 94.16, p = 0.042), while same day variation in hypoglycemia was not associated with variation in Digit Symbol Matching performance. This association remained significant (b = 97.46, p = 0.037) after controlling for within-person and between-person effects of negative affect. There were no significant within-person associations between time spent in hyperglycemia and Digit Symbol Matching, nor day/night hypoglycemia or hyperglycemia and Gradual Onset CPT or Multiple Object Tracking.
Conclusions:
Our findings from this EMA study suggest that when individuals with T1D experience more time in hypoglycemia at night (compared to their average), they have slower processing speed the following day, while same day hypoglycemia and hyperglycemia does not similarly impact processing speed performance. These results showcase the power of intensive longitudinal designs using ambulatory cognitive assessment to uncover novel determinants of cognitive variation in real world settings that have direct clinical applications for optimizing cognitive performance. Future research with larger samples is needed to replicate these findings.
The circular economy (CE) aims at the cycling of resources through restorative and regenerative strategies. To achieve circularity, coordination of several actors is necessary. The interaction among actors allows the connection between the CE and ecosystem research fields. Although fundamental, the relationships, mainly cooperation, among actors within an ecosystem to foster circularity is not deeply explored in the literature. The objective of this study was to identify the possibilities of cooperation within circular ecosystems, in particular, the motivations that make the actors interact to achieve a CE. A systematic literature review (SLR) and a case study of a Brazilian ecosystem specialized in the recycling of carton packages to manufacture ecological tiles were conducted. The goal was to identify the motivations through the SLR and the case study so the theoretical and the empirical results could be compared. As a result, 28 motivations for actors to engage in ecosystems driven by circularity were identified. In order to achieve a complete and circular solution, actors must be able to clearly understand their roles and relationships so that they can establish new partnerships or reframe those already established.
Aiming to decouple value creation from resource consumption, the Circular Economy is considered an alternative to the current linear model of production and consumption. Among the innovative circular business models, Product-Service Systems (PSS) have been recognized as a possible route to achieve enhanced sustainability performance through the extension of product lifespans and the reduction of product substitution. However, PSS may lead to rebound effects due to less careful behavior during the use phase, which compromises product durability. Currently, the effect of non-ownership models on product care is not yet fully understood, nor are the strategies that could enable better product care. This research aims to deeper comprehend the consumer-product relationships in PSS solutions, as well as to shed light on the potential role of emotional durability in PSS development for product attachment. In order to do so, this paper analyses twelve Product-Service System cases derived from a systematic literature review, categorizing the emotional attachment strategies in each case, and identifying how these strategies might hinder or potentialize PSS solutions.
Circular ecosystem is a growing research field that is gaining attention due to representing a more robust alignment structure than a single firm. However, prior research lacks empirical evidence on how circular ecosystems are structured and how orchestrators coordinate a set of actors towards a coherent circular value proposition. By studying nine organizations related to the carton packaging recycling ecosystem, we reveal the complexity of recovering and co-creating value in a systemic network with actors competing and collaborating simultaneously. Based on that, we propose a framework for orchestrating circular ecosystems. Our results indicate that orchestrators should integrate strategic actors, invest in infrastructure, and innovate in product design. We also discuss ecosystem resilience during and after the covid 19 pandemic, showing how the orchestrator was fundamental to the sustainability of the ecosystem. Overall, this paper contributes to increasing the understanding of inter-organizational relationships towards the circularity of resources.
Assisted conception is associated with a higher risk of multiple pregnancy than natural conception. Both ovulation induction and IVF are associated with a higher risk of multiple pregnancies, but the latter contributes to most of the multiple pregnancies following assisted conception treatment. The adverse obstetric and perinatal outcomes of multiple gestations are amplified if the pregnancy was conceived after infertility treatment. The risk of multiple pregnancy after ovulation induction (with or without intrauterine insemination) appears to be linked to the number of follicles recruited whilst the risk after IVF is related to the number of embryos transferred. Aiming for uni-follicular recruitment reduces the risk of multiple pregnancy following ovulation induction and performing a single embryo transfer in IVF cycles reduces the risk of dizygotic twinning. Some of the laboratory techniques used in IVF such as culture to the blastocyst stage and pre-implantation genetic testing elevate the risk of monozygotic twinning.
A substantial increase in wind energy deployment worldwide is required to help achieve international targets for decreasing global carbon emissions and limiting the impacts of climate change. In response to global concerns regarding the environmental effects of wind energy, the International Energy Agency Wind Technical Collaborative Program initiated Task 34 – Working Together to Resolve Environmental Effects of Wind Energy or WREN. As part of WREN, this study performed an international assessment with the global wind energy and environmental community to determine priority environmental issues over the next 5‒10 years and help support collaborative interactions among researchers, developers, regulators, and stakeholders.
Technical summary
A systematic assessment was performed using feedback from the international community to identify priority environmental issues for land-based and offshore wind energy development. Given the global nature of wind energy development, feedback was of interest from all countries where such development is underway or planned to help meet United Nations Intergovernmental Panel on Climate Change targets. The assessment prioritized environmental issues over the next 5–10 years associated with wind energy development and received a total of 294 responses from 28 countries. For land-based wind, the highest-ranked issues included turbine collision risk for volant species (birds and bats), cumulative effects on species and ecosystems, and indirect effects such as avoidance and displacement. For offshore wind, the highest-ranked issues included cumulative effects, turbine collision risk, underwater noise (e.g. marine mammals and fish), and displacement. Emerging considerations for these priorities include potential application to future technologies (e.g. larger turbines and floating turbines), new stressors and species in frontier regions, and cumulative effects for multiple projects at a regional scale. For both land-based and offshore wind, effectiveness of minimization measures (e.g. detection and deterrence technologies) and costs for monitoring, minimization, and mitigation were identified as overarching challenges.
Social media summary
Turbine collisions and cumulative effects among the international environmental priorities for wind energy development.
In the present study, we aimed to describe the composition of endoparasites associated with anurans from an altitudinal rainforest enclave in northeastern Brazil. Additionally, we tested if microhabitat use influences endoparasite abundance and richness, as well as the hypothesis that larger frogs tend to be more parasitized. We sampled 306 individuals from 25 anuran species that were necropsied and analysed using a stereomicroscope. The total endoparasite prevalence was 79.08%, with a parasitic community consisting of 46 taxa. Overall, we found the common pattern described for Neotropical amphibians, which is the predominance of generalist and direct-cycle parasites. Twenty new host records and two possible new parasite species were found, highlighting the importance of this type of inventory. We also observed that microhabitat use was associated with a significant difference in parasite richness between groups, in which arboreal and terrestrial species, and aquatic and arboreal species contributed to these differences. Moreover, larger frogs tended to be more parasitized regarding only an interspecific view. Our results suggest that parasite richness is directly related to infection cycle and how the host exploits its habitat.
Dehydroepiandrosterone (DHEA) is produced primarily from the adrenal gland (85%) under the influence of adrenocorticotropic hormone (ACTH) and to a lesser extent by the ovaries. DHEA is an intermediate in the sex steroid pathway and is converted to testosterone and estradiol within the ovaries. The anti-ageing properties of DHEA were first described in 1996, together with the decline in DHEA with advancing age. In reproductive medicine, DHEA has been hypothesised to play a role in improving folliculogenesis through multiple mechanisms. The first report of a possible benefit from DHEA in an IVF setting was in a case report published in 2005. A 42-year-old woman with an initial diagnosis of reduced ovarian reserve and who had one oocyte retrieved in her first IVF cycle self-medicated concomitantly with over-the-counter DHEA supplements and acupuncture. Her oocyte yield was noted to be steadily increasing with each ovarian stimulation, with 17 oocytes being retrieved after her ninth stimulation attempt.
The interest in the Circular Economy (CE) has grown in recent years. Digital technologies (DTs) have demonstrated a potential synergy to achieve circular goals at the micro, meso, and macro-level. Although several studies in literature explore DTs and CE linkage, they have not been identified according to their primary research themes. This paper aims to identify the main research streams addressing CE and DTs. From a Systematic Literature Review and Content Analysis, we reviewed 40 articles and classified three primary research streams. (1) Industry 4.0 (I4.0) focuses on the relevance and role of I4.0 in the transition to a CE. (2) The Business research stream evaluated the connection between digital transformation and business. (3) The Sustainability research stream discusses sustainability issues such as waste management and smart cities. Based on the analyzed studies' purposes and gaps, we provide a research agenda for further research. Additionally, we explain the implications of DTs and CE to research on engineering design. Our paper guides researchers in their future research to focus on gaps that have not been answered and position their studies according to their research streams.
Enteric illness outbreaks are complex events, therefore, outbreak investigators use many different hypothesis generation methods depending on the situation. This scoping review was conducted to describe methods used to generate a hypothesis during enteric illness outbreak investigations. The search included five databases and grey literature for articles published between 1 January 2000 and 2 May 2015. Relevance screening and article characterisation were conducted by two independent reviewers using pretested forms. There were 903 outbreaks that described hypothesis generation methods and 33 papers which focused on the evaluation of hypothesis generation methods. Common hypothesis generation methods described are analytic studies (64.8%), descriptive epidemiology (33.7%), food or environmental sampling (32.8%) and facility inspections (27.9%). The least common methods included the use of a single interviewer (0.4%) and investigation of outliers (0.4%). Most studies reported using two or more methods to generate hypotheses (81.2%), with 29.2% of studies reporting using four or more. The use of multiple different hypothesis generation methods both within and between outbreaks highlights the complexity of enteric illness outbreak investigations. Future research should examine the effectiveness of each method and the contexts for which each is most effective in efficiently leading to source identification.
Little study has been done on the adoption of End-of-Life (EoL) strategies on the medical devices industry, despite the reasons why it is an important area of study for the implementation of circularity. The rates of waste in the medical field are alarming and tend to grow. Though presenting a wide potential for EoL strategies implementation, the medical field is also inherently challenging, considering the rigid regulations and product's risk to patients life. This paper analyses 17 Product-Service System case studies identified in the literature. Eleven of them are from various fields of industry, whereas the other six are applied to the medical devices industry. The adoption of EoL strategies - namely repair, reconditioning, remanufacture and recycling - is analysed in each case and compared for the two categories of cases. This adoption is related to the sources of value creation in Circular Economy, to the PSS typology and, at last, special EoL treatment for medical devices is discussed.
Requirements elicitation for assistive technology (AT) product development must be collaborative and systemic. This process must ensure that the needs of all different users are identified. For this, UCD methods introduce different tools that seek user involvement and their needs identification. One method commonly used in software development is User Stories. The aim of this paper is to analyse the use of User Stories for requirements elicitation in an AT product development project. This method was applied with three types of users: patients, companions and occupational therapists. For the involvement of these users, the method was customized and two main adaptations were adopted: the stories were written by the development team and all user needs were identified through observations of interactions between patients and prototype. As a result, the development team was able to identify numerous product requirements to be used in later development phases. These requirements were generated by the user needs identified with User Stories. Thus, the method with necessary adaptations, was efficient for requirements elicitation in the AT product development process.
What explains the remarkable resilience of pension regulation in postauthoritarian Chile, even after decades of majoritarian voter discontent and growing international and domestic criticism of Pinochet’s pioneering private capitalization system? This puzzling outcome can be understood only by looking at the combined effect of the pension industry’s long-term power-building investments and its short-term political actions to outmaneuver state and societal challengers. Engaging new theoretical developments in political economy and historical institutionalism, this study examines the long-term process by which the previously nonexistent Chilean pension industry expanded and leveraged its power during key episodes of open contestation. The analysis of pension regulation in Chile between the 1980s and the 2010s illustrates the importance of placing business power in time, motivating new rounds of theory building in the quest to address the perennial question of how business gets what it wants in the political arena.
Urbanisation and climate change are altering the pattern of California serogroup viruses in North America. As La Crosse virus (LACV) is the most pathogenic of the California serogroup, it is important to identify changes in distribution, transmission and pathogenesis. A scoping review (ScR) was prioritised to summarise the global evidence on LACV. A comprehensive search strategy was used, identified references were screened for relevance and relevant articles were characterised. Each step was conducted by two independent reviewers using pre-tested forms. Analysis identified areas of research saturation and gaps. The ScR included 481 research articles that were mostly journal articles (78.2%) conducted in North America (90.9%) from 1969 to 2016. Most evidence focused on epidemiology (44.9%), virus characteristics (25.8%), transmission conditions (18.7%) and pathogenesis of LACV in hosts (18.3%). Fewer studies evaluated the accuracy of diagnostic tests (8.7%), the efficacy of treatments (3.5%), prevention and control strategies (3.1%), the economic burden of infection (0.6%) and social impact (0.2%) of LACV. None of the literature predicted the impact of climate change on LACV, nor were any cases reported in Canada. These findings are intended to guide research to close knowledge gaps and inform evidence-based decisions surrounding activities for the prevention and control of LACV.
We surveyed the nematode assemblages associated with populations of the parthenogenetic whiptail lizard Ameivula nativo from six coastal restinga areas in eastern Brazil: Setiba, Comboios and Guriri (State of Espirito Santo) and Guaratiba, Prado and Maraú (State of Bahia). A total of five nematode species (Physaloptera retusa, Physalopteroides venancioi, Skrjabinelazia intermedia, Subulura lacertilia and Parapharyngodon sp.) were recorded from the six different populations of A. nativo. There was considerable variation in overall prevalence of infection (1–42%) among study sites, but geographical distance among areas did not influence similarity in the composition of nematode assemblages. Overall intensity of infection was not affected by lizard body size and did not seem to affect host body condition, based on pooled data of all populations. The studied populations of the unisexual A. nativo had relatively low prevalences and intensities of infection compared to some bisexual congeners and to sympatric lizards from other families for which such data are available. We believe that the low richness of the nematode fauna associated with A. nativo, both locally and regionally, may reflect its narrow geographic distribution and the low diversity of habitats it occupies.