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Chapter 14 - Management of ovarian and endometrial cancer in older adults

from Part 2 - Management of solid tumors in older adults

Published online by Cambridge University Press:  05 August 2011

By
William P. Tew  and
Vivian von Gruenigen
Edited by
Arti Hurria  and
Harvey Jay Cohen
Arti Hurria
Affiliation:
City of Hope Cancer Center, California
Harvey Jay Cohen
Affiliation:
Duke University Medical Center, Durham
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Information
Practical Geriatric Oncology , pp. 201 - 218
Publisher: Cambridge University Press
Print publication year: 2010

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References

Edwards, BK, Howe, HL, Ries, . Annual report to the nation on the status of cancer, 1973–1999, featuring implications of age and aging on U.S. cancer burden. Cancer. 2002;94:2766–2792.CrossRefGoogle ScholarPubMed
Yancik, R, Ries, . Cancer in older persons: an international issue in an aging world. Semin Oncol. 2004;31:128–136.CrossRefGoogle Scholar
Thigpen, T, Brady, MF, Omura, GA. Age as a prognostic factor in ovarian carcinoma. The Gynecologic Oncology Group experience. Cancer. 1993;71:606–614.CrossRefGoogle ScholarPubMed
Hightower, RD, Nguyen, HN, Averette, HE. National survey of ovarian carcinoma. IV: Patterns of care and related survival for older patients. Cancer. 1994;73:377–383.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Pignata, S, Vermorken, JB. Ovarian cancer in the elderly. Crit Rev Oncol Hematol. 2004;49: 77–86.CrossRefGoogle ScholarPubMed
Jemal, A, Siegel, R, Ward, E. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96.CrossRefGoogle ScholarPubMed
Ries, , Melbert, D, Krapcho, M. SEER Cancer Statistics Review, 1975–2005. Bethesda, MD: National Cancer Institute; 2008.Google Scholar
Watson, P, Butzow, R, Lynch, HT. The clinical features of ovarian cancer in hereditary nonpolyposis colorectal cancer. Gynecol Oncol. 2001;82:223–228.CrossRefGoogle ScholarPubMed
Chen, S, Iversen, ES, Friebel, T. Characterization of BRCA1 and BRCA2 mutations in a large United States sample. J Clin Oncol. 2006;24:863–871.CrossRefGoogle Scholar
Haber, D.Prophylactic oophorectomy to reduce the risk of ovarian and breast cancer in carriers of BRCA mutations. N Engl J Med. 2002;346: 1660–1662.CrossRefGoogle ScholarPubMed
Kauff, ND, Domchek, SM, Friebel, TM. Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: a multicenter, prospective study. J Clin Oncol. 2008;26: 1331–1337.CrossRefGoogle ScholarPubMed
Chi, DS, Sabbatini, P. Advanced ovarian cancer. Curr Treat Options Oncol. 2000;1:139–146.CrossRefGoogle ScholarPubMed
Mirhashemi, R, Nieves-Neira, W, Averette, HE. Gynecologic malignancies in older women. Oncology. 2001;15:580–586; discussion 592–594, 597–598.Google ScholarPubMed
Lambrou, NC, Bristow, RE. Ovarian cancer in elderly women. Oncology. 2003;17:1075–1081; discussion 1081, 1085–1086, 1091.Google ScholarPubMed
Ryerson, AB, Eheman, C, Burton, J. Symptoms, diagnoses, and time to key diagnostic procedures among older U.S. women with ovarian cancer. Obstet Gynecol. 2007;109:1053–1061.CrossRefGoogle ScholarPubMed
Winter III, WE, Maxwell, GL, Tian, C. Prognostic factors for stage III epithelial ovarian cancer: a Gynecologic Oncology Group Study. J Clin Oncol. 2007;25:3621–3627.CrossRefGoogle Scholar
Chan, JK, Loizzi, V, Lin, YG. Stages III and IV invasive epithelial ovarian carcinoma in younger versus older women: what prognostic factors are important?Obstet Gynecol. 2003;102:156–161.Google ScholarPubMed
Chan, JK, Urban, R, Cheung, MK. Ovarian cancer in younger vs older women: a population-based analysis. Br J Cancer. 2006;95: 1314–1320.CrossRefGoogle ScholarPubMed
Markman, M, Lewis, Jr JL, Saigo, P. Impact of age on survival of patients with ovarian cancer. Gynecol Oncol. 1993;49:236–239.CrossRefGoogle ScholarPubMed
Petignat, P, Fioretta, G, Verkooijen, HM. Poorer survival of elderly patients with ovarian cancer: a population-based study. Surg Oncol. 2004;13:181–186.CrossRefGoogle ScholarPubMed
Du, XL, Sun, CC, Milam, MR. Ethnic differences in socioeconomic status, diagnosis, treatment, and survival among older women with epithelial ovarian cancer. Int J Gynecol Cancer. 2008; 18(4):660–669.CrossRefGoogle ScholarPubMed
Pectasides, D, Fountzilas, G, Aravantinos, G. Epithelial ovarian carcinoma in younger vs older women: is age an independent prognostic factor? The Hellenic Oncology Cooperative Group experience. Int J Gynecol Cancer. 2007;17: 1003–1010.CrossRefGoogle ScholarPubMed
Bristow, RE, Tomacruz, RS, Armstrong, DK. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: a meta-analysis. J Clin Oncol. 2002;20:1248–1259.CrossRefGoogle ScholarPubMed
Wimberger, P, Lehmann, N, Kimmig, R. Impact of age on outcome in patients with advanced ovarian cancer treated within a prospectively randomized phase III study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group (AGO-OVAR). Gynecol Oncol. 2006;100:300–307.CrossRefGoogle Scholar
Uyar, D, Frasure, HE, Markman, M. Treatment patterns by decade of life in elderly women (> or = 70 years of age) with ovarian cancer. Gynecol Oncol. 2005;98:403–408.CrossRefGoogle ScholarPubMed
Wright, JD, Herzog, TJ, Powell, MA. Morbidity of cytoreductive surgery in the elderly. Am J Obstet Gynecol. 2004;190:1398–1400.CrossRefGoogle ScholarPubMed
Sharma, S, Driscoll, D, Odunsi, K. Safety and efficacy of cytoreductive surgery for epithelial ovarian cancer in elderly and high-risk surgical patients. Am J Obstet Gynecol. 2005;193: 2077–2082.CrossRefGoogle ScholarPubMed
Eisenhauer, EL, Tew, WP, Levine, DA. Response and outcomes in elderly patients with stages IIIC–IV ovarian cancer receiving platinum-taxane chemotherapy. Gynecol Oncol. 2007;106:381–387.CrossRefGoogle ScholarPubMed
Bruchim, I, Altaras, M, Fishman, A. Age contrasts in clinical characteristics and pattern of care in patients with epithelial ovarian cancer. Gynecol Oncol. 2002;86:274–278.CrossRefGoogle ScholarPubMed
Nordin, AJ, Chinn, DJ, Moloney, I. Do elderly cancer patients care about cure? Attitudes to radical gynecologic oncology surgery in the elderly. Gynecol Oncol. 2001;81:447–455.CrossRefGoogle ScholarPubMed
Cloven, NG, Manetta, A, Berman, ML. Management of ovarian cancer in patients older than 80 years of Age. Gynecol Oncol. 1999;73: 137–139.CrossRefGoogle ScholarPubMed
Susini, T, Scambia, G, Margariti, PA. Gynecologic oncologic surgery in the elderly: a retrospective analysis of 213 patients. Gynecol Oncol. 1999;75:437–443.CrossRefGoogle ScholarPubMed
Diaz-Montes, TP, Zahurak, ML, Giuntoli, II RL. Surgical care of elderly women with ovarian cancer: a population-based perspective. Gynecol Oncol. 2005;99:352–357.CrossRefGoogle ScholarPubMed
McGuire, WP, Hoskins, WJ, Brady, MF. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med. 1996;334:1–6.CrossRefGoogle ScholarPubMed
Ozols, RF, Bundy, BN, Greer, BE. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol. 2003;21: 3194–3200.CrossRefGoogle ScholarPubMed
Maas, HA, Kruitwagen, RF, Lemmens, VE. The influence of age and co-morbidity on treatment and prognosis of ovarian cancer: a population-based study. Gynecol Oncol. 2005;97:104–109.CrossRefGoogle ScholarPubMed
Hershman, D, Jacobson, JS, McBride, R. Effectiveness of platinum-based chemotherapy among elderly patients with advanced ovarian cancer. Gynecol Oncol. 2004;94:540–549.CrossRefGoogle ScholarPubMed
Sundararajan, V, Hershman, D, Grann, VR. Variations in the use of chemotherapy for elderly patients with advanced ovarian cancer: a population-based study. J Clin Oncol. 2002;20:173–178.CrossRefGoogle ScholarPubMed
Pignata, S, Monfardini, S. Single agents should be administered in preference to combination chemotherapy for the treatment of patients over 70 years of age with advanced ovarian carcinoma. Eur J Cancer. 2000;36:817–820.CrossRefGoogle ScholarPubMed
Pignata, S, Breda, E, Scambia, G. A phase II study of weekly carboplatin and paclitaxel as first-line treatment of elderly patients with advanced ovarian cancer. A Multicentre Italian Trial in Ovarian cancer (MITO-5) study. Crit Rev Oncol Hematol. 2008:66(3):229–236.CrossRefGoogle ScholarPubMed
Tredan, O, Geay, JF, Touzet, S. Carboplatin/cyclophosphamide or carboplatin/paclitaxel in elderly patients with advanced ovarian cancer? Analysis of two consecutive trials from the Groupe d';Investigateurs Nationaux pour l';Etude des Cancers Ovariens. Ann Oncol. 2007;18: 256–262.CrossRefGoogle ScholarPubMed
Fader, AN, Gruenigen, VV, Gibbons, H. Improved tolerance of primary chemotherapy with reduced-dose carboplatin and paclitaxel in elderly ovarian cancer patients. Gynecol Oncol. 2008.CrossRefGoogle ScholarPubMed
Group, ICON: Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: the ICON3 randomised trial. Lancet. 2002;360: 505–515.Google Scholar
Villella, JA, Chaudhry, T, Pearl, ML. Comparison of tolerance of combination carboplatin and paclitaxel chemotherapy by age in women with ovarian cancer. Gynecol Oncol. 2002;86:316–322.CrossRefGoogle ScholarPubMed
Ceccaroni, M, D';Agostino, G, Ferrandina, G. Gynecological malignancies in elderly patients: is age 70 a limit to standard-dose chemotherapy? An Italian retrospective toxicity multicentric study. Gynecol Oncol. 2002;85:445–450.CrossRefGoogle ScholarPubMed
Alberts, DS, Liu, PY, Hannigan, EV. Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer. N Engl J Med. 1996;335: 1950–1955.CrossRefGoogle ScholarPubMed
Markman, M, Bundy, BN, Alberts, DS. Phase III trial of standard-dose intravenous cisplatin plus paclitaxel versus moderately high-dose carboplatin followed by intravenous paclitaxel and intraperitoneal cisplatin in small-volume stage III ovarian carcinoma: an intergroup study of the Gynecologic Oncology Group, Southwestern Oncology Group, and Eastern Cooperative Oncology Group. J Clin Oncol. 2001;19: 1001–1007.CrossRefGoogle ScholarPubMed
Armstrong, DK, Bundy, B, Wenzel, L. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med. 2006;354:34–43.CrossRefGoogle ScholarPubMed
Wenzel, LB, Huang, HQ, Armstrong, DK. Health-related quality of life during and after intraperitoneal versus intravenous chemotherapy for optimally debulked ovarian cancer: a Gynecologic Oncology Group Study. J Clin Oncol. 2007;25:437–443.CrossRefGoogle ScholarPubMed
Brenner, BM, Meyer, TW, Hostetter, TH. Dietary protein intake and the progressive nature of kidney disease: the role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N Engl J Med. 1982;307:652–659.Google ScholarPubMed
Launay-Vacher, V, Chatelut, E, Lichtman, SM. Renal insufficiency in elderly cancer patients: International Society of Geriatric Oncology clinical practice recommendations. Ann Oncol. 2007;18:1314–1321.CrossRefGoogle ScholarPubMed
Launay-Vacher, V, Oudard, S, Janus, N. Prevalence of renal insufficiency in cancer patients and implications for anticancer drug management: the renal insufficiency and anticancer medications (IRMA) study. Cancer. 2007;110:1376–1384.CrossRefGoogle ScholarPubMed
Lichtman, SM, Wildiers, H, Launay-Vacher, V. International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency. Eur J Cancer. 2007;43:14–34.CrossRefGoogle ScholarPubMed
Lichtman, SM, Hollis, D, Miller, AA. Prospective evaluation of the relationship of patient age and paclitaxel clinical pharmacology: Cancer and Leukemia Group B (CALGB 9762). J Clin Oncol. 2006;24:1846–1851.CrossRefGoogle Scholar
Lichtman, SM, Wildiers, H, Chatelut, E. International Society of Geriatric Oncology Chemotherapy Taskforce: evaluation of chemotherapy in older patients – an analysis of the medical literature. J Clin Oncol. 2007;25: 1832–1843.CrossRefGoogle ScholarPubMed
Parmar, MK, Ledermann, JA, Colombo, N. Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Lancet. 2003;361:2099–2106.Google ScholarPubMed
Pfisterer, J, Plante, M, Vergote, I. Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: an intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG. J Clin Oncol. 2006;24:4699–4707.CrossRefGoogle ScholarPubMed
Bukowski, RM, Ozols, RF, Markman, M. The management of recurrent ovarian cancer. Semin Oncol. 2007;34:S1–S15.CrossRefGoogle ScholarPubMed
Gridelli, C, Langer, C, Maione, P. Lung cancer in the elderly. J Clin Oncol. 2007;25: 1898–1907.CrossRefGoogle ScholarPubMed
Wildiers, H, Kunkler, I, Biganzoli, L. Management of breast cancer in elderly individuals: recommendations of the International Society of Geriatric Oncology. Lancet Oncol. 2007;8:1101–1115.CrossRefGoogle ScholarPubMed
Gronlund, B, Hogdall, C, Hansen, HH. Performance status rather than age is the key prognostic factor in second-line treatment of elderly patients with epithelial ovarian carcinoma. Cancer. 2002;94:1961–1967.CrossRefGoogle ScholarPubMed
Gordon, AN, Tonda, M, Sun, S. Long-term survival advantage for women treated with pegylated liposomal doxorubicin compared with topotecan in a phase 3 randomized study of recurrent and refractory epithelial ovarian cancer. Gynecol Oncol. 2004;95:1–8.CrossRefGoogle Scholar
Morris, RT.Weekly topotecan in the management of ovarian cancer. Gynecol Oncol. 2003;90: S34–S38.CrossRefGoogle ScholarPubMed
Kabbinavar, FF, Hurwitz, HI, Yi, J. Addition of bevacizumab to fluorouracil-based first-line treatment of metastatic colorectal cancer: pooled analysis of cohorts of older patients from two randomized clinical trials. J Clin Oncol. 2009;27:199–205.CrossRefGoogle ScholarPubMed
Burger, RA.Experience with bevacizumab in the management of epithelial ovarian cancer. J Clin Oncol. 2007;25:2902–2908.CrossRefGoogle ScholarPubMed
Lewin, SN, Buttin, BM, Powell, MA. Resource utilization for ovarian cancer patients at the end of life: how much is too much?Gynecol Oncol. 2005;99:261–266.CrossRefGoogle ScholarPubMed
Hurria, A, Lichtman, SM, Gardes, J. Identifying vulnerable older adults with cancer: integrating geriatric assessment into oncology practice. J Am Geriatr Soc. 2007;55:1604–1608.CrossRefGoogle ScholarPubMed
Freyer, G, Geay, JF, Touzet, S. Comprehensive geriatric assessment predicts tolerance to chemotherapy and survival in elderly patients with advanced ovarian carcinoma: a GINECO study. Ann Oncol. 2005;16:1795–1800.CrossRefGoogle ScholarPubMed
Cella, DF, Tulsky, DS, Gray, G. The Functional Assessment of Cancer Therapy (FACT) Scale: development and validation of the general measure. J Clin Oncol. 1993;11:570–579.CrossRefGoogle ScholarPubMed
Sweeney, C, Schmitz, KH, Lazovich, D. Functional limitations in elderly female cancer survivors. J Natl Cancer Inst. 2006;98:521–529.CrossRefGoogle ScholarPubMed
Gruenigen, VE, Gil, K, Huang, H. Quality of life in ovarian cancer patients during chemotherapy: a Gynecologic Oncology Group study. Gynecol Oncol. 2008;108:S28–S29.Google Scholar
Gruenigen, VE, Frasure, HE, Grandon, M. Longitudinal assessment of quality of life and lifestyle in newly diagnosed ovarian cancer patients: the roles of surgery and chemotherapy. Gynecol Oncol. 2006;103:120–126.CrossRefGoogle Scholar
Schink, JC, Weller, E, Harris, LS. Outpatient taxol and carboplatin chemotherapy for suboptimally debulked epithelial carcinoma of the ovary results in improved quality of life: an Eastern Cooperative Oncology Group phase II study (E2E93). J Cancer. 2001;7:155–164.Google Scholar
Bezjak, A, Tu, P, Bacon, M. Quality of life in ovarian cancer patients: comparison of paclitaxel plus cisplatin, with cyclophosphamide plus cisplatin in a randomized study. J Clin Oncol. 2004;22:4595–4603.CrossRefGoogle Scholar
Wan, GJ, Counte, MA, Cella, DF. An analysis of the impact of demographic, clinical and social factors on health related quality of life. Value Health. 1999;2:308–318.CrossRefGoogle ScholarPubMed
Movsas, B, Scott, C, Watkins-Bruner, D. Pretreatment factors significantly influence quality of life in cancer patients: a Radiation Therapy Oncology Group (RTOG) analysis. Int J Radiat Oncol Biol Phys. 2006;65: 830–835.CrossRefGoogle ScholarPubMed
Gil, KM, Gibbons, HE, Hopkins, MP. Baseline characteristics influencing quality of life in gynecologic cancer. Health Qual Life Outcomes. 2007;5:25–32.CrossRefGoogle Scholar
Earle, CC, Landrum, MB, Souza, JM. Aggressiveness of cancer care near the end of life: is it a quality-of-care issue?J Clin Oncol. 2008;26:3860–3866.CrossRefGoogle ScholarPubMed
Gruenigen, VE, Daly, B, Gibbons, HE. Indicators of survival duration in ovarian cancer and implications for aggressiveness of care. Cancer. 2008;112(10):2221–2227.CrossRefGoogle Scholar
Bruchim, I, Biron-Shental, T, Altaras, MM. Combination of endometrial thickness and time since menopause in predicting endometrial cancer in women with postmenopausal bleeding. J Clin Ultrasound. 2004;32(5):219–224.CrossRefGoogle ScholarPubMed
Doorn, HC, Opmeer, BC, Jitze Duk, M. The relation between age, time since menopause, and endometrial cancer in women with postmenopausal bleeding. Int J Gynecol Cancer. 2007;17(5):1118–1123.CrossRefGoogle ScholarPubMed
Somoye, G, Olaitan, A, Mocroft, A. Age related trends in the incidence of endometrial cancer in South East England 1962–1997. J Obstet Gynaecol. 2005;25(1):35–38.CrossRefGoogle Scholar
Olson, JE, Sellers, TA, Anderson, KE. Does a family history of cancer increase the risk for postmenopausal endometrial carcinoma? A prospective cohort study and a nested case-control family study of older women. Cancer. 1999;85(11):2444–2449.3.0.CO;2-M>CrossRefGoogle Scholar
Farley, JH, Nycum, LR, Birrer, MJ. Age-specific survival of women with endometrioid adenocarcinoma of the uterus. Gynecol Oncol. 2000;79(1):86–89.CrossRefGoogle ScholarPubMed
Ueda, SM, Kapp, DS, Cheung, MK. Trends in the demographics and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths. Am J Obstet Gynecol. 2008;198(218): E1–E6.CrossRefGoogle ScholarPubMed
Chan, JK, Tian, C, Monk, BJ. Gynecologic Oncology Group. Prognostic factors for high-risk early-stage epithelial ovarian cancer: a Gynecologic Oncology Group study. Cancer. 2008;112(10):2202–2210.CrossRefGoogle ScholarPubMed
Calle, EE, Rodriguez, C, Walker-Thurmond, K. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625–1638.CrossRefGoogle Scholar
Ahmed, A, Zamba, G, DeGeest, K. The impact of surgery on survival of elderly women with endometrial cancer in the SEER program from 1992–2002. Gynecol Oncol. 2008;111(1):35–40.CrossRefGoogle ScholarPubMed
Gruenigen, VE, Tian, C, Frasure, H. Treatment toxicity, disease recurrence and survival as related to obesity in women with early endometrial carcinoma: a Gynecologic Oncology Group study. Cancer. 2006;107:2786–2791.CrossRefGoogle Scholar
Trimble, EL, Kosary, C, Park, RC. Lymph node sampling and survival in endometrial cancer. Gynecol Oncol. 1998;71(3):340–343.CrossRefGoogle ScholarPubMed
Chan, JK, Lin, YG, Monk, BJ. Vaginal hysterectomy as primary treatment of endometrial cancer in medically compromised women. Obstet Gynecol. 2001;97(5 Pt 1):707–711.Google ScholarPubMed
Susini, T, Massi, G, Amunni, G. Vaginal hysterectomy and abdominal hysterectomy for treatment of endometrial cancer in the elderly. Gynecol Oncol. 2005;96(2):362–367.CrossRefGoogle ScholarPubMed
Nag, S, Erickson, B, Parikh, S. The American Brachytherapy Society recommendations for high-dose-rate brachytherapy for carcinoma of the endometrium. Int J Radiat Oncol Biol Phys. 2000;48(3):779–790.CrossRefGoogle ScholarPubMed
Fader, AN, Michener, CM, Giannios, N. Total laparoscopic hysterectomy versus laparoscopic-assisted vaginal hysterectomy in endometrial cancer: surgical and survival outcomes. J Min Inv Gynecol. 2009;16(3):333–339.CrossRefGoogle ScholarPubMed
Gehrig, PA, Cantrell, , Shafer, A. What is the optimal minimally invasive surgical procedure for endometrial cancer staging in the obese and morbidly obese woman?Gynecol Oncol. 2008;111(1):41–45.CrossRefGoogle ScholarPubMed
Boggess, JF, Gehrig, PA, Cantrell, L. A comparative study of 3 surgical methods for hysterectomy with staging for endometrial cancer: robotic assistance, laparoscopy, laparotomy. Am J Obstet Gynecol. 2008;199:360–362.CrossRefGoogle ScholarPubMed
Seamon, LG, Cohn, , Richardson, DL. Robotic hysterectomy and pelvic-aortic lymphadenectomy for endometrial cancer. Obstet Gynecol. 2008;112:1207–1213.CrossRefGoogle ScholarPubMed
Lachance, JA, Everett, EN, Greer, B. The effect of age on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer. Gynecol Oncol. 2006;101(3): 470–475.CrossRefGoogle ScholarPubMed
Truong, PT, Kader, HA, Lacy, B. The effects of age and comorbidity on treatment and outcomes in women with endometrial cancer. Am J Clin Oncol. 2005;28(2):157–164.CrossRefGoogle ScholarPubMed
Alektiar, KM, Venkatraman, E, Abu-Rustum, et al . Is endometrial carcinoma intrinsically more aggressive in elderly patients?Cancer. 2003;98(11):2368–2377.CrossRefGoogle ScholarPubMed
Jolly, S, Vargas, CE, Kumar, T. The impact of age on long-term outcome in patients with endometrial cancer treated with postoperative radiation. Gynecol Oncol. 2006;103(1):87–93.CrossRefGoogle ScholarPubMed
Creutzberg, CL, Putten, WL, Warlam-Rodenhuis, CC. Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: the Postoperative Radiation Therapy in Endometrial Carcinoma Trial. J Clin Oncol. 2004;22(7):1234–1241.CrossRefGoogle Scholar
Creutzberg, CL, Putten, WL, Koper, PC. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet. 2000;355(9213):1404–1411.CrossRefGoogle Scholar
Keys, HM, Roberts, JA, Brunetto, VL. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004;92(3):744–751.CrossRefGoogle ScholarPubMed
Citron, JR, Sutton, H, Yamada, SD. Pathologic stage I-II endometrial carcinoma in the elderly: radiotherapy indications and outcome. Int J Radiat Oncol Biol Phys. 2004;59(5):1432–1438.CrossRefGoogle ScholarPubMed
Alektiar, KM, Venkatraman, E, Chi, DS. Intravaginal brachytherapy alone for intermediate-risk endometrial cancer. Int J Radiat Oncol Biol Phys. 2005;62(1):111–117.CrossRefGoogle ScholarPubMed
Fleming, GF.Systemic chemotherapy for uterine carcinoma: metastatic and adjuvant. J Clin Oncol. 2007;25(20):2983–2990.CrossRefGoogle ScholarPubMed
Alvarez Secord, A, Havrilesky, LJ, Bae-Jump, V. The role of multi-modality adjuvant chemotherapy and radiation in women with advanced stage endometrial cancer. Gynecol Oncol. 2007;107(2):285–291.CrossRefGoogle ScholarPubMed
Goldberg, H, Miller, RC, Abdah-Bortnyak, R. Rare Cancer Network. Outcome after combined modality treatment for uterine papillary serous carcinoma: a study by the Rare Cancer Network (RCN). Gynecol Oncol. 2008;108(2):298–305.CrossRefGoogle Scholar
Randall, ME, Filiaci, VL, Muss, H. Gynecologic Oncology Group Study. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2006;24(1):36–44.CrossRefGoogle ScholarPubMed
Arterburn, , Crane, PK, Sullivan, SD. The coming epidemic of obesity in elderly Americans. J Am Geriatr Soc. 2004;52(11):1907–1912.CrossRefGoogle ScholarPubMed
Gruenigen, VE, Frasure, HE, Grandon, M. Impact of obesity and age on quality of life in gynecologic surgery. Am J Obstet Gynecol. 2005;193:1369–1375.CrossRefGoogle Scholar
Everett, E, Tamini, H, Geer, B. The effect of body mass index on clinical/pathologic features, surgical morbidity, and outcome in patients with endometrial cancer. Gynecol Oncol. 2003;90: 150–157.CrossRefGoogle ScholarPubMed
Cassileth, BR, Lusk, EJ, Strouse, TB. Psychosocial status in chronic illness: a comparative analysis of six diagnostic groups. N Engl J Med. 1984;311(8):506–511.CrossRefGoogle ScholarPubMed
Gruenigen, VE, Courneya, K, Gibbons, H. Feasibility and effectiveness of a lifestyle intervention program in obese endometrial cancer patients: a randomized trial. Gynecol Oncol. 2008;109(1):19–26.CrossRefGoogle Scholar
Larsson, U, Karlsson, J, Sullivan, M. Impact of overweight and obesity on health-related quality of life: a Swedish population study. Int J Obes Relat Metab Disord. 2002;26(3):417–424.CrossRefGoogle ScholarPubMed
Lopez-Garcia, E, Banegas, JR, Gutierrez-Fisac, JL. Relation between body weight and health-related quality of life among the elderly in Spain. Int J Obes. 2003;27:701–709.CrossRefGoogle ScholarPubMed
Apovian, CM, Frey, CM, Wood, GC. Body mass index and physical function in older women. Obes Res. 2002;10:740–747.CrossRefGoogle ScholarPubMed
Doll, HA, Petersen, SE, Stewart-Brown, SL. Obesity and physical and emotional well-being: associations between body mass index, chronic illness and the physical and mental components of the SF-36 questionnaire. Obes Res. 2000;8(2):160–170.CrossRefGoogle ScholarPubMed
Fontaine, KR, Barofsk, I, Andersen, RE. Impact of weight loss on health-related quality of life. Qual Life Res. 1999;8:275–277.CrossRefGoogle ScholarPubMed
Hulens, M, Vansant, G, Claessens, AL. Health-related quality of life in physically active and sedentary obese women. Am J Hum Biol. 2002;14:777–785.CrossRefGoogle ScholarPubMed
Hassan, MK, Joshi, AV, Madhavan, SS. Obesity and health-related quality of life: a cross-sectional analysis of the US population. Int J Obes. 2003;27:1227–1232.CrossRefGoogle ScholarPubMed
Lutgendorf, SK, Anderson, B, Rothrock, N. Quality of life and mood in women receiving extensive chemotherapy for gynecologic cancer. Cancer. 2002;87:178–184.Google Scholar
Miller, BE, Pittman, B, Case, D. Quality of life after treatment for gynecologic malignancies: a pilot study in an outpatient clinic. Gynecol Oncol. 2002;87(2):178–184.CrossRefGoogle Scholar
Chan, YM, Ngan, HY, Li, BY. A longitudinal study on quality of life after gynecologic cancer treatment. Gynecol Oncol. 2001;83(1):10–19.CrossRefGoogle ScholarPubMed
Klee, M, Machin, D. Health-related quality of life of patients with endometrial cancer who are disease-free following external irradiation. Acta Oncol. 2001;40(7):816–824.Google ScholarPubMed
Li, C, Samsioe, G, Iosif, C. Quality of life in endometrial cancer survivors. Maturitas. 1999;31(3):227–236.CrossRefGoogle ScholarPubMed
Poll-Franse, LV, Mols, F, Essink-Bot, ML. Impact of external beam adjuvant radiotherapy on health-related quality of life for long-term survivors of endometrial adenocarcinoma: a population-based study. Int J Radiat Oncol Biol Phys. 2007;69(1):125–132.CrossRefGoogle ScholarPubMed
Blanchard, CM, Courneya, KS, Stein, K. Cancer survivors'; adherence to lifestyle behavior recommendations and associations with health-related quality of life: results from the American Cancer Society's SCS-II. J Clin Oncol. 2008;26(13):2198–2204.CrossRefGoogle ScholarPubMed
Moore, DH, Kauderer, JT, Bell, J. An assessment of age and other factors influencing protocol versus alternative treatments for patients with epithelial ovarian cancer referred to member institutions: a Gynecologic Oncology Group study. Gynecol Oncol. 2004;94:368–374.CrossRefGoogle ScholarPubMed

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