Book contents
- Stories of Stroke
- Stories of Stroke
- Copyright page
- Contents
- Contributors
- Why This Book Needed to Be Written
- Preface
- Part I Early Recognition
- Part II Basic Knowledge, Sixteenth to Early Twentieth Centuries
- Part III Modern Era, Mid-Twentieth Century to the Present
- Types of Stroke
- Some Key Physicians
- Imaging
- Care
- Treatment
- Chapter Forty Three Clinical Stroke Trials
- Chapter Forty Four Heparin
- Chapter Forty Five Warfarin
- Chapter Forty Six Direct Oral Anticoagulants
- Chapter Forty Seven Aspirin
- Chapter Forty Eight Other Antiplatelets
- Chapter Forty Nine Other Medical Treatments
- Chapter Fifty Neuroprotection
- Chapter Fifty One Thrombolysis
- Chapter Fifty Two Treatment of Cerebral Venous Thrombosis
- Chapter Fifty three Recovery and Rehabilitation
- Chapter Fifty Four Carotid Artery Surgery
- Chapter Fifty Five Angioplasty and Stenting
- Chapter Fifty Six Endovascular Treatment of Acute Ischemic Stroke
- Chapter Fifty Seven Brain Aneurysm Treatment
- Chapter Fifty Eight Medical and Surgical Treatments of Intracerebral Hemorrhage
- Chapter Fifty Nine Treatment of Vascular Malformations
- Part IV Stroke Literature, Organizations, and Patients
- Index
- References
Chapter Forty Four - Heparin
from Treatment
Published online by Cambridge University Press: 13 December 2022
Book contents
- Stories of Stroke
- Stories of Stroke
- Copyright page
- Contents
- Contributors
- Why This Book Needed to Be Written
- Preface
- Part I Early Recognition
- Part II Basic Knowledge, Sixteenth to Early Twentieth Centuries
- Part III Modern Era, Mid-Twentieth Century to the Present
- Types of Stroke
- Some Key Physicians
- Imaging
- Care
- Treatment
- Chapter Forty Three Clinical Stroke Trials
- Chapter Forty Four Heparin
- Chapter Forty Five Warfarin
- Chapter Forty Six Direct Oral Anticoagulants
- Chapter Forty Seven Aspirin
- Chapter Forty Eight Other Antiplatelets
- Chapter Forty Nine Other Medical Treatments
- Chapter Fifty Neuroprotection
- Chapter Fifty One Thrombolysis
- Chapter Fifty Two Treatment of Cerebral Venous Thrombosis
- Chapter Fifty three Recovery and Rehabilitation
- Chapter Fifty Four Carotid Artery Surgery
- Chapter Fifty Five Angioplasty and Stenting
- Chapter Fifty Six Endovascular Treatment of Acute Ischemic Stroke
- Chapter Fifty Seven Brain Aneurysm Treatment
- Chapter Fifty Eight Medical and Surgical Treatments of Intracerebral Hemorrhage
- Chapter Fifty Nine Treatment of Vascular Malformations
- Part IV Stroke Literature, Organizations, and Patients
- Index
- References
Summary
The story of heparin began in 1880, with a report by German researcher Adolf Schmidt-Mulheim describing the possibility that mammals harbor indigenous anticoagulants. In 1905, Paul Morawitz reviewed peptone shock research and concluded that the analytical methods available did not enable precise characterization of the anticoagulant. This remained the case until another decade, when further progress was made by William Henry Howell and Jay McLean [1].
- Type
- Chapter
- Information
- Stories of StrokeKey Individuals and the Evolution of Ideas, pp. 427 - 433Publisher: Cambridge University PressPrint publication year: 2022
References
Notes and References
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Charles, AF, Scott, DA. Studies on heparin I. The preparation of heparin. J. Biol. Chem. 1933 Oct 1;102(2):425–429.Google Scholar
Lever, R, Mulloy, B, Page, C. Heparin: A Century of Progress. Berlin: Springer Healthcare, 2012, pp. 4–18.Google Scholar
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Caplan, L, Saver, J. Treatment. In Caplan, L (ed.), Caplan’s Stroke: A Clinical Approach, 5th ed. Cambridge: Cambridge University Press, 2016, pp. 170–177.Google Scholar
Saxena, R, Lewis, S, Berge, E, Sandercock, PA, Koudstaal, PJ. Risk of early death and recurrent stroke and effects of heparin in 3169 patients with acute ischemic stroke and atrial fibrillation in the International Stroke Trial. Stroke 2001;32:2333–2337.CrossRefGoogle ScholarPubMed
Resnick, SB, Resnick, SH, Weintraub, JL, Kothary, N. Heparin in interventional radiology: A therapy in evolution. Semin. Interv. Radiol. 2005 Jun;22(2):95–107.Google Scholar