Field studies were conducted in 2009 at Clinton, NC and 2014 at Pontotoc, MS to determine the influence of simulated glyphosate drip on sweetpotato yield and quality. Treatments consisted of three glyphosate solution (140 g ae L–1) drip volumes (0.16, 0.32 and 0.48 ml) by four application timings [(4 wk after transplanting (WAP); 6 WAP; 8 WAP; and 4 WAP followed by (fb) 6 WAP fb 8 WAP]. A non-treated check was included for comparison. Visual sweetpotato injury consisted of chlorosis at the shoot tips approximately 1 wk after treatment fb necrosis and stunting. At 6 WAP and 8 WAP, sweetpotato injury following glyphosate applied 4 WAP was 71 and 65%, respectively. Injury from glyphosate applied 4 WAP fb 6 WAP was 78%. Injury from glyphosate applied 6 WAP was 26% at 8 WAP. In 2009, jumbo, no. 1, canner, and marketable yield of the non-treated check were two to three times greater than glyphosate treatments (0.16, 0.32, 0.48 ml). Likewise, yield of the non-treated check was substantially greater than those treated with 0.16 to 0.48 ml glyphosate solution in 2014. In 2009 and 2014, sweetpotato yield of all grades increased as glyphosate application timing was delayed. In 2009, no. 1 yield from glyphosate 8 WAP (8,210 kg ha–1) was similar to the non-treated check. In 2009, there were no cracked storage roots in the non-treated check. However, sweetpotatoes receiving 0.16 to 0.48 ml glyphosate solution displayed 8 to 17%, 11 to 18%, 5 to 13%, and 11 to 16% cracking (by weight) in jumbo, no. 1, canner, and marketable storage roots, respectively. Compared to the non-treated check, glyphosate applied 4 WAP, 6 WAP, or 4 WAP fb 6 WAP fb 8 WAP had a greater percentage of cracked marketable sweetpotato storage roots.