Seventeen flexible crinoids, including three new species, are reported from the Fort Payne Formation with new material from Cumberland, Clinton, and Russell Counties in south-central Kentucky and from Clay County, Tennessee. This study extends the geographic range of all taxa studied, as only seven species were previously known from the Fort Payne Formation. Fort Payne flexible crinoids include Taxocrinus colletti, Onychocrinus ramulosus, O. grandis n. sp., Nipterocrinus monroensis, Mespilocrinus romingeri, M. kentuckyensis n. sp., Gaulocrinus veryi, G. robustus, G. trauscholdi, G. bordeni, G. symmetros n. sp., Metichthyocrinus tiaraeformis, M. clarkensis, Forbesiocrinus pyriformis, F. saffordi, F. wortheni, and Wachsmuthicrinus spinosulus. Mespilocrinus columnals are also described, and the diagnosis of N. monroensis is emended. The Fort Payne Formation occurrence of O. exsculptus could not be verified. Forbesiocrinus multibrachiatus and Parichthyocrinus crawfordsvillensis are considered to be junior synonyms of Forbesiocrinus wortheni. Fort Payne flexible crinoids in the Lake Cumberland area occur at nine localities in four facies types. No more than three species occur at any Fort Payne locality.