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11 - Management of the preterm neonate

Published online by Cambridge University Press:  07 August 2009

By
Richa Gupta  and
Michael Weindling
Edited by
Jane Norman  and
Ian Greer
Jane Norman
Affiliation:
University of Glasgow
Ian Greer
Affiliation:
University of Glasgow
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Summary

Immediate resuscitation of the preterm neonate

Introduction

The importance of a planned and coordinated approach to the initial resuscitation, stabilisation and subsequent management of babies born between 27 and 28 completed weeks' gestation was emphasised in the Confidential Enquiries of Stillbirths and Deaths in Infancy (CESDI) Project 27/28 Enquiry (Mackintosh 2003). This chapter covers many of the aspects of care that the report highlighted as contributing to optimising the care of the premature infant. More than 90% of the babies studied for the CESDI report required resuscitation. Having a resuscitation system based on the needs of infants is the recommended approach. The resuscitation guidelines used by the neonatal life support course have been formalised for the term neonate based on combined evidence from the limited pool of resuscitation trials, consensus views on best practice and experimental animal models (Kattwinkel et al. 1999; Niermeyer et al. 2000). The basic approach to resuscitating a preterm neonate is similar to that of the term neonate with emphasis on maintaining body heat and possible earlier progression to advanced manoeuvres to stabilise the airway and administer exogenous surfactant.

Anticipation

Communication forms a cornerstone of the management of imminent preterm deliveries. Liaison between the delivery suite and the Neonatal Intensive Care Unit (NICU) is thus essential to ensure that potential problems are anticipated and that appropriate cot spaces are available.

Type
Chapter
Information
Preterm Labour
Managing Risk in Clinical Practice
 , pp. 260 - 306
Publisher: Cambridge University Press
Print publication year: 2005

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References

American Academy of Pediatrics Committee on Fetus and Newborn. (2002) Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infantsPediatrics 109, 330–8.CrossRef
Adiotomre, P. N., Johnstone, F. D. and Laing, I. A. (1997) Effect of absent end diastolic flow velocity in the fetal umbilical artery on subsequent outcome. Arch. Dis. Child. Fetal Neonatal Ed. 76, F35–8.CrossRefGoogle ScholarPubMed
Ainsworth, S. B., Beresford, M. W., Milligan, D. W.et al. (2000). Pumactant and poractant alfa for treatment of respiratory distress syndrome in neonates born at 25–29 weeks' gestation: a randomised trial. Lancet 355(9213), 1387–92.CrossRefGoogle ScholarPubMed
Alagappan, A., Shattuck, K. E. and Malloy, M. H. (1998) Impact of transfusion guidelines on neonatal transfusions. J. Perinatol. 18, 92–7.Google ScholarPubMed
Askie, L. M. and Henderson-Smart, D. J. (2001) Restricted versus liberal oxygen exposure for preventing morbidity and mortality in preterm or low birthweight infants. Cochrane Database Syst. Rev. 4, CD001077.CrossRefGoogle Scholar
Bandstra, E. S., Montalvo, B. M., Goldberg, R. N.et al. (1988) Prophylactic indomethacin for prevention of intraventricular haemorrhage in premature infants. Pediatrics 82, 533–42.Google ScholarPubMed
Back, S. A., Luo, N. L., Borenstein, N. S.et al. (2001) Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. J. Neurosci. 21(4), 1302–12.CrossRefGoogle ScholarPubMed
Banker, B. and Larroche, J. (1962) Periventricular leukomalacia of infancy: a form of neonatal anoxic encephalopathy. Arch. Neurol. 7, 386–410.CrossRefGoogle ScholarPubMed
Baud, O., Ville, Y., Zupan, V.et al. (1998) Are neonatal brain lesions due to intrauterine infection related to mode of delivery?BJOG 105, 121–4.CrossRefGoogle ScholarPubMed
Bell, E. F., Warburton, D., Stonestreet, B. S. and Oh, W. (1979) High volume fluid intake predisposes premature infants to necrotising enterocolitis. Lancet ii, 90.CrossRefGoogle Scholar
Bell, E. F., Warburton, D., Stonestreet, B. S. and Oh, W.(1980) Effect of fluid administration on the development of symptomatic patent ductus arteriosus and congestive heart failure in premature infants. N. Engl. J. Med. 302, 598–604.CrossRefGoogle ScholarPubMed
Bell, E. F. and Acarregui, M. J. (2001) Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants. Cochrane Database Syst. Rev. 3, CD000503.CrossRefGoogle Scholar
Benders, M. J., Bel, F. and Bor, M. (1998) The effect of phototherapy on cerebral blood flow velocity in preterm infants. Acta Paediatr. (7), 786–91.CrossRefGoogle Scholar
Berseth, C. L. (1990) Neonatal small intestinal motility: the motor responses to feeding in term and preterm infants. J. Pediatr. 117, 777–82.CrossRefGoogle ScholarPubMed
Berseth, C. L., Kenny, J. D., and Durand, R. (1986) Longitudinal development in pediatric residents of attitudes towards neonatal resuscitation. American J. Dis. Child. 140 (8): 766–9.Google Scholar
Bourchier, D. and Weston, P. J. (1997) Randomised trial of dopamine compared with hydrocortisone for the treatment of hypotensive very low birthweight infants. Arch. Dis. Child. Fetal Neonatal Ed. 76, F174–8.CrossRefGoogle ScholarPubMed
Bratlid, D. (2001) Criteria for treatment of neonatal jaundice. J. Perinatol. 21 supp1, S88–92.CrossRefGoogle ScholarPubMed
Cairo, M. S., Seth, T. and Fanaroff, A. (1996) A double-blinded, randomized placebo controlled pilot study of RhGM-CSF in low birthweight neonates. Paediatr. Res. 39, 294A.CrossRefGoogle Scholar
Calvert, S. A., Hoskins, E. M., Fong, K. W. and Forsyth, S. C. (1987) Etiological factors associated with the development of periventricular leukomalacia. Acta Paediatr. Scand. 76, 254–9.CrossRefGoogle ScholarPubMed
Cashore, W. J. (2000) Bilirubin and jaundice in the micropremie. Clin. Perinatol. 27(1), 171–9, vii.CrossRefGoogle ScholarPubMed
Cole, F. S. (2000) Extremely preterm birth – Defining the limits of hope. N. Engl. J. Med. 343, 429–30.CrossRefGoogle ScholarPubMed
Costarino, A. T., Gruskay, J. A., Corcoran, L., Polin, R. A. and Baumgart, S. (1992) Sodium restriction versus daily maintenance replacement in very low birthweight premature neonates: a randomised, blind therapeutic trial. J. Pediatr. 120, 99–106.CrossRefGoogle Scholar
Costeloe, K., Hennessy, E., Gibson, A. T., Marlow, N. and Wilkinson, A. R. (2000) The EPICure study: outcomes to discharge from hospital for infants born at the threshold of viability. Pediatrics 106, 659–71.CrossRefGoogle ScholarPubMed
Cross, K. W. (1973) Cost of preventing retrolental fibroplasia?Lancet ii, 954–6.CrossRefGoogle Scholar
Crowley, P. (1995) Antenatal corticosteroid therapy: a meta-analysis of the randomized trials 1972–1994. Am. J. Obstet. Gynecol. 173, 322–35.CrossRefGoogle Scholar
Crowley, P., (1999) Prophylactic corticosteroids for preterm delivery. In The Cochrane Library Issue 2. Oxford: Update Software.Google Scholar
Cryotherapy for Retinopathy of Prematurity Cooperative Group. (1988) Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Pediatrics 81, 697–706.
Dammann, O. and Leviton, A. (1997) Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn. Pediatr. Res. 42, 1–8.CrossRefGoogle ScholarPubMed
Dani, C., Bertini, G., Reali, M. F.et al. (2000) Prophylaxis of patent ductus arteriosus with ibuprofen in preterm infants. Acta Paediatr. 89, 1369–74.CrossRefGoogle ScholarPubMed
da Costa, D. E., Pai, Mg. and Al Khusabiby, S. M. (1999) Comparative trial of artificial and natural surfactants in the treatment of respiratory distress syndrome of prematurity: experiences in a developing country. Pediatr. Pulmonol. 27(5), 303–4.3.0.CO;2-N>CrossRefGoogle Scholar
Davis, P. G. and Henderson-Smart, D. J. (2002) Prophylactic post-extubation nasal CPAP in preterm infants. (Cochrane Review) In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Davis, P. G., Lemyre, B. and Paoli, A. G. (2002) Nasal intermittent positive pressure ventilation (NIPPV) versus nasal continuous positive airway pressure (NCPAP) for preterm neonates after extubation (Cochrane Review). In The Cochrane Library, Issue 2. Oxford: Update Software.Google Scholar
Carolis, M. P., Romagnoli, C., Polimeni, V.et al. (2000) Prophylactic ibuprofen therapy of patent ductus arteriosus in preterm infants. Eur. J. Pediatr. 159, 364–8.CrossRefGoogle ScholarPubMed
Delivoria-Papadopoulos, M. and McGowan, J. E. (1998) Oxygen transport and delivery. In Polin, R. A. and Fox, W. W.Fetal and Neonatal Physiology. eds., W. B. Saunders Co, pp. 1105–17.Google Scholar
de Vries, L. and Levene, M. I. (1995) Cerebral ischaemic lesions. In Levene, M. I., Lilford, R. J., Bennet, M. J. and Punt, J. eds., Fetal and Neonatal Neurology and Neurosurgery. Edinburg: Churchill Livingstone, pp. 367–860.Google Scholar
Ebbesen, F., Agati, G. and Pratesi, R. (2003) Phototherapy with turquoise versus blue light. Arch. Dis. Child. Fetal Neonatal Ed. 88(5), F430–1.CrossRefGoogle ScholarPubMed
Fang, S., Kempley, S. T. and Gamsu, H. R. (2001) Prediction of early tolerance to enteral feeding in preterm infants by measurement of superior mesenteric artery blood flow velocity. Arch. Dis. Child. Fetal Neonatal Ed. 85, F42–5.CrossRefGoogle ScholarPubMed
Finer, N. N., Rich, W., Craft, A. and Henderson, C. (2001) Comparison of methods of bag and mask ventilation for neonatal resuscitation. Resuscitation 49 (3), 299–305.CrossRefGoogle ScholarPubMed
Fowlie, P. W. and Davis, P. G. (2002) Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Genen, L. H. and Klenoff, H. (2002) Iron supplementation for erythropoietin-treated preterm infants (Protocol for a Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Gersony, W. M., Peckham, G. J., Ellison, R. C., Mettinen, O. S. and Nadas, A. S. (1983) Effects of indomethacin in premature infants with patent ductus arteriosus: results of a national collaborative study. J. Pediatr. 102, 895–906.CrossRefGoogle ScholarPubMed
Gill, A. B. and Weindling, A. M. (1993) Randomised controlled trial of plasma protein fraction versus dopamine in hypotensive very low birthweight infants. Arch. Dis. Child. 69, 284–7.CrossRefGoogle ScholarPubMed
Goldenberg, R. L., Hauth, J. C. and Andrews, W. W. (2000) Intrauterine infection and preterm delivery. N. Engl. J. Med. 342, 1500–7.CrossRefGoogle ScholarPubMed
Greisen, G., Munck, H. and Lou, H. (1987) Severe hypocarbia in preterm infants and neurodevelopmental deficit. Acta Paediatr. Scand. 76, 401–4.CrossRefGoogle ScholarPubMed
Grunhagen, D. J., Boer, M. G., Beaufort, A. J. and Walther, F. J. (2002). Transepidermal water loss during halogen spotlight phototherapy in preterm infants. Pediatr. Res. 51(3), 402–5.CrossRefGoogle ScholarPubMed
Hack, M., Flannery, D. J., Schluchter, M.et al. (2002) Outcomes in young adulthood for very low birthweight babies. N. Engl. J. Med. 346 (3), 149–57.CrossRefGoogle Scholar
Hammarlund, K. and Sedin, G. (1979) Transepidermal water loss in newborn infants. III Relation to gestational age. Acta Paediatr. Scand. 68, 795–801.CrossRefGoogle ScholarPubMed
Hartnoll, G., Betremieux, P. and Modi, N. (2000) Randomised controlled trial of postnatal sodium supplementation on body composition in 25 to 30 week infants. Arch. Dis. Child. Fetal Neonatal Ed. 82, F24–8.CrossRefGoogle Scholar
Heckmann, M., Trotter, A., Pohlandt, F. and Lindner, W. (2002) Epinephrine treatment of hypotension in very low birthweight infants. Acta Paediatr. 91, 566–70.CrossRefGoogle ScholarPubMed
Heird, W. (1992) Parenteral feeding. In Sinclair, J. C. and Bracken, M. B., eds., Effective Care of the Newborn. Oxford: Oxford University Press, pp. 141–160.Google Scholar
Henderson-Smart, D. J., Bhuta, T., Cools, F. and Offringa, M. (2002) Elective high frequency oscillatory ventilation versus conventional ventilation for acute pulmonary dysfunction in preterm infants (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
HIFI Study Group. (1990) High frequency oscillatory ventilation compared with conventional mechanical ventilation in the treatment of respiratory failure in preterm infants: neurodevelopmental status at 16 to 24 months of post-term ageJ. Pediatr. 117, 939–46.CrossRef
Hudak, M. L., Farrell, E. E., Rosenberg, A. A.et al. (1996) A multi-centre randomized masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome. J. Pediatr. 128, 396–406.CrossRefGoogle Scholar
Hudgins, R. J., Boydston, W. R., Hudgins, P. A. and Adler, S. R. (1994) Treatment of intraventricular hemorrhage in the premature infant with urokinase. A preliminary study. Pediatr Neurosurg. 20, 190–7.CrossRefGoogle Scholar
Hudson, I., Cooke, A., Holland, B.et al. (1990) Red cell volume and cardiac output in anaemic preterm infants. Arch. Dis. Child. 65, 672–5.CrossRefGoogle ScholarPubMed
Isaacs, D. and Moxon, E. R. (1999) (eds) Handbook of Neonatal Infections, a Practical Guide. London: W. B. Saunders.
Jobe, A. H., Kramer, B. W., Moss, T. J., Newnham, J. P. and Ikegami, M. (2002) Decreased indicators of lung injury with continuous positive expiratory pressure in preterm lambsPediatr. Res. 52, 387–92.CrossRefGoogle ScholarPubMed
Jonsson, B., Katz-Salamon, M., Faxelius, G., Broberger, U. and Lagercrantz, H. (1997) Neonatal care of very-low-birthweight infants in special-care units and neonatal intensive-care units in Stockholm. Early nasal continuous positive airway pressure versus mechanical ventilation: gains and losses. Acta Paediatr. Suppl. 419, 4–10.CrossRefGoogle ScholarPubMed
Karsdorp, V. H., Vugt, J. M., Geijn, H. P.et al. (1994) Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery. Lancet 344, 1664–8.CrossRefGoogle ScholarPubMed
Kattwinkel, J., Niermeyer, S., Nadkarni, V.et al. (1999) ILCOR advisory statement: resuscitation of the newly born infant: an advisory statement from pediatric working group of the International Liason Committee on Resuscitation. Circulation 99, 1927–38.CrossRefGoogle Scholar
Kavvadia, V., Greenough, A., Dimitrou, G. and Hooper, R. (2000) Randomised trial of fluid restriction in ventilated very low birthweight infants. Arch. Dis. Child. Fetal Neonatal Ed. 83, F91–6.CrossRefGoogle ScholarPubMed
Kemp, A. S. and Campbell, D. E. (1996) The neonatal immune system. Semin. Neonatol. 1, 67–75.CrossRefGoogle Scholar
Kempley, S. and Gamsu, H. R. (1992) Superior mesenteric artery blood flow velocity in necrotising enterocolitis. Arch. Dis. Child. 67, 793–6.CrossRefGoogle ScholarPubMed
Kempley, S. T., Gamsu, H. R., Vyas, S. and Nicolaides, K. (1991) Effects of intrauterine growth retardation on postnatal visceral and cerebral blood flow velocity. Arch. Dis. Child. 66, 1115–18.CrossRefGoogle ScholarPubMed
Kennedy, K. A., Tyson, J. E. and Chamnanvanikij, S. (2002). Early versus delayed initiation of progressive enteral feedings for parenterally fed low birthweight or preterm infants (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Kinney, H. C. and Back, S. A. (1998) Human oligodendroglial development: relationship to periventricular leukomalacia. Semin. Pediatr. Neurol. 5, 180–9.CrossRefGoogle ScholarPubMed
Klein, J. O. and Marcy, S. M. (1995) Bacterial sepsis and meningitis In Remington, J. S. and Klein, J. O., eds., Infectious Diseases of the Fetus and Newborn Infant, 4th edn. Philadelphia: W. B. Saunders, pp. 835–90.Google Scholar
Lachance, C., Chessex, P., Fouron, J. C., Widness, J. A. and Bard, H. (1994) Myocardial, erythropoietic, and metabolic adaptations to anaemia of prematurity. J. Pediatr. 125, 278–82.CrossRefGoogle Scholar
Lee, C. S., Hwang, B., Lu, J. H., Soong, W. J. and Chen, S. J. (1998) Symptomatic patent ductus arteriosus in very low birthweight infants. Zhonghua Yi Xue Za Zhi (Taipei) 61, 93–8.Google Scholar
LeFlore, J. L., Salhab, W. A., Broyles, R. S. and Engle, W. D. (2002) Association of antenatal and postnatal dexamethasone exposure with outcomes in extremely low birthweight neonates. Pediatrics 110, 275–9.CrossRefGoogle Scholar
Liverpool Women's Hospital. (2001) Neonatal Intensive Care Unit, Fluid and Electrolyte Administration Guidelines (unpublished).
Lucas, A. and Cole, J. (1990) Breastfeeding and necrotising enterocolitis. Lancet 336, 1519–23.CrossRefGoogle ScholarPubMed
Lundstrom, U. (1977) At what age does iron supplementation become necessary in low-birth-weight infants. J. Pediatr. 91, 878–83.CrossRefGoogle ScholarPubMed
Lundstom, K. E., Pryds, O and Greisen, G. (1995) Oxygen at birth and prolonged cerebral vasoconstriction in preterm infants. Arch. Dis. Child. 73, F81–6.CrossRefGoogle Scholar
Lyon, A. J., McIntosh, N., Wheeler, K. and Brooke, O. G. (1984) Hypercalcaemia in extremely low birthweight infants. Arch. Dis. Child. 59, 1141–4.CrossRefGoogle ScholarPubMed
Maayan-Metzger, A., Yosipovitch, G., Hadad, E., and Sirota, L. (2001) Transepidermal water loss and skin hydration in preterm infants during phototherapy. Am. J. Perinatol. 18(7), 393–6.CrossRefGoogle ScholarPubMed
McCormick, M. C. (1999) Conceptualizing child health status: observations from studies of very premature infants. Perspect. Biol. Med. 42, 372–86.CrossRefGoogle ScholarPubMed
Mackintosh, M. (2003) CESDI. Project 27/28: An enquiry into quality of care and its effect on the survival of babies born at 27–28 weeks. London:The Stationary Office.
Maier, R. F., Obladen, M., Scigalla, P.et al. European Multicenter Erythropoietin Beta Study Group. (1994) The effect of epoetin beta (recombinant human erythropoietin) on the need for transfusion in very-low-birthweight infants. N. Engl. J. Med. 330(17), 1173–8.CrossRefGoogle Scholar
Maier, R. F., Obladen, M., Muller-Hansen, I.et al.; European Multicenter Erythropoietin Beta Study Group. (2002) Early treatment with erythropoietin beta ameliorates anemia and reduces transfusion requirements in infants with birthweights below 1000 g. J. Pediatr. 141, 8–15.CrossRefGoogle Scholar
Malcolm, G., Ellwood, D., Devonald, K., Beilby, R. and Henderson-Smart, D. (1991) Absent or reversed end diastolic flow velocity in the umbilical artery and necrotising enterocolitis. Arch. Dis. Child. 66, 805–7.CrossRefGoogle ScholarPubMed
Martinez, A. M., Padbury, J. F. and Thio, S. (1992) Dobutamine pharmacokinetics and cardiovascular responses in critically ill neonates. Pediatrics 89, 47–51.Google ScholarPubMed
Mehr, S. S., Vervaart, P., Henschke, P., Doyle, L. W. and Rice G. E. (1999) The predictive value of interleukin-6 (IL-6) and interleukin-8 (IL-8) in infants with bacterial sepsis (abstract) Proceedings of the Perinatal Society of Australia and New Zealand 3rdAnnual Congress.
Ment, L. R., Oh, W., Ehrenkranz, R. A.et al. (1994) Low-dose indomethacin therapy and extension of intraventricular hemorrhage: a multicenter randomized trial. J. Pediatr. 124, 951–5.CrossRefGoogle ScholarPubMed
Mills, J. F., Tudehope, D. (2001) Fibreoptic phototherapy for neonatal jaundice. Cochrane Database Syst. Rev. 1, CD002060.CrossRef
Mondanlou, H., Beharry, K., Padilla, G. and Norris, K. (1997) Comparative efficacy of Exosurf and Survanta surfactants on early clinical course of respiratory distress syndrome and complications of prematurity. J. Perinatol. 17, 455–60.Google Scholar
Morley, C. (1999) Personal Practice: Continuous distending pressure. Arch. Dis. Child. Fetal Neonatal Ed. 81, F152–6.CrossRefGoogle Scholar
Niermeyer, S., Kattwinkel, J., Reempts, P.et al. (2000) International Guidelines for Resuscitation: An excerpt from the Guidelines 2000 for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care: International Consensus on Science. Contributors and reviewers for the Neonatal Resuscitation GuidelinesPediatrics 106(3), E29.Google ScholarPubMed
Nijima, S., Shortland, D. B., Levene, M. I.et al. (1988) Transient hyperoxia and cerebral blood flow velocity in infants born prematurely and at full term. Arch. Dis. Child. 63, 1126–30.CrossRefGoogle Scholar
Ng, A., Subhedar, N., Primhak, R. A. and Shaw, N. J. (1998) Arterial oxygen saturation profiles in healthy preterm infants. Arch. Dis. Child Fetal Neonatal Ed. 79, F64–6.CrossRefGoogle ScholarPubMed
O'Donnell, A. I., Gray, P. H. and Rogers, and Y. M. (1998) Mortality and neurodevelopmental outcome for infants receiving adrenaline in neonatal resuscitation. Journal of Paediatrics and Child Health 34(6), 551–6.CrossRefGoogle ScholarPubMed
Ogawa, Y., Miyasaka, K., Kawano, T.et al. (1993) A multi-centre randomised trial of high frequency oscillatory ventilation as compared with conventional mechanical ventilation in preterm infants with respiratory failure. Early Hum. Dev. 32, 1–10.CrossRefGoogle Scholar
Ohls, R. K., Osborne, K. A. and Christensen, R. D. (1995) Efficacy and cost analysis of treating very low birthweight infants with erythropoietin during their first two weeks of life: a randomized, placebo controlled trial. J. Pediatr. 126, 421–6.CrossRefGoogle ScholarPubMed
Ohlsson, A. and Lacy, J. B. (2002) Intravenous immunoglobulin for preventing infection in preterm and/or low-birth-weight infants (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Pape, K. E. and Wigglesworth, J. S. (1979) Haemorrhage, ischaemia and the perinatal brain. Clinics in Developmental Medicine Nos 69/70. London: Spastics International Medical Publications. William Heinemann.Google Scholar
Papile, L. A., Burstein, J., Burstein, R. and Koffler, H. (1978) Incidence and evolution of subependymal and intraventricular haemorrhage: a study of infants with birthweights less than 1,500 gm. J. Pediatr. 92, 529–34.CrossRefGoogle Scholar
Pezzati, M., Biagiotti, R., Vangi, V.et al. (2000) Changes in mesenteric blood flow response to feeding: conventional versus fiber-optic phototherapy. Pediatrics 105(2), 350–3.CrossRefGoogle ScholarPubMed
Pharoah, P. O. and Cooke, T. (1996) Cerebral palsy and multiple births. Arch. Dis. Child. Fetal Neonatal Ed. 75, F174–7.CrossRefGoogle ScholarPubMed
Pharoah, P. O. and Cooke, T. (1997) A hypothesis for the aetiology of spastic cerebral palsy–the vanishing twin. Dev. Med. Child Neurol. 39, 292–6.CrossRefGoogle ScholarPubMed
Phelps, D. L. and Watts, J. L. (2002) Early light reduction for preventing retinopathy of prematurity in very low birthweight infants (Cochrane Review). In the Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Phelps, D. L., Lakatos, L. and Watts, J. L. (2002) D-Penicillamine for the preventing retinopathy of prematurity in preterm infants (Cochrane Review) In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Pryds, O. (1994) Low neonatal cerebral oxygen delivery is associated with brain injury in preterm infants. Acta Paediatr. 83, 1233–6.CrossRefGoogle ScholarPubMed
Rager, R. and Finegold, M. J. (1975) Cholestasis in immature infants: is parenteral alimentation responsible?J. Pediatr. 86 (2), 264–9.CrossRefGoogle ScholarPubMed
Ramji, S., Ahuja, S., Thirupuram, S.et al. (1993) Resuscitation of asphyxiated newborn infants with room air or 100% oxygen. Pediatr. Res. 34, 809–12.CrossRefGoogle ScholarPubMed
Resuscitation Council UK. (2001) Algorithm for neonatal life support. In Resuscitation at Birth; The Newborn Life Support Provider Course Manual (ISBN 1 903823 011), p. 64.
Rodwell, R. L., Taylor, K. M., Tudehope, D. I. and Gray, P. H. (1993) Haematologic scoring system in the early diagnosis of sepsis in neutropenic newborns. Pediatr. Infect. Dis. J. 12, 372–6.CrossRefGoogle ScholarPubMed
Romero, R., Ghidini, A., Mazor, M. and Behnke, E. (1991) Microbial invasion of the amniotic cavity in premature rupture of membranes. Clin Obstet. Gynecol. 34, 769–78.CrossRefGoogle ScholarPubMed
Saugstad, O. D., Rootwelt, T. and Aalen, O. (1998) Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study. Pediatrics 102(1), E1.CrossRefGoogle ScholarPubMed
Sedin, G. (1996) Fluid management in the extremely preterm infant. In Hansen, T. N. and McIntosh, N., eds., Current Topics in Neonatology. London: W. B. Saunders, pp. 50–66.Google Scholar
Shannon, K. M., Keith, J. F. 3rd, Mentzer, W. C.et al. (1995) Recombinant human erythropoietin stimulates erythropoiesis and reduces erythrocyte transfusions in very low birthweight preterm infants. Pediatrics 95, 1–8.Google Scholar
Simon, T. L., Alverson, D. C., AuBuchon, J.et al. (1998) Practice parameter for the use of red blood cell transfusions: developed by the Red Blood Cell Administration Practice Guideline Development Task Force of the College of American Pathologists. Arch. Pathol. Lab. Med. 122, 130–8.Google ScholarPubMed
Sims, D. G., Heal, C. A. and Bartle, S. M. (1994) Use of adrenaline and atropine in neonatal resuscitation. Arch. Dis. Child. Fetal Neonatal Ed. 70 (1): F3–9.CrossRefGoogle ScholarPubMed
Sinclair, J. C., (2002) Servo-control for maintaining abdominal skin temperature at 36C in low birthweight infants (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
So, K. W., Fok, T. F., Ng, P. C., Wong, W. W. and Cheung, K. L. (1997) Randomised controlled trial of colloid or crystalloid in hypotensive preterm infants. Arch. Dis. Child. 76, F43–6.CrossRefGoogle ScholarPubMed
Soll, R. F., Blanco, F. (2003) Natural surfactant versus synthetic surfactant for neonatal respiratory distress syndrome (Cochrane Review). In The Cochrane Library, Issue 4. Chichester, UK: John Wiley & Sons, Ltd. CD000144.
Soll, R. F. and McQueen, M. C. (1992) In Sinclair, J. C. and Bracken, M. B., eds., Effective Care of the Newborn Infant. Oxford: Oxford University Press, 325–58.Google Scholar
Spinillo, A., Capuzzo, E., Stronati, M.et al. (1995) Effect of preterm premature rupture of membranes on neurodevelopmental outcome: follow up at two years of age. BJOG 102, 882–7.CrossRefGoogle Scholar
Stanley, F. J. and Alberman, E. D. (1978) Infants of very low birthweight. 1 Factors affecting survival. Dev. Med. Child Neurol. (20), 300–12.CrossRefGoogle Scholar
Steer, P. A., Lucas, A. and Sinclair, J. (1992) Feeding the low birthweight infant In Sinclair, J. C. and Bracken, M. B., eds., Effective Care of the Newborn. Oxford: Oxford University Press, pp 94–140.Google Scholar
Stockman, J. A., Garcia, J. F. and Oski, F. A. (1977) The anaemia of prematurity. Factors governing the erythropoietin response. N. Engl. J. Med. 296, 647–50.CrossRefGoogle ScholarPubMed
Stoll, B. J., Hansen, N., Fanaroff, A. A.et al. (2002) Late-onset sepsis in very low birthweight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110, 285–91.CrossRefGoogle ScholarPubMed
Subhedar, N. V. and Shaw, N. J. (2002) Dopamine versus dobutamine for hypotensive preterm infants (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Subramaniam, P., Henderson-Smart, D. J. and Davis, P. G. (2000) Prophylactic nasal continuous positive airways pressure for preventing morbidity and mortality in very preterm infants (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Tan, A., Schulze, A. and Davis, P. G. (2002) Air versus oxygen for resuscitation of infants at birth (Protocol for a Cochrane review) In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Thompson, M. and Kempley, S. (1999) Proceedings of Debate: Early prophylactic versus rescue administration of surfactant. Royal London Hospital Ventilation Workshop, July 1999 (unpublished).
Trounce, J. Q., Rutter, N. and Levene, M. I. (1986) Periventricular leukomalacia and intraventricular haemorrhage in the preterm neonate. Arch. Dis. Child. 61, 1196–202.CrossRefGoogle ScholarPubMed
Tyson, J. E. and Kennedy, K. A. (2002) Minimal enteral nutrition for promoting feeding tolerance and preventing morbidity in parenterally fed infants (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Marter, L. J., Leviton, A., Allred, E. N., Pagano, M. and Kuban, K. C. (1990) Hydration in the first days of life and the risk of bronchopulmonary dysplasia in low birthweight infants. J. Pediatr. 116, 942–9.CrossRefGoogle Scholar
Marter, L. J., Allred, E. N., Pagano, M.et al. (2000) Do clinical markers of barotrauma and oxygen toxicity explain interhospital variation in rates of chronic lung disease? The Neonatology Committee for the Developmental Network. Pediatrics 105, 1194–201.CrossRefGoogle ScholarPubMed
Vento, M., Asensi, M., Sastre, J.et al. (2001) Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics 107, 642–7.CrossRefGoogle ScholarPubMed
Ventriculomegaly Trial Group. (1990) Randomised trial of early tapping in neonatal post-haemorrhagic ventricular dilatation. Arch. Dis. Child. 65, 3–10.CrossRef
Verma, U., Tejani, N., Klein, S.et al. (1997) Obstetric antecedents of intraventricular hemorrhage and periventricular leukomalacia in the low-birth-weight neonate. Am. J. Obstet. Gynecol. 176, 275–81.CrossRefGoogle ScholarPubMed
Volpe, J. J. (1998) Neurologic outcome of prematurity. Arch. Neurol. 55, 297–300.CrossRefGoogle Scholar
Wardle, S. P., Garr, R., Yoxall, C. W. and Weindling, A. M. (2002) A pilot randomised controlled trial of peripheral fractional oxygen extraction to guide blood transfusions in preterm infants. Arch. Dis. Child. Fetal Neonatal Ed. 86, F22–7.CrossRefGoogle ScholarPubMed
Weindling, A. M. (2002) Epinephrine treatment in hypotensive newborns. Acta Paediatr. 91, 500–2.CrossRefGoogle ScholarPubMed
Weindling, A. M., Wilkinson, A. R., Cook, J.et al. (1985b) Perinatal events which precede periventricular haemorrhage and leukomalacia in the newborn. BJOG 92, 1218–23.CrossRefGoogle Scholar
Weindling, A. M., Rochefort, M. J., Calvert, S. A., Fok, T. F. and Wilkinson, A. (1985a) Development of cerebral palsy after ultrasonographic detection of periventricular cysts in the newborn. Dev. Med. Child. Neurol. 27, 800–6.CrossRefGoogle Scholar
Weindling, A. M., Hallam, P., Gregg, J.et al. (1996) A randomized controlled trial of early physiotherapy for high-risk infants. Acta Paediatr. 85, 1107–11.CrossRefGoogle ScholarPubMed
Whitelaw, A., (2002) Repeated lumbar or ventricular punctures in newborns with intraventricular hemorrhage (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Whitelaw, A., Rivers, R., Creighton, L. and Gaffney, P. (1992) Low dose intraventricular fibrinolytic therapy to prevent posthaemorrhagic hydrocephalus. Arch. Dis. Child. 67, F12–4.CrossRefGoogle ScholarPubMed
Whitelaw, A., Saliba, E., Fellman, V.et al. (1996) Phase 1 study of intraventricular recombinant tissue plasminogen activator for treatment of posthaemorrhagic hydrocephalus. Arch. Dis. Child. Fetal Neonatal Ed. 74, F20–6.CrossRefGoogle Scholar
Whyte, R. K. and Bifano, E. M. (2002) Early erythrocyte transfusion in very-low-birth-weight infants (Protocol for a Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar
Wood, N. S., Marlow, N., Costeloe, K., Gibson, A. T. and Wilkinson, A. R. (2000) Neurologic and developmental disability after extremely preterm birth. N. Engl. J. Med. 343, 378–84.CrossRefGoogle ScholarPubMed
Wyckoff, M. H., Perlman, J. and Niermeyer, S. (2001) Medications during resuscitation – what is the evidence? Semin. Neonatol. 6 (3), 251–9.CrossRefGoogle ScholarPubMed
Wu, Y. W. and Colford, J. M. (2000) Chorioamnionitis as a risk factor for cerebral palsy. A meta-analysis. JAMA 284, 1417–24.CrossRefGoogle ScholarPubMed
Yoon, B. H., Romero, R., Yang, S. H.et al. (1996) Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am. J. Obstet. Gynecol. 174, 1433–40.CrossRefGoogle ScholarPubMed
Yoon, B. H., Chong, C. J., Romero, R.et al. (1997) Experimentally induced intrauterine infection causes fetal brain white matter lesions in rabbits. Am. J. Obstet. Gynecol. 177, 797–802.CrossRefGoogle ScholarPubMed
Yost, C. C. and Soll, R. F. (2002) Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome (Cochrane Review). In The Cochrane Library, Issue 4. Oxford: Update Software.Google Scholar

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