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Chapter 38 - Botulinum Neurotoxin Applications in Urological Disorders

Published online by Cambridge University Press:  02 November 2023

By
Brigitte Schurch  and
Stefano Carda
Edited by
Daniel Truong ,
Dirk Dressler ,
Mark Hallett ,
Christopher Zachary  and
Mayank Pathak
Daniel Truong
Affiliation:
University of California, Riverside
Dirk Dressler
Affiliation:
Hannover Medical School
Mark Hallett
Affiliation:
National Institutes of Health (NIH)
Christopher Zachary
Affiliation:
University of California, Irvine
Mayank Pathak
Affiliation:
Truong Neuroscience Institute
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Summary

Botulinum neurotoxin (BoNT) is licensed for the treatment of a number of conditions characterized by striated muscle spasticity. However, in recent years, their unlicensed use in the treatment of lower urinary tract conditions has been described (Smith et al., 2004). Chief among these are conditions characterized by detrusor overactivity. Treatment of vulvodynia and chronic pelvic pain, benign prostate hyperplasia (BPH) and detrusor sphincter dyssynergia (DSD) are other emerging indications with promising positive results. This chapter details the use of BoNT for these conditions, giving a clinical definition of each condition, reviewing pertinent studies and describing the injection technique, percutaneous or endoscopic, using anatomical illustrations, and providing dosing recommendations.

Keywords

Botulinum neurotoxinBoNToveractive bladderdetrussor hyperreflexiavulvodyniapelvic painbladder painprostate painbenign prostatic hyperplasiadetrussor sphincter dyssynergiaautonomic dysreflexia
Type
Chapter
Information
Manual of Botulinum Toxin Therapy , pp. 323 - 331
Publisher: Cambridge University Press
Print publication year: 2023

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References

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