Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-848d4c4894-p2v8j Total loading time: 0.001 Render date: 2024-06-04T04:17:05.125Z Has data issue: false hasContentIssue false

Chapter 29 - Botulinum Toxin in Wound Healing

Published online by Cambridge University Press:  02 November 2023

By
Holger G. Gassner
Edited by
Daniel Truong ,
Dirk Dressler ,
Mark Hallett ,
Christopher Zachary  and
Mayank Pathak
Daniel Truong
Affiliation:
University of California, Riverside
Dirk Dressler
Affiliation:
Hannover Medical School
Mark Hallett
Affiliation:
National Institutes of Health (NIH)
Christopher Zachary
Affiliation:
University of California, Irvine
Mayank Pathak
Affiliation:
Truong Neuroscience Institute
Get access

Summary

Visible scars in the face are an important clinical entity, especially in the wake of trauma and cancer surgery. The first phase of wound healing is the inflammatory phase; the second phase of wound healing, the proliferative phase, is characterized by epithelial regeneration and collagen synthesis.

Tension is the overriding factor adversely affecting all phases of wound healing. Repetitive tension leads to inflammation, which in turn causes increased collagen synthesis and deposition of glycosaminoglycans, resulting in prolonged erythema and scar hypertrophy.

Underlying musculature can generate dynamic tension on a healing wound, particularly in the face.

A reduction of secondary tension and movement of the healing scar was achieved with injection of botulinum toxin into the musculature subjacent to the scar. As a result, repetitive movement of the wound edges was minimized, unfavorable effects of repetitive microtrauma on wound healing reduced and healing improved.

Keywords

Botulinum toxinwound healingchemoimmobilization
Type
Chapter
Information
Manual of Botulinum Toxin Therapy , pp. 237 - 244
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Chang, CS, Wallace, CG, Hsiao, Y-C, Chang, C-J, Chen, P K-T (2014). Botulinum toxin to improve results in cleft lip repair. Plast Reconstr Surg, 134, 511–16.CrossRefGoogle ScholarPubMed
Gassner, HG, Brissett, AE, Otley, CC et al. (2006). Botulinum toxin to improve facial wound healing: a prospective, blinded, placebo-controlled study. Mayo Clin Proc, 81, 1023–8.CrossRefGoogle ScholarPubMed
Gassner, HG, Sherris, DA, Otley, CC (2000). Treatment of facial wounds with botulinum toxin A improves cosmetic outcome in primates. Plast Reconstr Surg, 105, 1948–53.CrossRefGoogle ScholarPubMed
Haubner, F, Ohmann, E, Müller-Vogt, U et al. (2012). Effects of botulinum toxin A on cytokine synthesis in a cell culture model of cutaneous scarring. Arch Facial Plast Surg, 14, 122–6.CrossRefGoogle Scholar
Sonane, J, Sharma, RK, John, JR et al. (2022). Botulinum toxin for a better scar in cleft lip surgery: a prospective randomized control trial. J Craniofac Surg, 33, 198–202.CrossRefGoogle ScholarPubMed
Larrabee, WF Jr. (1986). A finite element model of skin deformation. I. Biomechanics of skin and soft tissue: a review. Laryngoscope, 96, 399–405.CrossRefGoogle ScholarPubMed
Larrabee, WF Jr., Sutton, D (1986). A finite element model of skin deformation. II. An experimental model of skin deformation. Laryngoscope, 96, 406–12.Google Scholar
Phillips, TJ, Fung, E, Rigby, MH et al. (2019). The use of botulinum toxin type A in the healing of thyroidectomy wounds: a randomized, prospective, placebo-controlled study. Plast Reconstr Surg, 143, 375e–81eCrossRefGoogle ScholarPubMed
Wang, L, Tai, NZ, Fan, ZH (2009). Effect of botulinum toxin type A injection on hypertrophic scar in rabbit ear model. J Plastic Surg, 25, 284–7.Google ScholarPubMed
Xiao, Z, Zhang, F, Cui, Z (2009). Treatment of hypertrophic scars with intralesional botulinum toxin type A injections: a preliminary report. Aesthetic Plast Surg, 33, 409–12.CrossRefGoogle ScholarPubMed
Zimbler, MS, Holds, JB, Kokoska, MS et al. (2001). Effect of botulinum toxin pretreatment on laser resurfacing results: a prospective, randomized, blinded trial. Arch Facial Plast Surg, 3, 165–9.Google Scholar
Qiao, Z, Yang, H, Jin, L, Li, S, Wang, X (2021). The efficacy and safety of botulinum toxin injections in preventing postoperative scars and improving scar quality: a systematic review and meta-analysis. Aesthetic Plast Surg, 45, 2350–62.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×