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7 - Special Populations and Circumstances

Older Bipolar Disorder Patients; Child and Adolescent Bipolar Disorder Patients; Pregnant and Breastfeeding Patients; Lithium Use During Renal Dialysis

Published online by Cambridge University Press:  09 February 2024

Jonathan M. Meyer
Affiliation:
University of California, San Diego
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

The 2017 International Society for Bipolar Disorders (ISBD) Task Force report on pediatric bipolar disorder (BD) cemented the concept that BD can have onset before the age 18, and that establishing the diagnosis should be based on symptoms of mania or hypomania, while chronic irritability by itself is not sufficient to establish a BD diagnosis [1, 2]. A 2010 study of 1566 patients from six international sites documented that approximately 5% of BD-1 and 5% of BD-2 cases had onset before the age of 20 (Figure 7.1), although the authors noted that only 34.1% of patients were evaluated at onset of their BD, so investigators had to rely on patient recall for two-thirds of the sample.

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The Lithium Handbook
Stahl's Handbooks
, pp. 362 - 427
Publisher: Cambridge University Press
Print publication year: 2023

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References

Goldstein, B. I., Birmaher, B., Carlson, G. A., et al. (2017). The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. Bipolar Disord, 19, 524543.CrossRefGoogle ScholarPubMed
Singh, M. K., Chang, K. D., Goldstein, B. I., et al. (2020). Isn’t the evidence base for pediatric bipolar disorder already sufficient to inform clinical practice? Bipolar Disord, 22, 664665.CrossRefGoogle ScholarPubMed
Baldessarini, R. J., Bolzani, L., Cruz, N., et al. (2010). Onset-age of bipolar disorders at six international sites. J Affect Disord, 121, 143146.CrossRefGoogle ScholarPubMed
Solmi, M., Radua, J., Olivola, M., et al. (2022). Age at onset of mental disorders worldwide: Large-scale meta-analysis of 192 epidemiological studies. Mol Psychiatry, 27, 281295.CrossRefGoogle ScholarPubMed
Van Meter, A. R., Burke, C., Kowatch, R. A., et al. (2016). Ten-year updated meta-analysis of the clinical characteristics of pediatric mania and hypomania. Bipolar Disord, 18, 1932.CrossRefGoogle ScholarPubMed
Findling, R. L., Stepanova, E., Youngstrom, E. A., et al. (2018). Progress in diagnosis and treatment of bipolar disorder among children and adolescents: An international perspective. Evid Based Ment Health, 21, 177181.CrossRefGoogle ScholarPubMed
Comparelli, A., Polidori, L., Sarli, G., et al. (2022). Differentiation and comorbidity of bipolar disorder and attention deficit and hyperactivity disorder in children, adolescents, and adults: A clinical and nosological perspective. Front Psychiatry, 13, 949375.CrossRefGoogle ScholarPubMed
Ribeiro-Fernández, M., Díez-Suárez, A. and Soutullo, C. (2019). Phenomenology and diagnostic stability of paediatric bipolar disorder in a Spanish sample. J Affect Disord, 242, 224233.CrossRefGoogle Scholar
Wozniak, J., DiSalvo, M., Farrell, A., et al. (2022). Long term outcomes of pediatric bipolar-I disorder: A prospective follow-up analysis attending to full syndomatic, subsyndromal and functional types of remission. J Psychiatr Res, 151, 667675.CrossRefGoogle ScholarPubMed
Findling, R. L., McNamara, N. K., Pavuluri, M., et al. (2019). Lithium for the maintenance treatment of bipolar I disorder: A double-blind, placebo-controlled discontinuation study. J Am Acad Child Adolesc Psychiatry, 58, 287296.CrossRefGoogle ScholarPubMed
Sun, A. Y., Woods, S., Findling, R. L., et al. (2019). Safety considerations in the psychopharmacology of pediatric bipolar disorder. Expert Opin Drug Saf, 18, 777794.CrossRefGoogle ScholarPubMed
Stepanova, E. and Findling, R. L. (2017). Psychopharmacology of bipolar disorders in children and adolescents. Pediatr Clin North Am, 64, 12091222.CrossRefGoogle ScholarPubMed
Duffy, A. and Grof, P. (2018). Lithium treatment in children and adolescents. Pharmacopsychiatry, 51, 189193.Google ScholarPubMed
Duffy, A., Heffer, N., Goodday, S. M., et al. (2018). Efficacy and tolerability of lithium for the treatment of acute mania in children with bipolar disorder: A systematic review. A report from the ISBD–IGSLi joint task force on lithium treatment. Bipolar Disord, 20, 583593.CrossRefGoogle ScholarPubMed
Velosa, J., Delgado, A., Finger, E., et al. (2020). Risk of dementia in bipolar disorder and the interplay of lithium: A systematic review and meta-analyses. Acta Psychiatr Scand, 141, 510521.CrossRefGoogle ScholarPubMed
Ochoa, E. L. M. (2022). Lithium as a neuroprotective agent for bipolar disorder: An overview. Cell Mol Neurobiol, 42, 8597.CrossRefGoogle ScholarPubMed
De Fazio, P., Gaetano, R., Caroleo, M., et al. (2017). Lithium in late-life mania: A systematic review. Neuropsychiatr Dis Treat, 13, 755766.CrossRefGoogle ScholarPubMed
Findling, R. L., Robb, A., McNamara, N. K., et al. (2015). Lithium in the acute treatment of bipolar I disorder: A double-blind, placebo-controlled discontinuation study. Pediatrics, 136, 885894.CrossRefGoogle Scholar
Young, R. C., Mulsant, B. H., Sajatovic, M., et al. (2017). GERI-BD: A randomized double-blind controlled trial of lithium and divalproex in the treatment of mania in older patients with bipolar disorder. Am J Psychiatry, 174, 10861093.CrossRefGoogle ScholarPubMed
Fotso Soh, J., Klil-Drori, S. and Rej, S. (2019). Using lithium in older age bipolar disorder: Special considerations. Drugs Aging, 36, 147154.CrossRefGoogle ScholarPubMed
Lambrichts, S., Detraux, J., Vansteelandt, K., et al. (2021). Does lithium prevent relapse following successful electroconvulsive therapy for major depression? A systematic review and meta-analysis. Acta Psychiatr Scand, 143, 294306.CrossRefGoogle ScholarPubMed
Juurlink, D. N., Mamdani, M. M., Kopp, A., et al. (2004). Drug-induced lithium toxicity in the elderly: A population-based study. J Am Geriatr Soc, 52, 794798.CrossRefGoogle ScholarPubMed
Rej, S., Yu, C., Shulman, K., et al. (2015). Medical comorbidity, acute medical care use in late-life bipolar disorder: A comparison of lithium, valproate, and other pharmacotherapies. Gen Hosp Psychiatry, 37, 528532.CrossRefGoogle ScholarPubMed
Ljubic, N., Ueberberg, B., Grunze, H., et al. (2021). Treatment of bipolar disorders in older adults: A review. Ann Gen Psychiatry, 20, 4555.CrossRefGoogle ScholarPubMed
Golic, M., Aiff, H., Attman, P. O., et al. (2021). Starting lithium in patients with compromised renal function – is it wise? J Psychopharmacol, 35, 190197.CrossRefGoogle ScholarPubMed
Bauer, M. and Gitlin, M. (2016). The Essential Guide to Lithium Treatment. Basle: Springer International Publishing AG.CrossRefGoogle Scholar
Kirkham, E., Skinner, J., Anderson, T., et al. (2014). One lithium level >1.0 mmol/L causes an acute decline in eGFR: Findings from a retrospective analysis of a monitoring database. BMJ Open, 4, e006020.CrossRefGoogle ScholarPubMed
Castro, V. M., Roberson, A. M., McCoy, T. H., et al. (2016). Stratifying risk for renal insufficiency among lithium-treated patients: An electronic health record study. Neuropsychopharmacology, 41, 11381143.CrossRefGoogle ScholarPubMed
Heald, A. H., Holland, D., Stedman, M., et al. (2021). Can we check serum lithium levels less often without compromising patient safety? BJPsych Open, 8, e18.CrossRefGoogle ScholarPubMed
Heath, L. J., Billups, S. J., Gaughan, K. M., et al. (2018). Risk factors for utilization of acute care services for lithium toxicity. Psychiatr Serv, 69, 671676.CrossRefGoogle ScholarPubMed
Tsai, S.-Y., Shen, R.-S., Kuo, C.-J., et al. (2020). The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder. Aust N Z J Psychiatry, 54, 11251134.CrossRefGoogle ScholarPubMed
Chen, P. H., Hsiao, C. Y., Chiang, S. J., et al. (2023). Cardioprotective potential of lithium and role of fractalkine in euthymic patients with bipolar disorder. Aust N Z J Psychiatry, 57, 104114.CrossRefGoogle ScholarPubMed
Moore, C. M., Demopulos, C. M., Henry, M. E., et al. (2002). Brain-to-serum lithium ratio and age: An in vivo magnetic resonance spectroscopy study. Am J Psychiatry, 159, 12401242.CrossRefGoogle ScholarPubMed
Forester, B. P., Streeter, C. C., Berlow, Y. A., et al. (2009). Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: A lithium-7 magnetic resonance spectroscopy study. Am J Geriatr Psychiatry, 17, 1323.CrossRefGoogle ScholarPubMed
Machado-Vieira, R., Otaduy, M. C., Zanetti, M. V., et al. (2016). A selective association between central and peripheral lithium levels in remitters in bipolar depression: A 3 T-(7) Li magnetic resonance spectroscopy study. Acta Psychiatr Scand, 133, 214220.CrossRefGoogle Scholar
Delgado, C., Baweja, M., Crews, D. C., et al. (2021). A unifying approach for GFR estimation: Recommendations of the NKF–ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease. Am J Kidney Dis, 79, 268–288.e261.Google ScholarPubMed
Inker, L. A., Eneanya, N. D., Coresh, J., et al. (2021). New creatinine- and cystatin C-based equations to estimate GFR without race. N Engl J Med, 385, 17371749.CrossRefGoogle ScholarPubMed
Forlenza, O. V., Hajek, T., Almeida, O. P., et al. (2022). Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder. Acta Psychiatr Scand, 146, 442455.CrossRefGoogle ScholarPubMed
Malhi, G. S., Gessler, D. and Outhred, T. (2017). The use of lithium for the treatment of bipolar disorder: Recommendations from clinical practice guidelines. J Affect Disord, 217, 266280.CrossRefGoogle ScholarPubMed
Huybrechts, K. F., Hernandez-Diaz, S., Patorno, E., et al. (2016). Antipsychotic use in pregnancy and the risk for congenital malformations. JAMA Psychiatry, 73, 938946.CrossRefGoogle ScholarPubMed
Imaz, M. L., Torra, M., Soy, D., et al. (2019). Clinical lactation studies of lithium: A systematic review. Front Pharmacol, 10, 1005.CrossRefGoogle ScholarPubMed
Newmark, R. L., Bogen, D. L., Wisner, K. L., et al. (2019). Risk–benefit assessment of infant exposure to lithium through breast milk: A systematic review of the literature. Int Rev Psychiatry, 31, 295304.CrossRefGoogle ScholarPubMed
Heinonen, E., Totterman, K., Back, K., et al. (2022). Lithium use during breastfeeding was safe in healthy full-term infants under strict monitoring. Acta Paediatr, 111, 18911898.CrossRefGoogle ScholarPubMed
Patorno, E., Huybrechts, K. F., Bateman, B. T., et al. (2017). Lithium use in pregnancy and the risk of cardiac malformations. NEJM, 376, 22452254.CrossRefGoogle ScholarPubMed
Deb, S., Austin, P. C., Tu, J. V., et al. (2016). A review of propensity-score methods and their use in cardiovascular research. Can J Cardiol, 32, 259265.CrossRefGoogle ScholarPubMed
Thomas, L., Li, F. and Pencina, M. (2020). Using propensity score methods to create target populations in observational clinical research. JAMA, 323, 466467.CrossRefGoogle ScholarPubMed
Kessing, L. V., Gerds, T. A., Feldt-Rasmussen, B., et al. (2015). Use of lithium and anticonvulsants and the rate of chronic kidney disease: A nationwide population-based study. JAMA Psychiatry, 72, 11821191.CrossRefGoogle ScholarPubMed
Nolen, W. A., Licht, R. W., Young, A. H., et al. (2019). What is the optimal serum level for lithium in the maintenance treatment of bipolar disorder? A systematic review and recommendations from the ISBD/IGSLI Task Force on treatment with lithium. Bipolar Disord, 21, 394409.CrossRefGoogle ScholarPubMed
Fornaro, M., Maritan, E., Ferranti, R., et al. (2020). Lithium exposure during pregnancy and the postpartum period: A systematic review and meta-analysis of safety and efficacy outcomes. Am J Psychiatry, 177, 7692.CrossRefGoogle ScholarPubMed
Werneke, U., Ott, M., Renberg, E. S., et al. (2012). A decision analysis of long-term lithium treatment and the risk of renal failure. Acta Psychiatr Scand, 126, 186197.CrossRefGoogle ScholarPubMed
McGrane, I. R., Omar, F. A., Morgan, N. F., et al. (2022). Lithium therapy in patients on dialysis: A systematic review. Int J Psychiatry Med, 57, 187201.CrossRefGoogle ScholarPubMed
Suetani, S., Whiteford, H. A. and McGrath, J. J. (2015). An urgent call to address the deadly consequences of serious mental disorders. JAMA Psychiatry, 72, 11661167.CrossRefGoogle ScholarPubMed
Hayes, J. F., Marston, L., Walters, K., et al. (2017). Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000–2014. Br J Psychiatry, 211, 175181.CrossRefGoogle ScholarPubMed
Chesney, E., Robson, D., Patel, R., et al. (2021). The impact of cigarette smoking on life expectancy in schizophrenia, schizoaffective disorder and bipolar affective disorder: An electronic case register cohort study. Schizophr Res, 238, 2935.CrossRefGoogle ScholarPubMed
Oakley, P. W., Whyte, I. M. and Carter, G. L. (2001). Lithium toxicity: An iatrogenic problem in susceptible individuals. Aust N Z J Psychiatry, 35, 833840.CrossRefGoogle ScholarPubMed
Puglisi-Allegra, S., Ruggieri, S. and Fornai, F. (2021). Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders. Transl Psychiatry, 11, 366.CrossRefGoogle ScholarPubMed
Haupt, M., Bahr, M. and Doeppner, T. R. (2021). Lithium beyond psychiatric indications: The reincarnation of a new old drug. Neural Regen Res, 16, 23832387.Google ScholarPubMed
Almeida, O. P., Singulani, M. P., Ford, A. H., et al. (2022). Lithium and stroke recovery: A systematic review and meta-analysis of stroke models in rodents and human data. Stroke, 53, 29352944.CrossRefGoogle ScholarPubMed
Amdisen, A. (1977). Serum level monitoring and clinical pharmacokinetics of lithium. Clin Pharmacokinet, 2, 7392.CrossRefGoogle ScholarPubMed
Finley, P. R., Warner, M. D. and Peabody, C. A. (1995). Clinical relevance of drug interactions with lithium. Clin Pharmacokinet, 29, 172191.CrossRefGoogle ScholarPubMed
Tueth, M. J., Murphy, T. K. and Evans, D. L. (1998). Special considerations: Use of lithium in children, adolescents, and elderly populations. J Clin Psychiatry, 59, 6673.Google ScholarPubMed
Lee, J. H., Adler, C., Norris, M., et al. (2012). 4-T 7Li 3D MR spectroscopy imaging in the brains of bipolar disorder subjects. Magn Reson Med, 68, 363368.CrossRefGoogle ScholarPubMed
Soares, J. C., Boada, F. and Keshavan, M. S. (2000). Brain lithium measurements with (7)Li magnetic resonance spectroscopy (MRS): A literature review. Eur Neuropsychopharmacol, 10, 151158.CrossRefGoogle Scholar
Luo, H., Chevillard, L., Bellivier, F., et al. (2021). The role of brain barriers in the neurokinetics and pharmacodynamics of lithium. Pharmacol Res, 166, 105480.CrossRefGoogle ScholarPubMed
Baldessarini, R. J., Tondo, L., Davis, P., et al. (2006). Decreased risk of suicides and attempts during long-term lithium treatment: A meta-analytic review. Bipolar Disord, 8, 625639.CrossRefGoogle ScholarPubMed
Biederman, J., Wozniak, J., Kiely, K., et al. (1995). CBCL clinical scales discriminate prepubertal children with structured interview-derived diagnosis of mania from those with ADHD. J Am Acad Child Adolesc Psychiatry, 34, 464471.CrossRefGoogle ScholarPubMed
Faedda, G. L., Baldessarini, R. J., Suppes, T., et al. (1995). Pediatric-onset bipolar disorder: A neglected clinical and public health problem. Harv Rev Psychiatry, 3, 171195.CrossRefGoogle ScholarPubMed
Wozniak, J., Biederman, J., Kiely, K., et al. (1995). Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry, 34, 867876.CrossRefGoogle ScholarPubMed
Sandstrom, A., Perroud, N., Alda, M., et al. (2021). Prevalence of attention-deficit/hyperactivity disorder in people with mood disorders: A systematic review and meta-analysis. Acta Psychiatr Scand, 143, 380391.CrossRefGoogle ScholarPubMed
Kasoff, L. I., Ahn, K., Gochman, P., et al. (2016). Strong treatment response and high maintenance rates of clozapine in childhood-onset schizophrenia. J Child Adolesc Psychopharmacol, 26, 428435.CrossRefGoogle ScholarPubMed
Strakowski, S. M., DelBello, M. P. and Adler, C. M., eds. (2014). Bipolar Disorder in Youth: Presentation, Treatment and Neurobiology (1st edn.). New York: Oxford University Press.CrossRefGoogle Scholar
Redden, L., DelBello, M., Wagner, K. D., et al. (2009). Long-term safety of divalproex sodium extended-release in children and adolescents with bipolar I disorder. J Child Adolesc Psychopharmacol, 19, 8389.CrossRefGoogle ScholarPubMed
Wagner, K. D., Redden, L., Kowatch, R. A., et al. (2009). A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry, 48, 519532.CrossRefGoogle ScholarPubMed
Findling, R. L., McNamara, N. K., Gracious, B. L., et al. (2003). Combination lithium and divalproex sodium in pediatric bipolarity. J Am Acad Child Adolesc Psychiatry, 42, 895901.CrossRefGoogle ScholarPubMed
Findling, R. L., McNamara, N. K., Stansbrey, R., et al. (2006). Combination lithium and divalproex sodium in pediatric bipolar symptom re-stabilization. J Am Acad Child Adolesc Psychiatry, 45, 142148.CrossRefGoogle ScholarPubMed
Amerio, A., Russo, D., Miletto, N., et al. (2021). Polypharmacy as maintenance treatment in bipolar illness: A systematic review. Acta Psychiatr Scand, 144, 259276.CrossRefGoogle ScholarPubMed
Inc, Glenmark Pharmaceuticals. (2020). Lithium Carbonate Capsule package insert. Mahwah, NJ.Google Scholar
Amerio, A., Ossola, P., Scagnelli, F., et al. (2018). Safety and efficacy of lithium in children and adolescents: A systematic review in bipolar illness. Eur Psychiatry, 54, 8597.CrossRefGoogle ScholarPubMed
Pharmaceuticals Inc, ANI. (2020). LithoBID package insert. Baudette, MN.Google Scholar
Pharma, Essential (2022). Camcolit Controlled Release product labeling. Egham, Surrey, UK.Google Scholar
Limited, Essential Pharma (2022). Priadel Prolonged Release Tablets product labeling. Birkirkara, Malta.Google Scholar
Findling, R. L., McNamara, N. K., Youngstrom, E. A., et al. (2005). Double-blind 18-month trial of lithium versus divalproex maintenance treatment in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry, 44, 409417.CrossRefGoogle ScholarPubMed
Geller, B., Luby, J. L., Joshi, P., et al. (2012). A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents. Arch Gen Psychiatry, 69, 515528.CrossRefGoogle ScholarPubMed
Findling, R. L., Kafantaris, V., Pavuluri, M., et al. (2011). Dosing strategies for lithium monotherapy in children and adolescents with bipolar I disorder. J Child Adolesc Psychopharmacol, 21, 195205.CrossRefGoogle ScholarPubMed
Findling, R. L., Kafantaris, V., Pavuluri, M., et al. (2013). Post-acute effectiveness of lithium in pediatric bipolar I disorder. J Child Adolesc Psychopharmacol, 23, 8090.CrossRefGoogle ScholarPubMed
Shim, S. H. and Kwon, Y. J. (2014). Adolescent with Tourette syndrome and bipolar disorder: A case report. Clin Psychopharmacol Neurosci, 12, 235239.CrossRefGoogle ScholarPubMed
Pisano, S., Pozzi, M., Catone, G., et al. (2019). Putative mechanisms of action and clinical use of lithium in children and adolescents: A critical review. Curr Neuropharmacol, 17, 318341.CrossRefGoogle ScholarPubMed
Kowatch, R. A., Suppes, T., Carmody, T. J., et al. (2000). Effect size of lithium, divalproex sodium, and carbamazepine in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry, 39, 713720.CrossRefGoogle ScholarPubMed
Sanchez, M., Lytle, S., Neudecker, M., et al. (2021). Medication adherence in pediatric patients with bipolar disorder: A systematic review. J Child Adolesc Psychopharmacol, 31, 8694.CrossRefGoogle ScholarPubMed
Drotar, D., Greenley, R. N., Demeter, C. A., et al. (2007). Adherence to pharmacological treatment for juvenile bipolar disorder. J Am Acad Child Adolesc Psychiatry, 46, 831839.CrossRefGoogle ScholarPubMed
Velligan, D. I., Wang, M., Diamond, P., et al. (2007). Relationships among subjective and objective measures of adherence to oral antipsychotic medications. Psychiatric Services, 58, 11871192.CrossRefGoogle ScholarPubMed
Velligan, D. I., Weiden, P. J., Sajatovic, M., et al. (2009). The expert consensus guideline series: Adherence problems in patients with serious and persistent mental illness. J Clin Psychiatry, 70, 146.Google ScholarPubMed
Yaegashi, H., Kirino, S., Remington, G., et al. (2020). Adherence to oral antipsychotics measured by electronic adherence monitoring in schizophrenia: A systematic review and meta-analysis. CNS Drugs, 34, 579598.CrossRefGoogle ScholarPubMed
Meyer, J. M. and Stahl, S. M. (2021). The Clinical Use of Antipsychotic Plasma Levels (Stahl’s Handbooks). New York: Cambridge University Press.CrossRefGoogle Scholar
Sajatovic, M., Tatsuoka, C., Cassidy, K. A., et al. (2018). A 6-month, prospective, randomized controlled trial of Customized Adherence Enhancement versus bipolar-specific educational control in poorly adherent individuals with bipolar disorder. J Clin Psychiatry, 79, 17m12036 e12031–e12010.CrossRefGoogle ScholarPubMed
Canales, T., Rodman, S., Conklin, D., et al. (2022). Combining medication adherence support plus long-acting injectable antipsychotic medication: A post-hoc analysis of 3 pilot studies. Psychopharmacol Bull, 52, 4157.Google ScholarPubMed
McVoy, M., Delbello, M., Levin, J., et al. (2022). A customized adherence enhancement program for adolescents and young adults with suboptimal adherence and bipolar disorder: Trial design and methodological report. Contemp Clin Trials, 115, 106729.CrossRefGoogle Scholar
Findling, R. L., Landersdorfer, C. B., Kafantaris, V., et al. (2010). First-dose pharmacokinetics of lithium carbonate in children and adolescents. J Clin Psychopharmacol, 30, 404410.CrossRefGoogle ScholarPubMed
Landersdorfer, C. B., Findling, R. L., Frazier, J. A., et al. (2017). Lithium in paediatric patients with bipolar disorder: Implications for selection of dosage regimens via population pharmacokinetics/pharmacodynamics. Clin Pharmacokinet, 56, 7790.CrossRefGoogle ScholarPubMed
Viguera, A. C., Tondo, L., Koukopoulos, A. E., et al. (2011). Episodes of mood disorders in 2,252 pregnancies and postpartum periods. Am J Psychiatry, 168, 11791185.CrossRefGoogle Scholar
Viguera, A. C., Whitfield, T., Baldessarini, R. J., et al. (2007). Risk of recurrence in women with bipolar disorder during pregnancy: Prospective study of mood stabilizer discontinuation. Am J Psychiatry, 164, 1817–1824.CrossRefGoogle ScholarPubMed
Deiana, V., Chillotti, C., Manchia, M., et al. (2014). Continuation versus discontinuation of lithium during pregnancy: A retrospective case series. J Clin Psychopharmacol, 34, 407410.CrossRefGoogle ScholarPubMed
Diav-Citrin, O., Shechtman, S., Tahover, E., et al. (2014). Pregnancy outcome following in utero exposure to lithium: A prospective, comparative, observational study. Am J Psychiatry, 171, 785794.CrossRefGoogle ScholarPubMed
Stephens, E. H. and Dearani, J. A. (2022). Ebstein Anomaly – of veils and visions. JAMA, 327, 21732174.CrossRefGoogle ScholarPubMed
Boyle, B., Garne, E., Loane, M., et al. (2017). The changing epidemiology of Ebstein’s anomaly and its relationship with maternal mental health conditions: A European registry-based study. Cardiology in the Young, 27, 677685.CrossRefGoogle ScholarPubMed
Kan, A. C. O., Chan, J. K. N., Wong, C. S. M., et al. (2022). Psychotropic drug utilization patterns in pregnant women with bipolar disorder: A 16-year population-based cohort study. Eur Neuropsychopharmacol, 57, 7585.CrossRefGoogle ScholarPubMed
McCloskey, L. R., Wisner, K. L., Cattan, M. K., et al. (2021). Contraception for women with psychiatric disorders. Am J Psychiatry, 178, 247255.CrossRefGoogle ScholarPubMed
Poels, E. M., Sterrenburg, K., Wierdsma, A. I., et al. (2021). Lithium exposure during pregnancy increases fetal growth. J Psychopharmacol, 35, 178183.CrossRefGoogle ScholarPubMed
Wesseloo, R., Wierdsma, A. I., van Kamp, I. L., et al. (2017). Lithium dosing strategies during pregnancy and the postpartum period. Br J Psychiatry, 211, 3136.CrossRefGoogle ScholarPubMed
Dickens, L. T., Cifu, A. S. and Cohen, R. N. (2019). Diagnosis and management of thyroid disease during pregnancy and the postpartum period. JAMA, 321, 1928–1929.CrossRefGoogle ScholarPubMed
Huybrechts, K. F., Palmsten, K., Avorn, J., et al. (2014). Antidepressant use in pregnancy and the risk of cardiac defects. N Engl J Med, 370, 23972407.CrossRefGoogle ScholarPubMed
Swanson, S. A., Hernandez-Diaz, S., Palmsten, K., et al. (2015). Methodological considerations in assessing the effectiveness of antidepressant medication continuation during pregnancy using administrative data. Pharmacoepidemiol Drug Saf, 24, 934942.CrossRefGoogle ScholarPubMed
Sujan, A. C. (2022). What do we know about in-utero antidepressant exposure, and are these medications safe to use during pregnancy? Acta Psychiatr Scand, 145, 541543.CrossRefGoogle ScholarPubMed
Poels, E. M. P., Schrijver, L., Kamperman, A. M., et al. (2018). Long-term neurodevelopmental consequences of intrauterine exposure to lithium and antipsychotics: A systematic review and meta-analysis. Eur Child Adolesc Psychiatry, 27, 12091230.CrossRefGoogle ScholarPubMed
Harel, Z., McArthur, E., Hladunewich, M., et al. (2019). Serum creatinine levels before, during, and after pregnancy. JAMA, 321, 205207.CrossRefGoogle Scholar
Westin, A. A., Brekke, M., Molden, E., et al. (2017). Changes in drug disposition of lithium during pregnancy: A retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway. BMJ Open, 7, e015738.CrossRefGoogle ScholarPubMed
Newton, E. R. and Hale, T. W. (2015). Drugs in breast milk. Clin Obstet Gynecol, 58, 868884.CrossRefGoogle ScholarPubMed
Uguz, F. and Sharma, V. (2016). Mood stabilizers during breastfeeding: A systematic review of the recent literature. Bipolar Disord, 18, 325333.CrossRefGoogle ScholarPubMed
McAllister-Williams, R. H., Baldwin, D. S., Cantwell, R., et al. (2017). British Association for Psychopharmacology consensus guidance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017. J Psychopharmacol, 31, 519552.CrossRefGoogle ScholarPubMed
Caviness, J. N. and Evidente, V. G. (2003). Cortical myoclonus during lithium exposure. Arch Neurol, 60, 401404.CrossRefGoogle ScholarPubMed
Friedman, J. H. (2020). Movement disorders induced by psychiatric drugs that do not block dopamine receptors. Parkinsonism Relat Disord, 79, 6064.CrossRefGoogle Scholar
Mifsud, S., Cilia, K., Mifsud, E. L., et al. (2020). Lithium-associated hyperparathyroidism. Br J Hosp Med (Lond), 81, 19.CrossRefGoogle ScholarPubMed
Pattan, V., Singh, B., Abdelmoneim, S. S., et al. (2021). Lithium-induced hyperparathyroidism: An ill-defined territory. Psychopharmacol Bull, 51, 6571.Google ScholarPubMed

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To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

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