Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-25T06:03:02.778Z Has data issue: false hasContentIssue false

Chapter 30 - CD34+ Cell Selection: Current Concepts, Methods, and Controversies

from Section 9 - Selection of Conditioning Regimen and Challenges with Different Types of T-Cell Depletion Methods

Published online by Cambridge University Press:  24 May 2017

By
Melody Smith  and
Miguel-Angel Perales
Edited by
Hillard M. Lazarus ,
Robert Peter Gale ,
Armand Keating ,
Andrea Bacigalupo ,
Reinhold Munker  and
Kerry Atkinson
Edited in association with
Syed Ali Abutalib
Hillard M. Lazarus
Affiliation:
Case Western Reserve University, Ohio
Robert Peter Gale
Affiliation:
Imperial College London
Armand Keating
Affiliation:
University of Toronto
Andrea Bacigalupo
Affiliation:
Ospedale San Martino, Genoa
Reinhold Munker
Affiliation:
Louisiana State University, Shreveport
Kerry Atkinson
Affiliation:
University of Queensland
Syed Ali Abutalib
Affiliation:
Midwestern Regional Medical Center, Cancer Treatment Centers of America, Chicago
Get access
Type
Chapter
Information
Hematopoietic Cell Transplants
Concepts, Controversies and Future Directions
 , pp. 283 - 290
Publisher: Cambridge University Press
Print publication year: 2000

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Nash, RA, Antin, JH, Karanes, C, Fay, JW, Avalos, BR, Yeager, AM, et al. Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors. Blood. 2000;96(6):2062–8. PubMed PMID: 10979948. Epub 2000/09/09. eng.Google Scholar
Inamoto, Y, Flowers, ME, Appelbaum, FR, Carpenter, PA, Deeg, HJ, Furlong, T, et al. A retrospective comparison of tacrolimus versus cyclosporine with methotrexate for immunosuppression after allogeneic hematopoietic cell transplantation with mobilized blood cells. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2011;17(7):1088–92. PubMed PMID: 21421070. Pubmed Central PMCID: Pmc3114191. Epub 2011/03/23. eng.Google Scholar
Martin, PJ, Rowley, SD, Anasetti, C, Chauncey, TR, Gooley, T, Petersdorf, EW, et al. A phase I-II clinical trial to evaluate removal of CD4 cells and partial depletion of CD8 cells from donor marrow for HLA-mismatched unrelated recipients. Blood. 1999;94(7):2192–9. PubMed PMID: 10498588. Epub 1999/09/25. eng.Google Scholar
Alyea, EP, Weller, E, Fisher, DC, Freedman, AS, Gribben, JG, Lee, S, et al. Comparable outcome with T-cell-depleted unrelated-donor versus related-donor allogeneic bone marrow transplantation. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2002;8(11):601–7. PubMed PMID: 12463479. Epub 2002/12/05. eng.Google Scholar
Jakubowski, AA, Small, TN, Kernan, NA, Castro-Malaspina, H, Collins, N, Koehne, G, et al. T cell-depleted unrelated donor stem cell transplantation provides favorable disease-free survival for adults with hematologic malignancies. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2011;17(9):1335–42. PubMed PMID: 21232623. Pubmed Central PMCID: Pmc3094599. Epub 2011/01/15. eng.Google Scholar
Jakubowski, AA, Small, TN, Young, JW, Kernan, NA, Castro-Malaspina, H, Hsu, KC, et al. T cell depleted stem-cell transplantation for adults with hematologic malignancies: sustained engraftment of HLA-matched related donor grafts without the use of antithymocyte globulin. Blood. 2007;110(13):4552–9. PubMed PMID: 17717135. Pubmed Central PMCID: Pmc2234775. Epub 2007/08/25. eng.CrossRefGoogle ScholarPubMed
Papadopoulos, EB, Carabasi, MH, Castro-Malaspina, H, Childs, BH, Mackinnon, S, Boulad, F, et al. T-cell-depleted allogeneic bone marrow transplantation as postremission therapy for acute myelogenous leukemia: freedom from relapse in the absence of graft-versus-host disease. Blood. 1998;91(3):1083–90. PubMed PMID: 9446672. Epub 1998/02/03. eng.Google Scholar
Young, JW, Papadopoulos, EB, Cunningham, I, Castro-Malaspina, H, Flomenberg, N, Carabasi, MH, et al. T-cell-depleted allogeneic bone marrow transplantation in adults with acute nonlymphocytic leukemia in first remission. Blood. 1992;79(12):3380–7. PubMed PMID: 1596577. Epub 1992/06/15. eng.Google Scholar
Aversa, F, Terenzi, A, Carotti, A, Felicini, R, Jacucci, R, Zei, T, et al. Improved outcome with T-cell-depleted bone marrow transplantation for acute leukemia. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 1999;17(5):1545–50. PubMed PMID: 10334542. Epub 1999/05/20. eng.Google Scholar
Reisner, Y, Kapoor, N, Kirkpatrick, D, Pollack, MS, Dupont, B, Good, RA, et al. Transplantation for acute leukaemia with HLA-A and B nonidentical parental marrow cells fractionated with soybean agglutinin and sheep red blood cells. Lancet. 1981;2(8242):327–31. PubMed PMID: 6115110. Epub 1981/08/15. eng.Google Scholar
de Witte, T, Hoogenhout, J, de Pauw, B, Holdrinet, R, Janssen, J, Wessels, J, et al. Depletion of donor lymphocytes by counterflow centrifugation successfully prevents acute graft-versus-host disease in matched allogeneic marrow transplantation. Blood. 1986;67(5):1302–8. PubMed PMID: 3516253. Epub 1986/05/01. eng.Google Scholar
Wagner, JE, Donnenberg, AD, Noga, SJ, Cremo, CA, Gao, IK, Yin, HJ, et al. Lymphocyte depletion of donor bone marrow by counterflow centrifugal elutriation: results of a phase I clinical trial. Blood. 1988;72(4):1168–76. PubMed PMID: 3048436. Epub 1988/10/01. eng.Google Scholar
Sao, H, Kitaori, K, Kasai, M, Shimokawa, T, Kato, C, Yamanishi, H, et al. A new marrow T cell depletion method using anti-CD6 monoclonal antibody-conjugated magnetic beads and its clinical application for prevention of acute graft-vs.-host disease in allogeneic bone marrow transplantation: results of a phase I-II trial. International journal of hematology. 1999;69(1):27–35. PubMed PMID: 10641440. Epub 2000/01/21. eng.Google Scholar
Handgretinger, R. Negative depletion of CD3(+) and TcRalphabeta(+) T cells. Current Opinion in Hematology. 2012;19(6):434–9. PubMed PMID: 22914586. Epub 2012/08/24. eng.Google Scholar
Aversa, F, Terenzi, A, Tabilio, A, Falzetti, F, Carotti, A, Ballanti, S, et al. Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2005;23(15):3447–54. PubMed PMID: 15753458. Epub 2005/03/09. eng.Google Scholar
Devine, SM, Carter, S, Soiffer, RJ, Pasquini, MC, Hari, PN, Stein, A, et al. Low-risk of chronic graft-versus-host disease and relapse associated with T cell-depleted peripheral blood stem cell transplantation for acute myelogenous leukemia in first remission: results of the blood and marrow transplant clinical trials network protocol 0303. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2011;17(9):1343–51. PubMed PMID: 21320619. Pubmed Central PMCID: Pmc3150599. Epub 2011/02/16. eng.Google Scholar
Finke, J, Brugger, W, Bertz, H, Behringer, D, Kunzmann, R, Weber-Nordt, RM, et al. Allogeneic transplantation of positively selected peripheral blood CD34+ progenitor cells from matched related donors. Bone Marrow Transplantation. 1996 Dec;18(6):1081–6. PubMed PMID: 8971376. Epub 1996/12/01. eng.Google Scholar
Urbano-Ispizua, A, Brunet, S, Solano, C, Moraleda, JM, Rovira, M, Zuazu, J, et al. Allogeneic transplantation of CD34+-selected cells from peripheral blood in patients with myeloid malignancies in early phase: a case control comparison with unmodified peripheral blood transplantation. Bone Marrow Transplantation. 2001;28(4):349–54. PubMed PMID: 11571506. Epub 2001/09/26. eng.Google Scholar
Watts, MJ, Somervaille, TC, Ings, SJ, Ahmed, F, Khwaja, A, Yong, K, et al. Variable product purity and functional capacity after CD34 selection: a direct comparison of the CliniMACS (v2.1) and Isolex 300i (v2.5) clinical scale devices. British Journal of Haematology. 2002;118(1):117–23. PubMed PMID: 12100134. Epub 2002/07/09. eng.Google Scholar
Martin, PJ, Hansen, JA, Buckner, CD, Sanders, JE, Deeg, HJ, Stewart, P, et al. Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts. Blood. 1985;66(3):664–72. PubMed PMID: 3896348. Epub 1985/09/01. eng.Google Scholar
Dykes, JH, Toporski, J, Juliusson, G, Bekassy, AN, Lenhoff, S, Lindmark, A, et al. Rapid and effective CD3 T-cell depletion with a magnetic cell sorting program to produce peripheral blood progenitor cell products for haploidentical transplantation in children and adults. Transfusion. 2007;47(11):2134–42. PubMed PMID: 17958543. Epub 2007/10/26. eng.Google Scholar
Schumm, M, Lang, P, Bethge, W, Faul, C, Feuchtinger, T, Pfeiffer, M, et al. Depletion of T-cell receptor alpha/beta and CD19 positive cells from apheresis products with the CliniMACS device. Cytotherapy. 2013;15(10):1253–8. PubMed PMID: 23993299. Epub 2013/09/03. eng.Google Scholar
Castro-Malaspina, H, Harris, RE, Gajewski, J, Ramsay, N, Collins, R, Dharan, B, et al. Unrelated donor marrow transplantation for myelodysplastic syndromes: outcome analysis in 510 transplants facilitated by the National Marrow Donor Program. Blood. 2002;99(6):1943–51. PubMed PMID: 11877264. Epub 2002/03/06. eng.Google Scholar
Laurent, G, Maraninchi, D, Gluckman, E, Vernant, JP, Derocq, JM, Gaspard, MH, et al. Donor bone marrow treatment with T101 Fab fragment-ricin A-chain immunotoxin prevents graft-versus-host disease. Bone Marrow Transplantation. 1989;4(4):367–71. PubMed PMID: 2789084. Epub 1989/07/01. eng.Google Scholar
Mitsuyasu, RT, Champlin, RE, Gale, RP, Ho, WG, Lenarsky, C, Winston, D, et al. Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. A prospective, randomized, double-blind trial. Annals of Internal Medicine. 1986;105(1):20–6. PubMed PMID: 3521427. Epub 1986/07/01. eng.Google Scholar
Prentice, HG, Blacklock, HA, Janossy, G, Gilmore, MJ, Price-Jones, L, Tidman, N, et al. Depletion of T lymphocytes in donor marrow prevents significant graft-versus-host disease in matched allogeneic leukaemic marrow transplant recipients. Lancet. 1984;1(8375):472–6. PubMed PMID: 6142207. Epub 1984/03/03. eng.Google Scholar
Soiffer, RJ, Fairclough, D, Robertson, M, Alyea, E, Anderson, K, Freedman, A, et al. CD6-depleted allogeneic bone marrow transplantation for acute leukemia in first complete remission. Blood. 1997;89(8):3039–47. PubMed PMID: 9108425. Epub 1997/04/15. eng.Google Scholar
Bayraktar, UD, de Lima, M, Saliba, RM, Maloy, M, Castro-Malaspina, HR, Chen, J, et al. Ex vivo T cell-depleted versus unmodified allografts in patients with acute myeloid leukemia in first complete remission. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2013;19(6):898–903. PubMed PMID: 23467126. Pubmed Central PMCID: Pmc4059063. Epub 2013/03/08. eng.Google Scholar
Pasquini, MC, Devine, S, Mendizabal, A, Baden, LR, Wingard, JR, Lazarus, HM, et al. Comparative outcomes of donor graft CD34+ selection and immune suppressive therapy as graft-versus-host disease prophylaxis for patients with acute myeloid leukemia in complete remission undergoing HLA-matched sibling allogeneic hematopoietic cell transplantation. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2012;30(26):3194–201. PubMed PMID: 22869882. Pubmed Central PMCID: Pmc3434978. Epub 2012/08/08. eng.Google Scholar
Clarke, E, Potter, MN, Hale, G, Waldmann, H, Lankester, A, Cornish, JM, et al. Double T cell depletion of bone marrow using sequential positive and negative cell immunoaffinity or CD34+ cell selection followed by Campath-1M; effect on CD34+ cells and progenitor cell recoveries. Bone Marrow Transplantation. 1998;22(2):117–24. PubMed PMID: 9707017. Epub 1998/08/26. eng.Google Scholar
Butt, NM, McGinnity, N, Clark, RE. CD34 positive selection as prophylaxis against graft versus host disease in allogeneic peripheral blood stem cell transplantation. Leukemia & Lymphoma. 2003;44(9):1509–13. PubMed PMID: 14565652. Epub 2003/10/21. eng.Google Scholar
Sehn, LH, Alyea, EP, Weller, E, Canning, C, Lee, S, Ritz, J, et al. Comparative outcomes of T-cell-depleted and non-T-cell-depleted allogeneic bone marrow transplantation for chronic myelogenous leukemia: impact of donor lymphocyte infusion. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 1999;17(2):561–8. PubMed PMID: 10080600. Epub 1999/03/18. eng.Google Scholar
Goldberg, JD, Linker, A, Kuk, D, Ratan, R, Jurcic, J, Barker, JN, et al. T cell-depleted stem cell transplantation for adults with high-risk acute lymphoblastic leukemia: long-term survival for patients in first complete remission with a decreased risk of graft-versus-host disease. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2013;19(2):208–13. PubMed PMID: 22982534. Pubmed Central PMCID: Pmc3963704. Epub 2012/09/18. eng.Google Scholar
Lewin, SR, Heller, G, Zhang, L, Rodrigues, E, Skulsky, E, van den Brink, MR, et al. Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations. Blood. 2002;100(6):2235–42. PubMed PMID: 12200390. Epub 2002/08/30. eng.Google Scholar
McIver, Z, Melenhorst, JJ, Wu, C, Grim, A, Ito, S, Cho, I, et al. Donor lymphocyte count and thymic activity predict lymphocyte recovery and outcomes after matched-sibling hematopoietic stem cell transplant. Haematologica. 2013;98(3):346–52. PubMed PMID: 23065508. Pubmed Central PMCID: Pmc3659951. Epub 2012/10/16. eng.Google Scholar
Clave, E, Busson, M, Douay, C, Peffault de Latour, R, Berrou, J, Rabian, C, et al. Acute graft-versus-host disease transiently impairs thymic output in young patients after allogeneic hematopoietic stem cell transplantation. Blood. 2009;113(25):6477–84. PubMed PMID: 19258596. Epub 2009/03/05. eng.Google Scholar
Olkinuora, H, von Willebrand, E, Kantele, JM, Vainio, O, Talvensaari, K, Saarinen-Pihkala, U, et al. The impact of early viral infections and graft-versus-host disease on immune reconstitution following paediatric stem cell transplantation. Scandinavian Journal of Immunology. 2011;73(6):586–93. PubMed PMID: 21323694. Epub 2011/02/18. eng.Google Scholar
Small, TN, Avigan, D, Dupont, B, Smith, K, Black, P, Heller, G, et al. Immune reconstitution following T-cell depleted bone marrow transplantation: effect of age and posttransplant graft rejection prophylaxis. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 1997;3(2):65–75. PubMed PMID: 9267666. Epub 1997/06/01. eng.Google Scholar
Small, TN, Papadopoulos, EB, Boulad, F, Black, P, Castro-Malaspina, H, Childs, BH, et al. Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood. 1999;93(2):467–80. PubMed PMID: 9885208. Epub 1999/01/13. eng.Google Scholar
van Heijst, JW, Ceberio, I, Lipuma, LB, Samilo, DW, Wasilewski, GD, Gonzales, AM, et al. Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation. Nature Medicine. 2013;19(3):372–7. PubMed PMID: 23435170. Pubmed Central PMCID: Pmc3594333. Epub 2013/02/26. eng.CrossRefGoogle ScholarPubMed
Geyer, MB, Ricci, AM, Jacobson, JS, Majzner, R, Duffy, D, Van de Ven, C, et al. T cell depletion utilizing CD34(+) stem cell selection and CD3(+) addback from unrelated adult donors in paediatric allogeneic stem cell transplantation recipients. British Journal of Haematology. 2012;157(2):205–19. PubMed PMID: 22313507. Epub 2012/02/09. eng.Google Scholar
Perales, MA, Goldberg, JD, Yuan, J, Koehne, G, Lechner, L, Papadopoulos, EB, et al. Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood. 2012;120(24):4882–91. PubMed PMID: 23012326. Pubmed Central PMCID: Pmc3520625. Epub 2012/09/27. eng.Google Scholar
Goldberg, GL, Zakrzewski, JL, Perales, MA, van den Brink, MR. Clinical strategies to enhance T cell reconstitution. Seminars in Immunology. 2007;19(5):289–96. PubMed PMID: 17964803. Pubmed Central PMCID: Pmc2696308. Epub 2007/10/30. eng.Google Scholar
Incefy, GS, Flomenberg, N, Heller, G, Kernan, NA, Brochstein, J, Kirkpatrick, D, et al. Evidence that appearance of thymulin in plasma follows lymphoid chimerism and precedes development of immunity in patients with lethal combined immunodeficiency transplanted with T cell-depleted haploidentical marrow. Transplantation. 1990;50(1):55–61. PubMed PMID: 2368151. Epub 1990/07/01. eng.Google ScholarPubMed
Reisner, Y, Kapoor, N, Kirkpatrick, D, Pollack, MS, Cunningham-Rundles, S, Dupont, B, et al. Transplantation for severe combined immunodeficiency with HLA-A,B,D,DR incompatible parental marrow cells fractionated by soybean agglutinin and sheep red blood cells. Blood. 1983;61(2):341–8. PubMed PMID: 6217853. Epub 1983/02/01. eng.Google Scholar
Castro-Malaspina, H, Jabubowski, AA, Papadopoulos, EB, Boulad, F, Young, JW, Kernan, NA, et al. Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2008;14(4):458–68. PubMed PMID: 18342789. Epub 2008/03/18. eng.Google Scholar
Perales, MA, Jenq, R, Goldberg, JD, Wilton, AS, Lee, SS, Castro-Malaspina, HR, et al. Second-line age-adjusted International Prognostic Index in patients with advanced non-Hodgkin lymphoma after T-cell depleted allogeneic hematopoietic SCT. Bone Marrow Transplantation. 2010;45(9):1408–16. PubMed PMID: 20062091. Pubmed Central PMCID: Pmc3076892. Epub 2010/01/12. eng.Google Scholar
Bethge, WA, Faul, C, Bornhauser, M, Stuhler, G, Beelen, DW, Lang, P, et al. Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: an update. Blood Cells, Molecules & Diseases. 2008;40(1):13–9. PubMed PMID: 17869547. Epub 2007/09/18. eng.Google Scholar
Federmann, B, Bornhauser, M, Meisner, C, Kordelas, L, Beelen, DW, Stuhler, G, et al. Haploidentical allogeneic hematopoietic cell transplantation in adults using CD3/CD19 depletion and reduced intensity conditioning: a phase II study. Haematologica. 2012;97(10):1523–31. PubMed PMID: 22491731. Pubmed Central PMCID: Pmc3487553. Epub 2012/04/12. eng.Google Scholar
Eissens, DN, Schaap, NP, Preijers, FW, Dolstra, H, van Cranenbroek, B, Schattenberg, AV, et al. CD3+/CD19+-depleted grafts in HLA-matched allogeneic peripheral blood stem cell transplantation lead to early NK cell cytolytic responses and reduced inhibitory activity of NKG2A. Leukemia. 2010;24(3):583–91. PubMed PMID: 20033055. Epub 2009/12/25. eng.Google Scholar
Wagner, JE, Thompson, JS, Carter, SL, Kernan, NA. Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II-III trial. Lancet. 2005;366(9487):733–41. PubMed PMID: 16125590. Epub 2005/08/30. eng.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×