We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure coreplatform@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Intravenous fluids are solutions containing various quantities of water, electrolytes, salts, and sugar. They are used to maintain haemostasis when the enteral route is insufficient to meet physiological demand. Fluid therapy maintains hydration, oxygen delivery, and thus organ function. Poor perioperative fluid control is associated with impaired physiological function, resulting in patient harm and increasing healthcare costs. Perioperative fluid management is based upon three distinct but related factors: patient (age and comorbidities), surgical (urgency, indication and duration) and anaesthetic. This chapter is an introduction to intravenous fluids, highlighting the physiological control mechanisms, the composition of intravenous fluids, and important clinical assessment principles.
Critical ill patients are often haemodynamically unstable and accurate continuous monitoring is vital. Haemodynamic monitoring describes the measurement of the cardiovascular stability of the patient. Invasive blood pressure monitoring and central venous pressure monitoring provide a ‘real time’ measurement of the patients haemodynamic status and better allows clinicians to pre-emptively treat a patient before a more serious problem arises. Although invasive blood pressure monitoring has several advantages compared to non-invasive blood pressure monitoring, it is not without risk. Central venous pressure monitoring is similarly beneficial in that it supports the clinical decision making regarding a patient’s fluid status but also comes with additional risks. This chapter explores invasive blood pressure and central venous pressure monitoring in detail.
This chapter argues that American horror is defined both by its “paraliterary” status and by its representations of the bloodied body in pain. Unlike the more culturally prestigious category of the Gothic, which typically dwells on the crisis of the rational mind, horror has tended to appear in culturally maligned or ephemeral forms and focus on corporeal pain, violence, and distress. Horror's focus on the body, it is further suggested, stems from the modern American state's withholding of freedoms according to embodied characteristics: race, gender, sexuality, ability, and so on. The historical appearance of horror narratives often correlates to crisis and tensions surrounding the expansion of the civil and political rights that centrist liberalism promised, so that when previously excluded or marginalized groups begin to demand inclusion and recognition of their past disempowerment, horror becomes a medium especially electric with these concerns.
William Harvey’s demonstration of the circulation of the blood is one of the Scientific Revolution’s most influential and lasting achievements. But in spite of Harvey’s innovation, and paradoxically given the extent to which he came to be represented as a founder of modern science, he tied himself to ancient authorities and sought to insulate natural philosophy and the art of medicine from the new mechanical-corpuscular and chemical philosophies of the period. The reception of Harvey’s work, both in physiology and later in embryology, shows that Harvey’s research program won numerous early converts, who used his program for their own ends, including support for the new philosophies, in the cases of René Descartes and Robert Boyle. Untethered from his preferred Scholastic framework, Harvey’s conceptual foundations, techniques, and conclusions led to new discoveries, and unresolved questions in Harvey’s account about the movement of the heart, nature of the blood, and respiration would motivate intense inquiry. The circulation of the blood and later physiology therefore provide an essential perspective for the examination of early modern disputes about experimentation and its limits, the rhetoric of novelty, the unity of nature, and the very notion of life.
SARS-CoV-2 has been found in the heart of COVID-19 patients. It is unclear how the virus passes from the upper respiratory tract to the myocardium. We hypothesized that SARS-CoV-2 is present in the blood of COVID-19 infected patients, spreading to other organs such as heart.
Methods:
We targeted two viroporins, Orf3a and E, in SARS-CoV-2. Orf3a and E form non-voltage-gated ion channels. A combined fluorescence potassium ion assay with three channel modulators (4-aminopyridine, emodin-Orf3a channel blocker, and gliclazide-E channel blocker) was developed to detect SARS-CoV-2 Orf3a/E channel activity. In blood samples, we subtracted the fluorescence signals in the absence and presence of emodin/gliclazide to detect Orf3a and E channel activity.
Results:
In lentivirus-spiked samples, we detected significant channel activity of Orf3a/E based on increase in fluorescence induced by 4-aminopyridine, and this increase in fluorescence was inhibited by emodin and gliclazide. In 18 antigen/PCR-positive samples, our test results found 15 are positive, demonstrating 83.3% concordance. In 24 antigen/PCR-negative samples, our test results found 21 are negative, showing 87.5% concordance.
Conclusions:
We developed a cell-free test that can detect Orf3a/E channel activity of SARS-CoV-2 in blood samples from COVID-19-infected individuals, confirming a hypothesis that the virus spreads to the heart via blood circulation.
The chapter focuses on the role of the heart and the image of the world as a cardiovascular system in the post-Chrysippean tradition. Within this picture, then, it will be shown that in later Stoicism, not only the heart but the blood first and foremost was used in explaining the essence and features of the soul and eventually employed as a model to explain the universe. The existence of a ‘hematic’ variation within cardiocentrism will thus be highlighted, which allows some Stoics to better justify the spreading and the action of the soul within the body, and that of god throughout the cosmos. By doing so, the post-Chrysippean tradition recalls Empedocles’ position. This topic will be first of all studied in Diogenes of Babylon, who stresses the importance of the heart in the wake of his master Chrysippus, yet apparently providing a different definition of the soul as (made of) blood. The chapter examines then Posidonius, whose cardiocentrism – though not strictly ‘hematic’ – differs from that of both Aristotle and Chrysippus and is crucial for his understanding of living beings and natural phenomena. Lastly, the contribution considers Seneca and Manilius, who often represent the universe as a cardiovascular system enlivened by a network of blood vessels.
Keith Michael Green’s “Disabling Freedom: Bloody Shirt Rhetoric in Postbellum Slave Narratives” explores the mystifications and erasures of anti-Black violence that characterized Reconstruction-era writing. Green pays deep attention to how select narratives – especially the much-neglected Story of Mattie Jackson and Keckley’s better-known Behind the Scenes – strategically employed oblique narrativizations of Black pain and personhood to avoid pernicious narratives of Black unfitness and hyper-embodiment. Green draws on what he calls the “poetics of the bloody shirt” to study the ventriloquization of injury through surrogate objects and persons, with emphasis on not only Jackson and Keckley’s texts but also works by Sojourner Truth, Still, and William Wells Brown to underscore how indirect representations of injury helped postbellum slave narratives articulate the contradictions and risks of Black life and to revise ableist visions of freedom – in the process, contesting the erasure of Black pain in post-emancipation discourse.
Blood is a concentrated suspension of deformable, aggregating, red blood cells within a medium of other cells and proteins. It is a complex colloidal system with a non-Newtonian rheology that is characterized by viscoplasticity, thixotropy, and viscoelasticity. After reviewing some of the key biological characteristics of human blood, and after presenting a short historical review of the subject, we present some recent accomplishments. These range from the development of a parameterized Casson model, based on the hematocrit and fibrinogen levels, to the discussion of several recent structural models that are able to capture several of the time-dependent rheological effects of blood. A comparison is also offered between model predictions and the results of recent transient measurements, some involving a newly proposed variant of LAOS: the Unidirectional LAOS. The latter experiment is especially appropriate for the study of blood rheology as it follows roughly the flow experienced by blood in the arterial circulation. It consists of a superposition of steady and large amplitude oscillatory flow in such a way that flow reversal is avoided. Some additional models are discussed along with the challenges and opportunities for future research.
The chapter unites anthropological accounts of blood. It introduces refrains that unify themes of the entire book. It argues that blood marks the bounds of religious and social bodies, using Durkheim, Douglas, and Bildhauer; Irenaeus, Maximus, and Aquinas. Iron compounds make blood red, but societies draft its color and stickiness for their own purposes. Inside, blood carries life. Outside, blood marks the body fertile or at risk. But that’s a social fiction. Skin makes a membrane to pass when a body breathes, eats, perspires, eliminates, menstruates, ejaculates, conceives, or bleeds. Only blood evokes so swift and social a response: It brings parent to child, bystander to victim, ambulance to patient, soldier to comrade, midwife to mother, defender to border. The New Testament names the blood of Christ three times as often as his cross – five times as often as his death. The blood of Jesus is the blood of Christ; the wine of communion is the blood of Christ; the means of atonement is the blood of Christ; the kinship of believers is the blood of Christ; the cup of salvation is the blood of Christ; icons ooze with the blood of Christ; and the blood of Christ is the blood of God.
“Jesus and the Gender of Blood.” Here’s a place blood seeps in where it hardly seems to belong: Crucifixion kills not by blood loss but suffocation. Neither crucifixion nor a common meal requires blood. Hands and feet can be lashed without nails. Why must Jesus bleed? Gospel writers portray Jesus at the Last Supper as mobilizing the language of blood to transform a structure of violent oppression – crucifixion – into a peaceful feast. The image of the Woman with a Flow of Blood, read as dysmenorrhea, recognizes a kinship: three gospels identify both the woman and Jesus with their bleeding, as leaky. The stories feminize Jesus by turning his blood away from male-gendered violence and toward female-gendered purposes of new life and rebirth. Reflections on the Eucharist and taboo.
In modern creationism, blood-language (even more than a high view of scripture) determines whether evolution can be true. In One Blood, leading creationist Ken Ham finds evolution too bloody for a good God. A good God could hardly use predation, extinction, and death as a means. For Ham, blood sets humans at one with or apart from the “dumb beasts.” But Ham drafts too narrow an atonement, where the blood of Christ makes up only for sin. Blood must also mean solidarity. Uses Irenaeus, William Jennings Bryan, Marilyn Adams, Teilhard de Chardin, Sergei Bulgakov.
“Blood after Isaac” reads the binding of Isaac, where some interpreters see blood, although the story never mentions it. This chapter introduces the pattern that blood seeps in where it seems not to belong. The little word "na," untranslated in English versions of the story, in modern Hebrew means simply "please," but in the Hebrew Bible indicates irony, as in "say, go ahead, see if I care." The chapter argues that the story of Isaac is best understood in terms of divine irony, God imitating Abraham as a trickster. Why does Abraham not catch on?
In Reconquista Spain, a barely united state turned its anxieties inward with anti-Semitic laws on blood purity among converts from Judaism and Islam. The same insecure state turned outward to conquer Mexico, where Franciscans spent fifty years recording Aztec human sacrifice in codices and color drawings. Castilians and Aztecs alike marked their external bounds and internal bonds with blood. Ethnicizing ideas of blood purity crossed the Atlantic to ruddy Christian perceptions of Mesoamerican sacrifice. Two blood-obsessed cultures met to reveal disturbing resonances in Christian blood language. Uses Sircoff on limpieza de sangre and Timothy Radcliffe on cultic irony in Hebrews.
Maximus the Confessor's theory of the logoi in the Logos applied to human evolution. God's use of material things – such as stones – to bring about the incarnation. Maximus's pregnant mentions of the blood of Christ as the intelligibility of things.
For and against nutritive theories of the Eucharist – theories based on digesting versus eating. Why God became simian. The primatology of the incarnation. Aquinas's Commentary on John.
In 2007 the bishops of the US Episcopal Church invited my advice on a “theology of same-sex relationships.” Of what other panelists said – PhDs teaching at respected institutions – the most arresting was: “The trouble with same-sex relationships is they impugn the blood of Christ.” They do what? The original remark attempted a hazing; the final result bestowed a gift, the gift of blood made strange. Blood is supposed to wash gay people with the atonement, even as self-accepting gay people say they don’t need cleansing. It’s supposed to unite Christians in communion, even as sexuality debates divide the churches. It’s supposed to protect the succession of priests, even as bishops shield them for sexual crimes. To some Christians, such failures of Christ’s blood amount to a cosmological disturbance. But what if Jesus becomes a bridegroom of blood, who stays on the cross for love of the (male) thief to whom he promises a life together in paradise? Reflects on Anselm, Abelard, Sebastian Moore, and "pleading the blood."
“Blood after Leviticus” observes there is initially not “enough” blood in Leviticus, which only “daubs” or “sprinkles” it, with the rest poured on the ground, removed from cultic use. The reinterpretation of Leviticus in the New Testament book of Hebrews imagines much more. Leviticus’ reception history shows how drops of blood become floods in imagination: Blood burgeons at need. The chapter includes accounts of Christian animal sacrifice at sites of St. George in the West Bank and Samaritan animal sacrifice at passover. It reflects on tropes of infinite blood.
The unsettling language of blood has been invoked throughout the history of Christianity. But until now there has been no truly sustained treatment of how Christians use blood to think with. Eugene F. Rogers Jr. discusses in his much-anticipated new book the sheer, surprising strangeness of Christian blood-talk, exploring the many and varied ways in which it offers a language where Christians cooperate, sacrifice, grow and disagree. He asks too how it is that blood-talk dominates when other explanations would do, and how blood seeps into places where it seems hardly to belong. Reaching beyond academic disputes, to consider how religious debates fuel civil ones, he shows that it is not only theologians or clergy who engage in blood-talk, but also lawmakers, judges, generals, doctors and voters at large. Religious arguments have significant societal consequences, Rogers contends; and for that reason secular citizens must do their best to understand them.
This essay explores the significance of genealogy and inheritance in Shakespeare’s history plays; specifically, the idea that national and racial characteristics were passed down through the generations in the blood. The word "race" is often applied to peoples produced by the intermingling of different lineages and with different characteristics. The essay shows that such issues were important not just for royal dynasties but for the people they ruled, as is demonstrated through readings of King Henry V, King Richard II, and King John. When races are imagined in such ways the word "bastard" assumes particular importance, as the progeny of two different people(s) taking on new characteristics from a combination of those of the parents. Shakespeare demonstrates in his English history plays that nations and races are never pure, but are always intermingled, compromised, revitalized, and constantly transformed by their union with other peoples, especially the neighbours in terms of whom they define themselves.
The Merchant of Venice establishes a connection between racial and religious identity, between outside (body features) and inside (blood and faith), through examining Jessica’s relationship to her father Shylock; the play interrogates the extent to which father and daughter share the same flesh and blood. Two distinct but interrelated understandings of race in the early modern period emerge in the play: race as marked by bodily features and behaviors, and race as defined through the blood that connects individuals to a line of descent. Through alluding to religious teachings and discourses that pointed to bodily and genealogical differences between Jews (and black Africans) and white Christians, The Merchant of Venice racializes religious identity, asserting that both racial and religious identity are inherited from one’s ancestors, passed from parents to children through sexual reproduction, and express themselves on the body and through the body’s behaviors.