Chapter 6 explores the interconnection between natural philosophy and liberation from rebirth, arguing first that knowledge of the world is necessary to change one’s being from mortal to divine nature and, second, that purifications play a central role in knowledge acquisition. After a consideration of epistemic reflections at Empedocles’ time and the role of initiation in attaining true knowledge, it is shown that Empedocles explains the change of being into divine nature at the level of the elements. Indeed, in processes of perception and knowledge acquisition, elements coming from external effluvia interact with elements in the body and thereby modify the mind’s mixture. It follows that the revelation of Empedocles’ philosophy can change our mind to the point that it will become a divine mind. The possibility of becoming divine through knowledge of the world goes along with the training one must undergo to be adequately prepared to receive it. This training coincides with processes of purification, and Empedocles explains from a physiological standpoint how these enable the structure of the elements of our mind to be enhanced to the point where it becomes attuned to the divine.