Background: Hypothalamic hamartomas (HH) are a challenging cause of seizure in children, partly because the neural circuitry involved in ictogenesis is incompletely understood. We review our institutions’ use of magnetic resonance imaging-guided laser interstitial thermal therapy (MRgLITT) to treat hypothalamic hamartoma (HH) with resting-state fMRI performed immediately before and after ablation. Methods: Seed-based whole brain connectivity to thalamic regions of interest was performed immediately pre- and post- MRgLITT. Multivariable generalized linear models were used to correlate resting-state data with seizure outcomes. Results: Eight patients underwent MRgLITT treatments for HH, with a mean follow up of 29 months. Four patients (50%) were seizure free at 12 months and two (25%) had a significant improvement in seizure frequency. We identified reduced thalamocortical connectivity involving the anterior cingulate and posterior parietal regions, consistent with disconnection of the mammillothalamic tract and interruption of Papez circuit. Large-scale thalamocortical connectivity changes were driven by children who subsequently became seizure free. Conclusions: Disconnection of the mammillothalamic tract and interruption of thalamic circuitry in patients undergoing MRgLITT for HH appears to be associated with improved seizure outcomes. The ability to assess network changes immediately post- MRgLITT could enable operative adjustments to be made mid-procedure to optimize seizure outcome in real time.

The subsistence practices of Holocene communities living in the Nile Valley of Central Sudan are comparatively little known. Recent excavations at Khor Shambat, Sudan, have yielded well-defined Mesolithic and Neolithic stratigraphy. Here, for the first time, archaeozoological, palaeobotanical, phytolith and dental calculus studies are combined with lipid residue analysis of around 100 pottery fragments and comparative analysis of faunal remains and organic residues. This holistic approach provides valuable information on changes in adaptation strategies, from Mesolithic hunter-gatherers to Neolithic herders exploiting domesticates. A unique picture is revealed of the natural environment and human subsistence, demonstrating the potential wider value of combining multiple methods.

Over the past decade, a growing interest has developed on the archaeology, palaeontology, and palaeoenvironments of the Arabian Peninsula. It is now clear that hominins repeatedly dispersed into Arabia, notably during pluvial interglacial periods when much of the peninsula was characterised by a semiarid grassland environment. During the intervening glacial phases, however, grasslands were replaced with arid and hyperarid deserts. These millennial-scale climatic fluctuations have subjected bones and fossils to a dramatic suite of environmental conditions, affecting their fossilisation and preservation. Yet, as relatively few palaeontological assemblages have been reported from the Pleistocene of Arabia, our understanding of the preservational pathways that skeletal elements can take in these types of environments is lacking. Here, we report the first widespread taxonomic and taphonomic assessment of Arabian fossil deposits. Novel fossil fauna are described and overall the fauna are consistent with a well-watered semiarid grassland environment. Likewise, the taphonomic results suggest that bones were deposited under more humid conditions than present in the region today. However, fossils often exhibit significant attrition, obscuring and fragmenting most finds. These are likely tied to wind abrasion, insolation, and salt weathering following fossilisation and exhumation, processes particularly prevalent in desert environments.

We present preliminary results from MUSE on the Lyα luminosity function in the Hubble Deep Field South (HDFS). Using a large homogeneous sample of LAEs selected through blind spectroscopy, we utilise the unprecedented detection power of MUSE to study the progenitors of L* galaxies back to when the Universe was just ~2 Gyr old. We present these results in the context of the current literature, and highlight the importance of the forthcoming Hubble Ultra Deep Field (HUDF) study with MUSE, which will increase the size of our sample by a factor of ~ 10.

Fossil land mammals were collected by G. G. Simpson in 1933–1934 at and near the Tapera de López in central Chubut Province, Patagonia, southern Argentina, from rocks now mapped as the Sarmiento Formation. These fossils are assigned to land mammal faunas of Casamayoran (Early Eocene), Mustersan (Middle Eocene), and Deseadan (late Early Oligocene through Early Miocene) age.

40K-40Ar age determinations of eight basalt and two tuff units associated with the Deseadan age local fauna at Scarritt Pocket establish a geochronologic framework that calibrates the biostratigraphic record at this locality. The radioisotope dates obtained at Scarritt Pocket range from 23.4 Ma to about 21.0 Ma, and equate with earliest Miocene time. The Scarritt Pocket local fauna is the youngest dated Deseadan age fauna yet known in South America.

Seven other localities have, or were reputed to have, local faunas of Deseadan age associated with dated volcanic units. Six of these localities are in Argentina (Gran Barranca, Cerro Blanco, Valle Hermoso, Pico Truncado, Cañadón Hondo, Quebrada Fiera de Malargüe) and one in Bolivia (Estratos Salla in the Salla-Luribay Basin). The stratigraphic relationships of the volcanic units with these local faunas is discussed, and the taxonomic content of each is reassessed.

The Deseadan Land Mammal Age is defined by the earliest record of the land mammal genus Pyrotherium, which is from below a basalt dated at 33.6 Ma at Pico Truncado. Other early records of Pyrotherium occur below basalts dated at about 29 Ma at the Gran Barranca and Valle Hermoso, and from a 28.5 Ma level of the Estratos Salla. Thus, the lower boundary for Deseadan time is about 34 Ma.

The youngest record of Pyrotherium is in the upper levels of the Estratos Salla dated at about 24 Ma. However, the Scarritt Pocket local fauna, which lacks Pyrotherium, permits placement of the upper boundary for Deseadan time at about 21.0 Ma. Late Deseadan time is surely, and the end of Deseadan time is apparently, marked by the last record of such groups as Proborhyaeninae (Proborhyaena), Rhynchippinae (Rhynchippus), Archaeohyracidae (Archaeohyrax), and the genera Platypittamys (Octodontidae), Scarrittia (Leontiniidae), Propachyrucos and Prohegetotherium (Hegetotheriidae), and Argyrohyrax (Interatheriidae), as these taxa are recorded in the Scarritt Pocket local fauna. Thus, Deseadan time extends from about 34.0 Ma to about 21.0 Ma, making it the Land Mammal Age with the longest known duration in South America.

Background: There is a strong evidence base for psychological treatments in younger adults with schizophrenia, but limited work has been done on adapting these interventions for older people. Aims: We describe a study of a pilot psychosocial intervention group specifically designed to meet the needs of older people with schizophrenia in NHS settings. Method: We used a mixed-methods approach to evaluate the group. We assessed feasibility and acceptability by monitoring uptake and retention in the study. We used a within groups design comparing participants on a range of potentially relevant outcomes at baseline and posttreatment. Treatment acceptability was also assessed by semi-structured interviews conducted at the end of treatment. Results: We recruited 11 participants to the study and 7 of these completed the majority of the group sessions. At a group level participants made improvements in self-esteem and negative symptoms that were statistically significant even in this small sample. Feedback interviews suggested that participants valued the social contact provided by the group and made actual changes in their day-to-day lives as a result of attending. Conclusion: The intervention could offer help with some of the secondary disability associated with the diagnosis of schizophrenia and is acceptable to older adults. Further evaluation is, however, warranted.

We give a preliminary report on a multi-wavelength study of specular reflections from the oceans and clouds of Earth. We use space-borne observations from a distance sufficient to ensure that light rays reflected from all parts of Earth are closely parallel, as they will be when studying exoplanets. We find that the glint properties of Earth in this far-field vantage point are surprising - in the sense that some of the brightest reflections are not from conventional ocean-glints, but appear to arise from cirrus cloud crystals. The Earth observations discussed here were acquired with the High Resolution Instrument (HRI) - a 0.3 m f/35 telescope on the Deep Impact (DI) spacecraft during the Extrasolar Planet Observation and Characterization (EPOCh) investigation.

This article highlights the relevance of attachment theory for psychiatric rehabilitation services and discusses practice implications derived from the theory. Attachment theory can guide the development of interpersonal relationships during recovery and this aspect of rehabilitation is emphasised here. Attachment theory can also be used to help staff predict and understand problematic behaviours such as violence and aggression, and different styles of recovery. The theory can help promote positive staff–service-user relationships by highlighting the qualities of effective caregivers and the way in which people with different attachment styles might benefit from different approaches. We conclude by suggesting ways of teaching rehabilitation staff to become more effective attachment figures.

The Catholic political tradition is at the very center of contemporary Italian politics, but the process by which that tradition came into existence and how it evolved remains obscure and often is subjected to extremely simplistic explanations. Modern Catholic political theory began to take shape during the period of the French Revolution. However, it was the Risorgimento that decisively influenced the political consciousness of Italy's Catholics. The unification of the country in 1860 came about largely at the Church's expense. Pius IX, once the darling of Catholic liberals, responded to the Risorgimento with a fusillade of counterrevolutionary invective in Sillabo degli errori del nostro tempo (8 December 1864), still the most notorious example of anguished Catholic imprecations in the post-Risorgimento period. The Church, never comfortable in the post-1789 world, now made unforgettably clear her utter and irrevocable rejection of that world. Her role as the aggressive critic of modernity hardened into one of the outstanding conventions of nineteenthcentury European culture.

The NASA Discovery mission EPOXI, utilizing the Deep Impact flyby spacecraft, comprises two phases: EPOCh (Extrasolar Planet Observation and Characterization) and DIXI (Deep Impact eXtended Investigation). With EPOCh, we use the 30-cm high resolution visible imager to obtain ultraprecise photometric light curves of known transiting planet systems. We will analyze these data for evidence of additional planets, via transit timing variations or transits; for planetary moons or rings; for detection of secondary eclipses and the constraint of geometric planetary albedos; and for refinement of the system parameters. Over a period of four months, EPOCh observed four known transiting planet systems, with each system observed continuously for several weeks. Here we present an overview of EPOCh, including the spacecraft and science goals, and preliminary photometry results.

EPOXI (EPOCh + DIXI) is a NASA Discovery Program Mission of Opportunity using the Deep Impact flyby spacecraft. The EPOCh (Extrasolar Planet Observation and Characterization) Science Investigation will gather photometric time series of known transiting exoplanet systems from January through August 2008. Here we describe the steps in the photometric extraction of the time series and present preliminary results of the first four EPOCh targets.