We study approximations for the Lévy area of Brownian motion which are based on the Fourier series expansion and a polynomial expansion of the associated Brownian bridge. Comparing the asymptotic convergence rates of the Lévy area approximations, we see that the approximation resulting from the polynomial expansion of the Brownian bridge is more accurate than the Kloeden–Platen–Wright approximation, whilst still only using independent normal random vectors. We then link the asymptotic convergence rates of these approximations to the limiting fluctuations for the corresponding series expansions of the Brownian bridge. Moreover, and of interest in its own right, the analysis we use to identify the fluctuation processes for the Karhunen–Loève and Fourier series expansions of the Brownian bridge is extended to give a stand-alone derivation of the values of the Riemann zeta function at even positive integers.

Pompe disease results from lysosomal acid α-glucosidase deficiency, which leads to cardiomyopathy in all infantile-onset and occasional late-onset patients. Cardiac assessment is important for its diagnosis and management. This article presents unpublished cardiac findings, concomitant medications, and cardiac efficacy and safety outcomes from the ADVANCE study; trajectories of patients with abnormal left ventricular mass z score at enrolment; and post hoc analyses of on-treatment left ventricular mass and systolic blood pressure z scores by disease phenotype, GAA genotype, and “fraction of life” (defined as the fraction of life on pre-study 160 L production-scale alglucosidase alfa). ADVANCE evaluated 52 weeks’ treatment with 4000 L production-scale alglucosidase alfa in ≥1-year-old United States of America patients with Pompe disease previously receiving 160 L production-scale alglucosidase alfa. M-mode echocardiography and 12-lead electrocardiography were performed at enrolment and Week 52. Sixty-seven patients had complete left ventricular mass z scores, decreasing at Week 52 (infantile-onset patients, change −0.8 ± 1.83; 95% confidence interval −1.3 to −0.2; all patients, change −0.5 ± 1.71; 95% confidence interval −1.0 to −0.1). Patients with “fraction of life” <0.79 had left ventricular mass z score decreasing (enrolment: +0.1 ± 3.0; Week 52: −1.1 ± 2.0); those with “fraction of life” ≥0.79 remained stable (enrolment: −0.9 ± 1.5; Week 52: −0.9 ± 1.4). Systolic blood pressure z scores were stable from enrolment to Week 52, and no cohort developed systemic hypertension. Eight patients had Wolff–Parkinson–White syndrome. Cardiac hypertrophy and dysrhythmia in ADVANCE patients at or before enrolment were typical of Pompe disease. Four-thousand L alglucosidase alfa therapy maintained fractional shortening, left ventricular posterior and septal end-diastolic thicknesses, and improved left ventricular mass z score.

Trial registry: ClinicalTrials.gov Identifier: NCT01526785 https://clinicaltrials.gov/ct2/show/NCT01526785.

Social Media Statement: Post hoc analyses of the ADVANCE study cohort of 113 children support ongoing cardiac monitoring and concomitant management of children with Pompe disease on long-term alglucosidase alfa to functionally improve cardiomyopathy and/or dysrhythmia.

As colleges and universities respond to the COVID-19 outbreak, many in the media call it unprecedented. This is not the first time that institutions of higher education have had to respond to an epidemic, however. A historical review of college and university reactions to illnesses such as yellow fever and the 1918 influenza pandemic provides prior examples of institutional responses to epidemic diseases.

Although dicamba-resistant crops can provide an effective weed management option, risk of dicamba off-site movement to sensitive crops is a concern. Previous research with indeterminate soybean identified 14 injury criteria associated with dicamba applied at V3/V4 or R1/R2 at 0.6 to 280 g ae ha−1. Injury criteria rated on a 0 to 5 scale (none to severe), along with percent visible injury and plant height reduction, and canopy height collected 7 and 15 d after treatment (DAT) were analyzed using multiple regression with a forward-selection procedure to develop yield prediction models. Variables included in the 15 DAT models (in order of selection) for V3/V4 were lower stem base lesions/cracking, plant height reduction, terminal leaf epinasty, leaf petiole droop, leaf petiole base swelling, and stem epinasty, whereas for R1/R2 variables were lower stem base lesions/cracking, terminal leaf chlorosis, leaf petiole base swelling, stem epinasty, terminal leaf necrosis, and terminal leaf cupping. To validate the models, experiments including the same dicamba rates and application timings used in previous research were conducted at two locations. For the variables specific to each model, data collected for the dicamba rates were used to predict yield. For the V3/V4 15 DAT model, predicted yield reduction (compared with the nontreated control for dicamba at 0.6 to 4.4 g ha−1) underestimated or overestimated observed yield reduction by an average of 1 and 3 percentage points. For 8.8 g ha−1, predicted yield reduction overestimated observed yield reduction by 8 points and for 17.5 g ha−1 by 20 points. For the R1/R2 15 DAT model, predicted yield reduction for 0.6 to 4.4 g ha−1 overestimated observed yield reduction by an average of 3 to 5 percentage points. For dicamba at 8.8 g ha−1, predicted yield reduction underestimated observed yield reduction by 8 points and for 17.5 g ha−1 overestimated by 6 points.

Breakthrough Listen is a 10-yr initiative to search for signatures of technologies created by extraterrestrial civilisations at radio and optical wavelengths. Here, we detail the digital data recording system deployed for Breakthrough Listen observations at the 64-m aperture CSIRO Parkes Telescope in New South Wales, Australia. The recording system currently implements two modes: a dual-polarisation, 1.125-GHz bandwidth mode for single-beam observations, and a 26-input, 308-MHz bandwidth mode for the 21-cm multibeam receiver. The system is also designed to support a 3-GHz single-beam mode for the forthcoming Parkes ultra-wideband feed. In this paper, we present details of the system architecture, provide an overview of hardware and software, and present initial performance results.

Ongoing, rapid innovations in fields ranging from microelectronics, aerospace, and automotive to defense, energy, and health demand new advanced materials at even greater rates and lower costs. Traditional materials R&D methods offer few paths to achieve both outcomes simultaneously. Materials informatics, while a nascent field, offers such a promise through screening, growing databases of materials for new applications, learning new relationships from existing data resources, and building fast predictive models. We highlight key materials informatics successes from the atomic-scale modeling community, and discuss the ecosystem of open data, software, services, and infrastructure that have led to broad adoption of materials informatics approaches. We then examine emerging opportunities for informatics in materials science and describe an ideal data ecosystem capable of supporting similar widespread adoption of materials informatics, which we believe will enable the faster design of materials.

Research conducted in the field identified 14 injury criteria associated with dicamba (Clarity® diglycolamine salt) applied at 0.6 to 280 g ae ha–1 (1/1,000 to 1/2 of 560 g ha–1 use rate) to indeterminate soybean at V3/V4 or R1/R2. For each criterion, injury was rated using a scale of 0=no injury, 1=slight, 2=slight to moderate, 3=moderate, 4=moderate to severe, and 5=severe. Greatest crop injury 15 d after treatment (DAT) was observed for dicamba rates of 0.6 to 4.4 g ha–1 for upper canopy pale leaf margins (3.8 to 4.2) at V3/V4 and for terminal leaf cupping (4.1 to 5.0) at R1/R2, and for rates of 0.6 to 8.8 g ha–1 for upper canopy leaf cupping (3.8 to 4.8) and upper canopy leaf surface crinkling (3.4 to 4.4) at V3/V4. Injury 15 DAT was equivalent to the nontreated control for dicamba rates as high as 4.4 g ha–1 for lower stem base swelling at V3/V4 and for upper canopy leaf rollover/inversion and terminal leaf necrosis at R1/R2; for rates as high as 8.8 g ha–1 for leaf petiole base swelling and stem epinasty at R1/R2, and lower stem base lesions/cracking (V3/V4 and R1/R2 average); and for rates as high as 17.5 g ha–1 for lower leaf soil contact at V3/V4 and leaf petiole droop at R1/R2. The response to increasing dicamba rate observed for the injury criteria was in contrast to the steady increase in visual injury and plant height reduction rated as 0 to 100%. The moderate to severe upper canopy leaf cupping, pale leaf margins, and leaf surface crinkling, and terminal leaf cupping 15 DAT with dicamba at 0.6 to 4.4 g ha–1 corresponded to soybean yield loss of 1% to 9% for application at V3/V4 and 2% to 17% at R1/R2.

Organizations are undergoing unprecedented transformation in the area of talent management (TM). Companies are rapidly adopting new tools and approaches in a variety of what has traditionally been core areas of industrial and organizational (I-O) psychology such as performance management, employee attitudes, recruiting, testing and assessment, and career development. Increasingly, however, these new approaches have little to no research backing behind them, and they do not tend to be the focus of I-O psychology theory and research. We call this trend anti-industrial and organizational psychology (AIO), as we believe these forces to do not advance the field for long-term strategic impact. We present a framework that describes how AIO practices are adopted by organizations, and how I-O psychologists often gravitate away from these practices rather than actively help to separate the wheat from the chaff. We found support for our hypothesis through a brief analysis of Industrial and Organizational Psychology: Perspectives on Science and Practice, the peer-reviewed journal of the Society of Industrial and Organizational Psychology (SIOP). In this analysis, we found that only 10% of the focal articles from 2008 to 2016 represented topics that we call frontier—emerging areas in organizations but where there is no research support for them. We propose a set of recommendations for the field of I-O psychology and call for a more strategic approach to identifying and vetting new TM trends in order to increase the relevancy and impact of I-O psychology for our key stakeholders.

Greenhouse and field experiments were conducted to evaluate the use of a carbon band to provide a “safe zone” for seedling emergence and growth of three native grass species. ‘KIKA677’ streambed bristlegrass germplasm, ‘Alamo’ switchgrass, and ‘Waelder’ shortspike windmillgrass germplasm were used in combination with several PRE- and POST-applied herbicides including cloransulam, flumioxazin, imazapic, imazethapyr, and 2,4-D. In a greenhouse experiment, switchgrass emergence was improved when a carbon band was used with imazapic or imazethapyr at 0.04 and 0.07 kg ai ha−1 or 2,4-D at 2.12 kg ae ha−1. Windmillgrass emergence was improved when carbon was used in combination with flumioxazin at 0.05 and 0.1 kg ai ha−1, imazapic at 0.04 and 0.07 kg ha−1, imazethapyr at 0.07 kg ha−1, and 2,4-D at 1.06 kg ha−1, whereas bristlegrass emergence was improved when carbon was used in combination with flumioxazin at 0.1 kg ai ha−1, imazapic at both rates, and imazethapyr at 0.04 kg ha−1. Field studies indicated that flumioxazin at 0.05 and 0.1 kg ha−1, imazapic at 0.04 kg ha−1, and imazethapyr at 0.04 and 0.07 kg ha−1, were safened for bristlegrass and switchgrass emergence when used with carbon. Windmillgrass emergence and growth were improved when carbon was used in combination with flumioxazin at 0.1 kg ha−1.

Reintroduction practitioners must often make critical decisions about reintroduction protocols despite having little understanding of the reintroduction biology of the focal species. To enhance the available knowledge on the reintroduction biology of the warru, or black-footed rock-wallaby Petrogale lateralis MacDonnell Ranges race, we conducted a trial reintroduction of 16 captive individuals into a fenced predator and competitor exclosure on the An̲angu Pitjantjatjara Yankunytjatjara Lands in South Australia. We conducted seven trapping sessions and used radio-tracking and camera traps to monitor survival, reproduction and recruitment to the population over 36 months. Blood samples were collected pre-release and during two trapping sessions post-release to assess nutritional health. The survival rate of founders was 63%, with all losses occurring within 10 weeks of release. Post-release blood biochemistry indicated that surviving warru adapted to their new environment and food sources. Female warru conceived within 6 months of release; 28 births were recorded during the study period and 52% of births successfully recruited to the population. Our results suggest that captive-bred warru are capable of establishing and persisting in the absence of introduced predators. However, the high mortality rate immediately post-release, with only a modest recruitment rate, suggests that future releases into areas where predators and competitors are present should use a trial approach to determine the viability of reintroduction. We recommend that future releases of warru into unfenced areas include an intensive monitoring period in the first 3 months post-release followed by a comprehensive long-term monitoring schedule to facilitate effective adaptive management.

In 1969, Robert E. Gregg collected five species of ants (Hymenoptera: Formicidae) in three Subarctic localities near the town of Churchill, Manitoba, Canada, which he documented in a 1972 publication in The Canadian Entomologist. To determine whether there have been any additions to the local fauna – as might be predicted to occur in response to a warming climate and increased traffic to the Port of Churchill in the intervening 40 years – we re-collected ants from the same localities in 2012. We identified the ants we collected from Gregg’s sampling sites using both traditional morphological preparations and DNA barcoding. In addition, we examined specimens from Gregg’s initial collection that are accessioned at the Field Museum of Natural History (Chicago, Illinois, United States of America). Using this integrative approach we report seven species present at the same sites Gregg sampled 40 years earlier. We conclude that the apparent increase is likely not due to any arrivals from more southerly distributed ants, but to the increased resolution provided by DNA barcodes to resident species complexes with a complicated history. We provide a brief synopsis of these results and their taxonomic context.