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From the sixth to fourth centuries BCE, the Persian empire under the Teispid and Achaemenid dynasties ruled most of western Asia and neighbouring regions, from the Indus river to Egypt and the coasts of the Aegean Sea. Despite the sources’ disproportionate emphasis on the failures of military expeditions against the overseas Greeks, the Persians enjoyed a lengthy period of military success and overall stability due in part to their rulers’ skill in the formulation of strategy. In the initial conquests, Persia absorbed peer competitors such as Babylon and Egypt; most subsequent conflicts pitted the empire’s superior forces against localised rebellions. Persia’s control stretched to vital subject communities in frontier zones and they also projected influence over external allies and clients. Persian kings rarely campaigned in person after the early expansionist phase, but relied on an exemplary communication system to manage satraps and other delegates tasked with provincial and frontier operations. To carry out military objectives, they relied on networks of provincial recruitment, supported as necessary by elements of a standing army associated with the royal court. Persian military activities were augmented by diplomatic outreach, most notably in Persia’s Greek relations after the failed invasion of mainland Greece. Persia’s strategic capabilities remained formidable until they were caught off guard by the tactical superiority of Alexander’s Macedonian invaders.
Hydrodynamic interactions between swimming or flying organisms can lead to complex flows on the scale of the group. These emergent fluid dynamics are often more complex than a linear superposition of individual organism flows, especially at intermediate Reynolds numbers. This paper presents an approach to estimate the flow induced by multiple swimmer wakes in proximity using a semianalytical model that conserves mass and momentum in the aggregation. The key equations are derived analytically, while the implementation and solution of these equations are carried out numerically. This model was informed by and compared with empirical measurements of induced vertical migrations of brine shrimp, Artemia salina. The response of individual swimmers to ambient background flow and light intensity was evaluated. In addition, the time-resolved three-dimensional spatial configuration of the swimmers was measured using a recently developed laser scanning system. Numerical results using the model found that the induced flow at the front of the aggregation was insensitive to the presence of downstream swimmers, with the induced flow tending towards asymptotic beyond a threshold aggregation length. Closer swimmer spacing led to higher induced flow speeds, in some cases leading to model predictions of induced flow exceeding swimmer speeds required to maintain a stable spatial configuration. This result was reconciled by comparing two different models for the near-wake of each swimmer. The results demonstrate that aggregation-scale flows result from a complex, yet predictable interplay between individual organism wake structure and aggregation configuration and size.
The unsteady flow physics of wind-turbine wakes under dynamic forcing conditions are critical to the modelling and control of wind farms for optimal power density. Unsteady forcing in the streamwise direction may be generated by unsteady inflow conditions in the atmospheric boundary layer, dynamic induction control of the turbine or streamwise surge motions of a floating offshore wind turbine due to floating-platform oscillations. This study seeks to identify the dominant flow mechanisms in unsteady wakes forced by a periodic upstream inflow condition. A theoretical framework for the problem is derived, which describes travelling-wave undulations in the wake radius and streamwise velocity. These dynamics encourage the aggregation of tip vortices into large structures that are advected along in the wake. Flow measurements in the wake of a periodically surging turbine were obtained in an optically accessible towing-tank facility, with an average diameter-based Reynolds number of 300 000 and with surge-velocity amplitudes of up to 40 % of the mean inflow velocity. Qualitative agreement between trends in the measurements and model predictions is observed, supporting the validity of the theoretical analyses. The experiments also demonstrate large enhancements in the recovery of the wake relative to the steady-flow case, with wake-length reductions of up to 46.5 % and improvements in the available power at 10 diameters downstream of up to 15.7 %. These results provide fundamental insights into the dynamics of unsteady wakes and serve as additional evidence that unsteady fluid mechanics can be leveraged to increase the power density of wind farms.
We sought to examine the relative importance of surgical lesion complexity versus the presence of genetic/syndromic/extracardiac anomalies (GSAs) in determining survival, morbidity or need for reinterventions following repair for aortic arch hypoplasia.
Methods:
A single-centre, retrospective cohort study of infants undergoing biventricular aortic arch repair via sternotomy from 2010 to 2021 was conducted. Survival analysis was performed using Kaplan–Meier methods, with additional Bayesian survival modelling for subgroups. Composite morbidity comprised respiratory, renal, neurologic, or sepsis-related complications.
Results:
Of 83 included infants, n = 13/83 (15.7%) had complex repairs; 27/83 (32.5%) were GSA+. Operative mortality was significantly higher in GSA+ versus GSA− patients (18.5% vs. 1.8%; p = 0.01), though not for complex versus non-complex repairs. Overall 10-year Kaplan–Meier survival was 86.7%. Bayesian modelling suggested equivalent post-discharge attrition in non-complex/GSA+ and complex/GSA− patients, with the poorest outcomes in complex/GSA+ patients; non-complex/GSA− patients had 100% survival. GSA+ patients exhibited higher composite morbidity (44.4% vs. 7.1% in GSA− p < 0.001), with their mode of death seemingly related to a high incidence of respiratory and neurological morbidity, notably in Dandy–Walker syndrome. The 10-year freedom from arch reinterventions was 87.7%; neither complexity, GSA status, nor post-repair peak arch velocity predicted the need for arch reinterventions.
Conclusions:
Whilst anatomic complexity may have been somewhat neutralised as a risk factor for operative mortality, in contrast to GSA+ status, there is further post-discharge attrition attributable to complexity or GSA+ status, with additive risk effects. Morbidity directly related to certain syndromes underlies some of this risk. Non-anatomic substrates represent a persistent limitation to outcomes of surgical aortic arch repair in infants.
Among 143 cases of National Healthcare Safety Network (NHSN) catheter-associated urinary tract infections (CAUTI), 40% were considered catheter-associated asymptomatic bacteriuria (CA-ASB), and 18% clinical CAUTI. An alternative source of fever was present in 70% of CA-ASB. NHSN CAUTI may not be an effective metric for tracking hospital-level infection prevention efforts.
Linear stability analysis currently fails to predict turbulence transition in canonical viscous flows. We show that two alternative models of the boundary condition for incipient perturbations at solid walls produce linear instabilities that could be sufficient to explain turbulence transition. In many cases, the near-wall behaviour of the discovered instabilities is empirically indistinguishable from the classical no-slip condition. The ability of these alternative boundary conditions to predict linear instabilities that are consistent with turbulence transition suggests that the no-slip condition may be an overly simplified model of fluid–solid interface physics, particularly as a description of the flow perturbations that lead to turbulence transition in wall-bounded flows.
Interlayer cations and moisture content greatly influence the molecular vibrations of H2O in montmorillonite as shown through reflectance spectroscopy in the infrared. The absorptions due to H2O have been studied in montmorillonites exchanged with H, Na, Ca, Mg and Fe3+ interlayer cations under variable moisture environments. Band assignments have been made for absorptions in the 3 µm region due to structural OH vibrations, symmetric and asymmetric H2O stretching vibrations and the H2O bending overtone. Changes in the energies of the absorptions due to H2O stretching vibrations were observed as the samples were dehydrated by reducing the atmospheric pressure. Absorptions near 3620 cm−1 and 3550 cm−1 have been assigned to water bound directly to cations (inner sphere) and surface-bonded H2O and absorptions near 3450 cm−1 and 3350 cm−1 have been assigned to additional adsorbed water molecules. Band assignments have been made for combination bands in the near-infrared as well. Absorptions near 1.41 μm and 1.91 μm are assigned to bound H2O combination bands, while the shoulders near 1.46μm and 1.97 μm are assigned to combinations of additional H2O molecules adsorbed in the interlayer regions and along grain surfaces.
Recent research has shown the potential of speleothem δ13C to record a range of environmental processes. Here, we report on 230Th-dated stalagmite δ13C records for southwest Sulawesi, Indonesia, over the last 40,000 yr to investigate the relationship between tropical vegetation productivity and atmospheric methane concentrations. We demonstrate that the Sulawesi stalagmite δ13C record is driven by changes in vegetation productivity and soil respiration and explore the link between soil respiration and tropical methane emissions using HadCM3 and the Sheffield Dynamic Global Vegetation Model. The model indicates that changes in soil respiration are primarily driven by changes in temperature and CO2, in line with our interpretation of stalagmite δ13C. In turn, modelled methane emissions are driven by soil respiration, providing a mechanism that links methane to stalagmite δ13C. This relationship is particularly strong during the last glaciation, indicating a key role for the tropics in controlling atmospheric methane when emissions from high-latitude boreal wetlands were suppressed. With further investigation, the link between δ13C in stalagmites and tropical methane could provide a low-latitude proxy complementary to polar ice core records to improve our understanding of the glacial–interglacial methane budget.
The purpose of this study was to explore overall recovery time and post-concussive symptoms (PCSS) of pediatric concussion patients who were referred to a specialty concussion clinic after enduring a protracted recovery (>28 days). This included patients who self-deferred care or received management from another provider until recovery became complicated. It was hypothesized that protracted recovery patients, who initiated care within a specialty concussion clinic, would have similar recovery outcomes as typical acute injury concussion patients (i.e., within 3 weeks).
Participants and Methods:
Retrospective data were gathered from electronic medical records of concussion patients aged 6-19 years. Demographic data were examined based on age, gender, race, concussion history, and comorbid psychiatric diagnosis. Concussion injury data included days from injury to initial clinic visit, total visits, PCSS scores, days from injury to recovery, and days from initiating care with a specialty clinic to recovery. All participants were provided standard return-to-learn and return-to-play protocols, aerobic exercise recommendations, behavioral health recommendations, personalized vestibular/ocular motor rehabilitation exercises, and psychoeducation on the expected recovery trajectory of concussion.
Results:
52 patients were included in this exploratory analysis (Mean age 14.6, SD ±2.7; 57.7% female; 55.7% White, 21.2% Black or African American, 21.2% Hispanic). Two percent of our sample did not disclose their race or ethnicity. Prior concussion history was present in 36.5% of patients and 23.1% had a comorbid psychiatric diagnosis. The patient referral distribution included emergency departments (36%), local pediatricians (26%), neurologists (10%), other concussion clinics (4%), and self-referrals (24%).
Given the nature of our specialty concussion clinic sample, the data was not normally distributed and more likely to be skewed by outliers. As such, the median value and interquartile range were used to describe the results. Regarding recovery variables, the median days to clinic from initial injury was 50.0 (IQR=33.5-75.5) days, the median PCSS score at initial visit was 26.0 (IQR=10.0-53.0), and the median overall recovery time was 81.0 (IQR=57.0-143.3) days.
After initiating care within our specialty concussion clinic, the median recovery time was 21.0 (IQR=14.0-58.0) additional days, the median total visits were 2.0 (IQR=2.0-3.0), and the median PCSS score at follow-up visit was 7.0 (IQR=1-17.3).
Conclusions:
Research has shown that early referral to specialty concussion clinics may reduce recovery time and the risk of protracted recovery. Our results extend these findings to suggest that patients with protracted recovery returned to baseline similarly to those with an acute concussion injury after initiating specialty clinic care. This may be due to the vast number of resources within specialty concussion clinics including tailored return-to-learn and return-to-play protocols, rehabilitation recommendations consistent with research, and home exercises that supplement recovery. Future studies should compare outcomes of protracted recovery patients receiving care from a specialty concussion clinic against those who sought other forms of treatment. Further, evaluating the influence of comorbid factors (e.g., psychiatric and/or concussion history) on pediatric concussion recovery trajectories may be useful for future research.
In Benin, top businesspeople not only capture the economy but also the executive, and possibly legislative power. This book develops a comprehensive analysis aimed at identifying and reducing the institutional constraints that impede Benins rapid, sustainable, and inclusive development. The research reveals a chain of causality between four main categories of institutional weaknesses in Benin, namely corruption, inefficiencies in governance, opacity in public decision-making, and excessive informality in the Beninese economy. These institutional weaknesses are traced back to proximate and ultimate causes. The immediate causes include political instability, elite capture of key state functions, weakness of the state, and the possibility of easy but illegal rents. In turn, these causes are linked to deep-rooted underlying factors such as the nature of the political game, essentially neo-patrimonialism with multiple economic and/or political Big Men, but also geographical or ethnic factors. We elaborate on policy reforms aiming at overcoming or circumventing these institutional problems.
Benin–Nigeria relations are characterised by two-way informal cross-border trade (ICBT) facilitated through their long, porous border. First, Benin imports consumer goods that are subject to high import protection in Nigeria and then transships them to Nigeria through elaborate channels. Second, Benin illegally imports petroleum products from Nigeria, where consumer prices are highly subsidised. Also, consumer, intermediate, and capital goods are smuggled from Nigeria into Benin. This ICBT accounts for a significant share of Benin’s income, employment, and tax revenues on imported goods that are transferred to Nigeria. These benefits of ICBT to Benin, however, are very fragile as they are on the vagaries of economic policy in Nigeria. Moreover, ICBT has nurtured informality, corruption and political capture. It also crowds out private and public resources that could have been put to better use in agricultural and the manufacturing sectors. The way forward for Benin is to progressively move away from smuggling towards formal trade. Benin could aim to become a competitive, efficient regional centre for legal trade and services to its hinterland countries, as well as to Nigeria.
Is nationalism compatible with Islamic belief and practice? Debates on this question began with the rise of modern nationalism in the Muslim world during the nineteenth century and continue in varying forms in the twenty-first century. The middle of the twentieth century marked an important moment in the evolution of these debates. Muslim leaders and activists worked to define the political and cultural identity of the Muslim countries that were becoming independent from European imperialism. They were also defining the possible relationships between Islam and nationalism. The broad spectrum of their views reflects the fundamental issues involved in deciding whether nationalism is compatible with Islam.
The U.S. Department of Agriculture–Agricultural Research Service (USDA-ARS) has been a leader in weed science research covering topics ranging from the development and use of integrated weed management (IWM) tactics to basic mechanistic studies, including biotic resistance of desirable plant communities and herbicide resistance. ARS weed scientists have worked in agricultural and natural ecosystems, including agronomic and horticultural crops, pastures, forests, wild lands, aquatic habitats, wetlands, and riparian areas. Through strong partnerships with academia, state agencies, private industry, and numerous federal programs, ARS weed scientists have made contributions to discoveries in the newest fields of robotics and genetics, as well as the traditional and fundamental subjects of weed–crop competition and physiology and integration of weed control tactics and practices. Weed science at ARS is often overshadowed by other research topics; thus, few are aware of the long history of ARS weed science and its important contributions. This review is the result of a symposium held at the Weed Science Society of America’s 62nd Annual Meeting in 2022 that included 10 separate presentations in a virtual Weed Science Webinar Series. The overarching themes of management tactics (IWM, biological control, and automation), basic mechanisms (competition, invasive plant genetics, and herbicide resistance), and ecosystem impacts (invasive plant spread, climate change, conservation, and restoration) represent core ARS weed science research that is dynamic and efficacious and has been a significant component of the agency’s national and international efforts. This review highlights current studies and future directions that exemplify the science and collaborative relationships both within and outside ARS. Given the constraints of weeds and invasive plants on all aspects of food, feed, and fiber systems, there is an acknowledged need to face new challenges, including agriculture and natural resources sustainability, economic resilience and reliability, and societal health and well-being.
Energy-harvesting systems in complex flow environments, such as floating offshore wind turbines, tidal turbines and ground-fixed turbines in axial gusts, encounter unsteady streamwise flow conditions that affect their power generation and structural loads. In some cases, enhancements in time-averaged power generation above the steady-flow operating point are observed. To characterize these dynamics, a nonlinear dynamical model for the rotation rate and power extraction of a periodically surging turbine is derived and connected to two potential-flow representations of the induction zone upstream of the turbine. The model predictions for the time-averaged power extraction of the turbine and the upstream flow velocity and pressure are compared against data from experiments conducted with a surging-turbine apparatus in an open-circuit wind tunnel at a diameter-based Reynolds number $Re_D = 6.3\times 10^5$ and surge-velocity amplitudes up to 24 % of the wind speed. The combined modelling approach captures trends in both the time-averaged power extraction and the fluctuations in upstream flow quantities, while relying only on data from steady-flow measurements. The sensitivity of the observed increases in time-averaged power to steady-flow turbine characteristics is established, thus clarifying the conditions under which these enhancements are possible. Finally, the influence of unsteady fluid mechanics on time-averaged power extraction is explored analytically. The theoretical framework and experimental validation provide a cohesive modelling approach that can drive the design, control and optimization of turbines in unsteady flow conditions, as well as inform the development of novel energy-harvesting systems that can leverage unsteady flows for large increases in power-generation capacities.
This article highlights and evaluates the role of CEPI and its contribution to global equitable access to COVID-19 vaccines through its established partnerships for vaccine development. The article adds to the understanding of how and when such partnerships can work for public health, especially under emergency citations.
There has been increased interest in repurposing anti-inflammatories for the treatment of bipolar depression. Evidence from high-income countries suggests that these agents may work best for specific depressive symptoms in a subset of patients with biochemical evidence of inflammation but data from lower-middle income countries (LMICs) is scarce. This secondary analysis explored the relationship between pretreatment inflammatory markers and specific depressive symptoms, clinical measures, and demographic variables in participants with bipolar depression in Pakistan.
Methods
The current study is a cross-sectional secondary analysis of a randomized controlled trial of two anti-inflammatory medications (minocycline and celecoxib) for bipolar depression (n = 266). A series of logistic and linear regression models were completed to assess the relationship between C-reactive protein (CRP) (CRP > or < 3 mg/L and log10CRP) and clinical and demographic features of interest and symptoms of depression. Baseline clinical trial data was used to extract clinical and demographic features and symptoms of depression were assessed using the 24-item Hamilton Depression Rating Scale.
Results
The prevalence of low-grade inflammation (CRP > 3 mg/L) in the sample was 70.9%. After adjusting for baseline body mass index, socioeconomic status, age, gender, symptoms related to anhedonia, fatigue, and motor retardation were most associated with low-grade inflammation.
Conclusions
Bipolar disorder (BD) patients from LMICs may experience higher rates of peripheral inflammation than have been reported in Western populations with BD. Future trials of repurposed anti-inflammatory agents that enrich for participants with these symptom profiles may inform the development of personalized treatment for bipolar depression in LMICs.
Protoporphyrinogen oxidase (PPO)-inhibiting herbicides remain an important and useful chemistry 60 yr after their first introduction. In this review, based on topics introduced at the Weed Science Society of America 2021 symposium titled “A History, Overview, and Plan of Action on PPO Inhibiting Herbicides,” we discuss the current state of PPO-inhibiting herbicides. Renewed interest in the PPO-inhibiting herbicides in recent years, due to increased use and increased cases of resistance, has led to refinements in knowledge regarding the mechanism of action of PPO inhibitors. Herein we discuss the importance of the two isoforms of PPO in plants, compile a current knowledge of target-site resistance mechanisms, examine non–target site resistance cases, and review crop selectivity mechanisms. Consistent and reproducible greenhouse screening and target-site mutation assays are necessary to effectively study and compare PPO-inhibitor resistance cases. To this end, we cover best practices in screening to accurately identify resistance ratios and properly interpret common screens for point mutations. The future of effective and sustainable PPO-inhibitor use relies on development of new chemistries that maintain activity on resistant biotypes and the promotion of responsible stewardship of PPO inhibitors both new and old. We present the biorational design of the new PPO inhibitor trifludimoxazin to highlight the future of PPO-inhibitor development and discuss the elements of sustainable weed control programs using PPO inhibitors, as well as how responsible stewardship can be incentivized. The sustained use of PPO inhibitors in future agriculture relies on the effective and timely communication from mode of action and resistance research to agronomists, Extension workers, and farmers.
Introduction: from the new materialism to the old new spiritualism
Several contemporary approaches in both ontology and philosophy of mind (especially concerning the mind-body relation) have gathered under the banner of a ‘new materialism’ in the first two decades of the twenty-first century. Though this particular title covers a wide range of materialisms variously espoused through biology, neurology, physics, computer science and even mathematics, they have nonetheless become part of mainstream European thought in many circles. More broadly still, ‘materialism’ as such – be it ‘new’ or ‘old’, ‘historical’, ‘transcendental’ or even ‘performative’ – today represents the received wisdom in much contemporary philosophy. By contrast, what might be called ‘spiritual’ or ‘spiritualist’ philosophy is (ironically) all but dead in these fields. If there is a spiritual life for ‘continental’ philosophy, it keeps itself well hidden. Whereas small corners within Anglo-American ‘analytic’ philosophy have of late attempted to rehabilitate the spiritual – or consciousness – through panpsychism (in the work of Galen Strawson and David Charmers, for instance), or the process thought of Whitehead and his heirs, the European approach, with some exceptions, seems happiest when keeping a safe distance from anything with even a hint of the immaterial about it. Yet, as we will see, there are even more heterodox models of mind and life available to us than these Anglo-American views, ones that might be sustained without necessarily being accompanied with such (incompatible) associates as the immaterial, the ideal or the disembodied.
The most significant and current European materialism is undoubtedly what calls itself ‘new materialism’. It is built upon two premises that are noteworthy for us. The first concerns what counts as ‘new’ in its understanding of matter. Though Christopher Gamble, Joshua Hanan and Thomas Nail argue in their 2019 study of the movement that ‘there is currently no single definition of new materialism’, they do add that they share a ‘perceived neglect or diminishment of matter in the dominant Euro-Western tradition as a passive substance intrinsically devoid of meaning’ (Gamble et al. 2019: 111).