We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Diagnostic criteria for major depressive disorder allow for heterogeneous symptom profiles but genetic analysis of major depressive symptoms has the potential to identify clinical and etiological subtypes. There are several challenges to integrating symptom data from genetically informative cohorts, such as sample size differences between clinical and community cohorts and various patterns of missing data.
Methods
We conducted genome-wide association studies of major depressive symptoms in three cohorts that were enriched for participants with a diagnosis of depression (Psychiatric Genomics Consortium, Australian Genetics of Depression Study, Generation Scotland) and three community cohorts who were not recruited on the basis of diagnosis (Avon Longitudinal Study of Parents and Children, Estonian Biobank, and UK Biobank). We fit a series of confirmatory factor models with factors that accounted for how symptom data was sampled and then compared alternative models with different symptom factors.
Results
The best fitting model had a distinct factor for Appetite/Weight symptoms and an additional measurement factor that accounted for the skip-structure in community cohorts (use of Depression and Anhedonia as gating symptoms).
Conclusion
The results show the importance of assessing the directionality of symptoms (such as hypersomnia versus insomnia) and of accounting for study and measurement design when meta-analyzing genetic association data.
Kaolinites of all kinds (fine, ‘fireclay,’ ‘type IV,’ etc.), some of which do not expand or expand incompletely with the usual intercalation methods used for comparison, are expanded completely by treatment of dry (110°C) clay with dry CsCl salt, followed by contact with hydrazine for 1 day at 65°C and then with DMSO overnight at 90°C. Comparison treatments were grinding in KOAc, soaking in hydrazine, and Li-DMSO, as well as combination of these. Following the Cs-hydrazine-DMSO treatment, the 7.2 Å spacing of 1:1 dioctahedral layer silicates shifts to 11.2 Å and the 11.2 Å/(7.2 + 11.2 Å) ratio ≃1.0. The trioctahedral 1:1 layer silicates and chlorite are not expanded by the Cs-hydrazine-DMSO procedure.
Clinical outcomes of repetitive transcranial magnetic stimulation (rTMS) for treatment of treatment-resistant depression (TRD) vary widely and there is no mood rating scale that is standard for assessing rTMS outcome. It remains unclear whether TMS is as efficacious in older adults with late-life depression (LLD) compared to younger adults with major depressive disorder (MDD). This study examined the effect of age on outcomes of rTMS treatment of adults with TRD. Self-report and observer mood ratings were measured weekly in 687 subjects ages 16–100 years undergoing rTMS treatment using the Inventory of Depressive Symptomatology 30-item Self-Report (IDS-SR), Patient Health Questionnaire 9-item (PHQ), Profile of Mood States 30-item, and Hamilton Depression Rating Scale 17-item (HDRS). All rating scales detected significant improvement with treatment; response and remission rates varied by scale but not by age (response/remission ≥ 60: 38%–57%/25%–33%; <60: 32%–49%/18%–25%). Proportional hazards models showed early improvement predicted later improvement across ages, though early improvements in PHQ and HDRS were more predictive of remission in those < 60 years (relative to those ≥ 60) and greater baseline IDS burden was more predictive of non-remission in those ≥ 60 years (relative to those < 60). These results indicate there is no significant effect of age on treatment outcomes in rTMS for TRD, though rating instruments may differ in assessment of symptom burden between younger and older adults during treatment.
Evidence from previous research suggests that frame-of-reference (FOR) training is effective at improving assessor ratings in many organizational settings. Yet no research has presented a thorough examination of systematic sources of variance (assessor-related effects, evaluation settings, and measurement design features) that might influence training effectiveness. Using a factorial ANOVA and variance components analyses on a database of four studies of frame-of-reference assessor training, we found that (a) training is most effective at identifying low levels of performance and (b) the setting of the training makes little difference with respect to training effectiveness. We also show evidence of the importance of rater training as a key determinant of the quality of performance ratings in general. Implications for FOR training theory and practice are discussed.
Frontal ablation, the combination of submarine melting and iceberg calving, changes the geometry of a glacier's terminus, influencing glacier dynamics, the fate of upwelling plumes and the distribution of submarine meltwater input into the ocean. Directly observing frontal ablation and terminus morphology below the waterline is difficult, however, limiting our understanding of these coupled ice–ocean processes. To investigate the evolution of a tidewater glacier's submarine terminus, we combine 3-D multibeam point clouds of the subsurface ice face at LeConte Glacier, Alaska, with concurrent observations of environmental conditions during three field campaigns between 2016 and 2018. We observe terminus morphology that was predominately overcut (52% in August 2016, 63% in May 2017 and 74% in September 2018), accompanied by high multibeam sonar-derived melt rates (4.84 m d−1 in 2016, 1.13 m d−1 in 2017 and 1.85 m d−1 in 2018). We find that periods of high subglacial discharge lead to localized undercut discharge outlets, but adjacent to these outlets the terminus maintains significantly overcut geometry, with an ice ramp that protrudes 75 m into the fjord in 2017 and 125 m in 2018. Our data challenge the assumption that tidewater glacier termini are largely undercut during periods of high submarine melting.
Categorization – assimilating objects to psychological equivalence classes – is a crucial cognitive capacity that has always enhanced vertebrate fitness. This chapter reviews from a primate perspective the state of knowledge in comparative categorization’s subdomains: prototypes, exemplars, rules, and abstractions. Primate studies have made a profound contribution to the prototype-exemplar debate – essentially resolving it. They have illuminated the evolutionary emergence of a cognitive capacity for category rules, illuminating also the emergence of humans’ explicit-declarative cognition. In this area, primates appear as a pivotal transitional form. In the literature on abstract concepts (e.g., Same-Different), primate studies highlight the differences in cognitive capacities across vertebrate lines. The review will demonstrate the crucial role of a fitness/ecological perspective in understanding categorization as an adaptive, information-processing capability. It will raise important questions about the similarity structure of natural (and unnatural) kinds and categories. It will show strong continuities between human and animal cognition, but important discontinuities as well. In all the subdomains, the primates have been extraordinary behavioral ambassadors to the broader field of categorization.
Dysfunction of the endocrine glands can occur at any point in the life cycle. Although many endocrine diseases will present with classic signs and symptoms, atypical presentation of hormonal dysregulation can make diagnosis in the elderly particularly challenging. Normal physiologic changes associated with aging, as well as medical comorbidities and medications, may all cloud the identification of endocrine dysfunction in this complicated population. As such, the diagnosis of endocrinopathies in the elderly population requires a careful medical history, detailed physical exam, rational biochemical workup, and, if necessary, directed imaging. The management of endocrine disorders can be equally complex. Many endocrine disorders are treated with medications that may complicate an already-lengthy list, causing unwanted side effects or even drug–drug interactions. If therapy includes possible surgical referral, careful assessment of the risk–benefit ratio and candidacy of the elderly patient is imperative. Endocrine guidelines have been designed to assist the clinician with accurate diagnosis and therapeutic decision-making; however, guidelines cannot supplant the need for patient-centered care in this vulnerable population in whom disorders of the endocrine glands fail to adhere to “textbook” scenarios.
Undergraduate research experiences have been identified as a high-impact practice in higher education.Within the physics community, research experiences were cited as a critical educational experience for undergraduate students by many thriving physics programs. Furthermore, the discipline has, for many years, supported undergraduate research experiences by advocating for and funding such programs as well as providing opportunities for undergraduate students to present their research at professional conferences and in peer-reviewed professional journals. In this chapter, the authors briefly highlight the benefits of research experiences to undergraduate physics students along with some of the known or community-accepted best practices for engaging undergraduate students in research. The authors also discuss the challenges faced by the community surrounding equity and our ability to engage all students in this meaningful professional and educational experience. While challenges exist, there are opportunities for the physics community to successfully address them through hard work, creativity, and innovation.
OBJECTIVES/GOALS: Despite a disproportionate impact of COVID-19 on minority and under-resourced communities, nearly all COVID-19 resources have only been online in English. A statewide coalition of community and academic partners used community-engaged strategies to provide tailored outreach to diverse populations. METHODS/STUDY POPULATION: The STOP COVID-19 CA statewide team had a workgroup focused on communications. Members of this group represented different sectors, racial/ethnic groups, disciplines, and regions across the state. They had regular meetings to discuss and strategize how to overcome the impact of historic and structural racism on access to COVID-19 resources, including testing, vaccines, and protective equipment. The team also shared regular updates about changes in community concerns and needs as well as new, tailored resources. RESULTS/ANTICIPATED RESULTS: Together, the team has been able to reach diverse populations across the state, including providing information about COVID-19 in multiple languages and formats, from radio to virtual town halls to local health fairs. The multiple sites also increased access to vaccines and testing through trusted community leaders and locations, including church-based locations to bringing vaccines and testing directly to workplaces. These community pop-up vaccination sites have helped to vaccinate large numbers of diverse populations, some of whom were initially unsure about getting the vaccine, which has helped to reduce the gaps in community vaccination rates by race/ethnicity. DISCUSSION/SIGNIFICANCE: This network of community-engaged strategies utilized for rapid COVID-19 response could also be used to for responses to future public health emergencies, addressing chronic diseases (e.g., diabetes, hypertension), or even other complex issues that affect society and health (e.g., climate change).
Chapter 4 discusses restoration of the natural functions of degraded landforms and landforms that provide a limited number of shore protection or recreational values. The case is made to make beach/dune systems more dynamic to allow nature to undergo exchanges of sediment, nutrients, and biota; follow cycles of accretion, erosion, growth, and decay; and retain diversity, complexity, and the ability to deliver ecosystem services. Actions include reestablishing physical habitat characteristics (e.g., overwash areas and slacks), removing invasive species, and reinitiating cycles of growth and decay by reducing vegetation cover or destabilizing surfaces to favor reworking by waves and winds. Many of these actions are most appropriate for landscapes that are usually found within natural preserves and consistent with the regulations governing their management. Issues associated with removing wrack (beach cast), driving on the beach, restoring mined sites, and stabilizing dune fields that are overly mobile are also addressed in this chapter. Restoration actions in intensively developed areas where beach and dune evolution are under severe spatial constraints are addressed in subsequent chapters.
Chapter 3 discusses the ways foredunes can be built by human actions in locations where they have been eliminated. Alternative strategies for foredune development are reviewed including (1) using beach nourishment to provide a beach with sediment sizes that can be reworked by waves and winds; (2) constructing dunes by using earth-moving equipment to place fill sediment derived from external source areas, such as offshore borrow areas, navigation channels, or inland deposits; (3) using in-situ beach sand using earth-moving equipment (termed grading or scraping); (4) deploying sand-trapping fences; (5) planting vegetation; and (6) using a combination or multiple of these strategies. Time and space are critical to the evolution of landforms and vegetation gradients on developed coasts, and choice of techniques for dune building are evaluated under these constraints. The case is made that once newly built foredunes achieve their protective function, they should be allowed to evolve as naturally functioning environments to the extent allowable.
Chapter 8 identifies the rationale and components of an integrated, locally based program for increasing the number, size, and cumulative benefits of natural environments in developed municipalities. Elements include (1) getting stakeholders to accept natural landforms and habitats as appropriate elements in a developed coastal landscape; (2) identifying environmental indicators and target reference conditions for new restoration sites using characteristics of nearby natural enclaves; (3) establishing demonstration sites to evaluate the positive and negative effects of return to a more dynamic system; (4) developing guidelines and protocols for restoring and managing landforms and habitats; and (5) developing education programs to establish an appreciation for naturally functioning landscape components. Suggestions are also made for managing litter and wrack, grading landforms, controlling vehicles on the beach, managing access paths across dunes, reducing structures on beaches and dunes, using vegetation for landscaping private lots, establishing programs for monitoring and adaptive management, and developing compatible legislation.