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Chapter 30 - Magnetic resonance spectroscopy in demyelination and inflammation

from Section 4 - Infection, inflammation and demyelination

Published online by Cambridge University Press:  05 March 2013

By
Gioacchino Tedeschi  and
Simona Bonavita
Edited by
Jonathan H. Gillard ,
Adam D. Waldman  and
Peter B. Barker
Jonathan H. Gillard
Affiliation:
University of Cambridge
Adam D. Waldman
Affiliation:
Imperial College London
Peter B. Barker
Affiliation:
The Johns Hopkins University School of Medicine
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Summary

Introduction

MR spectroscopy (MRS) furnishes in vivo metabolic information in central nervous system (CNS) diseases. This chapter addresses the application of proton MRS to the study of acquired demyelinating and inflammatory disorders of the CNS.

The major findings from single-voxel and MRS imaging (MRSI, also known as chemical shift imaging) studies are discussed. The choice of the technique depends on the disease being considered and on the questions being asked. Both MRS and MRSI have advantages and disadvantages. The former is easier to perform quantitatively, and is well suited to the study of focal lesions or single brain locations, but it provides limited anatomical coverage. In contrast, MRSI allows a more extensive regional sampling of diffuse CNS disorders, as well as of large and more heterogeneous lesions, but it mostly yields metabolite ratios and may have less biochemical sensitivity and specificity. In either case, it should be borne in mind that the maximum resolution of approximately 0.5 cm3 voxel size may often be too large to assess tiny lesions or small CNS structures.

Type
Chapter
Information
Clinical MR Neuroimaging
Physiological and Functional Techniques
 , pp. 475 - 487
Publisher: Cambridge University Press
Print publication year: 2009

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References

Lublin, FD, Reingold, SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996; 46: 907–911.CrossRefGoogle ScholarPubMed
Kapeller, P, McLean, MA, Griffin, CM, et al. Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing remitting multiple sclerosis: a quantitative MR spectroscopic imaging study. J Neurol 2001; 248: 131–138.CrossRefGoogle ScholarPubMed
De Stefano, N, Matthews, PM, Antel, JP, et al. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 1995; 38: 901–909.CrossRefGoogle ScholarPubMed
Narayana, PA, Doyle, TJ, Lai, D, Wolinsky, JS.Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 1998; 43: 56–71.CrossRefGoogle ScholarPubMed
Hurd, R, Napapon, S, Srinivasan, R, et al. Measurement of brain glutamate using TE-averaged PRESS at 3 T. Magn Reson Med 2004; 51: 435–446.CrossRefGoogle Scholar
Srinivasan, R, Sailasuta, N, Hurd, R, Nelson, S, Pelletier, D. Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T. Brain 2005; 128: 1016–1025.CrossRefGoogle ScholarPubMed
De Stefano, N, Matthews, PM, Arnold, DL. Reversible decreases in N-acetylaspartate after acute brain injury. Magnet Reson Med 1995; 34: 721–727.CrossRefGoogle ScholarPubMed
Bitsch, A, Bruhn, AA, Vougioukas, V, et al. Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. AJNR Am J Neuroradiol 1999; 20: 1619–1627.Google ScholarPubMed
Cianfoni, A, Niku, S, Imbesi, SG. Metabolite findings in tumefactive demyelinating lesions utilizing short echo time proton magnetic resonance spectroscopy. AJNR J Neuroradiol 2007; 28: 272–277.Google ScholarPubMed
Fu, L, Matthews, P, De Stefano, N, et al. Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain 1998; 121: 103–113.CrossRefGoogle ScholarPubMed
De Stefano, N, Narayanan, S, Matthews, PM, et al. In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis. Brain 1999; 122: 1933–1939.CrossRefGoogle ScholarPubMed
Tedeschi, G, Bonavita, S, McFarland, HF, et al. Proton MR spectroscopic imaging in multiple sclerosis. Neuroradiology 2002; 44: 37–42.CrossRefGoogle ScholarPubMed
Tartaglia, MC, Narayanan, S, De Stefano, N, et al. Choline is increased in pre-lesional normal appearing white matter in multiple sclerosis. J Neurol 2002; 249: 1382–1390.CrossRefGoogle ScholarPubMed
Sharma, R, Narayana, PA, Wolinsky, JS. Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging. Mult Scler 2001; 7: 221–226.CrossRefGoogle ScholarPubMed
Sarchielli, P, Presciutti, O, Tarducci, R, et al. Localized (1)H magnetic resonance spectroscopy in mainly cortical gray matter of patients with multiple sclerosis. J Neurol 2002; 249: 902–910.CrossRefGoogle ScholarPubMed
Cifelli, A, Arridge, M, Jezzard, P, et al. Thalamic neurodegeneration in multiple sclerosis. Ann Neurol 2002; 52: 650–653.CrossRefGoogle ScholarPubMed
Wylezinska, M, Cifelli, A, Jezzard, P et al. Thalamic neurodegeneration in relapsing–remitting multiple sclerosis. Neurology 60: 1949–1954.Google Scholar
Chard, DT, Griffin, CM, McLean, MA, et al. Brain metabolite changes in cortical grey matter and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosisBrain 2002; 125: 2342–2352.CrossRefGoogle ScholarPubMed
Ciccarelli, O, Wheeler-Kingshott, CA, McLean MA, M. et al. Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis. Brain 2007; 130: 2220–2231.CrossRefGoogle ScholarPubMed
Marliani, AF, Clementi, V, Albini-Riccioli, L, et al. Quantitative proton magnetic resonance spectroscopy of the human cervical spinal cord at 3 tesla. Magn Reson Med 2007; 57: 160–163.CrossRefGoogle ScholarPubMed
Brex, PA, Gomez-Anson, B, Parker, GJ, et al. Proton MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis. J Neurol Sci 1999; 166: 16–22.CrossRefGoogle ScholarPubMed
Tourbah, A, Stievenart, JL, Gout, O, et al. Localized proton magnetic resonance spectroscopy in relapsing remitting versus secondary progressive multiple sclerosis. Neurology 1999; 53: 1091–1097.CrossRefGoogle ScholarPubMed
De Stefano, N, Narayanan, S, Francis, GS, et al. Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Arch Neurol (Chicago) 2001; 58: 65–70.CrossRefGoogle ScholarPubMed
Mews, I, Bergmann, M, Bunkowski, S, et al. Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions. Mult Scler 1998; 4: 55–62.CrossRefGoogle ScholarPubMed
Narayana, PA, Wolinsky, JS, Rao, SB, et al. Multicentre proton magnetic resonance spectroscopy imaging of primary progressive multiple sclerosis. Mult Scler 2004; 10(Suppl 1): S73–S78.CrossRefGoogle ScholarPubMed
Traber, F, Block, W, Freymann, N, et al. A multicenter reproducibility study of single-voxel 1H-MRS of the medial temporal lobe. Eur Radiol 2006; 16: 1096–1103.CrossRefGoogle ScholarPubMed
Narayanan, S, De Stefano, N, Pouwels, PJ, et al. The effect of oral glatiramer acetate treatment on axonal integrity in multiple sclerosis: results from the multicentre CORAL MRS sub-study. Mult Scler 2005; 11: 112.Google Scholar
De Stefano, N, Filippi, M, Miller, D, et al. Guidelines for using proton MR spectroscopy in multicenter clinical MS studiesNeurology 2007; 69: 1942–1952.CrossRefGoogle ScholarPubMed
Bizzi, A, Ulug, AM, Crawford, T, et al. Quantitative proton MR spectroscopic imaging in acute disseminated encephalomyelitis. AJNR Am J Neuroradiol 2001; 22: 1125–1130.Google ScholarPubMed
Bonavita, S, Virta, A, Jeffries, N, et al. Diffuse neuroaxonal involvement in mucolipidosis IV as assessed by proton magnetic resonance spectroscopic imaging. J Child Neurol 2003; 18: 443–449.CrossRefGoogle ScholarPubMed
Auer, DP, Schirmer, T, Heidenreich, JO, et al. Altered white and gray matter metabolism in CADASIL: a proton MR spectroscopy and MRSI study. Neurology 2001; 56: 635–642.CrossRefGoogle ScholarPubMed
De Stefano, N, Dotti, MT, Mortilla, M, et al. Magnetic resonance imaging and spectroscopic changes in brains of patients with cerebrotendinous xanthomatosis. Brain 2001; 124: 121–131.CrossRefGoogle ScholarPubMed
Willemsen, MA, IJlst, L, Steijlen, PM, et al. Clinical, biochemical and molecular genetic characteristics of 19 patients with the Sjögren–Larsson syndrome. Brain 2001; 124: 1426–1437.CrossRefGoogle Scholar
Varho, T, Komu, M, Sonninen, P, et al. A new metabolite contributing to N-acetyl signal in MRS of the brain in Salla disease. Neurology 1999; 53: 1162.Google Scholar
Schiffmann, R, Tedeschi, G, Kinkel, RP, et al. Leuko-dystrophy in patients with ovarian dysgenesis. Ann Neurol 1997; 41: 654–661.CrossRefGoogle Scholar

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