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Chapter 6 - Principles of radiation oncology in older adults

from Part 1 - Key principles in geriatric oncology

Published online by Cambridge University Press:  05 August 2011

Arti Hurria
Affiliation:
City of Hope Cancer Center, California
Harvey Jay Cohen
Affiliation:
Duke University Medical Center, Durham
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Publisher: Cambridge University Press
Print publication year: 2010

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References

Bartelink, H, Horiot, JC, Poortmans, P. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med. 2001;345(19):1378–1387.CrossRefGoogle ScholarPubMed
Bartelink, H, Horiot, JC, Poortmans, PM. Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881–10882 trial. J Clin Oncol. 2007; 25(22):3259–3265.CrossRefGoogle ScholarPubMed
Creutzberg, CL, Putten, WL, Koper, PC. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet. 2000;355(9213):1404–1411.CrossRefGoogle Scholar
Hutchins, LF, Unger, JM, Crowley, JJ. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med. 1999;341(27):2061–2067.CrossRefGoogle ScholarPubMed
Wong, ND, Thakral, G, Franklin, SS. Preventing heart disease by controlling hypertension: impact of hypertensive subtype, stage, age, and sex. Am Heart J. 2003;145(5):888–895.CrossRefGoogle ScholarPubMed
Black, DM, Cummings, SR, Karpf, DB. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet. 1996;348(9041):1535–1541.CrossRefGoogle ScholarPubMed
Solin, LJ, Fourquet, A, Vicini, FA. Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast. Cancer. 2005;103(6):1137–1146.CrossRefGoogle ScholarPubMed
Clarke, M, Collins, R, Darby, S. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;366(9503):2087–2106.Google ScholarPubMed
Page, DL, Dupont, WD, Rogers, LW. Continued local recurrence of carcinoma 15–25 years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy. Cancer. 1995;76(7):1197–1200.3.0.CO;2-0>CrossRefGoogle ScholarPubMed
Fonseca, R, Hartmann, LC, Petersen, IA. Ductal carcinoma in situ of the breast. Ann Intern Med. 1997;127(11):1013–1022.CrossRefGoogle ScholarPubMed
Fisher, B, Land, S, Mamounas, E. Prevention of invasive breast cancer in women with ductal carcinoma in situ: an update of the national surgical adjuvant breast and bowel project experience. Semin Oncol. 2001;28(4):400–418.CrossRefGoogle ScholarPubMed
Bijker, N, Meijnen, P, Peterse, JL. Breast-conserving treatment with or without radiotherapy in ductal carcinoma-in-situ: ten-year results of European Organisation for Research and Treatment of Cancer randomized phase III trial 10853 – a study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group. J Clin Oncol. 2006;24(21):3381–3387.CrossRefGoogle ScholarPubMed
Emdin, SO, Granstrand, B, Ringberg, A. SweDCIS: radiotherapy after sector resection for ductal carcinoma in situ of the breast: results of a randomised trial in a population offered mammography screening. Acta Oncol. 2006;45(5):536–543.CrossRefGoogle Scholar
Houghton, J, George, WD, Cuzick, J. Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ of the breast in the UK, Australia, and New Zealand: randomised controlled trial. Lancet. 2003;362(9378):95–102.CrossRefGoogle ScholarPubMed
Viani, GA, Stefano, EJ, Afonso, SL. Breast-conserving surgery with or without radiotherapy in women with ductal carcinoma in situ: a meta-analysis of randomized trials. Radiat Oncol. 2007;2:28.CrossRefGoogle ScholarPubMed
Smith, BD, Haffty, BG, Buchholz, TA. Effectiveness of radiation therapy in older women with ductal carcinoma in situ. J Natl Cancer Inst. 2006;98(18):1302–1310.CrossRefGoogle ScholarPubMed
Charlson, ME, Pompei, P, Ales, KL. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40(5):373–383.CrossRefGoogle ScholarPubMed
Fisher, B, Anderson, S, Bryant, J. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–1241.CrossRefGoogle ScholarPubMed
Veronesi, U, Cascinelli, N, Mariani, L. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347(16):1227–1232.CrossRefGoogle ScholarPubMed
Hughes, KS, Schnaper, , Berry, D. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer. N Engl J Med. 2004;351(10):971–977.CrossRefGoogle ScholarPubMed
Hughes, KS, Schnaper, , Berry, D. Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer: a report of further follow-up [abstract]. Proc San Antonio Breast Cancer Symp. 2006;A11.Google Scholar
Fyles, AW, McCready, DR, Manchul, . Tamoxifen with or without breast irradiation in women 50 years of age or older with early breast cancer. N Engl J Med. 2004;351(10):963–970.CrossRefGoogle ScholarPubMed
Carlson, RW, Anderson, BO, Burstein, HJ. Breast cancer. J Natl Compr Canc Netw. 2005;3(3):238–289.Google ScholarPubMed
Smith, BD, Gross, CP, Smith, GL. Effectiveness of radiation therapy for older women with early breast cancer. J Natl Cancer Inst. 2006;98(10):681–690.CrossRefGoogle ScholarPubMed
Overgaard, M, Hansen, PS, Overgaard, J. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med. 1997;337(14):949–955.CrossRefGoogle ScholarPubMed
Ragaz, J, Olivotto, IA, Spinelli, JJ. Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial. J Natl Cancer Inst. 2005;97(2):116–126.CrossRefGoogle ScholarPubMed
Overgaard, M, Jensen, MB, Overgaard, J. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet. 1999;353(9165):1641–1648.CrossRefGoogle ScholarPubMed
Truong, PT, Lee, J, Kader, HA. Locoregional recurrence risks in elderly breast cancer patients treated with mastectomy without adjuvant radiotherapy. Eur J Cancer. 2005;41(9):1267– 1277.CrossRefGoogle ScholarPubMed
Smith, BD, Haffty, BG, Hurria, A. Postmastectomy radiation and survival in older women with breast cancer. J Clin Oncol. 2006;24(30):4901–4907.CrossRefGoogle ScholarPubMed
Whelan, T, MacKenzie, R, Julian, J. Randomized trial of breast irradiation schedules after lumpectomy for women with lymph node-negative breast cancer. J Natl Cancer Inst. 2002;94(15):1143–1150.CrossRefGoogle ScholarPubMed
Whelan, TJ, Pignol, JP, Julian, J. Long-term results of a randomized trial of accelerated hypofractionated whole breast irradiation following breast conserving surgery in women with node-negative breast cancer. Int J Radiat Oncol Biol Phys. 2008;72(suppl 1): S28.CrossRefGoogle Scholar
Bentzen, SM, Agrawal, RK, Aird, EG. The UK Standardisation of Breast Radiotherapy (START) Trial B of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet. 2008;371(9618):1098–1107.Google ScholarPubMed
Bentzen, SM, Agrawal, RK, Aird, EG. The UK Standardisation of Breast Radiotherapy (START) Trial A of radiotherapy hypofractionation for treatment of early breast cancer: a randomised trial. Lancet Oncol. 2008;9(4):331–341.Google Scholar
Arthur, DW, Vicini, FA. Accelerated partial breast irradiation as a part of breast conservation therapy. J Clin Oncol. 2005;23(8):1726–1735.CrossRefGoogle ScholarPubMed
,NSABP Protocol B-39/RTOG Protocol 0413: a randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) for women with stage 0, I, or II breast cancer. Radiation Therapy Oncology Group Web site. Available at: http://www.rtog.org/members/protocols/0413/0413.pdf.
Vlastos, G, Mirza, NQ, Meric, F. Breast conservation therapy as a treatment option for the elderly. The M. D. Anderson experience. Cancer. 2001;92(5):1092–1100.3.0.CO;2-P>CrossRefGoogle Scholar
Deutsch, M.Radiotherapy after lumpectomy for breast cancer in very old women. Am J Clin Oncol. 2002;25(1):48–49.CrossRefGoogle ScholarPubMed
D';Amico, AV, Whittington, R, Malkowicz, SB. Predicting prostate specific antigen outcome preoperatively in the prostate specific antigen era. J Urol. 2001;166(6):2185–2188.CrossRefGoogle Scholar
Bill-Axelson, A, Holmberg, L, Ruutu, M. Radical prostatectomy versus watchful waiting in early prostate cancer. N Engl J Med. 2005;352(19):1977–1984.CrossRefGoogle ScholarPubMed
Mohler, J, Babaian, RJ, Bahnson, RR. Prostate cancer: clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2007;5(7):650–683.Google Scholar
McCloskey, SA, Kuettel, MR. Counterpoint: prostate cancer life expectancy can not be accurately predicted from currently available tools. J Natl Compr Canc Netw. 2007;5(7):709–713.CrossRefGoogle Scholar
Klotz, L.Active surveillance for prostate cancer: for whom?J Clin Oncol. 2005;23(32):8165–8169.CrossRefGoogle ScholarPubMed
Wong, YN, Mitra, N, Hudes, G. Survival associated with treatment vs observation of localized prostate cancer in elderly men. J Am Med Assoc. 2006;296(22):2683–2693.CrossRefGoogle ScholarPubMed
Albertsen, PC, Hanley, JA, Fine, J. 20-year outcomes following conservative management of clinically localized prostate cancer. J Am Med Assoc. 2005;293(17):2095–2101.CrossRefGoogle ScholarPubMed
Widmark, A, Klepp, O, Solberg, A. Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial. Lancet. 2009;373(9660):301–308.CrossRefGoogle ScholarPubMed
Bolla, M, Collette, L, Tienhoven, G. Ten year results of long term adjuvant androgen deprivation with goserelin in patients with locally advanced prostate cancer treated with radiotherapy: a phase III EORTC study [abstract]. Int J Radiat Oncol Biol Phys. 2008;72(suppl 1):A65, S30.CrossRefGoogle Scholar
Bolla, M, Collette, L, Blank, L. Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial. Lancet. 2002;360(9327):103–106.CrossRefGoogle ScholarPubMed
Bolla, M, Tienhoven, G, Reijke, TM. Concomitant and adjuvant androgen deprivation (ADT) with external beam irradiation (RT) for locally advanced prostate cancer: 6 months versus 3 years ADT – results of the randomized EORTC phase III trial 22961 [abstract]. J Clin Oncol. 2007;25(suppl 18):5238s.Google Scholar
Kuban, DA, Tucker, SL, Dong, L. Long-term results of the M. D. Anderson randomized dose-escalation trial for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70(1):67–74.CrossRefGoogle Scholar
Peeters, ST, Heemsbergen, WD, Koper, PC. Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy. J Clin Oncol. 2006;24(13):1990–1996.CrossRefGoogle ScholarPubMed
Zietman, AL, DeSilvio, ML, Slater, JD. Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. J Am Med Assoc. 2005;294(10):1233–1239.CrossRefGoogle ScholarPubMed
Zelefsky, MJ, Levin, EJ, Hunt, M. Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70(4):1124–1129.CrossRefGoogle ScholarPubMed
Lawton, CA, DeSilvio, M, Roach, M. An update of the phase III trial comparing whole pelvic to prostate only radiotherapy and neoadjuvant to adjuvant total androgen suppression: updated analysis of RTOG 94-13, with emphasis on unexpected hormone/radiation interactions. Int J Radiat Oncol Biol Phys. 2007;69(3):646–655.CrossRefGoogle ScholarPubMed
Bach, PB, Cramer, LD, Warren, JL. Racial differences in the treatment of early-stage lung cancer. N Engl J Med. 1999;341(16):1198–1205.CrossRefGoogle ScholarPubMed
Bradley, J, Graham, MV, Winter, K. Toxicity and outcome results of RTOG 9311: a phase I–II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma. Int J Radiat Oncol Biol Phys. 2005;61(2):318–328.CrossRefGoogle ScholarPubMed
Fang, LC, Komaki, R, Allen, P. Comparison of outcomes for patients with medically inoperable stage I non-small-cell lung cancer treated with two-dimensional vs. three-dimensional radiotherapy. Int J Radiat Oncol Biol Phys. 2006;66(1):108–116.CrossRefGoogle Scholar
Sibley, GS.Radiotherapy for patients with medically inoperable stage I nonsmall cell lung carcinoma: smaller volumes and higher doses – a review. Cancer. 1998;82(3):433–438.3.0.CO;2-Q>CrossRefGoogle Scholar
Lind, PA, Marks, LB, Hollis, D. Receiver operating characteristic curves to assess predictors of radiation-induced symptomatic lung injury. Int J Radiat Oncol Biol Phys. 2002;54(2):340–347.CrossRefGoogle ScholarPubMed
Starkschall, G, Forster, KM, Kitamura, K. Correlation of gross tumor volume excursion with potential benefits of respiratory gating. Int J Radiat Oncol Biol Phys. 2004;60(4):1291– 1297.CrossRefGoogle ScholarPubMed
Timmerman, RD, Park, C, Kavanagh, BD. The North American experience with stereotactic body radiation therapy in non-small cell lung cancer. J Thorac Oncol. 2007;2(7 suppl 3): S101–S112.CrossRefGoogle ScholarPubMed
Timmerman, R, McGarry, R, Yiannoutsos, C. Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer. J Clin Oncol. 2006;24(30):4833–4839.CrossRefGoogle Scholar
Chang, JY, Dong, L, Liu, H. Image-guided radiation therapy for non-small cell lung cancer. J Thorac Oncol. 2008;3(2):177–186.CrossRefGoogle ScholarPubMed
Chang, JY, Balter, PA, Dong, L. Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2008;72(4):967–971.CrossRefGoogle ScholarPubMed
Dillman, RO, Herndon, J, Seagren, SL. Improved survival in stage III non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B (CALGB) 8433 trial. J Natl Cancer Inst. 1996;88(17):1210–1215.CrossRefGoogle Scholar
Sause, W, Kolesar, P, Taylor, SI. Final results of phase III trial in regionally advanced unresectable non-small cell lung cancer: Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group, and Southwest Oncology Group. Chest. 2000;117(2):358–364.CrossRefGoogle ScholarPubMed
Fournel, P, Robinet, G, Thomas, P. Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer: Groupe Lyon-Saint-Etienne d';Oncologie Thoracique-Groupe Francais de Pneumo-Cancerologie NPC 95–01 Study. J Clin Oncol. 2005;23(25):5910–5917.CrossRefGoogle ScholarPubMed
Furuse, K, Fukuoka, M, Kawahara, M. Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer. J Clin Oncol. 1999;17(9):2692–2699.CrossRefGoogle ScholarPubMed
Huber, RM, Flentje, M, Schmidt, M. Simultaneous chemoradiotherapy compared with radiotherapy alone after induction chemotherapy in inoperable stage IIIA or IIIB non-small-cell lung cancer: study CTRT99/97 by the Bronchial Carcinoma Therapy Group. J Clin Oncol. 2006;24(27):4397–4404.CrossRefGoogle ScholarPubMed
Schild, SE, Stella, PJ, Geyer, SM. The outcome of combined-modality therapy for stage III non-small-cell lung cancer in the elderly. J Clin Oncol. 2003;21(17):3201–3206.CrossRefGoogle ScholarPubMed
Albain, KS, Rusch, VW, Crowley, JJ. Concurrent cisplatin/etoposide plus chest radiotherapy followed by surgery for stages IIIA (N2) and IIIB non-small-cell lung cancer: mature results of Southwest Oncology Group phase II study 8805. J Clin Oncol. 1995;13(8):1880–1892.CrossRefGoogle Scholar
Meerbeeck, JP, Kramer, GW, Schil, PE. Randomized controlled trial of resection versus radiotherapy after induction chemotherapy in stage IIIA-N2 non-small-cell lung cancer. J Natl Cancer Inst. 2007;99(6):442–450.CrossRefGoogle ScholarPubMed
Bradley, J. A review of radiation dose escalation trials for non-small cell lung cancer within the Radiation Therapy Oncology Group. Semin Oncol. 2005;32(2 suppl 3):S111–S113.CrossRefGoogle ScholarPubMed
Rosenzweig, KE, Fox, JL, Yorke, E. Results of a phase I dose-escalation study using three-dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma. Cancer. 2005;103(10):2118–2127.CrossRefGoogle ScholarPubMed
Ruysscher, D, Wanders, S, Haren, E. Selective mediastinal node irradiation based on FDG-PET scan data in patients with non-small-cell lung cancer: a prospective clinical study. Int J Radiat Oncol Biol Phys. 2005;62(4):988–994.CrossRefGoogle ScholarPubMed
Rodrigues, G, Lock, M, D';Souza, D. Prediction of radiation pneumonitis by dose – volume histogram parameters in lung cancer – a systematic review. Radiother Oncol. 2004;71(2):127–138.CrossRefGoogle ScholarPubMed
Movsas, B, Scott, C, Langer, C. Randomized trial of amifostine in locally advanced non-small-cell lung cancer patients receiving chemotherapy and hyperfractionated radiation: radiation therapy oncology group trial 98-01. J Clin Oncol. 2005;23(10):2145–2154.CrossRefGoogle ScholarPubMed
Hensley, ML, Hagerty, KL, Kewalramani, T. American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants. J Clin Oncol. 2009;27(1):127–145.CrossRefGoogle Scholar
Mac Manus, MP, Hicks, RJ, Ball, DL. F-18 fluorodeoxyglucose positron emission tomography staging in radical radiotherapy candidates with nonsmall cell lung carcinoma: powerful correlation with survival and high impact on treatment. Cancer. 2001;92(4): 886–895.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Werner-Wasik, M, Scott, C, Cox, JD. Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): identification of five groups with different survival. Int J Radiat Oncol Biol Phys. 2000;48(5):1475–1482.CrossRefGoogle ScholarPubMed
Turrisi 3rd, AT, Kim, K, Blum, R. Twice-daily compared with once-daily thoracic radiotherapy in limited small-cell lung cancer treated concurrently with cisplatin and etoposide. N Engl J Med. 1999;340(4):265–271.CrossRefGoogle Scholar
Yuen, AR, Zou, G, Turrisi, AT. Similar outcome of elderly patients in intergroup trial 0096: cisplatin, etoposide, and thoracic radiotherapy administered once or twice daily in limited stage small cell lung carcinoma. Cancer. 2000;89(9):1953–1960.3.3.CO;2-Y>CrossRefGoogle ScholarPubMed
Auperin, A, Arriagada, R, Pignon, JP. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. Prophylactic Cranial Irradiation Overview Collaborative Group. N Engl J Med. 1999;341(7):476–484.CrossRefGoogle ScholarPubMed
Arriagada, R, Chevalier, T, Borie, F. Prophylactic cranial irradiation for patients with small-cell lung cancer in complete remission. J Natl Cancer Inst. 1995;87(3):183–190.CrossRefGoogle ScholarPubMed
Grosshans, DR, Meyers, CA, Allen, PK. Neurocognitive function in patients with small cell lung cancer: effect of prophylactic cranial irradiation. Cancer. 2008;112(3):589–595.CrossRefGoogle ScholarPubMed
Falk, SJ, Girling, DJ, White, RJ. Immediate versus delayed palliative thoracic radiotherapy in patients with unresectable locally advanced non-small cell lung cancer and minimal thoracic symptoms: randomised controlled trial. Br Med J. 2002;325(7362):452–453.CrossRefGoogle ScholarPubMed
Erridge, SC, Gaze, MN, Price, A. Symptom control and quality of life in people with lung cancer: a randomised trial of two palliative radiotherapy fractionation schedules. Clin Oncol (R Coll Radiol). 2005;17(1):61–67.CrossRefGoogle ScholarPubMed
Kramer, GW, Wanders, SL, Noordijk, EM. Results of the Dutch national study of the palliative effect of irradiation using two different treatment schemes for non-small-cell lung cancer. J Clin Oncol. 2005;23(13):2962–2970.CrossRefGoogle ScholarPubMed
Sundstrom, S, Bremnes, R, Aasebo, U. Hypofractionated palliative radiotherapy (17 Gy per two fractions) in advanced non-small-cell lung carcinoma is comparable to standard fractionation for symptom control and survival: a national phase III trial. J Clin Oncol. 2004;22(5):801–810.CrossRefGoogle ScholarPubMed
Gorlia, T, Bent, MJ, Hegi, ME. Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981–22981/CE.3. Lancet Oncol. 2008;9(1):29–38.CrossRefGoogle ScholarPubMed
Curran Jr, WJ, Scott, CB, Horton, J. Recursive partitioning analysis of prognostic factors in three Radiation Therapy Oncology Group malignant glioma trials. J Natl Cancer Inst. 1993;85(9):704–710.CrossRefGoogle Scholar
Peschel, RE, Wilson, L, Haffty, B. The effect of advanced age on the efficacy of radiation therapy for early breast cancer, local prostate cancer and grade III–IV gliomas. Int J Radiat Oncol Biol Phys. 1993;26(3):539–544.CrossRefGoogle ScholarPubMed
Keime-Guibert, F, Chinot, O, Taillandier, L. Radiotherapy for glioblastoma in the elderly. N Engl J Med. 2007;356(15):1527–1535.CrossRefGoogle ScholarPubMed
Roa, W, Brasher, PM, Bauman, G. Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol. 2004;22(9):1583–1588.CrossRefGoogle ScholarPubMed
Bleehen, NM, Stenning, SP. A Medical Research Council trial of two radiotherapy doses in the treatment of grades 3 and 4 astrocytoma. The Medical Research Council Brain Tumour Working Party. Br J Cancer. 1991;64(4):769–774.CrossRefGoogle ScholarPubMed
Stupp, R, Mason, WP, Bent, MJ. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987–996.CrossRefGoogle ScholarPubMed
,A predictive model for aggressive non-Hodgkin's lymphoma. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. N Engl J Med. 1993;329(14):987–994.Google Scholar
Solal-Celigny, P, Roy, P, Colombat, P. Follicular lymphoma international prognostic index. Blood. 2004;104(5):1258–1265.CrossRefGoogle ScholarPubMed
Bonnet, C, Fillet, G, Mounier, N. CHOP alone compared with CHOP plus radiotherapy for localized aggressive lymphoma in elderly patients: a study by the Groupe d';Etude des Lymphomes de l';Adulte. J Clin Oncol. 2007;25(7):787–792.CrossRefGoogle Scholar
Zelenetz, AD, Advani, RH, Byrd, JC. Non-Hodgkin's lymphomas. J Natl Compr Canc Netw. 2008;6(4):356–421.Google ScholarPubMed
Haas, RL, Poortmans, P, Jong, D. High response rates and lasting remissions after low-dose involved field radiotherapy in indolent lymphomas. J Clin Oncol. 2003;21(13):2474– 2480.CrossRefGoogle ScholarPubMed
Haas, RL, Poortmans, P, Jong, D. Effective palliation by low dose local radiotherapy for recurrent and/or chemotherapy refractory non-follicular lymphoma patients. Eur J Cancer. 2005;41(12):1724–1730.CrossRefGoogle ScholarPubMed
Murthy, V, Thomas, K, Foo, K. Efficacy of palliative low-dose involved-field radiation therapy in advanced lymphoma: a phase ii study. Clin Lymphoma Myeloma. 2008;8(4): 241–245.CrossRefGoogle ScholarPubMed

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