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Chapter 1 - Geriatric assessment for the older adult with cancer

from Part 1 - Key principles in geriatric oncology

Published online by Cambridge University Press:  05 August 2011

Arti Hurria
Affiliation:
City of Hope Cancer Center, California
Harvey Jay Cohen
Affiliation:
Duke University Medical Center, Durham
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Print publication year: 2010

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References

,SEER cancer statistics review, 1975–2005. National Cancer Institute Web site. Available at: http://seer.cancer.gov/csr/1975_2005/.
He, W, Sengupta, M, Velkoff, V. U.S. Census Bureau, current population reports, P23-209, 65+ in the United States: 2005. Washington, DC: U.S. Government Printing Office; 2005.
,Department of Economic and Social Affairs/Population Division. World population to 2300. United Nations Web site. Available at: http://secint24.un.org/esa/population/publications/longrange2/WorldPop2300final.pdf.
Smith, BD, Smith, GL, Hurria, A. Future of cancer incidence in the United States: burdens upon an aging, changing nation. J Clin Oncol. 2009;27(17):2758–2765.CrossRefGoogle Scholar
Karnofsky, D, Burchenal, J. The clinical evaluation of chemotherapeutic agents in cancer. In: Macleod, CM, ed. Evaluation of Chemotherapeutic Agents. New York: Columbia University Press; 1948: 191–205.Google Scholar
Zubrod, C, Schneiderman, M, Frei, E. Appraisal of methods for the study of chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chron Dis. 1960;11:7–33.CrossRefGoogle Scholar
Katz, S, Ford, AB, Moskowitz, RW. Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. J Am Med Assoc. 1963;185:914–919.CrossRefGoogle ScholarPubMed
Lawton, MP, Brody, EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9(3):179–186.CrossRefGoogle ScholarPubMed
Mor, V, Wilcox, V, Rakowski, W. Functional transitions among the elderly: patterns, predictors, and related hospital use. Am J Public Health 1994;84:1274–1280.CrossRefGoogle ScholarPubMed
Barberger-Gateau, P, Fabrigoule, C, Helmer, C. Functional impairment in instrumental activities of daily living: an early clinical sign of dementia?J Am Geriatr Soc. 1999;47(6)(4):456–462.CrossRefGoogle Scholar
Reuben, DB, Rubenstein, LV, Hirsch, SH. Value of functional status as a predictor of mortality: results of a prospective study. Am J Med. 1992;93:663–669.CrossRefGoogle ScholarPubMed
Ponzetto, M, Maero, B, Maina, P. Risk factors for early and late mortality in hospitalized older patients: the continuing importance of functional status. J Gerontol A Biol Sci Med Sci. Series A. 2003;58 (11):1049–1054.CrossRefGoogle ScholarPubMed
Inouye, SK, Peduzzi, PN, Robison, JT. Importance of functional measures in predicting mortality among older hospitalized patients. J Am Med Assoc. 1998;279(15):1187–1193.CrossRefGoogle ScholarPubMed
Sleiman, I, Rozzini, R, Barbisoni, P. Functional trajectories during hospitalization: a prognostic sign for elderly patients. J Gerontol A Biol Sci Med Sci. Series A. 2009;64(6):659–663.CrossRefGoogle ScholarPubMed
Sleiman, I, Rozzini, R, Barbisoni, P. Functional trajectories during hospitalization: a prognostic sign for elderly patients. J Gerontol A Biol Sci Med Sci. Series A. 2009;64(6):659–663.CrossRefGoogle ScholarPubMed
Stafford, RS, Cyr, PL. The impact of cancer on the physical function of the elderly and their utilization of health care. Cancer. 1997;80(10): 1973–1980.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Keating, NL, Norredam, M, Landrum, MB. Physical and mental health status of older long-term cancer survivors. J Am Geriatr Soc. 2005;53(12):2145–2152.CrossRefGoogle ScholarPubMed
Repetto, L, Fratino, L, Audisio, RA. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J Clin Oncol. 2002;20(2):494–502.CrossRefGoogle Scholar
Del Mastro, L, Perrone, F, Repetto, L. Weekly paclitaxel as first-line chemotherapy in elderly advanced breast cancer patients: a phase II study of the Gruppo Italiano di Oncologia Geriatrica (GIOGer). Ann Oncol. 2005;16(2):253–258.CrossRefGoogle Scholar
Flood, KL, Carroll, MB, Le, CV. Geriatric syndromes in elderly patients admitted to an oncology-acute care for elders unit. J Clin Oncol. 2006;24(15):2298–2303.CrossRefGoogle Scholar
Hurria, A, Wong, FL, Villaluna, D. The role of age and health in treatment recommendations for older adults with breast cancer: the perspective of oncologists and primary care providers. J Clin Oncol. 2008;26(33):5386–5392.CrossRefGoogle ScholarPubMed
Maione, P, Perrone, F, Gallo, C. Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced non-small-cell lung cancer receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study. J Clin Oncol. 2005;23(28):6865–6872.CrossRefGoogle ScholarPubMed
Wedding, U, Rohrig, B, Klippstein, A. Impairment in functional status and survival in patients with acute myeloid leukaemia. J Cancer Res Clin Oncol. 2006;132(10):665–671.CrossRefGoogle ScholarPubMed
Extermann, M, Overcash, J, Lyman, GH. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol. 1998;16(4):1582–1587.CrossRefGoogle ScholarPubMed
Firat, S, Bousamra, M, Gore, E. Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys. 2002;52:1047–1057.CrossRefGoogle ScholarPubMed
Piccirillo, JF, Tierney, RM, Costas, I. Prognostic importance of comorbidity in a hospital-based cancer registry. J Am Med Assoc. 2004;291(20):2441–2447.CrossRefGoogle Scholar
Satariano, WA, Ragland, DR. The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med. 1994;120:104–110.CrossRefGoogle ScholarPubMed
Hughes, KS, Schnaper, , Berry, D. Lumpectomy plus breast cancer. N Engl J Med. 2004;351(10):971–977.CrossRefGoogle ScholarPubMed
Charlson, ME, Pompei, P, Ales, KL. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40(5):373–383.CrossRefGoogle ScholarPubMed
Frasci, G, Lorusso, V, Panza, N. Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer. J Clin Oncol. 2000;18(13):2529– 2536.CrossRefGoogle ScholarPubMed
Muss, HB, Berry, DA, Cirrincione, CT. Adjuvant chemotherapy in older women with early-stage breast cancer. N Engl J Med. 2009;360(20):2055–2065.CrossRefGoogle ScholarPubMed
Covinsky, KE, Hilton, J, Lindquist, K. Development and validation of an index to predict activity of daily living dependence in community-dwelling elders. Med Care. 2006;44(2):149–157.CrossRefGoogle ScholarPubMed
Suter, TM, Procter, M, Veldhuisen, DJ. Trastuzumab-associated cardiac adverse effects in the herceptin adjuvant trial. J Clin Oncol. 2007;25(25):3859–3865.CrossRefGoogle ScholarPubMed
Perez, EA, Suman, VJ, Davidson, NE. Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial. J Clin Oncol. 2008;26(8):1231–1238.CrossRefGoogle ScholarPubMed
Zauderer, M, Patil, S, Hurria, A. Feasibility and toxicity of dose-dense adjuvant chemotherapy in older women with breast cancer. Breast Cancer Res Treat. 2008;117(1):205–210.CrossRefGoogle ScholarPubMed
Meyerhardt, JA, Catalano, PJ, Haller, DG. Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol. 2003;21(3):433–440.CrossRefGoogle ScholarPubMed
Walter, LC, Brand, RJ, Counsell, SR. Development and validation of a prognostic index for 1-year mortality in older adults after hospitalization. J Am Med Assoc. 2001;285(23):2987–2994.CrossRefGoogle ScholarPubMed
Lee, SJ, Lindquist, K, Segal, MR. Development and validation of a prognostic index for 4-year mortality in older adults. J Am Med Assoc. 2006;295(7):801–808.CrossRefGoogle ScholarPubMed
Charlson, ME, Pompei, P, Ales, KL. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis. 1987;40(5):373–383.CrossRefGoogle ScholarPubMed
Charlson, M, Szatrowski, TP, Peterson, J. Validation of a combined comorbidity index. J Clin Epidemiol. 1994;47(11):1245–1251.CrossRefGoogle ScholarPubMed
Eagles, JM, Beattie, JA, Restall, DB. Relation between cognitive impairment and early death in the elderly. Br Med J. 1990;300(6719):239–240.CrossRefGoogle ScholarPubMed
Wolfson, C, Wolfson, DB, Asgharian, M. A reevaluation of the duration of survival after the onset of dementia. N Engl J Med. 2001;344(15): 1111–1116.CrossRefGoogle Scholar
Landi, F, Onder, G, Cattel, C. Functional status and clinical correlates in cognitively impaired community-living older people. J Geriatr Psychiatry Neurol. 2001;14(1):21–27.CrossRefGoogle ScholarPubMed
Feil, D, Marmon, T, Unutzer, J. Cognitive impairment, chronic medical illness, and risk of mortality in an elderly cohort. Am J Geriatr Psychiatry. 2003;11(5):551–560.CrossRefGoogle Scholar
Rogers, LQ, Courneya, KS, Robbins, KT. Factors associated with fatigue, sleep, and cognitive function among patients with head and neck cancer. Head Neck. 2008;30(10):1310–1317.CrossRefGoogle ScholarPubMed
Gupta, SK, Lamont, EB. Patterns of presentation, diagnosis, and treatment in older patients with colon cancer and comorbid dementia. J Am Geriatr Soc. 2004;52(10):1681–1687.CrossRefGoogle ScholarPubMed
Goodwin, JS, Hunt, WC, Samet, JM. Determinants of cancer therapy in elderly patients. Cancer. 1993;72(2):594–601.3.0.CO;2-#>CrossRefGoogle ScholarPubMed
Weineke, M, Dienst, E. Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancer. Psychooncology. 1995;4:61–66.CrossRefGoogle Scholar
Dam, FS, Schagen, SB, Muller, MJ. Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy. J Natl Cancer Inst. 1998;90(3): 210–218.Google ScholarPubMed
Schagen, SB, Dam, FS, Muller, MJ. Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma. Cancer. 1999;85(3):640–650.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Schagen, SB, Muller, MJ, Boogerd, W. Cognitive dysfunction and chemotherapy: neuropsychological findings in perspective. Clin Breast Cancer. 2002;3(suppl 3):S100–108.CrossRefGoogle Scholar
Brezden, CB, Phillips, KA, Abdolell, M. Cognitive function in breast cancer patients receiving adjuvant chemotherapy. J Clin Oncol. 2000;18(14):2695–2701.CrossRefGoogle ScholarPubMed
Tchen, N, Juffs, HG, Downie, FP. Cognitive function, fatigue, and menopausal symptoms in women receiving adjuvant chemotherapy for breast cancer. J Clin Oncol. 2003;21(22): 4175–4183.CrossRefGoogle ScholarPubMed
Castellon, SA, Ganz, PA, Bower, JE. Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifen. J Clin Exp Neuropsychol. 2004;26(7): 955–969.CrossRefGoogle ScholarPubMed
Wefel, JS, Lenzi, R, Theriault, RL. The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer. 2004;100(11):2292–2299.CrossRefGoogle ScholarPubMed
Hurria, A, Rosen, C, Hudis, C. Cognitive function of older patients receiving adjuvant chemotherapy for breast cancer: a pilot prospective longitudinal study. J Am Geriatr Soc. 2006;54(6):925–931.CrossRefGoogle ScholarPubMed
Ernst, T, Chang, L, Cooray, D. The effects of tamoxifen and estrogen on brain metabolism in elderly women. J Natl Cancer Inst. 2002;94(8): 592–597.CrossRefGoogle ScholarPubMed
Shilling, V, Jenkins, V, Morris, R. The effects of adjuvant chemotherapy on cognition in women with breast cancer: preliminary results of an observational longitudinal study. Breast. 2005; 14(2):142–150.CrossRefGoogle ScholarPubMed
Hurria, A, Somlo, G, Ahles, T. Renaming “chemobrain.” Cancer Invest. 2007;25(6): 373–377.CrossRefGoogle ScholarPubMed
Fried, TR, Bradley, EH, Towle, VR. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002;346(14): 1061–1066.CrossRefGoogle ScholarPubMed
Ahles, TA, Saykin, AJ, Furstenberg, CT. Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. J Clin Oncol. 2002;20(2):485–493.CrossRefGoogle ScholarPubMed
Heflin, LH, Meyerowitz, BE, Hall, P. Cancer as a risk factor for long-term cognitive deficits and dementia. J Natl Cancer Inst. 2005;97(11): 854–856.CrossRefGoogle ScholarPubMed
Silverman, DH, Dy, CJ, Castellon, SA. Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5–10 years after chemotherapy. Breast Cancer Res Treat. 2006;103(3):303–311.CrossRefGoogle ScholarPubMed
Kreukels, BP, Schagen, SB, Ridderinkhof, KR. Electrophysiological correlates of information processing in breast-cancer patients treated with adjuvant chemotherapy. Breast Cancer Res Treat. 2005;94(1):53–61.CrossRefGoogle ScholarPubMed
Reynolds, MW, Fredman, L, Langenberg, P. Weight, weight change, mortality in a random sample of older community-dwelling women. J Am Geriatr Soc. 1999;47(12):1409–1414.CrossRefGoogle Scholar
Wallace, JI, Schwartz, RS, LaCroix, AZ. Involuntary weight loss in older outpatients: incidence and clinical significance. J Am Geriatr Soc. 1995;43(4):329–337.CrossRefGoogle ScholarPubMed
Diehr, P, Bild, , Harris, TB. Body mass index and mortality in nonsmoking older adults: the Cardiovascular Health Study. Am J Public Health. 1998;88(4):623–629.CrossRefGoogle ScholarPubMed
Newman, AB, Yanez, D, Harris, T. Weight change in old age and its association with mortality. J Am Geriatr Soc. 2001;49(10): 1309–1318.CrossRefGoogle ScholarPubMed
Dewys, WD, Begg, C, Lavin, PT, Band, PR. Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med. 1980;69(4):491–497.CrossRefGoogle ScholarPubMed
Andreyev, HJ, Norman, AR, Oates, J, Cunningham, D. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies?Eur J Cancer. 1998;34(4):503–509.CrossRefGoogle ScholarPubMed
Buccheri, G, Ferrigno, D. Importance of weight loss definition in the prognostic evaluation of non-small-cell lung cancer. Lung Cancer. 2001;34(3):433–440.CrossRefGoogle ScholarPubMed
Orsitto, G, Cascavilla, L, Franceschi, M. Influence of cognitive impairment and comorbidity on disability in hospitalized elderly patients. J Nutr Health Aging. 2005;9(3): 194–198.Google ScholarPubMed
Nourissat, A, Vasson, MP, Merrouche, Y. Relationship between nutritional status and quality of life in patients with cancer. Eur J Cancer. 2008;44(9):1238–1242.CrossRefGoogle ScholarPubMed
Penninx, BW, Guralnik, JM, Ferrucci, L. Depressive symptoms and physical decline in community-dwelling older persons. J Am Med Assoc. 1998;279(21):1720–1726.CrossRefGoogle ScholarPubMed
Langa, KM, Valenstein, MA, Fendrick, AM. Extent and cost of informal caregiving for older Americans with symptoms of depression. Am J Psychiatry. 2004;161(5):857–863.CrossRefGoogle ScholarPubMed
Kua, J.The prevalence of psychological and psychiatric sequelae of cancer in the elderly – how much do we know?Ann Acad Med Singapore. 2005;34(3):250–256.Google ScholarPubMed
Dalle, Carbonare L, Maggi, S, Noale, M. Physical disability and depressive symptomatology in an elderly population: a complex relationship. The Italian Longitudinal Study on Aging (ILSA). Am J Geriatr Psychiatry. 2009;17(2):144–154.CrossRefGoogle Scholar
Bruce, ML, Seeman, TE, Merrill, SS. The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging. Am J Public Health. 1994;84(11):1796–1799.CrossRefGoogle ScholarPubMed
Penninx, BW, Beekman, AT, Ormel, J. Psychological status among elderly people with chronic diseases: does type of disease play a part?J Psychosom Res. 1996;40(5):521–534.CrossRefGoogle ScholarPubMed
Walker, J, Waters, RA, Murray, G. Better off dead: suicidal thoughts in cancer patients.J Clin Oncol. 2008;26(29):4725–4730.CrossRefGoogle ScholarPubMed
Miller, M, Mogun, H, Azrael, D. Cancer and the risk of suicide in older Americans. J Clin Oncol. 2008;26(29):4720–4724.CrossRefGoogle ScholarPubMed
Seeman, TE, Kaplan, GA, Knudsen, L. Social network ties and mortality among the elderly in the Alameda County Study. Am J Epidemiol. 1987;126(4):714–723.CrossRefGoogle ScholarPubMed
Tomaka, J, Thompson, S, Palacios, R. The relation of social isolation, loneliness, and social support to disease outcomes among the elderly. J Aging Health. 2006;18(3):359–384.CrossRefGoogle ScholarPubMed
House, JS, Landis, KR, Umberson, D. Social relationships and health. Science. 1988;241(4865):540–545.CrossRefGoogle ScholarPubMed
Golden, J, Conroy, RM, Bruce, I. Loneliness, social support networks, mood and wellbeing in community-dwelling elderly. Int J Geriatr Psychiatry. 2009;24(7):694–700.CrossRefGoogle ScholarPubMed
Iwasaki, M, Otani, T, Sunaga, R. Social networks and mortality based on the Komo-Ise cohort study in Japan. Int J Epidemiol. 2002;31(6): 1208–1218.CrossRefGoogle ScholarPubMed
Osborne, C, Ostir, GV, Du, X. The influence of marital status on the stage at diagnosis, treatment, and survival of older women with breast cancer. Breast Cancer Res Treat. 2005;93(1):41–77.CrossRefGoogle ScholarPubMed
DiMatteo, MR. Social support and patient adherence to medical treatment: a meta-analysis. Health Psychol. 2004;23(2):207–218.CrossRefGoogle ScholarPubMed
,NCCN practice guidelines in oncology: senior adult oncology. National Comprehensive Cancer Network Web site. Available at: http://www.nccn.org/professionals/physician_gls/PDF/senior.pdf.
Ingram, SS, Seo, PH, Martell, RE. Comprehensive assessment of the elderly cancer patient: the feasibility of self-report methodology. J Clin Oncol. 2002;20(3):770–775.CrossRefGoogle ScholarPubMed
Hurria, A, Lichtman, SM, Gardes, J. Identifying vulnerable older adults with cancer: integrating geriatric assessment into oncology practice. J Am Geriatr Soc. 2007;55(10): 1604–1608.CrossRefGoogle ScholarPubMed
Hurria, A, Gupta, S, Zauderer, M. Developing a cancer-specific geriatric assessment: a feasibility study. Cancer. 2005;104(9):1998–2005.CrossRefGoogle ScholarPubMed
Larsson, A, Skoog, I, Aevarsson, AA. Regional cerebral blood flow in normal individuals aged 40, 75 and 88 years studied by 99Tc(m)-d,l-HMPAO SPET. Nucl Med Commun. 2001;22(7):741–746.CrossRefGoogle ScholarPubMed
Ito, H, Kanno, I, Ibaraki, M. Effect of aging on cerebral vascular response to Paco2 changes in humans as measured by positron emission tomography. J Cereb Blood Flow Metab. 2002;22(8):997–1003.CrossRefGoogle ScholarPubMed
Meier-Ruge, W, Ulrich, J, Bruhlmann, M. Age-related white matter atrophy in the human brain. Ann N Y Acad Sci. 1992;673:260–269.CrossRefGoogle ScholarPubMed
Fozard, JL, Vercryssen, M, Reynolds, SL. Age differences and changes in reaction time: the Baltimore Longitudinal Study of Aging. J Gerontol. 1994;49(4):P179–189.CrossRefGoogle ScholarPubMed
Petersen, RC, Smith, G, Kokmen, E. Memory function in normal aging. Neurology. 1992;42(2):396–401.CrossRefGoogle ScholarPubMed
Small, SA, Stern, Y, Tang, M. Selective decline in memory function among healthy elderly. Neurology. 1999;52(7):1392–1396.CrossRefGoogle ScholarPubMed
Helzner, EP, Cauley, JA, Pratt, SR. Race and sex differences in age-related hearing loss: the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2005;53(12):2119–2127.CrossRefGoogle ScholarPubMed
Tanaka, H, Monahan, KD, Seals, DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol. 2001;37(1):153–156.CrossRefGoogle ScholarPubMed
Ferrari, AU, Radaelli, A, Centola, M. Invited review: aging and the cardiovascular system. J Appl Physiol. 2003;95(6):2591–2597.CrossRefGoogle ScholarPubMed
Sawhney, R, Sehl, M, Naeim, A. Physiologic aspects of aging: impact on cancer management and decision making, part I. Cancer J. 2005;11(6): 449–460.CrossRefGoogle ScholarPubMed
Short, KR, Nair, KS. Mechanisms of sarcopenia of aging. J Endocrinol Invest. 1999;22(suppl 5): 95–105.Google Scholar
Sotaniemi, EA, Arranto, AJ, Pelkonen, O. Age and cytochrome P450-linked drug metabolism in humans: an analysis of 226 subjects with equal histopathologic conditions. Clin Pharmacol Ther. 1997;61(3):331–339.CrossRefGoogle ScholarPubMed
Fehrman-Ekholm, I, Skeppholm, L. Renal function in the elderly (>70 years old) measured by means of iohexol clearance, serum creatinine, serum urea and estimated clearance. Scand J Urol Nephrol. 2004;38(1):73–77.CrossRefGoogle ScholarPubMed
Rimon, E, Kagansky, N, Cojocaru, L. Can creatinine clearance be accurately predicted by formulae in octogenarian in-patients?Q J Med. 2004;97(5):281–287.CrossRefGoogle ScholarPubMed
Lindeman, RD, Tobin, J, Shock, NW. Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc. 1985;33(4):278–285.CrossRefGoogle ScholarPubMed
Tsuboi, I, Morimoto, K, Horie, T. Age-related changes in various hemopoietic progenitor cells in senescence-accelerated (SAM-P) mice. Exp Hematol. 1991;19(9):874–877.Google ScholarPubMed
Izaks, GJ, Westendorp, RG, Knook, DL. The definition of anemia in older persons. J Am Med Assoc. 1999;281(18):1714–1717.CrossRefGoogle ScholarPubMed
Artz, AS, Fergusson, D, Drinka, PJ. Prevalence of anemia in skilled-nursing home residents. Arch Gerontol Geriatr. 2004;39(3):201–206.CrossRefGoogle ScholarPubMed
Gomez, H, Hidalgo, M, Casanova, L. Risk factors for treatment-related death in elderly patients with aggressive non-Hodgkin's lymphoma: results of a multivariate analysis. J Clin Oncol. 1998;16(6):2065–2069.CrossRefGoogle ScholarPubMed
Balducci, L, Cohen, HJ, Engstrom, PF. Senior adult oncology clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005;3(4): 572–590.Google Scholar
Silber, JH, Fridman, M, DiPaola, RS. First-cycle blood counts and subsequent neutropenia, dose reduction, or delay in early-stage breast cancer therapy. J Clin Oncol. 1998;16(7):2392–2400.CrossRefGoogle ScholarPubMed
Dees, EC, O';Reilly, S, Goodman, SN. A prospective pharmacologic evaluation of age-related toxicity of adjuvant chemotherapy in women with breast cancer. Cancer Invest. 2000;18(6):521–529.CrossRefGoogle ScholarPubMed
Repetto, L, Carreca, I, Maraninchi, D. Use of growth factors in the elderly patient with cancer: a report from the Second International Society for Geriatric Oncology (SIOG) 2001 meeting. Crit Rev Oncol Hematol. 2003;45(2):123–128.CrossRefGoogle ScholarPubMed
Hurria, A, Brogan, K, Panageas, KS. Change in cycle 1 to cycle 2 haematological counts predicts toxicity in older patients with breast cancer receiving adjuvant chemotherapy. Drugs Aging. 2005;22(8):709–715.CrossRefGoogle ScholarPubMed
Abbatecola, AM, Ferrucci, L, Grella, R. Diverse effect of inflammatory markers on insulin resistance and insulin-resistance syndrome in the elderly. J Am Geriatr Soc. 2004;52(3): 399–404.CrossRefGoogle ScholarPubMed
Roubenoff, R, Harris, TB, Abad, LW. Monocyte cytokine production in an elderly population: effect of age and inflammation. J Gerontol. 1998;53(1):M20–26.CrossRefGoogle Scholar
Fagiolo, U, Cossarizza, A, Scala, E. Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol. 1993;23(9):2375–2378.CrossRefGoogle ScholarPubMed
Harris, TB, Ferrucci, L, Tracy, RP. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med. 1999;106(5):506–512.CrossRefGoogle ScholarPubMed
Reuben, DB, Ferrucci, L, Wallace, R. The prognostic value of serum albumin in healthy older persons with low and high serum interleukin-6 (IL-6) levels. J Am Geriatr Soc. 2000;48(11):1404–1407.CrossRefGoogle ScholarPubMed
Reuben, DB, Cheh, AI, Harris, TB. Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. J Am Geriatr Soc. 2002;50(4):638–644.CrossRefGoogle ScholarPubMed
Taaffe, DR, Harris, TB, Ferrucci, L. Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging. J Gerontol. 2000; 55(12):M709–715.CrossRefGoogle ScholarPubMed
Leng, S, Chaves, P, Koenig, K. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J Am Geriatr Soc. 2002;50(7): 1268–1271.CrossRefGoogle ScholarPubMed
Leng, SX, Xue, QL, Tian, J. Inflammation and frailty in older women. J Am Geriatr Soc. 2007; 55(6):864–871.CrossRefGoogle ScholarPubMed
Walston, J, McBurnie, MA, Newman, A. Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med. 2002;162(20): 2333–2341.CrossRefGoogle ScholarPubMed
Cesari, M, Penninx, BW, Pahor, M. Inflammatory markers and physical performance in older persons: the InCHIANTI study. J Gerontol. 2004;59(3):242–248.CrossRefGoogle ScholarPubMed
Cohen, HJ, Harris, T, Pieper, CF. Coagulation and activation of inflammatory pathways in the development of functional decline and mortality in the elderly. Am J Med. 2003;114(3):180–187.CrossRefGoogle ScholarPubMed
Geffken, DF, Cushman, M, Burke, GL. Association between physical activity and markers of inflammation in a healthy elderly population. Am J Epidemiol. 2001;153(3):242–250.CrossRefGoogle Scholar
Yaffe, K, Lindquist, K, Penninx, BW. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003;61(1):76–80.CrossRefGoogle ScholarPubMed
Pai, JK, Pischon, T, Ma, J. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med. 2004;351(25):2599–2610.CrossRefGoogle ScholarPubMed
Spranger, J, Kroke, A, Mohlig, M. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes. 2003;52(3):812–817.CrossRefGoogle ScholarPubMed
Ding, C, Parameswaran, V, Udayan, R. Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab. 2008;93(5):1952–1958.CrossRefGoogle ScholarPubMed
Shlipak, MG, Fried, LF, Crump, C. Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency. Circulation. 2003;107(1):87–92.CrossRefGoogle ScholarPubMed
Coussens, LM, Werb, Z. Inflammation and cancer. Nature. 2002;420(6917):860–867.CrossRefGoogle ScholarPubMed
Ames, BN, Gold, LS. The causes and prevention of cancer: the role of environment. Biotherapy. 1998;11:205–220.CrossRefGoogle ScholarPubMed
Christensen, S, Hagen, TM, Shigenaga, MK. Chronic inflammation, mutation, and cancer. In: Parsonnet, J, ed. Microbes and Malignancy: Infection as a Cause of Human Cancers. New York: Oxford University Press; 1999:35–88.Google Scholar
Caruso, C, Lio, D, Cavallone, L. Aging, longevity, inflammation, and cancer. Ann N Y Acad Sci. 2004;1028:1–13.CrossRefGoogle Scholar
Drachenberg, , Elgamal, AA, Rowbotham, R. Circulating levels of interleukin-6 in patients with hormone refractory prostate cancer. Prostate. 1999;41(2):127–133.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Songur, N, Kuru, B, Kalkan, F. Serum interleukin-6 levels correlate with malnutrition and survival in patients with advanced non-small cell lung cancer. Tumori. 2004;90(2):196–200.CrossRefGoogle ScholarPubMed
Lamb, GW, McArdle, PA, Ramsey, S. The relationship between the local and systemic inflammatory responses and survival in patients undergoing resection for localized renal cancer. BJU Int. 2008;102(6):756–761.CrossRefGoogle ScholarPubMed
Ramsey, S, Lamb, GW, Aitchison, M. Evaluation of an inflammation-based prognostic score in patients with metastatic renal cancer. Cancer. 2007;109(2):205–212.CrossRefGoogle ScholarPubMed
Blackwell, K, Hurwitz, H, Lieberman, G. Circulating D-dimer levels are better predictors of overall survival and disease progression than carcinoembryonic antigen levels in patients with metastatic colorectal carcinoma. Cancer. 2004;101(1):77–82.CrossRefGoogle ScholarPubMed
Blackwell, K, Haroon, Z, Broadwater, G. Plasma D-dimer levels in operable breast cancer patients correlate with clinical stage and axillary lymph node status. J Clin Oncol. 2000;18(3): 600–608.CrossRefGoogle ScholarPubMed
Zhang, SM, Lin, J, Cook, NR. C-reactive protein and risk of breast cancer. J Natl Cancer Inst. 2007;99(11):890–894.CrossRefGoogle ScholarPubMed
Siemes, C, Visser, , Coebergh, JW. C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study. J Clin Oncol. 2006;24(33): 5216–5222.CrossRefGoogle ScholarPubMed
Yancik, R.Cancer burden in the aged: an epidemiologic and demographic overview. Cancer. 1997;80(7):1273–1283.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
,Profile of general demographic characteristics 2000. 2000 Census of Population and Housing United States. Available at: http://www.census.gov/prod/cen2000/dp1/2kh00.pdf.

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