Book contents
- Frontmatter
- Contents
- PREFACE
- CONTRIBUTORS
- PART ONE ANATOMY AND THE AGING PROCESS
- PART TWO ANESTHESIA AND SEDATION FOR OFFICE COSMETIC PROCEDURES
- PART THREE FILLERS AND NEUROTOXINS
- Chap. 6 FILLERS: PAST, PRESENT, AND FUTURE
- Chap. 7 HYALURONIC ACID FILLERS: HOW STRUCTURE AFFECTS FUNCTION
- Chap. 8 RESTYLANE: GENERAL CONCEPTS
- Chap. 9 THE RESTYLANE FAMILY OF FILLERS: CANADIAN EXPERIENCE
- Chap. 10 THE JUVÉDERM FAMILY OF FILLERS
- Chap. 11 PURAGEN: A NEW DERMAL FILLER
- Chap. 12 PURAGEN: ASIAN EXPERIENCE
- Chap. 13 REVIEW OF COLLAGEN FILLERS
- Chap. 14 HUMAN AND BOVINE COLLAGEN-BASED FILLERS
- Chap. 15 PORCINE COLLAGEN: EVOLENCE
- Chap. 16 CALCIUM HYDROXYLAPATITE (RADIESSE): A FACIAL PLASTIC SURGEON'S APPROACH
- Chap. 17 CALCIUM HYDROXYLAPATITE (RADIESSE): A DERMASURGEON'S APPROACH
- Chap. 18 CALCIUM HYDROXYLAPATITE FOR HAND VOLUME RESTORATION
- Chap. 19 LONG-LASTING FILLERS: HOW STRUCTURE AFFECTS FUNCTION
- Chap. 20 ACRYLIC PARTICLE–BASED FILLERS: ARTEFILL
- Chap. 21 POLY-L-LACTIC ACID FILLERS
- Chap. 22 POLY-L-LACTIC ACID (SCULPTRA) FOR HAND VOLUME RESTORATION
- Chap. 23 BIOALKAMIDE
- Chap. 24 SILICONE
- Chap. 25 AUTOLOGOUS FAT TRANSFER: AN INTRODUCTION
- Chap. 26 SMALL-VOLUME FAT TRANSFER
- Chap. 27 LARGER-VOLUME FAT TRANSFER
- Chap. 28 FAMI TECHNIQUE AND FAT TRANSFER FOR HAND REJUVENATION
- Chap. 29 ADDING VOLUME TO THE AGING FACE: FAT GRAFTING VERSUS FILLERS AND IMPLANTS IN EUROPE
- Chap. 30 FILLERS: HOW WE DO IT
- Chap. 31 CHOOSING A FILLER
- Chap. 32 FILLER COMPLICATIONS
- Chap. 33 NEUROTOXINS: PAST, PRESENT, AND FUTURE
- Chap. 34 BOTOX: HOW WE DO IT
- Chap. 35 COSMETIC BOTOX: HOW WE DO IT
- Chap. 36 BOTOX: BEYOND THE BASICS
- Chap. 37 BOTOX FOR HYPERHIDROSIS
- Chap. 38 DYSPORT
- Chap. 39 NEUROTOXIN ALTERNATIVE: RADIOFREQUENCY CORRUGATOR DENERVATION
- Chap. 40 FILLERS AND NEUROTOXINS IN ASIA
- Chap. 41 FILLERS AND NEUROTOXINS IN SOUTH AMERICA
- PART FOUR COSMETIC APPLICATIONS OF LIGHT, RADIOFREQUENCY, AND ULTRASOUND ENERGY
- PART FIVE OTHER PROCEDURES
- INDEX
- References
Chap. 14 - HUMAN AND BOVINE COLLAGEN-BASED FILLERS
from PART THREE - FILLERS AND NEUROTOXINS
Published online by Cambridge University Press: 06 July 2010
- Frontmatter
- Contents
- PREFACE
- CONTRIBUTORS
- PART ONE ANATOMY AND THE AGING PROCESS
- PART TWO ANESTHESIA AND SEDATION FOR OFFICE COSMETIC PROCEDURES
- PART THREE FILLERS AND NEUROTOXINS
- Chap. 6 FILLERS: PAST, PRESENT, AND FUTURE
- Chap. 7 HYALURONIC ACID FILLERS: HOW STRUCTURE AFFECTS FUNCTION
- Chap. 8 RESTYLANE: GENERAL CONCEPTS
- Chap. 9 THE RESTYLANE FAMILY OF FILLERS: CANADIAN EXPERIENCE
- Chap. 10 THE JUVÉDERM FAMILY OF FILLERS
- Chap. 11 PURAGEN: A NEW DERMAL FILLER
- Chap. 12 PURAGEN: ASIAN EXPERIENCE
- Chap. 13 REVIEW OF COLLAGEN FILLERS
- Chap. 14 HUMAN AND BOVINE COLLAGEN-BASED FILLERS
- Chap. 15 PORCINE COLLAGEN: EVOLENCE
- Chap. 16 CALCIUM HYDROXYLAPATITE (RADIESSE): A FACIAL PLASTIC SURGEON'S APPROACH
- Chap. 17 CALCIUM HYDROXYLAPATITE (RADIESSE): A DERMASURGEON'S APPROACH
- Chap. 18 CALCIUM HYDROXYLAPATITE FOR HAND VOLUME RESTORATION
- Chap. 19 LONG-LASTING FILLERS: HOW STRUCTURE AFFECTS FUNCTION
- Chap. 20 ACRYLIC PARTICLE–BASED FILLERS: ARTEFILL
- Chap. 21 POLY-L-LACTIC ACID FILLERS
- Chap. 22 POLY-L-LACTIC ACID (SCULPTRA) FOR HAND VOLUME RESTORATION
- Chap. 23 BIOALKAMIDE
- Chap. 24 SILICONE
- Chap. 25 AUTOLOGOUS FAT TRANSFER: AN INTRODUCTION
- Chap. 26 SMALL-VOLUME FAT TRANSFER
- Chap. 27 LARGER-VOLUME FAT TRANSFER
- Chap. 28 FAMI TECHNIQUE AND FAT TRANSFER FOR HAND REJUVENATION
- Chap. 29 ADDING VOLUME TO THE AGING FACE: FAT GRAFTING VERSUS FILLERS AND IMPLANTS IN EUROPE
- Chap. 30 FILLERS: HOW WE DO IT
- Chap. 31 CHOOSING A FILLER
- Chap. 32 FILLER COMPLICATIONS
- Chap. 33 NEUROTOXINS: PAST, PRESENT, AND FUTURE
- Chap. 34 BOTOX: HOW WE DO IT
- Chap. 35 COSMETIC BOTOX: HOW WE DO IT
- Chap. 36 BOTOX: BEYOND THE BASICS
- Chap. 37 BOTOX FOR HYPERHIDROSIS
- Chap. 38 DYSPORT
- Chap. 39 NEUROTOXIN ALTERNATIVE: RADIOFREQUENCY CORRUGATOR DENERVATION
- Chap. 40 FILLERS AND NEUROTOXINS IN ASIA
- Chap. 41 FILLERS AND NEUROTOXINS IN SOUTH AMERICA
- PART FOUR COSMETIC APPLICATIONS OF LIGHT, RADIOFREQUENCY, AND ULTRASOUND ENERGY
- PART FIVE OTHER PROCEDURES
- INDEX
- References
Summary
Dermal matrix in adult skin is composed of type I (80 to 85%) and type III collagen (10 to 15%), in addition to glycosaminoglycans and elastin. Decreased collagen synthesis and increased levels of matrix metalloproteinases, including collagenase, result in reduction and alteration in dermal collagen. The art of soft tissue augmentation was directed toward collagen implants in the 1970s at Stanford University, where researchers first studied bovine- and human-derived collagen as injectable implants. In recent years, significant growth has been observed both in the development of newer dermal implants and in patients' interest in treatment with these products.
This chapter will discuss the available animal- and human-derived collagen products, in addition to their clinical applications, advantages, and disadvantages.
BOVINE-DERIVED COLLAGEN IMPLANTS
Bovine-derived collagen implants were introduced in the 1970s for correction of facial lines and were the most popular dermal implants for about two decades in the United States. These products include Zyderm I, Zyderm II, and Zyplast. Zyderm I and Zyderm II contain 35 mg/cc and 65 mg/cc of bovine collagen, respectively, dispersed in a phosphate-based solution and lidocaine. Zyplast is composed of 35 mg/cc of bovine collagen and is cross-linked by 0.0075% gluteraldehyde in addition to lidocaine. Zyderm I and II are intended for correction of superficial, etched-in rhytids and are expected to provide a duration of correction of two to three months. The cross-linked collagen in Zyplast provides more resistance to degradation and extends the duration of correction to four to five months.
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- Office-Based Cosmetic Procedures and Techniques , pp. 65 - 67Publisher: Cambridge University PressPrint publication year: 2010