Evolence and Evolence Breeze (ColBar LifeScience Ltd.) are the latest products available in the evolution of collagen-derived fillers. Both Evolence and Evolence Breeze are produced from the same porcine collagen and are formulated at collagen concentrations of 35 mg/mL. The products differ in their rheologic properties, which are reflected in their viscosity and injectability properties. The viscosity of Evolence Breeze is approximately 60% of the viscosity of Evolence and is injectable through a 30-gauge needle. The force that is needed to inject Evolence Breeze from the syringe (extrusion force) through a 30-gauge needle at a flow rate of 1 mL/min is 10 N. Evolence exhibits a similar extrusion force as Evolence Breeze of about 10 N when tested on a 27-gauge needle.

During production, collagen from porcine tendons is broken down into collagen molecules. Next, the antigenic telopeptides are removed from the molecules, which are then purified. Following purification, the monomeric collagen is polymerized to create collagen fibers, which are then cross-linked using d-ribose in a proprietary technique known as Glymatrix Technology. ColBar LifeScience contends that by using a natural and nontoxic cross-linking agent (d-ribose), a higher degree of cross-linking can be achieved than is possible with the use of other agents (e.g., formalin and glutaraldehyde), which are limited by toxicity.

Evolence is indicated for the treatment of moderate to deep facial lines and wrinkles as well as for lip augmentation.