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Chapter 16 - Non-amnestic mild cognitive impairment

Published online by Cambridge University Press:  01 December 2016

By
Julio C. Rojas  and
Brianne M. Bettcher
Edited by
Bruce L. Miller  and
Bradley F. Boeve
Bruce L. Miller
Affiliation:
University of California, San Francisco
Bradley F. Boeve
Affiliation:
Mayo Clinic, Minnesota
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The Behavioral Neurology of Dementia , pp. 232 - 244
Publisher: Cambridge University Press
Print publication year: 2016

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References

Hauw, JJ. The history of lacunes. In Donnan, GA, Norrving, B, Bamford, JM, Bogousslavsky, J, editors. Lacunar and Other Subcortical Infarctions. New York, NY: Oxford University Press; 1995. pp. 3–15.CrossRefGoogle ScholarPubMed
Roman, GC. Senile dementia of the Binswanger type. A vascular form of dementia in the elderly. JAMA 1987 Oct 2;258(13):1782–1788.CrossRefGoogle ScholarPubMed
Babikian, V, Ropper, AH. Binswanger’s disease: a review. Stroke 1987 Jan-Feb;18(1):2–12.CrossRefGoogle ScholarPubMed
Hachinski, VC, Lassen, NA, Marshall, J. Multi-infarct dementia. A cause of mental deterioration in the elderly. Lancet 1974 Jul 27;2(7874):207–210.CrossRefGoogle ScholarPubMed
Hachinski, VC, Iliff, LD, Zilhka, E, Du Boulay, GH, McAllister, VL, Marshall, J, et al. Cerebral blood flow in dementia. Arch Neurol 1975 Sep;32(9):632–637.CrossRefGoogle ScholarPubMed
Cummings, JL, Benson, DF. Subcortical dementia. Review of an emerging concept. Arch Neurol 1984 Aug;41(8):874–879.CrossRefGoogle ScholarPubMed
Petersen, RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004 Sep;256(3):183–194.CrossRefGoogle ScholarPubMed
Petersen, RC, Morris, JC. Mild cognitive impairment as a clinical entity and treatment target. Arch Neurol 2005 Jul;62(7):1160–3; discussion 1167.CrossRefGoogle Scholar
Winblad, B, Palmer, K, Kivipelto, M, Jelic, V, Fratiglioni, L, Wahlund, LO, et al. Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med 2004 Sep;256(3):240–246.CrossRefGoogle ScholarPubMed
Bickel, H, Mosch, E, Seigerschmidt, E, Siemen, M, Forstl, H. Prevalence and persistence of mild cognitive impairment among elderly patients in general hospitals. Dement Geriatr Cogn Disord 2006;21(4):242–250.CrossRefGoogle ScholarPubMed
Busse, A, Hensel, A, Guhne, U, Angermeyer, MC, Riedel-Heller, SG. Mild cognitive impairment: long-term course of four clinical subtypes. Neurology 2006 Dec 26;67(12):2176–2185.CrossRefGoogle ScholarPubMed
Delano-Wood, L, Bondi, MW, Sacco, J, Abeles, N, Jak, AJ, Libon, DJ, et al. Heterogeneity in mild cognitive impairment: differences in neuropsychological profile and associated white matter lesion pathology. J Int Neuropsychol Soc 2009 Nov;15(6):906–914.CrossRefGoogle ScholarPubMed
Libon, DJ, Xie, SX, Eppig, J, Wicas, G, Lamar, M, Lippa, C, et al. The heterogeneity of mild cognitive impairment: a neuropsychological analysis. J Int Neuropsychol Soc 2010 Jan;16(1):84–93.CrossRefGoogle Scholar
Manly, JJ, Tang, MX, Schupf, N, Stern, Y, Vonsattel, JP, Mayeux, R. Frequency and course of mild cognitive impairment in a multiethnic community. Ann Neurol 2008 Apr;63(4):494–506.CrossRefGoogle Scholar
Huey, ED, Manly, JJ, Tang, MX, Schupf, N, Brickman, AM, Manoochehri, M, et al. Course and etiology of dysexecutive MCI in a community sample. Alzheimers Dement 2013 Nov;9(6):632–639.CrossRefGoogle ScholarPubMed
Jak, AJ, Bondi, MW, Delano-Wood, L, Wierenga, C, Corey-Bloom, J, Salmon, DP, et al. Quantification of five neuropsychological approaches to defining mild cognitive impairment. Am J Geriatr Psychiatry 2009 May;17(5):368–375.CrossRefGoogle ScholarPubMed
Bondi, MW, Edmonds, EC, Jak, AJ, Clark, LR, Delano-Wood, L, McDonald, CR, et al. Neuropsychological criteria for mild cognitive impairment improves diagnostic precision, biomarker associations, and progression rates. J Alzheimers Dis 2014;42(1):275–289.CrossRefGoogle ScholarPubMed
Clark, LR, Delano-Wood, L, Libon, DJ, McDonald, CR, Nation, DA, Bangen, KJ, et al. Are empirically-derived subtypes of mild cognitive impairment consistent with conventional subtypes? J Int Neuropsychol Soc 2013 Jul;19(6):635–645.CrossRefGoogle Scholar
Loewenstein, DA, Acevedo, A, Small, BJ, Agron, J, Crocco, E, Duara, R. Stability of different subtypes of mild cognitive impairment among the elderly over a 2- to 3-year follow-up period. Dement Geriatr Cogn Disord 2009;27(5):418–423.CrossRefGoogle ScholarPubMed
Albert, MS, DeKosky, ST, Dickson, D, Dubois, B, Feldman, HH, Fox, NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011 May;7(3):270–9.CrossRefGoogle ScholarPubMed
Galluzzi, S, Geroldi, C, Amicucci, G, Bocchio-Chiavetto, L, Bonetti, M, Bonvicini, C, et al. Supporting evidence for using biomarkers in the diagnosis of MCI due to AD. J Neurol 2013 Feb;260(2):640–650.CrossRefGoogle ScholarPubMed
Guo, LH, Alexopoulos, P, Eisele, T, Wagenpfeil, S, Kurz, A, Perneczky, R. The National Institute on Aging-Alzheimer’s Association research criteria for mild cognitive impairment due to Alzheimer’s disease: predicting the outcome. Eur Arch Psychiatry Clin Neurosci 2013 Jun;263(4):325–333.CrossRefGoogle ScholarPubMed
Balasa, M, Sanchez-Valle, R, Antonell, A, Bosch, B, Olives, J, Rami, L, et al. Usefulness of biomarkers in the diagnosis and prognosis of early-onset cognitive impairment. J Alzheimers Dis 2014;40(4):919–927.Google Scholar
Diagnostic and Statistical Manual Of Mental Health Disorders. 2013. Arlington (VA): American Psychiatric Association.CrossRefGoogle ScholarPubMed
Roberts, R, Knopman, DS. Classification and epidemiology of MCI. Clin Geriatr Med 2013 Nov;29(4):753–772.CrossRefGoogle ScholarPubMed
Ferman, TJ, Smith, GE, Kantarci, K, Boeve, BF, Pankratz, VS, Dickson, DW, et al. Nonamnestic mild cognitive impairment progresses to dementia with Lewy bodies. Neurology 2013 Dec 3;81(23):2032–2038.CrossRefGoogle Scholar
Brodaty, H, Heffernan, M, Kochan, NA, Draper, B, Trollor, JN, Reppermund, S, et al. Mild cognitive impairment in a community sample: the Sydney Memory and Ageing Study. Alzheimers Dement 2013 May;9(3):310–317.e1.CrossRefGoogle ScholarPubMed
Fischer, P, Jungwirth, S, Zehetmayer, S, Weissgram, S, Hoenigschnabl, S, Gelpi, E, et al. Conversion from subtypes of mild cognitive impairment to Alzheimer dementia. Neurology 2007 Jan 23;68(4):288–291.CrossRefGoogle ScholarPubMed
Palmer, K, Backman, L, Winblad, B, Fratiglioni, L. Mild cognitive impairment in the general population: occurrence and progression to Alzheimer disease. Am J Geriatr Psychiatry 2008 Jul;16(7):603–611.CrossRefGoogle ScholarPubMed
Roberts, RO, Geda, YE, Knopman, DS, Cha, RH, Pankratz, VS, Boeve, BF, et al. The incidence of MCI differs by subtype and is higher in men: the Mayo Clinic Study of Aging. Neurology 2012 Jan 31;78(5):342–351.CrossRefGoogle Scholar
Luck, T, Riedel-Heller, SG, Luppa, M, Wiese, B, Wollny, A, Wagner, M, et al. Risk factors for incident mild cognitive impairment – results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe). Acta Psychiatr Scand 2010 Apr;121(4):260–272.CrossRefGoogle ScholarPubMed
Luck, T, Luppa, M, Briel, S, Matschinger, H, Konig, HH, Bleich, S, et al. Mild cognitive impairment: incidence and risk factors: results of the Leipzig Longitudinal Study of the Aged. J Am Geriatr Soc 2010 Oct;58(10):1903–1910.CrossRefGoogle ScholarPubMed
Pa, J, Boxer, A, Chao, LL, Gazzaley, A, Freeman, K, Kramer, J, et al. Clinical-neuroimaging characteristics of dysexecutive mild cognitive impairment. Ann Neurol 2009 Apr;65(4):414–423.CrossRefGoogle ScholarPubMed
Ghosh, S, Libon, D, Lippa, C. Mild cognitive impairment: A brief review and suggested clinical algorithm. Am J Alzheimers Dis Other Demen 2014 Jun;29(4): 293–302.CrossRefGoogle ScholarPubMed
Eppig, J, Wambach, D, Nieves, C, Price, CC, Lamar, M, Delano-Wood, L, et al. Dysexecutive functioning in mild cognitive impairment: derailment in temporal gradients. J Int Neuropsychol Soc 2012 Jan;18(1):20–28.CrossRefGoogle ScholarPubMed
Johnson, JK, Pa, J, Boxer, AL, Kramer, JH, Freeman, K, Yaffe, K. Baseline predictors of clinical progression among patients with dysexecutive mild cognitive impairment. Dement Geriatr Cogn Disord 2010;30(4):344–351.CrossRefGoogle ScholarPubMed
Grambaite, R, Selnes, P, Reinvang, I, Aarsland, D, Hessen, E, Gjerstad, L, et al. Executive dysfunction in mild cognitive impairment is associated with changes in frontal and cingulate white matter tracts. J Alzheimers Dis 2011;27(2):453–462.CrossRefGoogle ScholarPubMed
Whitwell, JL, Petersen, RC, Negash, S, Weigand, SD, Kantarci, K, Ivnik, RJ, et al. Patterns of atrophy differ among specific subtypes of mild cognitive impairment. Arch Neurol 2007 Aug;64(8):1130–1138.CrossRefGoogle ScholarPubMed
Farias, ST, Mungas, D, Reed, BR, Harvey, D, DeCarli, C. Progression of mild cognitive impairment to dementia in clinic- vs. community-based cohorts. Arch Neurol 2009 Sep;66(9):1151–1157.CrossRefGoogle ScholarPubMed
Possin, KL, Feigenbaum, D, Rankin, KP, Smith, GE, Boxer, AL, Wood, K, et al. Dissociable executive functions in behavioral variant frontotemporal and Alzheimer dementias. Neurology 2013 Jun 11;80(24):2180–2185.CrossRefGoogle Scholar
Dickerson, BC, Wolk, DA, Alzheimer’s Disease Neuroimaging Initiative. Dysexecutive versus amnesic phenotypes of very mild Alzheimer’s disease are associated with distinct clinical, genetic and cortical thinning characteristics. J Neurol Neurosurg Psychiatry 2011 Jan;82(1):45–51.CrossRefGoogle ScholarPubMed
Petersen, RC, Roberts, RO, Knopman, DS, Boeve, BF, Geda, YE, Ivnik, RJ, et al. Mild cognitive impairment: ten years later. Arch Neurol 2009 Dec;66(12):1447–1455.CrossRefGoogle ScholarPubMed
Frisoni, GB, Pievani, M, Testa, C, Sabattoli, F, Bresciani, L, Bonetti, M, et al. The topography of grey matter involvement in early and late onset Alzheimer’s disease. Brain 2007 Mar;130(Pt 3):720–730.CrossRefGoogle ScholarPubMed
Rascovsky, K, Hodges, JR, Knopman, D, Mendez, MF, Kramer, JH, Neuhaus, J, et al. Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 2011 Sep;134(Pt 9):2456–2477.Google ScholarPubMed
Sachdev, P, Brodaty, H. Vascular dementia: an Australian perspective. Alzheimer Dis Assoc Disord 1999 Oct–Dec;13 (Suppl 3):S206–12.CrossRefGoogle ScholarPubMed
Zanetti, M, Ballabio, C, Abbate, C, Cutaia, C, Vergani, C, Bergamaschini, L. Mild cognitive impairment subtypes and vascular dementia in community-dwelling elderly people: a 3-year follow-up study. J Am Geriatr Soc 2006 Apr;54(4):580–586.CrossRefGoogle ScholarPubMed
Rosenberg, PB, Mielke, MM, Appleby, B, Oh, E, Leoutsakos, JM, Lyketsos, CG. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int J Geriatr Psychiatry 2011 Apr;26(4):364–372.CrossRefGoogle ScholarPubMed
Chiaravalloti, ND, DeLuca, J. Cognitive impairment in multiple sclerosis. Lancet Neurol 2008 Dec;7(12):1139–1151.CrossRefGoogle ScholarPubMed
Cummings, JL, Benson, DF. Psychological dysfunction accompanying subcortical dementias. Annu Rev Med 1988;39:53–61.CrossRefGoogle ScholarPubMed
Bettcher, BM, Gelfand, JM, Irani, SR, Neuhaus, J, Forner, S, Hess, CP, et al. More than memory impairment in voltage-gated potassium channel complex encephalopathy. Eur J Neurol 2014 Oct;21(10):1301–1310.CrossRefGoogle ScholarPubMed
Crutch, SJ, Lehmann, M, Warren, JD, Rohrer, JD. The language profile of posterior cortical atrophy. J Neurol Neurosurg Psychiatry 2013 Apr;84(4):460–466.CrossRefGoogle ScholarPubMed
Lehmann, M, Barnes, J, Ridgway, GR, Wattam-Bell, J, Warrington, EK, Fox, NC, et al. Basic visual function and cortical thickness patterns in posterior cortical atrophy. Cereb Cortex 2011 Sep;21(9):2122–2132.CrossRefGoogle ScholarPubMed
Chan, LT, Lynch, W, De May, M, Horton, JC, Miller, BL, Rabinovici, GD. Prodromal posterior cortical atrophy: clinical, neuropsychological, and radiological correlation. Neurocase 2015 Feb;21(1):44–55.CrossRefGoogle ScholarPubMed
Borruat, FX. Posterior cortical atrophy: review of the recent literature. Curr Neurol Neurosci Rep 2013 Dec;13(12):406–013-0406–8.CrossRefGoogle ScholarPubMed
Mapstone, M, Steffenella, TM, Duffy, CJ. A visuospatial variant of mild cognitive impairment: getting lost between aging and AD. Neurology 2003 Mar 11;60(5):802–808.CrossRefGoogle ScholarPubMed
Crutch, SJ, Lehmann, M, Schott, JM, Rabinovici, GD, Rossor, MN, Fox, NC. Posterior cortical atrophy. Lancet Neurol 2012 Feb;11(2):170–178.Google ScholarPubMed
Boeve, BF. Mild cognitive impairment associated with underlying Alzheimer’s disease versus Lewy body disease. Parkinsonism Relat Disord 2012 Jan;18 Suppl 1:S41–4.CrossRefGoogle ScholarPubMed
Burrell, JR, Hodges, JR, Rowe, JB. Cognition in corticobasal syndrome and progressive supranuclear palsy: a review. Mov Disord 2014 Apr 15;29(5):684–693.CrossRefGoogle ScholarPubMed
Cooper, SA, Murray, KL, Heath, CA, Will, RG, Knight, RS. Isolated visual symptoms at onset in sporadic Creutzfeldt-Jakob disease: the clinical phenotype of the "Heidenhain variant". Br J Ophthalmol 2005 Oct;89(10):1341–1342.CrossRefGoogle ScholarPubMed
Fisher, CM. The posterior cerebral artery syndrome. Can J Neurol Sci 1986 Aug;13(3):232–239.CrossRefGoogle ScholarPubMed
Magnin, E, Chopard, G, Ferreira, S, Sylvestre, G, Dariel, E, Ryff, I, et al. Initial neuropsychological profile of a series of 20 patients with logopenic variant of primary progressive aphasia. J Alzheimers Dis 2013;36(4):799–808.CrossRefGoogle ScholarPubMed
Henry, ML, Gorno-Tempini, ML. The logopenic variant of primary progressive aphasia. Curr Opin Neurol 2010 Dec;23(6):633–637.CrossRefGoogle ScholarPubMed
Wilson, SM, Galantucci, S, Tartaglia, MC, Rising, K, Patterson, DK, Henry, ML, et al. Syntactic processing depends on dorsal language tracts. Neuron 2011 Oct 20;72(2):397–403.CrossRefGoogle ScholarPubMed
Gorno-Tempini, ML, Hillis, AE, Weintraub, S, Kertesz, A, Mendez, M, Cappa, SF, et al. Classification of primary progressive aphasia and its variants. Neurology 2011 Mar 15;76(11):1006–1014.CrossRefGoogle ScholarPubMed
Possin, KL, Laluz, VR, Alcantar, OZ, Miller, BL, Kramer, JH. Distinct neuroanatomical substrates and cognitive mechanisms of figure copy performance in Alzheimer’s disease and behavioral variant frontotemporal dementia. Neuropsychologia 2011 Jan;49(1):43–48.CrossRefGoogle ScholarPubMed
de Mendonca, A, Ribeiro, F, Guerreiro, M, Garcia, C. Frontotemporal mild cognitive impairment. J Alzheimers Dis 2004 Feb;6(1):1–9.CrossRefGoogle ScholarPubMed
Hartikainen, P, Rasanen, J, Julkunen, V, Niskanen, E, Hallikainen, M, Kivipelto, M, et al. Cortical thickness in frontotemporal dementia, mild cognitive impairment, and Alzheimer’s disease. J Alzheimers Dis 2012;30(4):857–874.Google Scholar

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