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Chapter 13 - Brain Metastases: Molecules to Medicine

from Section 2 - Clinical Neurosurgical Diseases

Published online by Cambridge University Press:  04 January 2024

By
Ethan S. Srinivasan ,
Vadim Tsvankin ,
Eric W. Sankey ,
Matthew M. Grabowski ,
Pakawat Chongsathidkiet  and
Peter E. Fecci
Edited by
Farhana Akter ,
Nigel Emptage ,
Florian Engert  and
Mitchel S. Berger
Farhana Akter
Affiliation:
Harvard University, Massachusetts
Nigel Emptage
Affiliation:
University of Oxford
Florian Engert
Affiliation:
Harvard University, Massachusetts
Mitchel S. Berger
Affiliation:
University of California, San Francisco
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Summary

Due to improvements in population health, systemic cancer therapies and screening tools, the incidence of brain cancer metastases has continued to rise. The constituent cells possess unique characteristics that allow them to penetrate the blood–brain barrier, colonize the central nervous system, and co-opt their surroundings to thrive while evading surveillance by the immune system. This presents a unique challenge both to the multidisciplinary teams that care for these patients and the investigators striving to leverage these tumors’ distinctive attributes into novel treatments. In this chapter, we outline the pathways and mechanisms underlying the development and survival of brain metastases, and how they inform current and emerging treatment strategies.

Type
Chapter
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Neuroscience for Neurosurgeons , pp. 193 - 213
Publisher: Cambridge University Press
Print publication year: 2024

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