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Chapter 22 - Vascular Neurosurgery

from Section 2 - Clinical Neurosurgical Diseases

Published online by Cambridge University Press:  04 January 2024

By
Karol P. Budohoski  and
Adib A. Abla
Edited by
Farhana Akter ,
Nigel Emptage ,
Florian Engert  and
Mitchel S. Berger
Farhana Akter
Affiliation:
Harvard University, Massachusetts
Nigel Emptage
Affiliation:
University of Oxford
Florian Engert
Affiliation:
Harvard University, Massachusetts
Mitchel S. Berger
Affiliation:
University of California, San Francisco
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Summary

Vascular neurosurgery is a diverse field focused on surgical and interventional treatment of cerebrovascular disease. Given this diverse disease pool vascular neurosurgery spans multiple fields, including neurology, cardiology, intensive care, interventional radiology, and clinical genetics and can affect involve both adult and pediatric patents. Despite extensive basic and translational research into the pathophysiology of cerebrovascular disease very few treatments have been successfully implemented into clinical practice. In this chapter we review the animal models used in the study of the pathophysiology of subarachnoid hemorrhage and its sequelae, such as early brain injury and delayed cerebral ischemia, highlighting the challenges and future direction. Furthermore, we will also discuss the animal models used to elucidate the mechanisms behind aneurysm formation.

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Neuroscience for Neurosurgeons , pp. 300 - 313
Publisher: Cambridge University Press
Print publication year: 2024

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