Accumulating evidence shows associations between rapid eating and overweight. Modifying eating rate might be a potential weight management strategy without imposing additional dietary restrictions. A comprehensive understanding of factors associated with eating speed will help with designing effective interventions. The aim of this review was to synthesize the current state of knowledge on the factors associated with eating rate. The socio-ecological model (SEM) was utilized to scaffold the identified factors. A comprehensive literature search of 11 databases was conducted to identify factors associated with eating rate. The 104 studies that met the inclusion criteria were heterogenous in design and methods of eating rate measurement. We identified 39 factors that were independently linked to eating speed and mapped them onto the individual, social and environmental levels of the SEM. The majority of the reported factors pertained to the individual characteristics (n=20) including demographics, cognitive/psychological factors and habitual food oral processing behaviours. Social factors (n=11) included eating companions, social and cultural norms, and family structure. Environmental factors (n=8) included food texture and presentation, methods of consumption or background sounds. Measures of body weight, food form and characteristics, food oral processing behaviours and gender, age and ethnicity were the most researched and consistent factors associated with eating rate. A number of other novel and underresearched factors emerged, but these require replication and further research. We highlight directions for further research in this space and potential evidence-based candidates for interventions targeting eating rate.

Helicity, an invariant under ideal-fluid (Euler) evolution, has a topological interpretation in terms of writhe and twist for a closed vortex tube, but accurately quantifying twist is challenging in viscous flows. With a novel helicity decomposition, we present a framework to construct the differential twist that establishes the theoretical relation between the total twisting number and the local twist rate of each vortex surface. This framework can characterize coiling vortex lines and internal structures within a vortex – important in laminar–turbulence transition, and in vortex instability, reconnection and breakdown. As a typical example, we explore the dynamics of vortex rings with differential twist via direct numerical simulation (DNS) of the Navier–Stokes equations. Two twist waves with opposite chiralities propagate towards each other along the ring and then collide whence the local twist rate rapidly surges. Local vortex surfaces are squeezed into a disk-like dipole structure containing coiled vortex lines, leading to vortex bursting. We derive a Burgers-equation-like model to quantify this process, which predicts a bursting time that agrees well with DNS.

Precision irrigation is a potential viable strategy for water use reductions on golf courses by making variable or site-specific irrigation applications. A group of US golf course superintendents were surveyed to examine whether and how superintendents’ risk preferences (attitudes) affect the adoption decisions of precision irrigation technologies on their golf courses. Under the prospect theory (PT) framework, a lottery experiment was used to elicit the measures of three risk attitudes, that is, risk curvature, probability distortion, and loss aversion. Using these three measures and other questions in the survey, we found that risk curvature has a significant positive effect on the precision irrigation technologies adoption on golf courses, while probability distortion affects the adoption negatively. Compared to the golf course in low precipitation areas, superintendents’ risk attitudes are more likely to affect the precision irrigation technologies adoption in the golf course in high precipitation areas. Additionally, risk curvature dominates the adoption decisions for newer technologies, while probability distortion dominates the older technologies adoption decisions. Our research enriches the literature on the decision-making behaviors of managers by considering how probability distortion, a factor typically ignored by other studies, affects technology adoption decisions and adds to the literature on examining the technology adoption behaviors under PT by focusing on golf course superintendents, a group that has not been studied.

Computer-aided design (CAD) plays an essential role in creative idea generation on 2D screens during the design process. In most CAD scenarios, virtual object translation is an essential operation, and it is commonly used when designers simulate their innovative solutions. The degrees of freedom (DoF) of virtual object translation modes have been found to directly impact users’ task performance and psychological aspects in simulated environments. Little is known in the existing literature about the sense of agency (SoA), which is a critical psychological aspect emphasizing the feeling of control, in translation modes on 2D screens during the design process. Hence, this study aims to assess users’ SoA in virtual object translation modes on mouse-based, touch-based, and handheld augmented reality (AR) interfaces through subjective and objective measures, such as self-report, task performance, and electroencephalogram (EEG) data. Based on our findings in this study, users perceived a greater feeling of control in 1DoF translation mode, which may help them come up with more creative ideas, than in 3DoF translation mode in the design process; additionally, the handheld AR interface offers less control feel, which may have a negative impact on design quality and creativity, as compared with mouse- and touch-based interfaces. This research contributes to the current literature by analyzing the association between virtual object translation modes and SoA, as well as the relationship between different 2D interfaces and SoA in CAD. As a result of these findings, we propose several design considerations for virtual object translation on 2D screens, which may enable designers to perceive a desirable feeling of control during the design process.

Contact force is one of the most significant feedback for robots to achieve accurate control and safe interaction with environment. For continuum robots, it is possible to estimate the contact force based on the feedback of robot shapes, which can address the difficulty of mounting dedicated force sensors on the continuum robot body with strict dimension constraints. In this paper, we use local curvatures to estimate the magnitude and location of single or multiple contact forces based on Cosserat rod theory. We validate the proposed method in a thin elastic tube and calculate the curvatures via Fiber Bragg Grating (FBG) sensors or image feedback. For the curvature feedback obtained from multicore FBG sensors, the overall force magnitude estimation error is $0.062 \pm 0.068$ N and the overall location estimation error is $3.51 \pm 2.60$ mm. For the curvature feedback obtained from image, the overall force magnitude estimation error is $0.049 \pm 0.048$ N and the overall location estimation error is $2.75 \pm 1.71$ mm. The results demonstrate that the curvature-based force estimation method is able to accurately estimate the contact force.

We propose the helicity-conserved Navier–Stokes (HCNS) equation by modifying the non-ideal force term in the Navier–Stokes (NS) equation. The corresponding HCNS flow has strict helicity conservation, and retains major NS dynamics with finite dissipation. Using the helical wave decomposition, we show that the pentadic interaction of Fourier helical modes in the HCNS dynamics is more complex than the triadic interaction in the NS dynamics, and enhanced variations for left- and right-handed helicity components cancel each other in the HCNS flow to keep the invariant helicity. A comparative study of HCNS and NS flow evolutions with direct numerical simulation elucidates the influence of the helicity conservation on flow structures and statistics in the vortex reconnection and isotropic turbulence. First, the HCNS flow evolves towards a Beltrami state with a $-4$ scaling law of the energy spectrum at high wavenumbers at long times. Second, large-scale flow structures are almost identical during the viscous reconnection of vortex tubes in the two flows, whereas many more small-scale helical structures are generated via the pentadic mode interaction in the HCNS flow than in the NS flow. Moreover, we demonstrate that parity breaking at small scales can trigger a notable helicity variation in the NS flow. These findings hint that the helicity may not be conserved in the inviscid limit of the NS flow.

High-molecular-weight glutenin subunits (HMW-GS) contribute to dough elasticity and bread baking quality in wheat. In this study, wheat varieties were classified based on their HMW-GS composition into three groups: 1Dx5 (5 + 10, Gaoyou 8901, Xinmai 28, Xinmai 19, Xinmai 26 and Jinbaoyin), 1Dx2 (2 + 12, Zhoumai 24, Xinmai 9 and Yumai) and 1Dx4 (4 + 12, Aikang 58). Sequence analysis showed that 1Dx-GY8901, 1Dx-XM28, 1Dx-XM19 and 1Dx-XM26 were similar to the 1Dx5 gene and clustered on the same branch, while 1Dx-AK58, 1Dx-ZM24, 1Dx-JBY, 1Dx-YM, 1Dx-XM9 and 1Dx-JBY were more similar to the 1Dx2 gene and clustered on the same branch with 1Dx.2.2. There was a mutation of Ser to Cys at position S2, for an extra Cys in the repeat regions of 1Dx-XM19, 1Dx-XM26, 1Dx-XM28 and 1Dx-GY8901. The wheat HMW-GS genes exhibited similar percentages of α-helix, extended strand, β-turn and random coil structure, with ranges of 13.33–13.59, 4.77–5.78, 7.08–9.18 and 72.3–73.94%, respectively. Sequence conservation and the composition of HMW-GS subunits were also analysed for a series of strong gluten wheat varieties, Xinmai 9 (1, 7 + 8, 2 + 12), Xinmai 19 (1, 7 + 9, 5 + 10), Xinmai 26 (1, 7 + 8, 5 + 10) and Xinmai 28 (1, 7 + 9, 5 + 10). The results of this work should facilitate future breeding efforts and provide the theoretical basis for wheat quality improvement.

Telocyte (TC)—a new type of interstitial cell with long telopodes, can form cellular junctions with various tissues or cells to participate in the regulation of multitudes of physiological activities and diseases. This study aimed to characterize the morphology, molecular features, and potential functions of hormone regulation in Chinese soft-shelled turtle (Pelodiscus sinensis) testis TCs at different reproductive stages by histological evaluation, immunohistochemistry (IHC), immunofluorescence (IF), and transmission electron microscopy. During hibernation, TCs were widely distributed in the interstitial tissue. In contrast, during reproductive activity, TCs were noted to be in close proximity with peritubular myoid cells surrounding the seminiferous tubule. Moreover, formed cell–cell junctions were observed between TCs and PTMs. The results of IHC and IF showed that the immunophenotype of testicular TCs in hibernating Chinese soft-shelled turtles is CD34+Vimentin−, while the reproductive telopodes (Tps) show low expression of vimentin. The androgen receptor is expressed in Tps of TCs of testis during hibernation. Our results showed also that TCs in seasonal breeding animals regulate the activity of neighboring cells by releasing extracellular microvesicles (EXMVs), thus influencing the activity of spermatogenesis and steroidogenesis. Consideration of our novel and interesting results indicate that the whole area warrants further research.

Older adults have been statistically proved to be at a higher risk of getting severely infected by the coronavirus COVID-19, evoking sweeping narratives of compassionate ageism surrounding them in different discourses. By analysing the media content, scholars from different areas have alerted us about the amplified ageism aroused by the pandemic crisis. However, we are still short of empirical evidence to learn how ageism is constructed in diverse sociocultural contexts in the wake of this global pandemic crisis. This study provides the case of Hong Kong to reflect on how ageism, as a set of social inequalities, is constructed. By examining 814 articles collected from the three most popular newspapers with different political orientations in Hong Kong, this study uses quantitative and qualitative content analysis to examine how older people have been generally represented. Then it further compares how these representations have been influenced by the media's liberal or conservative preferences. Third, it examines the relationship between the political orientation of newspapers and how different forms of ageism are constructed. The findings indicate that despite the liberal or conservative inclination of the three newspapers, they portray the older population as frail, dependent and deprived not only at the biomedical level but in all aspects of life. This study also reveals that the newspapers with a populist inclination in both camps have shown more hostile attitudes in representing compassionate ageism. In contrast, liberal and conservative-leaning media affirmed the government's dominant role in taking full responsibility for caring for the older population. The findings indicate that the polarised ageism frame cannot fully explain the underpinnings of ageism and implied policy processing in different contexts.

The dynamics of two slender Hopf-linked vortex rings at vortex Reynolds numbers ($Re \equiv \varGamma /\nu, \mathrm {circulation/viscosity}$) $2000$, $3000$ and $4000$ is studied using direct numerical simulations of the incompressible Navier–Stokes equations. Under self-induction, the initially perpendicularly placed vortex rings approach each other and reconnect to form two separate vortex rings. The leading ring is closely cuddled and further undergoes secondary reconnection to form two even smaller rings. At high $Re$, the leading ring and the subsequent smaller rings are unstable and break up into turbulent clouds consisting of numerous even smaller-scale structures. Although the global helicity $H$ remains constant before reconnection, it increases and then rapidly decays during reconnection – both the growth and decay rates increase with $Re$. In the two higher $Re$ (i.e. 3000 and 4000) cases, $H$ further rises after the first reconnection and reaches a quasi-plateau with the asymptotic value continuously increasing with $Re$ – suggesting that $H$ for viscous flows is not conserved at very high $Re$. Further flow analysis demonstrates that significant numbers of positive and negative helical structures are simultaneously generated before and during reconnection, and their different decay rates is the main reason for the complex evolution of $H$. By examining the topological aspects of the helicity dynamics, we find that, different from $H$, the sum of link and writhe ($L_k+W_r$) continuously drop during reconnection. Our results also clearly demonstrate that the twist, which increases with $Re$, plays a significant role in the helicity dynamics, particularly at high $Re$.

Topological transition and helicity conversion of vortex torus knots and links are studied using direct numerical simulations of the incompressible Navier–Stokes equations. We find three topological transitional routes (viz. merging, reconnection and transition to turbulence) in the evolution of vortex knots and links over a range of torus aspect ratios and winding numbers. The topological transition depends not only on the initial topology but also on the initial geometry of knots/links. For small torus aspect ratios, the initially knotted or linked vortex tube rapidly merges into a vortex ring with a complete helicity conversion from the writhe and link components to the twist. For large torus aspect ratios, the vortex knot or link is untied into upper and lower coiled loops via the first vortex reconnection, with a helicity fluctuation including loss of writhe and link, and generation of twist. Then, the relatively unstable lower loop can undergo a secondary reconnection to split into multiple small vortices with a similar helicity fluctuation. Surprisingly, for moderate torus aspect ratios, the incomplete reconnection of tangled vortex loops together with strong vortex interactions triggers transition to turbulence, in which the topological helicity decomposition fails due to the breakdown of vortex core lines.

This paper studies a composite problem involving decision-making about the optimal entry time and dynamic consumption afterwards. In Stage 1, the investor has access to full market information subject to some information costs and needs to choose an optimal stopping time to initiate Stage 2; in Stage 2, the investor terminates the costly full information acquisition and starts dynamic investment and consumption under partial observation of free public stock prices. Habit formation preferences are employed, in which past consumption affects the investor’s current decisions. Using the stochastic Perron method, the value function of the composite problem is proved to be the unique viscosity solution of some variational inequalities.

We investigate the effect of the secondary baroclinic vorticity (SBV) on the energy cascade in the mixing induced by the multi-mode Richtmyer–Meshkov instability (RMI). With the aid of vorticity-based simplified models and the vortex-surface field, we find that the effect of the SBV peaks at a critical time when the vortex reconnection widely occurs in the mixing zone. Before the critical time, spikes and bubbles evolve almost independently, and we demonstrate that the variation of the kinetic energy spectrum induced by the SBV has the $-1$ scaling law at intermediate wavenumbers using the model of vortex rings. This SBV effect causes the slope of the total energy spectrum at intermediate wavenumbers to evolve towards $-3/2$ at the critical time. Subsequently, the SBV effect diminishes and the energy spectrum decays to the $-5/3$ law. Inspired by the vortex dynamics, we develop a model for estimating the mixing width and validate the model using numerical simulations of the multi-mode RMI with various modes of initial perturbations. This model captures the nonlinear growth of the mixing width before the self-similar growth stage.

ITGB1 (Integrin β1, CD29) is a member of the integrin family and has a role as a major adhesion receptor. Gastric cancer (GC) is an important cause of mortality worldwide, especially in China. As a potential cancer enhancer, the role ITGB1 plays in GC progression remains unclear. In the current study, our assay on the databases of tumoassociated gene expression and interaction found that the high expression of ITGB1 was closely correlated with the poor prognosis of GC patients. To explore the roles, ITGB1 plays in GC progression, and an ITGB1-deleted cell line (ITGB1−/−SGC7901) was generated using the CRISPR/Cas9 method. The tumor malignancy-associated cell behaviors and microstructures were detected, imaged, and analyzed using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT), wound healing, transwell, scanning electron microscopy, laser scanning confocal microscopy, and others. The results indicated that ITGB1 deletion decreased the GC cell proliferation and motility, and inhibited motility-relevant microstructures, such as pseudopodia and filopodia, markedly in ITGB1-deleted SGC7901 cells. The analysis of STRING database and western blots indicated that ITGB1 contributes to the malignancy of GC mediated by Src-mediated FAK/PI3K/Akt signaling pathways. Taken together, the results showed that ITGB1 may be a potential targeting marker for GC diagnosis and therapy in the future.