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Increasing evidence supports sarcopenia as an important parameter for predicting cardiometabolic risks. The objective of this study was to investigate the relationship between muscle mass, muscle strength, and physical performance, and cardiovascular risk among older community-dwelling adults.
Design:
The associations between dynapenia, sarcopenia, and Framingham risk score (FRS) were estimated by multivariate regression models.
Setting:
Muscle mass is estimated by skeletal muscle mass index using a bioelectrical impedance analysis. Muscle strength is measured by handgrip strength using an analogue isometric dynamometer. Physical performance is measured by gait speed using a 6-m walking distance. Dynapenia was defined as low muscle strength and/or slow gait speed presents with normal muscle mass. The diagnosis of presarcopenia and sarcopenia was based on criteria proposed by the Asian Working Group for Sarcopenia in 2014. The FRS was used for evaluating 10-year coronary heart disease (CHD) risk.
Participants:
Adults aged 65 years and older who attended health examinations from 2015 to 2017 were recruited.
Results:
There were totally 709 subjects enrolled in this study. Dynapenic men (n 47) had 17·70 ± 5·08 % FRS and sarcopenic women (n 74) had 7·74 ± 6·06 % FRS. Participants with presarcopenia had the lowest FRS (men: 15·41 ± 5·35 %; women: 5·25 ± 3·70 %). Men with dynapenia had higher FRS than the presarcopenia group with odds ratio (OR) of 2·52 (95 % confidence interval (CI): 1·03, 6·14). Women with sarcopenia had significantly higher FRS than the presarcopenia group with OR of 2·81 (95 % CI: 1·09, 7·27).
Conclusion:
Older dynapenic men and older sarcopenic women had higher risks of 10-year CHD. Presarcopenic older adults had the lowest CHD risk in both genders.
Grey matter (GM) reduction is a consistent observation in established late stages of schizophrenia, but patients in the untreated early stages of illness display an increase as well as a decrease in GM distribution relative to healthy controls (HC). The relative excess of GM may indicate putative compensatory responses, though to date its relevance is unclear.
Methods
343 first-episode treatment-naïve patients with schizophrenia (FES) and 342 HC were recruited. Multivariate source-based morphometry was performed to identify covarying ‘networks' of grey matter concentration (GMC). Neurocognitive scores using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and symptom burden using the Positive and Negative Symptoms Scale (PANSS) were obtained. Bivariate linear relationships between GMC and cognition/symptoms were studied.
Results
Compared to healthy subjects, FES had prominently lower GMC in two components; the first consists of the anterior insula, inferior frontal gyrus, anterior cingulate and the second component with the superior temporal gyrus, precuneus, inferior/superior parietal lobule, cuneus, and lingual gyrus. Higher GMC was seen in adjacent areas of the middle and superior temporal gyrus, middle frontal gyrus, inferior parietal cortex and putamen. Greater GMC of this component was associated with lower duration of untreated psychosis, less severe positive symptoms and better performance on cognitive tests.
Conclusions
In untreated stages of schizophrenia, both a distributed lower and higher GMC is observable. While the higher GMC is relatively modest, it occurs across frontoparietal, temporal and subcortical regions in association with reduced illness burden suggesting a compensatory role for higher GMC in the early stages of schizophrenia.
General nonlinear equations describing reversed shear Alfvén eigenmode (RSAE) self-modulation via zero-frequency zonal structure (ZFZS) generation are derived using nonlinear gyrokinetic theory, which are then applied to study the spontaneous ZFZS excitation as well as RSAE nonlinear saturation. It is found that both electrostatic zonal flow and electromagnetic zonal current can be preferentially excited by finite-amplitude RSAE, depending on specific plasma parameters. The modification to local shear Alfvén wave continuum is evaluated using the derived saturation level of zonal current, which is shown to play a comparable role in saturating RSAE with the ZFZS scattering.
Deficits in event-related potential (ERP) including duration mismatch negativity (MMN) and P3a have been demonstrated widely in chronic schizophrenia (SZ) but inconsistent findings were reported in first-episode patients. Psychotropic medications and diagnosis might contribute to different findings on MMN/P3a ERP in first-episode patients. The present study examined MMN and P3a in first episode drug naïve SZ and bipolar disorder (BPD) patients and explored the relationships among ERPs, neurocognition and global functioning.
Methods
Twenty SZ, 24 BPD and 49 age and sex-matched healthy controls were enrolled in this study. Data of clinical symptoms [Positive and Negative Symptoms Scale (PANSS), Young Manic Rating Scale (YMRS), Hamilton Depression Rating Scale (HAMD)], neurocognition [Wechsler Adult Intelligence Scale (WAIS), Cattell's Culture Fair Intelligence Test (CCFT), Delay Matching to Sample (DMS), Rapid Visual Information Processing (RVP)], and functioning [Functioning Assessment Short Test (FAST)] were collected. P3a and MMN were elicited using a passive auditory oddball paradigm.
Results
Significant MMN and P3a deficits and impaired neurocognition were found in both SZ and BPD patients. In SZ, MMN was significantly correlated with FAST (r = 0.48) and CCFT (r = −0.31). In BPD, MMN was significantly correlated with DMS (r = −0.54). For P3a, RVP and FAST scores were significant predictors in SZ, whereas RVP, WAIS and FAST were significant predictors in BPD.
Conclusions
The present study found deficits in MMN, P3a, neurocognition in drug naïve SZ and BPD patients. These deficits appeared to link with levels of higher-order cognition and functioning.
To examine the association between sleep duration in different stages of life and amnestic mild cognitive impairment (aMCI).
Design, setting, and participants:
A total of 2472 healthy elderly and 505 patients with aMCI in China were included in this study. The study analyzed the association between aMCI and sleep duration in different stages of life.
Measurements:
We compared sleep duration in different stages of life and analyzed the association between Montreal Cognitive Assessment scores and sleep duration by curve estimation. Logistic regression was used to evaluate the association between aMCI and sleep duration.
Results:
In the analysis, there were no results proving that sleep duration in youth (P = 0.719, sleep duration < 10 hours; P = 0.999, sleep duration ≥ 10 hours) or midlife (P = 0.898, sleep duration < 9 hours; P = 0.504, sleep duration ≥ 9 hours) had a significant association with aMCI. In the group sleeping less than 7 hours in late life, each hour more of sleep duration was associated with approximately 0.80 of the original risk of aMCI (P = 0.011, odds ratio = 0.80, 95% confidence interval = 0.68–0.95).
Conclusions:
Among the elderly sleeping less than 7 hours, there is a decreased risk of aMCI for every additional hour of sleep.
In this paper, we study inertial and gravity wave transmissions near radiative–convective boundaries on the f-plane. Two configurations have been considered: waves propagate from the convective layer to the radiative stratified stable layer, or the other way around. It has been found that waves prefer to survive at low latitudes when the stable layer is strongly stratified ($N^2/(2\varOmega )^2>1$). When the stable layer is weakly stratified ($N^2/(2\varOmega )^2 < 1$), however, waves can survive at any latitude if the meridional wavenumber is large. Then we have discussed transmission ratios for two buoyancy frequency structures: the uniform stratification and the continuously varying stratification. For the uniform stratification, we have found that the transmission is efficient when the rotation is rapid, or when the wave is near the critical colatitude. For the continuously varying stratification, we have discussed the transmission ratio when the square of buoyancy frequency is an algebraic function $N^2\propto z^{\nu } (\nu >0)$. We have found that the transmission can be efficient when the rotation is rapid, or when the wave is near the critical colatitude, or when the thickness of the stratification layer is far greater than the horizontal wavelength. The transmission ratio does not depend on the configurations (radiative layer sits above convective layer, or vice versa; wave propagates outward or inward), but only on characteristics of the wave (frequency and wavenumber) and the fluid (degree of stratification).
The most important issue for the clinical application of sarcopenic obesity (SO) is the lack of a consensus definition. The aim of the present study was to determine the best measurement for SO by estimating the association between various definitions and the risk of falls and metabolic syndrome (MS). We studied a community of 765 adults aged 65 years and older in 2015–2017. Sarcopenia obesity was measured by sarcopenia (defined by low muscle mass with either low handgrip strength or low gait speed or both) plus obesity (defined by waist circumference, body fat percentage and BMI). The MS was defined according to the National Cholesterol Education Program ATP III. Logistic regression models were constructed to examine the relationships between sarcopenia obesity and risk of fall and MS. In the analysis of the fall risk with SO defined by waist circumference, the participants with non-sarcopenia/non-obesity were treated as the reference group. The OR to fall in participants with SO was 10·16 (95 % CI 2·71, 38·13) after adjusting for confounding covariates. In the analysis of the risk of the MS between participants with individual components of sarcopenia coupled with obesity defined by waist circumference, the risk was statistically significant for low gait speed (OR: 7·19; 95 % CI 3·61, 14·30) and low grip strength (OR: 9·19; 95 % CI 5·00, 16·91). A combination of low grip strength and abdominal obesity for identifying SO may be a more precise and practical method for predicting target populations with unfavourable health risks, such as falls risk and MS.
There have been calls for the expansion of protected areas (PAs) to tackle the ongoing biodiversity loss, yet it is unclear where future PAs might help to protect biodiversity in degraded landscapes under the conservation planning principles of complementarity, connectivity and cost-effectiveness. Our conservation goal is to increase the PA network coverage to up to 30% of the landscape of the Zhangjiang River Basin for target species in the karst area of southwest China, a global biodiversity hotspot. Zonation 4GUI was used to evaluate the adequacy of current PAs and to strategically expand PAs while maximizing the coverage of target species and considering ecological integrity and socioeconomic activities. The results show that significant habitat degradation has occurred across 77.9% of the basin. The current PAs cover 6.3% of the site and represent 8.7% of the total distribution of key species. With regards to the threshold of protection of 30% of the area, protecting an additional 27.2% of the site under an ecological integrity prioritization scenario and a scenario of the socioeconomic costs involved in iteration would cover 93.5% and 80.4% of the ranges of the key species, respectively. Our results can be used to inform the upcoming actions associated with karst area conservation-related policies.
In this paper, we study wave transmission in a rotating fluid with multiple alternating convectively stable and unstable layers. We have discussed wave transmissions in two different circumstances: cases where the wave is propagative in each layer and cases where wave tunnelling occurs. We find that efficient wave transmission can be achieved by ‘resonant propagation’ or ‘resonant tunnelling’, even when stable layers are strongly stratified, and we call this phenomenon ‘enhanced wave transmission’. Enhanced wave transmission only occurs when the total number of layers is odd (embedding stable layers are alternatingly embedded within clamping convective layers, or vice versa). For wave propagation, the occurrence of enhanced wave transmission requires that the clamping layers have similar properties, the thickness of each clamping layer is close to a multiple of the half-wavelength of the corresponding propagative wave and the total thickness of the embedded layers is close to a multiple of the half-wavelength of the corresponding propagating wave (resonant propagation). For wave tunnelling, we have considered two cases: tunnelling of gravity waves and tunnelling of inertial waves. In both cases, efficient tunnelling requires that the clamping layers have similar properties, the thickness of each embedded layer is much smaller than the corresponding e-folding decay distance and the thickness of each clamping layer is close to a multiple-and-a-half of the half-wavelength (resonant tunnelling).
We aim to determine the correlation between parental rearing, personality traits, and obsessive–compulsive disorder (OCD) in different quantiles. In particular, we created an intermediary effect model in which parental rearing affects OCD through personality traits. All predictors were measured at the time of the survey, comprising parental rearing (paternal rearing and maternal rearing), demographics (grade and gender), and personality traits (neuroticism, extroversion, and psychoticism). These results suggest that (a) paternal emotional warmth was negatively correlated with OCD at the 0.40–0.80 quantile, while maternal emotional warmth was positively correlated with the OCD at the 0.45–0.69 quantile. (b) The correlation between negative parental rearing and OCD ranged from the 0.67 to 0.95 quantile for paternal punishment, 0.14–0.82 quantile for paternal overprotection, 0.05–0.36 and >0.50 quantile for maternal over-intervention and overprotection, and 0.08–0.88 quantile for maternal rejection. (c) Extroversion, neuroticism, and psychoticism were not only associated with OCD in a particular quantile but also mediated between parental rearing (namely parental emotional warmth, paternal punishment, paternal overprotection, maternal rejection, maternal over-intervention, and overprotection) and OCD. These findings provide targets for early interventions of OCD to improve the form of family education and personality traits and warrant validation.
To evaluate the effects of dietary Ca intake and Ca supplementation during pregnancy on low birth weight (LBW) and small for gestational age (SGA) infants.
Design:
A birth cohort study was conducted in 2010–2012 at the Gansu Provincial Maternity and Child Care Hospital in Lanzhou, China.
Setting:
A birth cohort study.
Participants:
Totally, 9595 pregnant women who came to the hospital for delivery at 20 weeks of gestation or more, and who were 18 years of age or older.
Results:
Compared with non-users, Ca supplement users had a reduced risk of LBW infants (OR = 0·77, 95 % CI: 0·63, 0·95) and a reduced risk of nulliparous women giving birth to LBW infants (OR = 0·75, 95 % CI: 0·58, 0·98) (P < 0·05). More specifically, both the use of Ca supplement before conception and during pregnancy (OR = 0·44, 95 % CI: 0·19, 0·99) and during pregnancy only (OR = 0·80, 95 % CI: 0·65, 0·99) had the main effect of reducing risk of nulliparous women giving birth to LBW infants (P < 0·05). There was no association between Ca supplementation and SGA (OR = 0·87, 95 % CI: 0·75, 1·01) (P > 0·05). However, higher dietary Ca intake during pregnancy decreases the risk of both LBW (quartile 2: OR = 0·72, 95 % CI: 0·55, 0·94; quartile 3: OR = 0·68, 95 % CI: 0·50, 0·62) and SGA infants (quartile 2: OR = 0·77, 95 % CI: 0·63, 0·95; quartile 3: OR = 0·71, 95 % CI: 0·57, 0·88, quartile 4: OR = 0·71, 95 % CI: 0·57, 0·88) (P < 0·05).
Conclusions:
Ca supplementation and adequate dietary intake of Ca during pregnancy are associated with a decreased risk of LBW infants born to nulliparous women.
Understanding the patterns of treatment response is critical for the treatment of patients with schizophrenia; one way to achieve this is through using a longitudinal dynamic process study design.
Aims
This study aims to explore the response trajectory of antipsychotics and compare the treatment responses of seven different antipsychotics over 6 weeks in patients with schizoprenia (trial registration: Chinese Clinical Trials Registry Identifier: ChiCTR-TRC-10000934).
Method
Data were collected from a multicentre, randomised open-label clinical trial. Patients were evaluated with the Positive and Negative Syndrome Scale (PANSS) at baseline and follow-up at weeks 2, 4 and 6. Trajectory groups were classified by the method of k-means cluster modelling for longitudinal data. Trajectory analyses were also employed for the seven antipsychotic groups.
Results
The early treatment response trajectories were classified into a high-trajectory group of better responders and a low-trajectory group of worse responders. The results of trajectory analysis showed differences compared with the classification method characterised by a 50% reduction in PANSS scores at week 6. A total of 349 patients were inconsistently grouped by the two methods, with a significant difference in the composition ratio of treatment response groups using these two methods (χ2 = 43.37, P < 0.001). There was no differential contribution of high- and low trajectories to different drugs (χ2 = 12.52, P = 0.051); olanzapine and risperidone, which had a larger proportion in the >50% reduction at week 6, performed better than aripiprazole, quetiapine, ziprasidone and perphenazine.
Conclusions
The trajectory analysis of treatment response to schizophrenia revealed two distinct trajectories. Comparing the treatment responses to different antipsychotics through longitudinal analysis may offer a new perspective for evaluating antipsychotics.
We investigate the three-dimensional surface pattern and nonlinear dynamics of a condensing liquid layer suspended from a cooled substrate and in contact with a mixture of its vapour and an inert gas below. A vapour boundary layer (VBL) is introduced, to which the changes in gaseous composition and temperature are assumed to be confined. An interfacial transport equation is derived, which incorporates the physical effects of convection and diffusion of vapour within the VBL, coupled with a long-wave evolution equation for the location of the free surface. This work extends the study of Kanatani (J. Fluid Mech., vol. 732, 2013, pp. 128–149) on a sessile evaporating film to the Rayleigh–Taylor unstable condensing/evaporating case with nonlinear analyses which also accounts for the effect of vapour recoil due to mass transfer on interfacial evolution and that of gravity combined with buoyancy on the internal convection of pendent drops in a condensate layer. The coupled nonlinear evolutionary system is referred to as a $1.5$-sided model. It can be reduced to the conventional one-sided model when phase change is limited by processes in the liquid. An extended basic state is obtained, whose stability is investigated with pseudo-steady linear theory and time-dependent nonlinear simulations. With the one-sided model, the influences of vapour recoil and Marangoni effects are illustrated with three representative cases. In the one-sided simulations with a random perturbation, the interface is prone to finite-time rupture and the surface patterns feature isolated droplets when vapour recoil is significant, while it becomes more regular and even without rupture as vapour recoil is weakened relative to the Marangoni effect. This suggests that, in the absence of the convection and diffusion of vapour, the destabilizations of vapour recoil and negative gravity could prevail over the stabilizations of thermocapillarity, capillarity, viscous dissipation and mass gain. With an unsaturated initial interface concentration, $\tilde {x}_{A,I0}$, the $1.5$-sided model indicates that the liquid layer can be stabilized to a quasi-hexagon pattern and the Rayleigh–Taylor-driven rupture can be suppressed with the effects of vapour convection and diffusion near the interface. However, the initial dynamics is in contrast to the case with a saturated $\tilde {x}_{A,I0}$, where transition from weak evaporation to a condensation-dominated regime is seen in the later stage. The viewpoint of stability competition offers vital evidence for an induced Marangoni stabilization, which is a quintessential characteristic of the $1.5$-sided model. Comparisons of the theory and simulations with available experiments are included throughout.
Data on average iodine requirements for the Chinese population are limited following implementation of long-term universal salt iodisation. We explored the minimum iodine requirements of young adults in China using a balance experiment and the ‘iodine overflow’ hypothesis proposed by our team. Sixty healthy young adults were enrolled to consume a sequential experimental diet containing low, medium and high levels of iodine (about 20, 40 and 60 μg/d, respectively). Each dose was consumed for 4 d, and daily iodine intake, excretion and retention were assessed. All participants were in negative iodine balance throughout the study. Iodine intake, excretion and retention differed among the three iodine levels (P < 0·01 for all groups). The zero-iodine balance derived from a random effect model indicated a mean iodine intake of 102 μg/d, but poor correlation coefficients between observed and predicted iodine excretion (r 0·538 for μg/d data) and retention (r 0·304 for μg/d data). As iodine intake increased from medium to high, all of the increased iodine was excreted (‘overflow’) through urine and faeces by males, and 89·5 % was excreted by females. Although the high iodine level (63·4 μg/d) might be adequate in males, the corresponding level of 61·6 μg/d in females did not meet optimal requirements. Our findings indicate that a daily iodine intake of approximately half the current recommended nutrient intake (120 μg/d) may satisfy the minimum iodine requirements of young male adults in China, while a similar level is insufficient for females based on the ‘iodine overflow’ hypothesis.
Vision and language are two fundamental capabilities of human intelligence. Humans routinely perform tasks through the interactions between vision and language, supporting the uniquely human capacity to talk about what they see or hallucinate a picture on a natural-language description. The valid question of how language interacts with vision motivates us researchers to expand the horizons of computer vision area. In particular, “vision to language” is probably one of the most popular topics in the past 5 years, with a significant growth in both volume of publications and extensive applications, e.g. captioning, visual question answering, visual dialog, language navigation, etc. Such tasks boost visual perception with more comprehensive understanding and diverse linguistic representations. Going beyond the progresses made in “vision to language,” language can also contribute to vision understanding and offer new possibilities of visual content creation, i.e. “language to vision.” The process performs as a prism through which to create visual content conditioning on the language inputs. This paper reviews the recent advances along these two dimensions: “vision to language” and “language to vision.” More concretely, the former mainly focuses on the development of image/video captioning, as well as typical encoder–decoder structures and benchmarks, while the latter summarizes the technologies of visual content creation. The real-world deployment or services of vision and language are elaborated as well.