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Nutritional therapy is a cornerstone of burns management. The optimal macronutrient intake for wound healing after burn injury has not been identified, although high-energy, high-protein diets are favoured. This study aimed to identify the optimal macronutrient intake for burn wound healing. The Geometric Framework (GF) was used to analyse wound healing after a 10% TBSA contact burn in mice ad libitum fed one of 11 high-energy diets, varying in macronutrient composition with protein (P5%-60%), carbohydrate (C20%-75%) and fat (F20%-75%). In the GF study, the optimal ratio for wound healing was identified as a moderate-protein, high-carbohydrate diet with a protein:carbohydrate:fat (P:C:F) ratio of 1:4:2. High-carbohydrate intake was associated with lower mortality, improved body weight and a beneficial pattern of body fat reserves. Protein intake was essential to prevent weight loss and mortality, but a protein intake target of ~7 kJ/day (~15% of energy intake) was identified, above which no further benefit was gained. High-protein intake was associated with delayed wound healing and increased liver and spleen weight. As the GF study demonstrated that an initial very high-protein intake prevented mortality, a very high-protein, moderate-carbohydrate diet (P40:C42:F18) was specifically designed. The dynamic diet study was also designed to combine and validate the benefits of an initial very high-protein intake for mortality, and subsequent moderate-protein, high-carbohydrate intake for optimal wound healing. The dynamic feeding experiment showed switching from an initial very high-protein diet to the optimal moderate-protein, high-carbohydrate diet accelerated wound healing whilst preventing mortality and liver enlargement.
Aristotle's Ethica Eudemia (Eth. Eud.) and Ethica Nicomachea (Eth. Nic.), as is well known and much discussed, contain three books in common (Eth. Eud. 4–6 = Eth. Nic. 5–7). Less well known, at least until Dieter Harlfinger alerted scholars to the fact in 1971, is that some of the manuscripts of Eth. Eud. do, contrary to the then prevailing consensus, contain the text of these common books. Even less well known is that Harlfinger's discovery was anticipated some 50 years before by Walter Ashburner, who had uncovered this fact about Eth. Eud. MSS in the Laurentian library of Florence. Ashburner's anticipation of Harlfinger, however, is not the real value of his article. Its value rather is that it contains collations of readings for the common books, and thereby gives us an excellent resource for examining the text of the common books as this text is contained in exclusively Eth. Eud. MSS. The Eth. Eud. tradition of the common books has hitherto received little attention. Modern editions of Eth. Eud. do not include these books, and editions of Eth. Nic. have other MSS for the purpose. Ashburner's collations are the more valuable because they are taken from (among others) the one MS that, in Harlfinger's learned stemma, appears as the archetype for all the rest.