Recent studies of Middle Paleolithic lithic assemblages have focused on questions of interest to lithic analysts everywhere, including the effect of raw material availability, occupation span, and tool maintenance on assemblage characteristics. In this paper, we add to the growing database on Middle Paleolithic assemblages using material recently excavated at Combe-Capelle Bas in the Dordogne region of southern France. The site provides a unique opportunity for addressing questions concerning lithic assemblage variability because it is located on a high quality flint source. We present data on core reduction, blank selection, raw material procurement, and lithic transport that provide information on lithic use pertinent for both Old World and New World archaeologists. Our data show that raw material availability and group mobility influenced blank selection, production, and transport at Combe-Capelle.