Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

5 results

  • Brain Imaging Abnormalities in Mixed Alzheimer’s and Subcortical Vascular Dementia
  • Hyunwoo Lee, Vanessa Wiggermann, Alexander Rauscher, Christian Kames, Mirza Faisal Beg, Karteek Popuri, Roger Tam, Kevin Lam, Claudia Jacova, Elham Shahinfard, Vesna Sossi, Jacqueline A. Pettersen, Ging-Yuek Robin Hsiung
  • Journal: Canadian Journal of Neurological Sciences , First View
  • Published online by Cambridge University Press: 26 May 2022, pp. 1-14
    • Article
      • You have access
      • Open access
    • PDF
    • HTML
    • Export citation
  • View abstract
    Background:

    A large proportion of Alzheimer’s disease (AD) patients have coexisting subcortical vascular dementia (SVaD), a condition referred to as mixed dementia (MixD). Brain imaging features of MixD presumably include those of cerebrovascular disease and AD pathology, but are difficult to characterize due to their heterogeneity.

    Objective:

    To perform an exploratory analysis of conventional and non-conventional structural magnetic resonance imaging (MRI) abnormalities in MixD and to compare them to those observed in AD and SVaD.

    Methods:

    We conducted a cross-sectional, region-of-interest-based analysis of 1) hyperintense white-matter signal abnormalities (WMSA) on T2-FLAIR and hypointense WMSA on T1-weighted MRI; 2) diffusion tensor imaging; 3) quantitative susceptibility mapping; and 4) effective transverse relaxation rate (R2*) in N = 17 participants (AD:5, SVaD:5, MixD:7). General linear model was used to explore group differences in these brain imaging measures.

    Results:

    Model findings suggested imaging characteristics specific to our MixD group, including 1) higher burden of WMSAs on T1-weighted MRI (versus both AD and SVaD); 2) frontal lobar preponderance of WMSAs on both T2-FLAIR and T1-weighted MRI; 3) higher fractional anisotropy values within normal-appear white-matter tissues (versus SVaD, but not AD); and 4) lower R2* values within the T2-FLAIR WMSA areas (versus both AD and SVaD).

    Conclusion:

    These findings suggest a preliminary picture of the location and type of brain imaging characteristics associated with MixD. Future imaging studies may employ region-specific hypotheses to distinguish MixD more rigorously from AD or SVaD.

  • A Novel PS1 Gene Mutation in a Large Aboriginal Kindred
  • Rachel Butler, B. Lynn Beattie, Umamon Puang Thong, Emily Dwosh, Colleen Guimond, Howard H. Feldman, Ging-Yuek Robin Hsiung, Ekaterina Rogaeva, Peter St. George-Hyslop, A. Dessa Sadovnick
  • Journal: Canadian Journal of Neurological Sciences / Volume 37 / Issue 3 / May 2010
  • Published online by Cambridge University Press: 02 December 2014, pp. 359-364
    • Article
      • You have access
    • PDF
    • Export citation
  • View abstract
    Background:

    There is currently little information on the genetic epidemiology of Alzheimer disease (AD) among North American Aboriginal populations. No cases of familialAD (FAD) in these populations have been published to date.

    Methods:

    Here, we describe a large North American Aboriginal kindred with early onset FAD (EOFAD) in which genetic testing was done.

    Results and Conclusions:

    A novel Presenilin 1 (PS1) gene mutation (L250F) has been identified. In contrast to the three previously reported families with PS1 codon 250 mutations, affected members of this kindred demonstrate neither myoclonus nor seizures. Furthermore, the identification of a PS1 mutation in a North American Aboriginal kindred presents several unique challenges with respect to knowledge transfer and continuity of care in a geographically remote and culturally distinct community.

  • Case 13 - A lady with weakness, fasciculations, and failing memory
  • Edited by Serge Gauthier, McGill University, Montréal, Pedro Rosa-Neto, McGill University, Montréal
  • Book: Case Studies in Dementia
  • Published online: 16 May 2011
  • Print publication: 21 April 2011, pp 90-97
  • View abstract

    Summary

    This chapter presents the case of a 72-year-old man with a 10-year history of Parkinson's disease. He experienced visual hallucinations with preserved insight 2 years previously, subsiding on withdrawal of selegiline. Physical examination revealed a fairly symmetric and moderately severe parkinsonian syndrome, with akinetic-rigid features dominant and little in the way of rest tremor. The initial diagnostic impression was of a dementia syndrome relating to his Parkinson's disease, although the doctor was initially uncomfortable with what he regarded as a normal mini-mental state examination (MMSE) score of 27 out of 30. After 3 and 6 months, repeat MMSE scores were 23 and 25, respectively. Despite some initial diagnostic uncertainty, the patient was commenced on a cholinesterase inhibitor with considerable improvement in his psychotic features and lessening of his periods of confusion. Rationalization of anti-parkinsonian and other medications is an important first step in the management of PD-D.
  • Case 15 - Young man with progressive speech impairment and weakness
  • Edited by Serge Gauthier, McGill University, Montréal, Pedro Rosa-Neto, McGill University, Montréal
  • Book: Case Studies in Dementia
  • Published online: 16 May 2011
  • Print publication: 21 April 2011, pp 105-114
  • View abstract

    Summary

    This chapter presents a case of a 54 year old man Mr. H who had some neurotic personality features associated with some impulsivity. A majority of patients develop neuropsychiatric symptoms, also called behavioral and psychological symptoms of dementia (BPSD) during the course of their illnesses. Neuropsychiatrie symptoms are primary manifestations of the disease process, but other psychological and social factors also play a role in determining which patients will manifest behavioral symptoms. For Mr. H, irritability, anxiety, and delusion are related both to the personal history of the patient and his wife. They are also the consequences of the cognitive deficit and the patient psychological reaction to the perception of his memory loss. Mr. H. has a major loss of self-initiated behavior and interest. However, he is able to respond to external cognitive and emotional stimulation. This helps in choosing the best non-pharmacological strategies.