ABSTRACT IMPACT: This qualitative study describes health system barriers to high-quality care for Latino older adults with Alzheimer’s Disease and Related Dementias OBJECTIVES/GOALS: Compared to non-Latino Whites, Latino older adults are more likely to receive low-quality dementia care such as high-risk medications or services. Caregivers play a critical role in managing medical care for persons with dementia (PWD). Yet little is known about the perceptions and knowledge of dementia quality of care among Latino caregivers of PWD. METHODS/STUDY POPULATION: We used a qualitative research design and conducted interviews with Latino caregivers of PWD and caregiver advocates. We recruited both from community organizations, senior centers, and clinics. Our interview guide focused on experiences of caregiving, interactions with medical system, and knowledge and experiences managing behavioral and eating problems. We used Grounded Theory methodology for coding and analysis, focusing on contrasting and comparing experiences within and between caregivers and caregiver advocates. RESULTS/ANTICIPATED RESULTS: Preliminary results from interviews with two caregivers and two caregiver advocates illustrate that caregivers of persons with dementia have a difficult time receiving high quality care from primary care clinicians. All participants noted that many primary care doctors didn’t know how to diagnose ADRD and dismissed critical symptoms as part of old age. Caregivers also reported that they wished they had more information on what to expect with ADRD disease progression, noting they received little information from the formal medical care system. With respect to behavioral problems, caregiver advocates noted that primary care doctors often did not provide non-pharmacological alternatives to behavioral problems. DISCUSSION/SIGNIFICANCE OF FINDINGS: Findings from our pilot study demonstrate that there is a clear need to train primary care physicians who serve Latino older adults on ADRD care. Improved diagnosis and management could improve outcomes among Latino older adults with dementia.

We report the structure and synthesis approach for obtaining a ceramic nanocomposite pellet comprising ∼50 nm-sized TaC nanoparticles. A mixture of Ta metal powder and the carbon precursor 1,2,4,5-tetraphenylethynyl benzene, pelletized by vacuum pressing at 131 MPa, on further thermal treatment with Ar at 1400 °C yields such a ceramic composite. On air oxidation, the TaC nanoparticles are converted to Ta2O5 nanoparticles at 760 °C. Hardness measurements revealed that the composite exhibited a global hardness in the range of 1.23–1.57 GPa. However, nanoindentation studies showed that, locally, hardness of the TaC nanoparticles (∼15 GPa) approached that of the densified TaC ceramic. Superconducting studies of the pellet consistently exhibited two transitions with T c values of 10 K and 8.5 K, respectively, that corresponded to bulk TaC and to a component of unknown origin. The results discuss the morphological and constitutional characterizations of the TaC nanoparticle-containing composite.

The genome of bread wheat is hexaploid and contains 1·6×1010 bp of DNA, of which more than 80% is repetitive sequences. Its size and complexity represent a challenge for the isolation of agronomically important genes, for which we frequently know only their position on the genetic map. Recently, new genomic resources and databases from genome projects have simplified the molecular analysis of the wheat genome. The first genes to be isolated from wheat by map-based cloning include three resistance genes against the fungal diseases powdery mildew and leaf rust. In this review, we will describe the approaches and resources that have contributed to this progress, and discuss genomic strategies that will simplify positional cloning in wheat in the near future.