Book contents
- Frontmatter
- Contents
- CONTRIBUTORS
- PREFACE
- Chap 1 OVERVIEW OF SOFT TISSUE TUMORS
- Chap 2 RADIOLOGIC EVALUATION OF SOFT TISSUE TUMORS
- Chap 3 IMMUNOHISTOCHEMISTRY OF SOFT TISSUE TUMORS
- Chap 4 GENETICS OF SOFT TISSUE TUMORS
- Chap 5 MOLECULAR GENETICS OF SOFT TISSUE TUMORS
- Chap 6 FIBROBLAST BIOLOGY, FASCIITIS, RETROPERITONEAL FIBROSIS, AND KELOIDS
- Chap 7 FIBROMAS AND BENIGN FIBROUS HISTIOCYTOMAS
- Chap 8 FIBROMATOSES
- Chap 9 BENIGN FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS IN CHILDREN
- Chap 10 CHILDHOOD FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS OF VARIABLE BIOLOGIC POTENTIAL
- Chap 11 MYXOMAS AND OSSIFYING FIBROMYXOID TUMOR
- Chap 12 SOLITARY FIBROUS TUMOR, HEMANGIOPERICYTOMA, AND RELATED TUMORS
- Chap 13 FIBROBLASTIC AND MYOFIBROBLASTIC NEOPLASMS WITH MALIGNANT POTENTIAL
- Chap 14 LIPOMA VARIANTS AND CONDITIONS SIMULATING LIPOMATOUS TUMORS
- Chap 15 ATYPICAL LIPOMATOUS TUMOR AND LIPOSARCOMAS
- Chap 16 SMOOTH MUSCLE TUMORS
- Chap 17 GASTROINTESTINAL STROMAL TUMOR
- Chap 18 STROMAL TUMORS AND TUMOR-LIKE LESIONS OF THE FEMALE GENITAL TRACT
- Chap 19 ANGIOMYOLIPOMA AND RELATED TUMORS (PERIVASCULAR EPITHELIOID CELL TUMORS)
- Chap 20 RHABDOMYOMAS AND RHABDOMYOSARCOMAS
- Chap 21 HEMANGIOMAS, LYMPHANGIOMAS, AND REACTIVE VASCULAR PROLIFERATIONS
- Chap 22 HEMANGIOENDOTHELIOMAS, ANGIOSARCOMAS, AND KAPOSI'S SARCOMA
- Chap 23 GLOMUS TUMOR, SINONASAL HEMANGIOPERICYTOMA, AND MYOPERICYTOMA
- Chap 24 NERVE SHEATH TUMORS
- Chap 25 NEUROECTODERMAL TUMORS: MELANOCYTIC, GLIAL, AND MENINGEAL NEOPLASMS
- Chap 26 PARAGANGLIOMAS
- Chap 27 PRIMARY SOFT TISSUE TUMORS WITH EPITHELIAL DIFFERENTIATION
- Chap 28 MALIGNANT MESOTHELIOMA AND OTHER MESOTHELIAL PROLIFERATIONS
- Chap 29 MERKEL CELL CARCINOMA AND METASTATIC AND SARCOMATOID CARCINOMAS INVOLVING SOFT TISSUE
- Chap 30 CARTILAGE- AND BONE-FORMING TUMORS AND TUMOR-LIKE LESIONS
- Chap 31 SMALL ROUND CELL TUMORS
- Chap 32 ALVEOLAR SOFT PART SARCOMA
- Chap 33 PATHOLOGY OF SYNOVIA AND TENDONS
- Chap 34 MISCELLANEOUS TUMOR-LIKE LESIONS, AND HISTIOCYTIC AND FOREIGN BODY REACTIONS
- Chap 35 LYMPHOID, MYELOID, HISTIOCYTIC, AND DENDRITIC CELL PROLIFERATIONS IN SOFT TISSUES
- Chap 36 CYTOLOGY OF SOFT TISSUE LESIONS
- Chap 37 SURGICAL MANAGEMENT OF SOFT TISSUE SARCOMA: HISTOLOGIC TYPE AND GRADE GUIDE SURGICAL PLANNING AND INTEGRATION OF MULTIMODALITY THERAPY
- Chap 38 MEDICAL ONCOLOGY OF SOFT TISSUE SARCOMAS
- Index
- References
Chap 29 - MERKEL CELL CARCINOMA AND METASTATIC AND SARCOMATOID CARCINOMAS INVOLVING SOFT TISSUE
Published online by Cambridge University Press: 01 March 2011
- Frontmatter
- Contents
- CONTRIBUTORS
- PREFACE
- Chap 1 OVERVIEW OF SOFT TISSUE TUMORS
- Chap 2 RADIOLOGIC EVALUATION OF SOFT TISSUE TUMORS
- Chap 3 IMMUNOHISTOCHEMISTRY OF SOFT TISSUE TUMORS
- Chap 4 GENETICS OF SOFT TISSUE TUMORS
- Chap 5 MOLECULAR GENETICS OF SOFT TISSUE TUMORS
- Chap 6 FIBROBLAST BIOLOGY, FASCIITIS, RETROPERITONEAL FIBROSIS, AND KELOIDS
- Chap 7 FIBROMAS AND BENIGN FIBROUS HISTIOCYTOMAS
- Chap 8 FIBROMATOSES
- Chap 9 BENIGN FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS IN CHILDREN
- Chap 10 CHILDHOOD FIBROBLASTIC AND MYOFIBROBLASTIC PROLIFERATIONS OF VARIABLE BIOLOGIC POTENTIAL
- Chap 11 MYXOMAS AND OSSIFYING FIBROMYXOID TUMOR
- Chap 12 SOLITARY FIBROUS TUMOR, HEMANGIOPERICYTOMA, AND RELATED TUMORS
- Chap 13 FIBROBLASTIC AND MYOFIBROBLASTIC NEOPLASMS WITH MALIGNANT POTENTIAL
- Chap 14 LIPOMA VARIANTS AND CONDITIONS SIMULATING LIPOMATOUS TUMORS
- Chap 15 ATYPICAL LIPOMATOUS TUMOR AND LIPOSARCOMAS
- Chap 16 SMOOTH MUSCLE TUMORS
- Chap 17 GASTROINTESTINAL STROMAL TUMOR
- Chap 18 STROMAL TUMORS AND TUMOR-LIKE LESIONS OF THE FEMALE GENITAL TRACT
- Chap 19 ANGIOMYOLIPOMA AND RELATED TUMORS (PERIVASCULAR EPITHELIOID CELL TUMORS)
- Chap 20 RHABDOMYOMAS AND RHABDOMYOSARCOMAS
- Chap 21 HEMANGIOMAS, LYMPHANGIOMAS, AND REACTIVE VASCULAR PROLIFERATIONS
- Chap 22 HEMANGIOENDOTHELIOMAS, ANGIOSARCOMAS, AND KAPOSI'S SARCOMA
- Chap 23 GLOMUS TUMOR, SINONASAL HEMANGIOPERICYTOMA, AND MYOPERICYTOMA
- Chap 24 NERVE SHEATH TUMORS
- Chap 25 NEUROECTODERMAL TUMORS: MELANOCYTIC, GLIAL, AND MENINGEAL NEOPLASMS
- Chap 26 PARAGANGLIOMAS
- Chap 27 PRIMARY SOFT TISSUE TUMORS WITH EPITHELIAL DIFFERENTIATION
- Chap 28 MALIGNANT MESOTHELIOMA AND OTHER MESOTHELIAL PROLIFERATIONS
- Chap 29 MERKEL CELL CARCINOMA AND METASTATIC AND SARCOMATOID CARCINOMAS INVOLVING SOFT TISSUE
- Chap 30 CARTILAGE- AND BONE-FORMING TUMORS AND TUMOR-LIKE LESIONS
- Chap 31 SMALL ROUND CELL TUMORS
- Chap 32 ALVEOLAR SOFT PART SARCOMA
- Chap 33 PATHOLOGY OF SYNOVIA AND TENDONS
- Chap 34 MISCELLANEOUS TUMOR-LIKE LESIONS, AND HISTIOCYTIC AND FOREIGN BODY REACTIONS
- Chap 35 LYMPHOID, MYELOID, HISTIOCYTIC, AND DENDRITIC CELL PROLIFERATIONS IN SOFT TISSUES
- Chap 36 CYTOLOGY OF SOFT TISSUE LESIONS
- Chap 37 SURGICAL MANAGEMENT OF SOFT TISSUE SARCOMA: HISTOLOGIC TYPE AND GRADE GUIDE SURGICAL PLANNING AND INTEGRATION OF MULTIMODALITY THERAPY
- Chap 38 MEDICAL ONCOLOGY OF SOFT TISSUE SARCOMAS
- Index
- References
Summary
A Merkel cell carcinoma is a primary cutaneous neuroendocrine carcinoma that often involves soft tissue, especially the subcutis. Metastatic carcinomas are common diagnostic problems, especially in determining their primary origin. When sarcomatoid, carcinomas often simulate primary soft tissue sarcomas. The discussion of carcinomas from specific sources is therefore twofold in this chapter: (1) histologic features and specific markers to evaluate the site of origin, and (2) problems related to sarcomatoid carcinomas of a particular organ site or tumor type. This chapter includes the most common carcinomas, and selected practical, well-established, and important markers are emphasized. Clinical or radiologic correlation is always necessary to confirm the primary site for a metastasis from an unknown source. Carcinosarcoma of the gynecological tract is discussed in Chapter 18.
MERKEL CELL CARCINOMA (PRIMARY NEUROENDOCRINE CARCINOMA OF THE SKIN, TRABECULAR CARCINOMA OF THE SKIN)
Merkel cell carcinoma is a distinctive, relatively rare primary cutaneous or subcutaneous high-grade neuroendocrine carcinoma, originally reported as trabecular carcinoma of the skin by Toker in 1972. Its ultrastructural resemblance to Merkel cells, the cutaneous neuroendocrine cells that are scattered in the basal epidermis and hair shafts, led to its being named Merkel cell carcinoma during the early 1980s. Positivity for keratin 20 also mirrors Merkel cells, but in neurofilament positivity it differs from normal Merkel cells. Therefore, the histogenetic origin of Merkel cell carcinoma from Merkel cells is not uniformly agreed on, and some authors prefer the designation of primary neuroendocrine carcinoma of the skin.
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- Modern Soft Tissue PathologyTumors and Non-Neoplastic Conditions, pp. 834 - 861Publisher: Cambridge University PressPrint publication year: 2010