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10.6 - Environmental Causes of Neurodegenerative Disease

from 10 - Neurodegeneration

Published online by Cambridge University Press:  08 November 2023

Mary-Ellen Lynall
Affiliation:
University of Cambridge
Peter B. Jones
Affiliation:
University of Cambridge
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

In the seminal report of the Lancet Commission on dementia [54] the identification of contributory risk factors, their effect size and their modifiabilty, led to a startling conclusion: as much as 40% of dementia could be prevented by immediate application of known interventions. Not by a novel disease-modifying treatment but a systematic approach to resolve and reduce risk factors across the lifespan. Early-life education; mid-life obesity, hypertension and hearing loss; and later life exercise, smoking, social isolation, diabetes, depression and pollution contribute to this potential for dementia prevention.

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Publisher: Cambridge University Press
Print publication year: 2023

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