Book contents
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 10 Neurodegeneration
- 10.1 A Neurodegenerative Cascade of Causality
- 10.2 Prodromal Disease and Mild Cognitive Impairment
- 10.3 Preclinical Stages of Neurodegenerative Disease
- 10.4 Spectra, Domains and Dimensions of Neurodegenerative Disease
- 10.5 Reserve, Resilience and Resistance to Neurodegeneration
- 10.6 Environmental Causes of Neurodegenerative Disease
- 10.7 Comorbidity and Dual Pathology in Neurodegenerative Disorders
- Index
10.3 - Preclinical Stages of Neurodegenerative Disease
from 10 - Neurodegeneration
Published online by Cambridge University Press: 08 November 2023
- Cambridge Textbook Of Neuroscience for Psychiatrists
- Reviews
- Cambridge Textbook of Neuroscience for Psychiatrists
- Copyright page
- Contents
- Contributors
- Introduction
- 1 Cells
- 2 Neurotransmitters and Receptors
- 3 Basic Techniques in Neuroscience
- 4 Neuroanatomy
- 5 Neural Circuits
- 6 Modulators
- 7 Genetics
- 8 Neurodevelopment and Neuroplasticity
- 9 Integrated Neurobiology of Specific Syndromes and Treatments
- 10 Neurodegeneration
- 10.1 A Neurodegenerative Cascade of Causality
- 10.2 Prodromal Disease and Mild Cognitive Impairment
- 10.3 Preclinical Stages of Neurodegenerative Disease
- 10.4 Spectra, Domains and Dimensions of Neurodegenerative Disease
- 10.5 Reserve, Resilience and Resistance to Neurodegeneration
- 10.6 Environmental Causes of Neurodegenerative Disease
- 10.7 Comorbidity and Dual Pathology in Neurodegenerative Disorders
- Index
Summary
The advent of biomarkers highlighted the pre-symptomatic stage of neurodegenerative disease, among apparently healthy adults with normal cognition (Figure 10.3.1A). This preclinical stage comes before the period of mild early symptoms and signs, which is called the prodromal phase. With genetic aetiology, one can study healthy pre-symptomatic adult mutation carriers many years before symptoms. This is underway through international collaborations such as the Dominantly Inherited Alzheimer Network, the Genetic Frontotemporal Dementia Initiative and Parkinson’s Progression Markers Initiative genetic cohort. These international collaborations have much in common, with large cohorts (500–1,500) of patients and healthy first-degree relatives; followed longitudinally with ‘deep phenotyping’ of multiple blood, cerebrospinal fluid and imaging biomarkers and neuropsychological evaluation.
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- Information
- Cambridge Textbook of Neuroscience for Psychiatrists , pp. 563 - 566Publisher: Cambridge University PressPrint publication year: 2023