Skip to main content Accessibility help
×
Hostname: page-component-76fb5796d-x4r87 Total loading time: 0 Render date: 2024-04-28T00:33:22.737Z Has data issue: false hasContentIssue false

11A - Intralipid Therapy Has a Place in Infertility Treatment

For

from Section II - IVF Add-ons

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
Get access

Summary

Successful implantation depends on balanced immunological network. This fact is widely recognised, but the exact mechanism and the interaction between maternal and fetal components of this complex system are not entirely understood and ongoing research brings constant development in this area. Any imbalance to this system may lead to recurrent miscarriage and implantation failure. Increased numbers and cytotoxic activity of NK cells have been reported in women with reproductive failures and recurrent miscarriage. A number of studies reported that Intralipid infusion may modulate immune function with suppression of NK cytotoxicity and pro-inflammatory cytokine generation. Data analysing the use of intralipids in fertility is sparse; however, the existent data is encouraging. Studies have demonstrated improvement in biochemical and clinical pregnancy, implantation and baby birth rates.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Thum, MY, Bhaskaran, S, Abdalla, HI., et al. An increase in the absolute count of CD56dimCD16+CD69+ NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome. Hum Reprod. 2004 Oct;19(10):2395–400.CrossRefGoogle ScholarPubMed
Zhou, P, Wu, H, Lin, X, Wang, S, Zhang, S. The effect of intralipid on pregnancy outcomes in women with previous implantation failure in in vitro fertilization/intracytoplasmic sperm injection cycles: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2020 Sept;252:187–92.CrossRefGoogle ScholarPubMed
Roussev, RG, Acacio, B, Ng, SC, Coulam, CB. Duration of intralipid’s suppressive effect on NK cell’s functional activity. Am J Reprod Immunol. 2008 Sept;60(3):258–63.CrossRefGoogle ScholarPubMed
Roussev, RG, Ng, SC, Coulam, CB. Natural killer cell functional activity suppression by intravenous immunoglobulin, intralipid and soluble human leukocyte antigen-G. Am J Reprod Immunol. 2007 April;57(4):262–9.CrossRefGoogle ScholarPubMed
Singh, N, Davis, AA, Kumar, S, Kriplani, A. The effect of administration of intravenous intralipid on pregnancy outcomes in women with implantation failure after IVF/ICSI with non-donor oocytes: A randomised controlled trial. Eur J Obstet Gynecol Reprod Biol. 2019 Sept;240:4551.CrossRefGoogle ScholarPubMed
Mekinian, A, Cohen, J, Alijotas-Reig, J, et al. Unexplained recurrent miscarriage and recurrent implantation failure: is there a place for immunomodulation? Am J Reprod Immunol. 2016 July;76(1):828.CrossRefGoogle Scholar
Ndukwe, G. Recurrent embryo implantation failure after in vitro fertilisation: improved outcome following intralipid infusion in women with elevated T helper 1 response. Hum Fertil. 2011;14:21–2.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×