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8A - There Is a Role for Pre-conceptional Treatment with CoQ10

For

from Section II - IVF Add-ons

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

Making evidence-based decisions with a common primary outcome measure is a key tenet of ethical and effective clinical practice in ART in a rapidly evolving scientific landscape. However, interpretation of the evidence must be underpinned by sound biological reasoning, and this is especially true when it comes to adjunct antioxidant supplementation in IVF. Furthermore, study design for assessing natural compounds is typically based on protocols established to assess drug-based therapies that often fail to effectively evaluate efficacy of individual nutrients that occur naturally in vivo and often groups study patients together with many differing aetiologies. Finally, the gold standard in terms of IVF outcome measure is live birth rate (LBR), but it is vital that we move beyond this narrow perspective and consider obstetric and child health outcomes. With this in mind I will describe the role for pre-conceptional treatment with CoQ10.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2021

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References

Ramalho-Santos, R, Varum, S, Amaral, S, et al. Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells. Hum Reprod. Update 2009;15(5):553–72.CrossRefGoogle ScholarPubMed
Díaz-Casado, ME, Quiles, JL, Barriocanal-Casado, E, et al. The paradox of coenzyme Q10 in aging. Nutrients. 2019;11(9):2221.CrossRefGoogle ScholarPubMed
Ben-Meir, A, Yahalomi, S, Moshe, B, Shufaro, Y, Reubinoff, B, Saada, A. Coenzyme Q-dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging. Fertil Steril. 2015;104(3):724–7.CrossRefGoogle ScholarPubMed
Bentov, Y, Hannam, T, Jurisicova, A, Esfandiari, N, Casper, RF. Coenzyme Q10 supplementation and oocyte aneuploidy in women undergoing IVF-ICSI treatment. Clin Med Insights Reprod Health. 2014;8:31–6.CrossRefGoogle ScholarPubMed
Zhang, Y, Zhang, C, Shu, J, et al. Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis. Hum Reprod Update. 2020;26(2):247–63.CrossRefGoogle ScholarPubMed
Xu, Y, Nisenblat, V, Lu, C, et al. Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018;16(1):29.CrossRefGoogle ScholarPubMed
Florou, P, Anagnostis, P, Theocharis, P, Chourdakis, M, Goulis, D. Does coenzyme Q10 supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials. J Assist Reprod Genet. 2020;37(10):2377–87.CrossRefGoogle ScholarPubMed
Hernández-Camacho, JD, Bernier, M, López-Lluch, G, Navas, P. Coenzyme Q10 supplementation in aging and disease. Front Physiol. 2018;9.CrossRefGoogle ScholarPubMed
Fan, L, Feng, Y, Chen, GC, Qin, LQ, Fu, CL, Chen, LH. Effects of coenzyme Q10 supplementation on inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2017;119:128–36.CrossRefGoogle ScholarPubMed
Stephenson, J, Heslehurst, N, Hall, J, et al. Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. The Lancet. 2018;391:10132.CrossRefGoogle ScholarPubMed

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