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Chapter Thirty Five - Cerebral Blood Flow, Radionuclides, and Positron Emission Tomography

from Imaging

Published online by Cambridge University Press:  13 December 2022

Louis R. Caplan
Affiliation:
Beth Israel Deaconess Medical Centre
Aishwarya Aggarwal
Affiliation:
John F. Kennedy Medical Center
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Summary

The development of radionuclides and positron emission tomography (PET) resulted from important discoveries and advancements in physics, chemistry, physiology, mathematics, and computer science, notably, the discovery of computerized tomography by Hounsfield (see Chapter 32) [1]. PET was the first-ever technique to allow mapping of brain perfusion and metabolism in three dimensions. Understanding of cerebral blood flow (CBF) and metabolism coupled with technological advancements made it possible to functionally image the brain in healthy and diseased individuals. PET studies critically contributed to deciphering the mechanisms underlying cerebrovascular disease and stroke, which led to a revolution in clinical practice [2].

Type
Chapter
Information
Stories of Stroke
Key Individuals and the Evolution of Ideas
, pp. 338 - 351
Publisher: Cambridge University Press
Print publication year: 2022

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References

Notes and References

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