Hostname: page-component-76fb5796d-22dnz Total loading time: 0 Render date: 2024-04-27T11:44:41.517Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of L-Triiodothyronine and Chlorpromazine on Ankle Reflex Time and a Clinical Thyroid Scale in Schizophrenics and Controls

Published online by Cambridge University Press:  29 January 2018

Eric D. West  and
C. J. S. Walter
Eric D. West
Affiliation:
Belmont Hospital, Sutton, Surrey
C. J. S. Walter
Affiliation:
St. Thomas' Hospital, S.E.1, and formerly Psychiatric Registrar, Belmont Hospital
Get access Rights & Permissions [Opens in a new window]

Extract

Claims have been made that thyroid hormone treatment benefits some schizophrenic patients. Earlier studies reported the use of dried thyroid in a dose of 48 gr. (2·9G) daily in a schizophrenic (Hoskins and Sleeper, 1929) and in other psychiatric states up to 60 gr. (3·6G) daily (Minski, 1927), but recent papers describe the use of l-triiodothyrgnine in place of dried thyroid in treating schizophrenics (Lochner, Scheuing and Flach, 1963; Flach, Celian and Rawson, 1958). Huxley, Mayr, Osmond and Hoffer (1964) believe that schizophrenics are more resistant to the effects of some physiological substances, including thyroxine, as part of a genetic polymorphism.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 509 , April 1968 , pp. 451 - 457
Copyright
Copyright © Royal College of Psychiatrists, 1968 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Fejér, A. Gy, and Kun, M. (1964). “The Achilles reflex” Lancet, ii, 695.Google Scholar
Flach, F. F., Celian, C. I., and Rawson, R. W. (1958). “Treatment of psychiatric disorders with triiodothyronine” Am. J. Psychiat., 114, 841–842.Google Scholar
Good, W. W., Sterling Mac, , and Holtzman, W. H. (1958). “Termination of chlorpromazine with schizophrenic patients” Ibid., 115, 443–448.Google Scholar
Henatsch, H-D., and Ingvar, D. H. (1956). “Chlorpromazin und Spastizität: Eine experimentelle elektrophysiologische Untersuchung” Arch. Psychiat. Ztschr. Neurol., 195, 77–93.Google Scholar
Hoskins, R. G., and Sleeper, F. H. (1929). “A case of hebephrenic dementia praecox with marked improvement under thyroid treatment” Endocrinology, 13, 459–466.Google Scholar
Huxley, J., Mayr, E., Osmond, H., and Hoffer, A. (1964). “Schizophrenia as a genetic morphism” Nature, 204, 220–221.Google Scholar
Lochner, K. H., Scheuing, M. R., and Flach, F. (1963). “The effect of l-triiodothyronine on chronic schizophrenic patients” Acta psychiat. Scand., 39, 413–426.Google Scholar
Minski, L. (1927). “Endocrine therapy” J. ment Sci., 73, 414–418.Google Scholar
Sherman, L., Goldberg, M., and Larson, F. C. (1963). “The Achilles reflex, a diagnostic test of thyroid function” Lancet, i, 243–245.Google Scholar
Smart, G. A., and Robson, A. M. (1963). “A simple method for recording Achilles tendon reflexes” Ibid., i, 363–364.Google Scholar
Wayne, E. J. (1960). “Clinical and metabolic studies in thyroid disease” Brit. med. J., i, 1–11.Google Scholar
West, E. D., and Walter, C. J. S. (1965). “Ankle jerk in psychiatric patients” Ibid., i, 447.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.