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Correlation of Clinical Features of Depressed Out-Patients with Response to Amitriptyline and Protriptyline

  • N. McConaghy (a1), A. D. Joffe (a2), W. R. Kingston (a3), H. G. Stevenson (a3), I. Atkinson (a3), E. Cole (a3) and L. A. Fennessy (a4)...

Extract

Considerable inconsistency exists in the literature concerning the clinical features of depression associated with a good response to anti-depressant medication. Abraham et al. (1963) summarized the literature to that date; the general consensus of opinion was that imipramine had its best effect in depressions of the endogenous rather than those of the neurotic type, but their study on depressed out-patients did not support this conclusion. Browne et al. (1963), working with in-patients, reported that reactive depressives showed a better response to amitriptyline than did endogenous depressives. Burt et al. (1962), in their report of the response of 73 depressed female in-patients treated with imipramine or amitriptyline, demonstrated a much better response to both drugs by reactive as compared with endogenous depressives. Spear et al. (1964) found no significant difference in respect to “endogenicity”, in the response of depressed in- and out-patients to tranylcypromine and imipramine. Richmond and Roberts (1964) reported that out-patients suffering from endogenous depression responded much better to a variety of anti-depressant drugs than did those suffering from reactive depression.

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Abraham, H. C., Kanter, V. B., Rosen, I., and Standen, J. L. (1963). “A controlled clinical trial of imipramine (Tofranil) with out-patients.” Brit. J. Psychiat., 109, 286293.
Browne, M. W., Kreeger, L. C., and Kazamias, N. G. (1963). “A clinical trial of amitriptyline in treatment of depressive states.” Ibid., 109, 692694.
Burt, C. G., Gordon, W. F., Holt, N. F., and Hordern, A. (1962). “Amitriptyline in depressive states: A controlled trial.” J. ment. Sci., 108, 711730.
Clinical Psychiatry Committee of the Medical Research Council (1965). “Clinical trial of the treatment of depressive illness.” Brit. med. J., i, 881886.
Fleminger, J. J., and Groden, B. M. (1962). “Clinical features of depression and the response to imipramine (Tofranil).” J. ment. Sci., 108, 101104.
Hamilton, M. H., and White, J. M. (1960). “Factors related to the outcome of depression treated with E.C.T.” Ibid., 106, 10311041.
Hobson, R. F. (1953). “Prognostic factors in electric convulsive therapy.” J. Neurol. Neurosurg. Psychiat., 16, 275281.
Kiloh, L. G., Ball, J. R. B., and Garside, R. F. (1962). “Prognostic factors in treatment of depressive states with imipramine.” Brit. med. J., i, 12251227.
Kiloh, L. G., and Garside, R. F. (1963). “The independence of neurotic and endogenous depression.” Brit. J. Psychiat., 109 451463.
McConaghy, N., Kingston, W. R., Stevenson, H. G., Atkinson, I., Cole, E., and Fennessy, L. A. (1965). “A controlled trial comparing amitriptyline and protriptyline in the treatment of out-patient depressives.” Med. J. Aust., ii, 403405.
McConaghy, N., Joffe, A. D., and Murphy, B. (1966). “The independence of neurotic and endogenous depression.” Brit. J. Psychiat., 113, 479484.
Mendels, J. (1965). “Electroconvulsive therapy and depression: II. Significance of endogenous and reactive depression.” Brit. J. Psychiat., 111, 682686.
Mendels, J. (1965). “Electroconvulsive therapy and depression: III. A method for prognosis.” Ibid., 111, 687690.
Richmond, P. W., and Roberts, A. H. (1964). “A comparative trial of imipramine, amitriptyline, isocarboxazid and tranylcypromine in out-patient depressive illness.” Ibid., 110, 846850.
Spear, F. G., Hall, P., and Stirland, J. D. (1964). “A comparison of subjective responses to imipramine and tranylcypromine.” Ibid., 110, 5355.
Wechsler, H., Grosser, G. H., and Greenblatt, M. (1965). “Research evaluating antidepressant medications on hospitalized mental patients: a survey of published reports during a five-year period.” J. nerv. ment. Dis., 141, 231239.

Correlation of Clinical Features of Depressed Out-Patients with Response to Amitriptyline and Protriptyline

  • N. McConaghy (a1), A. D. Joffe (a2), W. R. Kingston (a3), H. G. Stevenson (a3), I. Atkinson (a3), E. Cole (a3) and L. A. Fennessy (a4)...

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Correlation of Clinical Features of Depressed Out-Patients with Response to Amitriptyline and Protriptyline

  • N. McConaghy (a1), A. D. Joffe (a2), W. R. Kingston (a3), H. G. Stevenson (a3), I. Atkinson (a3), E. Cole (a3) and L. A. Fennessy (a4)...
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