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Association between vitamin B12 intake and EURRECA's prioritized biomarkers of vitamin B12 in young populations: a systematic review

  • Iris Iglesia (a1), Rosalie AM Dhonukshe-Rutten (a2), Silvia Bel-Serrat (a1), Esmée L Doets (a2), Adrienne EJM Cavelaars (a2), Pieter van ‘t Veer (a2), Mariela Nissenshohn (a3), Vassiliki Benetou (a4), María Hermoso (a5), Cristiana Berti (a6), Lisette CPGM de Groot (a2) and Luis A Moreno (a1)...
  • Please note a correction has been issued for this article.



To review evidence on the associations between vitamin B12 intake and its biomarkers, vitamin B12 intake and its functional health outcomes, and vitamin B12 biomarkers and functional health outcomes.


A systematic review was conducted by searching electronic databases, until January 2012, using a standardized strategy developed in the EURRECA network. Relevant articles were screened and sorted based on title and abstract, then based on full text, and finally included if they met inclusion criteria. A total of sixteen articles were included in the review.


Articles covered four continents: America (n 4), Europe (n 8), Africa (n 1) and Asia (n 3).


Population groups included healthy infants, children and adolescents, and pregnant and lactating women.


From the total number of 5815 papers retrieved from the initial search, only sixteen were eligible according to the inclusion criteria: five for infants, five for children and adolescents, and six for pregnant and lactating women.


Only one main conclusion could be extracted from this scarce number of references: a positive association between vitamin B12 intake and serum vitamin B12 in the infant group. Other associations were not reported in the eligible papers or the results were not provided in a consistent manner. The low number of papers that could be included in our systematic review is probably due to the attention that is currently given to research on vitamin B12 in elderly people. Our observations in the current systematic review justify the idea of performing well-designed studies on vitamin B12 in young populations.

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1.Roberts, SB & McDonald, R (1998) The evolution of a new research field: metabolic programming by early nutrition. J Nutr 128, Suppl. 2, 400S.
2.Hermoso, M (2010) The nutritional requirements of infants. Towards EU alignment of reference values: the EURRECA network. Matern Child Nutr 6, Suppl. 2, 5583.
3.Iglesia, I (2010) Physiological and public health basis for assessing micronutrient requirements in children and adolescents. The EURRECA network. Matern Child Nutr 6, Suppl. 2, 8499.
4.Hall Moran, V, Lowe, N, Crossland, Net al. (2010) Nutritional requirements during lactation. Towards European alignment of reference values: the EURRECA network. Matern Child Nutr 6, Suppl. 2, 3954.
5.Berti, C, Decsi, T, Dykes, Fet al. (2010) Critical issues in setting micronutrient recommendations for pregnant women: an insight. Matern Child Nutr 6, Suppl. 2, 522.
6.Doets, EL, de Wit, LS, Dhonukshe-Rutten, RAet al. (2008) Current micronutrient recommendations in Europe: towards understanding their differences and similarities. Eur J Nutr 47, Suppl. 1, 1740.
7.Serra-Majem, L & Aranceta Bartrina, J (2004) Nutrición infantil y juvenil. Estudio enKid. Barcelona: Masson.
8.Tucker, KL, Rich, S, Rosenberg, Iet al. (2000) Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study. Am J Clin Nutr 71, 514522.
9.Allen, LH (2008) Causes of vitamin B12 and folate deficiency. Food Nutr Bull 29, Suppl. 2, S20S34.
10.Bor, MV, Lydeking-Olsen, E, Moller, Jet al. (2006) A daily intake of approximately 6 microg vitamin B-12 appears to saturate all the vitamin B-12-related variables in Danish postmenopausal women. Am J Clin Nutr 83, 5258.
11.Vogiatzoglou, A, Smith, AD, Nurk, Eet al. (2009) Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. Am J Clin Nutr 89, 10781087.
12.Kwan, LL, Bermudez, OI & Tucker, KL (2002) Low vitamin B-12 intake and status are more prevalent in Hispanic older adults of Caribbean origin than in neighborhood-matched non-Hispanic whites. J Nutr 132, 20592064.
13.Dhonukshe-Rutten, RA, Timotijevic, L, Cavelaars, AEet al. (2010) European micronutrient recommendations aligned: a general framework developed by EURRECA. Eur J Clin Nutr 64, Suppl. 2, S2S10.
14.Ashwell, M, Lambert, JP, Alles, MSet al. (2008) How we will produce the evidence-based EURRECA toolkit to support nutrition and food policy. Eur J Nutr 47, Suppl. 1, 216.
15.Atkinson, SA & Koletzko, B (2007) Determining life-stage groups and extrapolating nutrient intake values (NIVs). Food Nutr Bull 28, Suppl. 1, S61S76.
16.King, JC, Vorster, HH & Tome, DG (2007) Nutrient intake values (NIVs): a recommended terminology and framework for the derivation of values. Food Nutr Bull 28, Suppl. 1, S16S26.
17.Cavelaars, AE, Doets, EL, Dhonukshe-Rutten, RAet al. (2010) Prioritizing micronutrients for the purpose of reviewing their requirements: a protocol developed by EURRECA. Eur J Clin Nutr 64, Suppl. 2, S19S30.
18.Dror, DK & Allen, LH (2008) Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 66, 250255.
19.Kuschel, CA & Harding, JE (2004) Multicomponent fortified human milk for promoting growth in preterm infants. Cochrane Database Syst Rev issue 1, CD000343.
20.Mathews, F (1996) Antioxidant nutrients in pregnancy: a systematic review of the literature. Nutr Res Rev 9, 175195.
21.Molloy, AM, Kirke, PN, Brody, LCet al. (2008) Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull 29, Suppl. 2, S101S111.
22.Ramakrishnan, U, Aburto, N, McCabe, Get al. (2004) Multimicronutrient interventions but not vitamin A or iron interventions alone improve child growth: results of 3 meta-analyses. J Nutr 134, 25922602.
23.Ray, JG & Laskin, CA (1999) Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: a systematic review. Placenta 20, 519529.
24.Hoey, L, Strain, JJ & McNulty, H (2009) Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials. Am J Clin Nutr 89, issue 6, S1981S1996.
25.Fairweather-Tait, SJ & Harvey, LJ (2008) Micronutrient status methods: proceedings of the EURRECA workshop and working party on new approaches for measuring micronutrient status. Br J Nutr 99, S1.
26.Hooper, L, Ashton, K, Harvey, LJet al. (2009) Assessing potential biomarkers of micronutrient status by using a systematic review methodology: methods. Am J Clin Nutr 89, issue 6, S1953S1959.
27.Higgins J & Green S (editors) (2011) Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. The Cochrane Collaboration; available at
28.Bjorke-Monsen, AL, Torsvik, I, Saetran, Het al. (2008) Common metabolic profile in infants indicating impaired cobalamin status responds to cobalamin supplementation. Pediatrics 122, 8391.
29.Worthington-White, DA, Behnke, M & Gross, S (1994) Premature infants require additional folate and vitamin B-12 to reduce the severity of the anemia of prematurity. Am J Clin Nutr 60, 930935.
30.Jones, KM, Ramirez-Zea, M, Zuleta, Cet al. (2007) Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet. J Nutr 137, 13071313.
31.Hay, G, Johnston, C, Whitelaw, Aet al. (2008) Folate and cobalamin status in relation to breastfeeding and weaning in healthy infants. Am J Clin Nutr 88, 105114.
32.Dagnelie, PC & van Staveren, WA (1994) Macrobiotic nutrition and child health: results of a population-based, mixed-longitudinal cohort study in The Netherlands. Am J Clin Nutr 59, Suppl. 5, S1187S1196.
33.Papoutsakis, C, Yiannakouris, N, Manios, Yet al. (2006) The effect of MTHFR(C677T) genotype on plasma homocysteine concentrations in healthy children is influenced by gender. Eur J Clin Nutr 60, 155162.
34.Steluti, J, Martini, LA, Peters, BSet al. (2011) Folate, vitamin B6 and vitamin B12 in adolescence: serum concentrations, prevalence of inadequate intakes and sources in food. J Pediatr (Rio J) 87, 4349.
35.Yeung, LF, Cogswell, ME, Carriquiry, ALet al. (2011) Contributions of enriched cereal-grain products, ready-to-eat cereals, and supplements to folic acid and vitamin B-12 usual intake and folate and vitamin B-12 status in US children: National Health and Nutrition Examination Survey (NHANES), 2003–2006. Am J Clin Nutr 93, 172185.
36.Gewa, CA, Weiss, RE, Bwibo, NOet al. (2009) Dietary micronutrients are associated with higher cognitive function gains among primary school children in rural Kenya. Br J Nutr 101, 13781387.
37.Hay, G, Trygg, K, Whitelaw, Aet al. (2011) Folate and cobalamin status in relation to diet in healthy 2-y-old children. Am J Clin Nutr 93, 727735.
38.Baker, PN, Wheeler, SJ, Sanders, TAet al. (2009) A prospective study of micronutrient status in adolescent pregnancy. Am J Clin Nutr 89, 11141124.
39.Koebnick, C, Heins, UA, Dagnelie, PCet al. (2002) Longitudinal concentrations of vitamin B(12) and vitamin B(12)-binding proteins during uncomplicated pregnancy. Clin Chem 48, 928933.
40.Lindblad, B, Zaman, S, Malik, Aet al. (2005) Folate, vitamin B12, and homocysteine levels in South Asian women with growth-retarded fetuses. Acta Obstet Gynecol Scand 84, 10551061.
41.Morkbak, AL, Ramlau-Hansen, CH, Moller, UKet al. (2007) A longitudinal study of serum cobalamins and its binding proteins in lactating women. Eur J Clin Nutr 61, 184189.
42.Muthayya, S, Kurpad, AV, Duggan, CPet al. (2006) Low maternal vitamin B12 status is associated with intrauterine growth retardation in urban South Indians. Eur J Clin Nutr 60, 791801.
43.Takimoto, H, Hayashi, F, Kusama, Ket al. (2011) Elevated maternal serum folate in the third trimester and reduced fetal growth: a longitudinal study. J Nutr Sci Vitaminol (Tokyo) 57, 130137.
44.Duyvendak, M & Veldhuis, GJ (2009) Oral better than parenteral supplementation of vitamin B12. Ned Tijdschr Geneeskd 153, B485.
45.Rufenacht, P, Mach-Pascual, S & Iten, A (2008) Vitamin B12 deficiency: a challenging diagnosis and treatment. Rev Med Suisse 4, 22122214, 2216–2217.
46.Schneider, H & Miller, RK (2010) Receptor-mediated uptake and transport of macromolecules in the human placenta. Int J Dev Biol 54, 367375.
47.Molloy, AM, Mills, JL, McPartlin, Jet al. (2002) Maternal and fetal plasma homocysteine concentrations at birth: the influence of folate, vitamin B12, and the 5,10-methylenetetrahydrofolate reductase 677C–>T variant. Am J Obstet Gynecol 186, 499503.
48.Hvas, AM & Nexo, E (2005) Holotranscobalamin – a first choice assay for diagnosing early vitamin B deficiency? J Intern Med 257, 289298.
49.Nexo, E, Hvas, AM, Bleie, Oet al. (2002) Holo-transcobalamin is an early marker of changes in cobalamin homeostasis. A randomized placebo-controlled study. Clin Chem 48, 17681771.
50.Villamor, E, Mora-Plazas, M, Forero, Yet al. (2008) Vitamin B-12 status is associated with socioeconomic level and adherence to an animal food dietary pattern in Colombian school children. J Nutr 138, 13911398.
51.Honzik, T, Adamovicova, M, Smolka, Vet al. (2010) Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B12 deficiency – what have we learned? Eur J Paediatr Neurol 14, 488495.
52.Campbell, BA (1995) Megaloblastic anemia in pregnancy. Clin Obstet Gynecol 38, 455462.
53.Ray, JG & Blom, HJ (2003) Vitamin B12 insufficiency and the risk of fetal neural tube defects. QJM 96, 289295.
54.Acilmis, YG, Dikensoy, E, Kutlar, AIet al. (2011) Homocysteine, folic acid and vitamin B12 levels in maternal and umbilical cord plasma and homocysteine levels in placenta in pregnant women with pre-eclampsia. J Obstet Gynaecol Res 37, 4550.
55.Selhub, J, Morris, MS, Jacques, PFet al. (2009) Folate–vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency. Am J Clin Nutr 89, issue 2, S702S706.
56.Stabler, SP & Allen, RH (2004) Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr 24, 299326.
57.Bjorke-Monsen, AL & Ueland, PM (2011) Cobalamin status in children. J Inherit Metab Dis 34, 111119.
58.Monsen, AL, Refsum, H, Markestad, Tet al. (2003) Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem 49, 20672075.
59.Monsen, AL, Schneede, J & Ueland, PM (2006) Mid-trimester amniotic fluid methionine concentrations: a predictor of birth weight and length. Metabolism 55, 11861191.
60.Casanueva, E, Viteri, FE, Mares-Galindo, Met al. (2006) Weekly iron as a safe alternative to daily supplementation for nonanemic pregnant women. Arch Med Res 37, 674682.
61.Choudhry, VP, Saraya, AK & Ghai, OP (1972) Morphological changes in relation to haemopoietic nutrient deficiency in nutritional macrocytic anaemia in infancy and childhood. Indian J Med Res 60, 17641773.
62.Cikot, RJ, Steegers-Theunissen, RP, Thomas, CMet al. (2001) Longitudinal vitamin and homocysteine levels in normal pregnancy. Br J Nutr 85, 4958.
63.Couto, FD, Moreira, LM, Dos Santos, DBet al. (2007) Folate, vitamin B12 and total homocysteine levels in neonates from Brazil. Eur J Clin Nutr 61, 382386.
64.Cornel, MC, de Smit, DJ & de Jong-van den Berg, LT (2005) Folic acid – the scientific debate as a base for public health policy. Reprod Toxicol 20, 411415.
65.Czeizel, AE & Dudas, I (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327, 18321835.
66.Czeizel, AE & Medveczky, E (2003) Periconceptional multivitamin supplementation and multimalformed offspring. Obstet Gynecol 102, 12551261.
67.Dagnelie, PC, van Staveren, WA, Vergote, FJet al. (1989) Nutritional status of infants aged 4 to 18 months on macrobiotic diets and matched omnivorous control infants: a population-based mixed-longitudinal study. II. Growth and psychomotor development. Eur J Clin Nutr 43, 325338.
68.Dawson, EB, Evans, DR, Conway, MEet al. (2000) Vitamin B12 and folate bioavailability from two prenatal multivitamin/multimineral supplements. Am J Perinatol 17, 193199.
69.van Dusseldorp, M, Schneede, J, Refsum, Het al. (1999) Risk of persistent cobalamin deficiency in adolescents fed a macrobiotic diet in early life. Am J Clin Nutr 69, 664671.
70.Eilander, A, Muthayya, S, van der Knaap, Het al. (2010) Undernutrition, fatty acid and micronutrient status in relation to cognitive performance in Indian school children: a cross-sectional study. Br J Nutr 103, 10561064.
71.Gomber, S, Bhawna, , Madan, Net al. (2003) Prevalence & etiology of nutritional anaemia among school children of urban slums. Indian J Med Res 118, 167171.
72.Gomber, S, Kumar, S, Rusia, Uet al. (1998) Prevalence & etiology of nutritional anaemias in early childhood in an urban slum. Indian J Med Res 107, 269273.
73.Gordon, BA & Carson, RA (1976) Methylmalonic acidemia controlled with oral administration of vitamin B12. CMAJ 115, 233236.
74.Graham, SM, Arvela, OM & Wise, GA (1992) Long-term neurologic consequences of nutritional vitamin B12 deficiency in infants. J Pediatr 121, 710714.
75.Haggarty, P, McCallum, H, McBain, Het al. (2006) Effect of B vitamins and genetics on success of in-vitro fertilisation: prospective cohort study. Lancet 367, 15131519.
76.Haiden, N, Klebermass, K, Cardona, Fet al. (2006) A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity. Pediatrics 118, 180188.
77.Haiden, N, Schwindt, J, Cardona, Fet al. (2006) Effects of a combined therapy of erythropoietin, iron, folate, and vitamin B12 on the transfusion requirements of extremely low birth weight infants. Pediatrics 118, 20042013.
78.Hay, G, Clausen, T, Whitelaw, Aet al. (2010) Maternal folate and cobalamin status predicts vitamin status in newborns and 6-month-old infants. J Nutr 140, 557564.
79.Hininger, I, Favier, M, Arnaud, Jet al. (2004) Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: a randomized double-blind, placebo-controlled trial in apparently healthy pregnant women. Eur J Clin Nutr 58, 5259.
80.Hjelt, K & Krasilnikoff, PA (1990) The impact of gluten on haematological status, dietary intakes of haemopoietic nutrients and vitamin B12 and folic acid absorption in children with coeliac disease. Acta Paediatr Scand 79, 911919.
81.Huemer, M, Simma, B, Fowler, Bet al. (2005) Prenatal and postnatal treatment in cobalamin C defect. J Pediatr 147, 469472.
82.Järvenpää, J, Schwab, U, Lappalainen, Tet al. (2007) Fortified mineral water improves folate status and decreases plasma homocysteine concentration in pregnant women. J Perinat Med 35, 108114.
83.Johnson, TE, Janes, SJ, MacDonald, Aet al. (2002) An observational study to evaluate micronutrient status during enteral feeding. Arch Dis Child 86, 411415.
84.Knight, EM, Spurlock, BG, Edwards, CHet al. (1994) Biochemical profile of African American women during three trimesters of pregnancy and at delivery. J Nutr 124, Suppl. 6, S943S953.
85.Levy, R, Herzberg, GR, Andrews, WLet al. (1992) Thiamine, riboflavin, folate, and vitamin B12 status of low birth weight infants receiving parenteral and enteral nutrition. J Parenter Enteral Nutr 16, 241247.
86.López de Romaña, G, Cusirramos, S, López de Romaña, Det al. (2005) Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, growth, and morbidity of Peruvian infants. J Nutr 135, issue 3, S646S652.
87.Lovblad, K, Ramelli, G, Remonda, Let al. (1997) Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings. Pediatr Radiol 27, 155158.
88.Lundgren, J & Blennow, G (1999) Vitamin B12 deficiency may cause benign familial infantile convulsions: a case report. Acta Paediatr 88, 11581160.
89.Makedos, G, Papanicolaou, A, Hitoglou, Aet al. (2007) Homocysteine, folic acid and B12 serum levels in pregnancy complicated with preeclampsia. Arch Gynecol Obstet 275, 121124.
90.Mamlok, RJ, Isenberg, JN, Rassin, DKet al. (1986) A cobalamin metabolic defect with homocystinuria, methylmalonic aciduria and macrocytic anemia. Neuropediatrics 17, 9499.
91.Martin, I, Gibert, MJ, Pintos, Cet al. (2004) Oxidative stress in mothers who have conceived fetus with neural tube defects: the role of aminothiols and selenium. Clin Nutr 23, 507514.
92.Mathan, VI, Baker, SJ, Sood, SKet al. (1979) WHO sponsored collaborative studies on nutritional anaemia in India. The effects of ascorbic acid and protein supplementation on the response of pregnant women to iron, pteroylglutamic acid and cyanocobalamin therapy. Br J Nutr 42, 391398.
93.Maurage, C, Dalloul, C, Moussa, Fet al. (1995) Efficacy of oral administration of a micellaar solution of vitamin K during the neonatal period. Arch Pediatr 2, 328332.
94.Masalha, R, Afawi, Z, Mahajnah, Met al. (2008) The impact of nutritional vitamin B12, folate and hemoglobin deficiency on school performance of elementary school children. J Pediatr Neurol 6, 243248.
95.McCoy, H, Kenney, MA, Kirby, Aet al. (1984) Nutrient intakes of female adolescents from eight southern states. J Am Diet Assoc 84, 14531460.
96.McGrath, N, Bellinger, D, Robins, Jet al. (2006) Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania. Pediatrics 117, e216e225.
97.McNulty, H, Eaton-Evans, J, Cran, Get al. (1996) Nutrient intakes and impact of fortified breakfast cereals in schoolchildren. Arch Dis Child 75, 474481.
98.Mena, PN, Pittaluga, EP, Blanco, Aet al. (2001) B12 vitamin does not change the evolution of the anemia in preterm babies. Rev Chil Pediatr 72, 3439.
99.Merialdi, M, Caulfield, LE, Zavaleta, Net al. (2004) Randomized, controlled trial of prenatal zinc supplementation and fetal bone growth. Am J Clin Nutr 79, 826830.
100.Metcalf, R, Dilena, B, Gibson, Ret al. (1994) How appropriate are commercially available human milk fortifiers? J Paediatr Child Health 30, 350355.
101.Metz, J, Festenstein, H & Welch, P (1965) Effect of folic acid and vitamin B12 supplementation on tests of folate and vitamin B12 nutrition in pregnancy. Am J Clin Nutr 16, 472479.
102.Mills, EJ, Wu, P, Seely, Det al. (2005) Vitamin supplementation for prevention of mother-to-child transmission of HIV and pre-term delivery: a systematic review of randomized trial including more than 2800 women. AIDS Res Ther 2, 4.
103.Minet, JC, Bisse, E, Aebischer, CPet al. (2000) Assessment of vitamin B-12, folate, and vitamin B-6 status and relation to sulfur amino acid metabolism in neonates. Am J Clin Nutr 72, 751757.
104.Miyake, Y, Sasaki, S, Tanaka, Ket al. (2006) Dietary folate and vitamins B12, B6, and B2 intake and the risk of postpartum depression in Japan: the Osaka Maternal and Child Health Study. J Affect Disord 96, 133138.
105.Molloy, AM, Kirke, P, Hillary, Iet al. (1985) Maternal serum folate and vitamin B12 concentrations in pregnancies associated with neural tube defects. Arch Dis Child 60, 660665.
106.Molloy, AM, Mills, JL, Cox, Cet al. (2005) Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery. Am J Clin Nutr 82, 836842.
107.Monagle, PT & Tauro, GP (1997) Infantile megaloblastosis secondary to maternal vitamin B12 deficiency. Clin Lab Haematol 19, 2325.
108.Moran, VH (2007) Nutritional status in pregnant adolescents: a systematic review of biochemical markers. Matern Child Nutr 3, 7493.
109.Morkbak, AL, Hvas, AM, Milman, Net al. (2007) Holotranscobalamin remains unchanged during pregnancy. Longitudinal changes of cobalamins and their binding proteins during pregnancy and postpartum. Haematologica 92, 17111712.
110.Msolla, MJ & Kinabo, JL (1997) Prevalence of anaemia in pregnant women during the last trimester. Int J Food Sci Nutr 48, 265270.
111.Murphy, MM, Molloy, AM, Ueland, PMet al. (2007) Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring. J Nutr 137, 18631867.
112.Mwanda, OW & Dave, P (1999) Megaloblastic marrow in macrocytic anaemias at Kenyatta National and M P Shah Hospitals, Nairobi. East Afr Med J 76, 610614.
113.Neiger, R, Wise, C, Contag, SAet al. (1993) First trimester bleeding and pregnancy outcome in gravidas with normal and low folate levels. Am J Perinatol 10, 460462.
114.Nelen, WL, Blom, HJ, Steegers, EAet al. (2000) Homocysteine and folate levels as risk factors for recurrent early pregnancy loss. Obstet Gynecol 95, 519524.
115.Neri, I, Allais, G, Schiapparelli, Pet al. (2005) Acupuncture versus pharmacological approach to reduce hyperemesis gravidarum discomfort. Minerva Ginecol 57, 471475.
116.Neuhouser, ML, Beresford, SA, Hickok, DEet al. (1998) Absorption of dietary and supplemental folate in women with prior pregnancies with neural tube defects and controls. J Am Coll Nutr 17, 625630.
117.Neumann, CG & Harrison, GG (1994) Onset and evolution of stunting in infants and children. Examples from the Human Nutrition Collaborative Research Support Program. Kenya and Egypt studies. Eur J Clin Nutr 48, Suppl. 1, S90S102.
118.Niebyl, JR & Goodwin, TM (2002) Overview of nausea and vomiting of pregnancy with an emphasis on vitamins and ginger. Am J Obstet Gynecol 186, Suppl. 5, S253S255.
119.Nikolaus, E & Nikolaus, K (1979) Effect of a mixture of cyanocobalamin, glutamine and phosphoserine on performance and behavior of schoolchildren. Therapiewoche 29, 73537359.
120.Osganian, SK, Stampfer, MJ, Spiegelman, Det al. (1999) Distribution of and factors associated with serum homocysteine levels in children: Child and Adolescent Trial for Cardiovascular Health. JAMA 281, 11891196.
121.Patel, KD & Lovelady, CA (1998) Vitamin B12 status of east Indian vegetarian lactating women living in the United States. Nutr Res 18, 18391846.
122.Ratan, SK, Rattan, KN, Pandey, RMet al. (2008) Evaluation of the levels of folate, vitamin B12, homocysteine and fluoride in the parents and the affected neonates with neural tube defect and their matched controls. Pediatr Surg Int 24, 803808.
123.Ronnenberg, AG, Goldman, MB, Aitken, IWet al. (2000) Anemia and deficiencies of folate and vitamin B-6 are common and vary with season in Chinese women of childbearing age. J Nutr 130, 27032710.
124.Ronnenberg, AG, Goldman, MB, Chen, Det al. (2002) Preconception homocysteine and B vitamin status and birth outcomes in Chinese women. Am J Clin Nutr 76, 13851391.
125.Ronnenberg, AG, Goldman, MB, Chen, Det al. (2002) Preconception folate and vitamin B(6) status and clinical spontaneous abortion in Chinese women. Obstet Gynecol 100, 107113.
126.Ronnenberg, AG, Venners, SA, Xu, Xet al. (2007) Preconception B-vitamin and homocysteine status, conception, and early pregnancy loss. Am J Epidemiol 166, 304312.
127.Rumbold, A, Middleton, P & Crowther, CA (2005) Vitamin supplementation for preventing miscarriage. Cochrane Database Syst Rev issue 2, CD004073.
128.Sachdeva, R & Mann, SK (1994) Impact of nutrition counselling and supplements on the mineral nutriture of rural pregnant women and their neonates. Indian Pediatr 31, 643649.
129.Scatliff, CE, Koski, KG & Scott, ME (2011) Diarrhea and novel dietary factors emerge as predictors of serum vitamin B12 in Panamanian children. Food Nutr Bull 32, 5459.
130.Schneede, J, Dagnelie, PC, van Staveren, WAet al. (1994) Methylmalonic acid and homocysteine in plasma as indicators of functional cobalamin deficiency in infants on macrobiotic diets. Pediatr Res 36, 194201.
131.Shih, VE, Coulombe, JT, Maties, Met al. (1976) Methylmalonic aciduria in the newborn. N Engl J Med 295, 13201321.
132.Siekmann, JH, Allen, LH, Bwibo, NOet al. (2003) Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation. J Nutr 133, 11 Suppl. 2, 3972S3980S.
133.Singla, PN, Gupta, HP, Ahuja, Cet al. (1982) Deficiency anaemias in preschool children – estimation of prevalence based on response to haematinic supplementation. J Trop Pediatr 28, 7780.
134.Sivakumar, B, Nair, KM, Sreeramulu, Det al. (2006) Effect of micronutrient supplement on health and nutritional status of schoolchildren: biochemical status. Nutrition 22, 1 Suppl., S15S25.
135.Smith Fawzi, MC, Kaaya, SF, Mbwambo, Jet al. (2007) Multivitamin supplementation in HIV-positive pregnant women: impact on depression and quality of life in a resource-poor setting. HIV Med 8, 203212.
136.Sneed, SM, Zane, C & Thomas, MR (1981) The effects of ascorbic acid, vitamin B6, vitamin B12, and folic acid supplementation on the breast milk and maternal nutritional status of low socioeconomic lactating women. Am J Clin Nutr 34, 13381346.
137.Sohrabvand, F, Shariat, M & Haghollahi, F (2006) Vitamin B supplementation for leg cramps during pregnancy. Int J Gynaecol Obstet 95, 4849.
138.Steegers-Theunissen, RP, Boers, GH, Blom, HJet al. (1995) Neural tube defects and elevated homocysteine levels in amniotic fluid. Am J Obstet Gynecol 172, 14361441.
139.Steen, MT, Boddie, AM, Fisher, AJet al. (1998) Neural-tube defects are associated with low concentrations of cobalamin (vitamin B12) in amniotic fluid. Prenat Diagn 18, 545555.
140.Strand, TA, Taneja, S, Bhandari, Net al. (2007) Folate, but not vitamin B-12 status, predicts respiratory morbidity in north Indian children. Am J Clin Nutr 86, 139144.
141.Suarez, L, Hendricks, K, Felkner, Met al. (2003) Maternal serum B12 levels and risk for neural tube defects in a Texas–Mexico border population. Ann Epidemiol 13, 8188.
142.Thomas, NE, Cooper, SM, Baker, JSet al. (2008) Homocyst(e)ine, folate, and vitamin B12 status in a cohort of Welsh young people aged 12–13 years old. Res Sports Med 16, 233243.
143.Thompson, MD, Cole, DE & Ray, JG (2009) Vitamin B-12 and neural tube defects: the Canadian experience. Am J Clin Nutr 89, issue 2, S697S701.
144.Thoradeniya, T, Wickremasinghe, R, Ramanayake, Ret al. (2006) Low folic acid status and its association with anaemia in urban adolescent girls and women of childbearing age in Sri Lanka. Br J Nutr 95, 511516.
145.Thurlow, RA, Winichagoon, P, Green, Tet al. (2005) Only a small proportion of anemia in northeast Thai schoolchildren is associated with iron deficiency. Am J Clin Nutr 82, 380387.
146.Valman, HB (1972) Late vitamin B12 deficiency following resection of the ileum in the neonatal period. Acta Paediatr Scand 61, 561564.
147.Veena, SR, Krishnaveni, GV, Srinivasan, Ket al. (2010) Higher maternal plasma folate but not vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9- to 10-year-old children in South India. J Nutr 140, 10141022.
148.Verkleij-Hagoort, AC, van Driel, LM, Lindemans, Jet al. (2008) Genetic and lifestyle factors related to the periconception vitamin B12 status and congenital heart defects: a Dutch case–control study. Mol Genet Metab 94, 112119.
149.Villamor, E, Mora-Plazas, M, Forero, Yet al. (2008) Vitamin B-12 status is associated with socioeconomic level and adherence to an animal food dietary pattern in Colombian school children. J Nutr 138, 13911398.
150.Vinod Kumar, M & Rajagopalan, S (2008) Trial using multiple micronutrient food supplement and its effect on cognition. Indian J Pediatr 75, 671678.
151.Vujkovic, M, Ocke, MC, van der Spek, PJet al. (2007) Maternal Western dietary patterns and the risk of developing a cleft lip with or without a cleft palate. Obstet Gynecol 110, 378384.
152.Vujkovic, M, Steegers, EA, Looman, CWet al. (2009) The maternal Mediterranean dietary pattern is associated with a reduced risk of spina bifida in the offspring. BJOG 116, 408415.
153.Wald, NJ, Hackshaw, AD, Stone, Ret al. (1996) Blood folic acid and vitamin B12 in relation to neural tube defects. Br J Obstet Gynaecol 103, 319324.
154.Wright, ME (1995) A case–control study of maternal nutrition and neural tube defects in Northern Ireland. Midwifery 11, 146152.


Association between vitamin B12 intake and EURRECA's prioritized biomarkers of vitamin B12 in young populations: a systematic review

  • Iris Iglesia (a1), Rosalie AM Dhonukshe-Rutten (a2), Silvia Bel-Serrat (a1), Esmée L Doets (a2), Adrienne EJM Cavelaars (a2), Pieter van ‘t Veer (a2), Mariela Nissenshohn (a3), Vassiliki Benetou (a4), María Hermoso (a5), Cristiana Berti (a6), Lisette CPGM de Groot (a2) and Luis A Moreno (a1)...
  • Please note a correction has been issued for this article.


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