The use of fibrous wool protein as a model of the structural surface of receptors, possibly involved in the mechanism producing a model psychosis by drugs, was suggested by three lines of evidence.
First, the strong affinity (sorption) of certain basic compounds to keratins of low sulphur content as exemplified by the Gram-positiveness of epidermal (Fischer, 1953c) and nervous (Bailey, 1950) tissue.
Second, the accumulating evidence indicating the similarity in behaviour between keratins of high sulphur content (e.g. wool) and the protein component of certain cell membranes (Fischer, 1951; Fischer and Larose, l952a; idem, 1952b; Larose and Fischer, 1952; idem, l953a and 1953b).
Third, some preliminary experiments confirming the role of wool protein as a useful model to simulate some of those receptors for which certain drugs appear to compete.