Confusion is a hallmark of the effects of toxin upon the cerebrum. When very slight, special tests are required to elicit it. Interference with neuronal conductivity is the chief pathogenetic factor. The topical incidence of this is one of the determinants of the form taken by the psychosis, whether hallucinatory, disorientative, depressive, delusional, or what not. Another factor is the state of the body secretions as affected by the toxins; a third factor is the patient's psychological status, as determined by the capacity and the opportunity for experience.