A numerical simulation of the particle-gas flow in a vertical turbulent pipe flow was conducted. The main objective of the present article is to investigate the effects of dispersed phase (particles) on continuous phase (gas). In so doing, two general forms of Eulerian-Lagrangian approaches namely, one-way (when the fluid flow is not affected by the presence of the particles) and two-way (when the particles exert a feedback force on the fluid) couplings were used to describe the equations of motion of the two-phase flow. Gas-phase velocities which are within the order of magnitude as that of particles, volume fraction, and particle Stokes number were calculated and the results were subsequently compared with the available experimental data. The simulated results show that when the particles are added, the fluid velocity is attenuated. With an increase in particle volume fraction, particle mass loading and Stokes number, velocity attenuation also increases. Moreover, the results indicate that an increase in particle Stokes number reduces the special limited particle volume fraction, according to which one-way coupling method yields plausible results. The results have also indicated that the significance of particle fluid interaction is not merely a function of volume fraction and particle Stokes number.