Hostname: page-component-77c89778f8-7drxs Total loading time: 0 Render date: 2024-07-22T07:41:05.075Z Has data issue: false hasContentIssue false
  • English
  • Français

Bioavailability of magnesium and calcium from cow's milk and soya-bean beverage in rats

Published online by Cambridge University Press:  09 March 2007

Elizabeth J. Brink ,
Pieter R. Dekker ,
Emerentia C. H. Van Beresteijn  and
Anton C. Beynen
Elizabeth J. Brink
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Pieter R. Dekker
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Emerentia C. H. Van Beresteijn
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Anton C. Beynen
Affiliation:
Department of Laboratory Animal Science, State University, PO Box 80.166, 3508 TD Utrecht, The Netherlands Department of Human Nutrition, Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The milk components lactose and casein enhance the apparent absorption of magnesium and possibly also of calcium, whereas phytate, which occurs in soya-bean products, has an inhibitory effect. This implies that soya-bean beverage v. cow's milk could lower bioavailability of Mg and Ca. This hypothesis was tested in two experiments with growing rats. Feeding soya-bean beverage v. cow's milk consistently lowered body-weight gain, enhanced bone turnover, as measured by increased plasma alkaline phosphatase (EC 3.1.3.1) activity and increased urinary hydroxyproline excretion, and decreased Mg and Ca concentrations in the femur. Because the mineral compositions of the soya-bean beverage and the cow's milk were different, the intake of Mg was higher in rats fed on soya-bean beverage, whereas that of Ca was higher in rats fed on cow's milk. Supplementation of the soya-bean beverage either with phosphorus and Ca or with P, Ca and methionine, to concentrations identical to those in milk, restored growth and bone mineralization. When using diets carefully balanced for Mg, Ca, P, sodium, potassium and methionine, soya-bean beverage v. cow's milk in the diets decreased apparent absorption and urinary excretion of Mg and Ca. Hydrolysis of lactose in milk decreased absorption and urinary excretion of Mg; it did not significantly affect Ca absorption but lowered urinary Ca excretion. The present study shows that soya-bean beverage v. milk depresses Mg and Ca bioavailability, as would be predicted on the basis of reported effects of their purified components.

Keywords

Cow's milkSoya-bean beverageMineral bioavailabilityRats
Type
Mineral Metabolism
Information
British Journal of Nutrition , Volume 68 , Issue 1 , July 1992 , pp. 271 - 282
Copyright
Copyright © The Nutrition Society 1992

References

REFERENCES

American Institute of Nutrition (1977). Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. Journal of Nutrition 117, 1340–1348.Google Scholar
Andrieux, C. & Sacquet, E. (1983). Effect of microflora and lactose on the absorption of calcium, phosphorus and magnesium in the hindgut of the rat. Reproduction Nutrition Développement 23, 258–271.Google Scholar
Armbrecht, H. J. & Wasserman, R. H. (1976). Enhancement of Ca++ uptake by lactose in the rat small intestine. Journal of Nutrition 106, 1265–1271.CrossRefGoogle ScholarPubMed
Behling, A. R. & Greger, J. L. (1990). Importance of lactose in yogurt for mineral utilization. Journal of Agricultural and Food Chemistry 38, 200–204.Google Scholar
Brink, E. J., Dekker, P. R., van Beresteijn, E. C. H. & Beynen, A. C. (1991). Inhibitory effect of dietary soybean protein versus casein on magnesium absorption in rats. Journal of Nutrition 121, 1374–1381.Google Scholar
Brons, C. & Olieman, C. (1983). Study of high performance liquid chromatographic separation of reducing sugars applied to the determination of lactose in milk. Journal of Chromatography 259, 79–86.Google Scholar
Davies, N. T. (1979). Anti-nutrient factors affecting mineral utilization. Proceedings of the Nutrition Society 38, 121–126.Google Scholar
Favus, M. J. & Angeid-Backmann, E. (1984). Effects of lactose on calcium absorption and secretion by rat ileum. American Journal of Physiology 246, G281–G285.Google ScholarPubMed
Fiske, C. H. & Subbarow, Y. (1925). The colorimetric determination of phosphorus. Journal of Biological Chemistry 66, 375–400.Google Scholar
Fleiss, J. L. (1986). The Design and Analysis of Clinical Experiments, pp. 103–107. New York: John Wiley and Sons.Google Scholar
Fournier, P., Dupuis, Y. & Fournier, A. (1971). Effect of lactose on the absorption of alkaline earth metals and intestinal lactase activity. Israel Journal of Medical Sciences 7, 389–391.Google Scholar
Greger, J. L., Gutkowski, C. M. & Khazen, R. R. (1989). Interactions of lactose with calcium, magnesium and zinc in rats. Journal of Nutrition 119, 1691–1697.CrossRefGoogle ScholarPubMed
Greger, J. L., Krzykowski, C. E., Khazen, R. R. & Krashoc, C. (1987). Mineral utilization by rats fed commercially available calcium supplements or milk. Journal of Nutrition 117, 717–724.CrossRefGoogle ScholarPubMed
International Dairy Federation (1986). Determination of nitrogen content (Kjeldahl method) and calculation of crude protein content. International IDF standard no. 20A. Brussels: International Dairy Federation.Google Scholar
Irving, J. T. (1973). Calcium and Phosphorus Metabolism. New York: Academic Press.Google Scholar
Leichter, J. & Tolensky, A. F. (1975). Effect of dietary lactose on the absorption of protein, fat and calcium in the postweanling rat. American Journal of Clinical Nutrition 28, 238–241.CrossRefGoogle Scholar
Lonnerdal, B., Sandberg, A. S., Sandstrom, B. & Kunz, C. (1989). Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats. Journal of Nutrition 119, 211–214.CrossRefGoogle ScholarPubMed
Moore, S. (1963). On the determination of cystine as cysteic acid. Journal of Biological Chemistry 238, 235–237.CrossRefGoogle Scholar
Nwokolo, E. N. & Bragg, D. B. (1977). Influence of phytic acid and crude fibre on the availability of minerals from four protein supplements in growing chicks. Canadian Journal of Animal Science 57, 475–477.Google Scholar
Recker, R. R., Bammi, A., Barger-Lux, J. & Heaney, R. (1988). Calcium absorbability from milk products, an imitation milk and calcium carbonate. American Journal of Clinical Nutrition 47, 93–95.CrossRefGoogle ScholarPubMed
Reddy, N. R., Sathe, S. K. & Salunkhe, P. K. (1982). Phytates in legumes and cereals. Advances in Food Research 28, 1–92.Google Scholar
Schaafsma, G., Dekker, P. R. & de Waard, H. (1988). Nutritional aspects of yogurt. 2. Bioavailability of essential minerals and trace elements. Netherlands Milk and Dairy Journal 42, 135–146.Google Scholar
Sheikh, M. S., Santa Ana, C. A., Nicar, M. J., Schiller, L. R. & Fordtran, J. S. (1987). Gastrointestinal absorption of calcium salts. New England Journal of Medicine 317, 532–536.Google Scholar
Slump, P., Bos, K. D. & Wolters, M. G. E. (1987). Improved determination of phytate by HPLC. Euro Food Chemistry IV. Rapid Analysis in Food Processing and Food Control, vol. 1, pp. 151–155. Locn, Norway: Norwegian Food Research Institute.Google Scholar
Van der Meer, R., de Vries, H. T. & van Tintelen, G. (1988). The phosphorylation state of casein and the species-dependency of its hypercholesterolaemic effect. British Journal of Nutrition 59, 467–473.Google Scholar