The digestive maturation of the young rabbit is reviewed. It indicates that their nutritional needs and those of lactating females are antagonistic in many aspects. Energy requirements of lactating females are very high, whilst a low starch, high fibre diet around weaning improves the health of the young after weaning. To solve this problem, several feeding and management strategies are presented and discussed. If weaning occurs between 28 and 35 days of age, feeding the young with a specific diet, different from the female’s, seems an effective solution. Otherwise, it is necessary to find a compromise between the needs of the litter and of the doe. Early weaning (< 26 days) could be also a promising way to provide adequate feeding for the young as soon as they begin to eat solid food.

The systematic use of the same genotype in several different environments provides information that can be used to estimate genotype by environment interaction (G ✕ E) variances and parameters. Data from the UK Suffolk Sire Referencing Scheme Ltd were used to investigate a range of sire and dam by environment interactions in lamb weight (at 8 weeks and scanning) and body composition traits (muscle and fat depth). These interactions were calculated in a DFREML mixed model containing direct additive, maternal additive, maternal environmental random variance components and the covariance between direct and maternal additive effects. Sire interactions with year, flock and flock-year and dam effects within and between litters were investigated. The addition of all G ✕ E (co)variance components resulted in an improved fit of the model for all traits. Sire interactions accounted for between 2 and 3% of the phenotypic variance in all traits, usually at the expense of both additive effects. Maternal litter environmental variance components ranged from 10% (fat depth and muscle depth) to 20% (8-week weight) of phenotypic variance. Most of this variation was found in the residual component of variance when the term was omitted from the model. When fitting sire G✕ E components in a model the covariance between direct and maternal additive genetic effects, as a proportion of phenotypic variance, was reduced to a low level (from –0·36 to –0·08 for 8-week weight). Genotype by environment interactions form a significant source of variation in lamb growth and composition traits and reduce the high negative correlation between additive effects found previously in these traits.

Survival data were simulated under the Weibull model in a half-sib family design, and about 50% of the records were censored. The data were analysed using the proportional hazard model (PHM) and, after transformation to survival scores, using a linear and a binary (logit) model (LIN and BIN, respectively), where the survival scores are indicators of survival during time period t given survival up to period t – 1. Correlations between estimated and true breeding values of sires (accuracies of selection) were very similar for all three models (differences were smaller than 0·3%). Daughter effects were however less accurately predicted by the LIN model, i.e.taking proper account of the distribution of the survival data yields more accurate predictions of daughter effects. The estimated variance components and regressions of true on estimated breeding values were difficult to compare for the LIN models, because estimated breeding values were expressed as additive effects on survival scores while the simulated true breeding values were expressed on the underlying scale. Also the differences in accuracy of selection between sire and animal model breeding value estimates were small, probably due to the half-sib family design of the data. To estimate breeding values for functional survival, i.e. the component of survival that is genetically independent of production (here milk yield), two methods were compared: (i) breeding values were predicted by a single-trait linear model with a phenotypic regression on milk yield; and (ii) breeding values were predicted by a two-trait linear model for survival and milk yield, and breeding values for survival corrected for milk yield were obtained by a genetic regression on the milk yield breeding value estimates. Both methods yielded very similar accuracies of selection for functional survival, and are expected to be equivalent.

This paper examines a paradox at the centre of efforts to improve livestock production in sub-Saharan Africa. For decades livestock nutrition and animal food have been identified as critical constraints, yet producers have shown little interest in improved food technologies. The main argument is that the analyses highlighting nutrition and food as critical constraints have focused primarily on biological productivity, and are thus at odds with livestock producers’ perceptions. The paper concludes by suggesting that livestock research in Africa must taker greater account of different systems, situations and producers, as well as key characteristics of technology such as reliability and management flexibility.

Sheep of a line (S) selected on an index to increase lean weight and decrease fatness at an age, and a control line (C), were given a high quality food at different levels including ad libitum. Live performance was measured from about 21 to 114 kg live weight. The carcasses of each line were analysed for lean, fat and bone at three widely varying weights in both males and females. Level of feeding did not affect the extent to which S was superior to C in either the level of fatness in the carcass (0·86 as much) or the ratio of lean to fat (1·28 as much). The lean to bone ratio was slightly greater in S (1·028 of the value of C; P 0·05) and was higher on the lowest level of feeding compared with the two higher levels used (P 0·05 in one experiment on females and P 0·001 in another on males). On ad libitum feeding the S line grew 1·19 times as fast and was 1·17 times as efficient compared with C. These advantages to S decreased as level of feeding decreased to become virtually zero at the lowest level of feeding used, which allowed C to grow at only 0·53 of the rate seen on ad libitum feeding. On ad libitum feeding growth was well described by a Gompertz growth function of the form W = (Z/B) exp(-exp (G0 –B t)). The maximum growth rate is (Z/e). Line S had a value of Z that was 1·10 that of C averaged across the two sexes. A Spillman function W = W0 + (A-W0) (1-exp (-k F)) was used to describe weight, W, in terms of cumulative intake, F. It worked well for ad libitum feeding and for the two restricted regimes used. The value of the combined parameter (A k) varied across treatments in the same way as efficiency did.

Segregation analyses were applied to data from an experimental sheep flock to investigate the presence of a major gene affecting litter size. The data set contained 14 years of litter size data, with up to five parities per ewe, from Cheviot sheep carrying the putative Thoka fecundity gene from Icelandic sheep. Segregation analyses were performed using a Markov chain Monte Carlo method implemented using Gibbs sampling. Uniform priors were initially used for estimating variance components, the gene effect and fixed effects in the data. Genotypes in the base generation were assumed known based on the use of the imported Icelandic donor semen from the founder rams. The use of alternative priors (naïve and inverse-gamma distributions) for the variance components did not significantly affect the results, demonstrating the data to be sufficiently powerful for the analyses used. Segregation analyses detected a major gene for litter size in the Thoka Cheviot flock increasing litter size by 0·70 lambs per ewe lambing for a single copy of the gene. When the analysis was repeated without fixing the genotypes in the base population, the analyses predicted a different genotype than that previously used for one of the founder rams and suggested the major gene to be segregating in the Cheviot founder animals prior to the introduction of the Thoka rams. A liability threshold analysis was also applied to the data. As identified in other studies, the threshold analysis overestimated the heritability, but the estimated major gene effect was not significantly different from other analyses. The results confirm the segregation of the Thoka gene in a Cheviot flock and highlight the statistical method as a useful tool for identifying carrier animals to be used for future matings.

The aims of this study were to assess genetic variances, trends and mode of inheritance for hip and elbow dysplasia in Finnish dog populations. The influence of time-dependent fixed effects in the model when estimating the genetic trends was also studied. Official hip and elbow dysplasia screening records of 42 421 dogs from seven breeds were analysed with REML. To investigate the mode of inheritance of hip and elbow dysplasia, trait distributions, genetic variances and regressions of offspring phenotypes on parental predicted breeding values were studied separately in males and in females. Genetic trends for hip dysplasia between the years 1983 and 1998 were favourable only in the Rottweiler. In elbow dysplasia, the trends were favourable after the year 1992 in all the four breeds studied but the overall changes were small. The reason for this seemed to be negligible selection pressure against these traits. Time-dependent fixed effects in the model had an influence on the estimated genetic trends, resulting either in a more negative or more positive genetic trend compared with the model from which the time-dependent effects were removed. Mitochondrial or sex-linked inheritance did not seem likely in the expression of hip and elbow dysplasia in the populations studied. Regression coefficients of offspring phenotypes on estimated parental breeding values were approximately equal to their expected value in a situation with equal parental contribution. Furthermore, the phenotypic frequency distributions of hip and elbow dysplasia grades were similar among males and females in each breed studied. No indication of major genes was found in the offspring frequency distributions within individual sires. According to these Finnish data, mode of inheritance for both hip and elbow dysplasia is polygenic (quantitative) with equal expression of the genes from both parents, although the estimates of heritability for hip dysplasia in the Rough Collie and for elbow dysplasia in the German Shepherd and the Golden Retriever were somewhat different in males compared with females.

Real-time ultrasound data of backfat thickness, longissimus muscle depth and longissimus area were carried out on 335 pigs (164 gilts and 171 barrows) using the Pie Medical Scanner 200 equipped with an ASP-18 probe and 3·5 MHz to predict carcass lean content in positive stress Pietrain (TT) and negative stress Pietrain (CC or CT). They were given food ad libitum and slaughtered at an average age of 213 days and an average weight of 101 kg. The day before slaughter, longitudinal and transverse images were taken at the last rib. After slaughter, the lean meat content was estimated by a CGM (capteur gras-maigre) equipped with an 8-mm diameter Sydel probe. The carcass lean proportion was higher in homozygote TT than homozygote CC and heterozygote CT individuals (P < 0·05). Gilts had more lean meat than barrows (P < 0·05). The correlation between the lean meat proportion and ultrasound backfat thickness (UBFT) or ultrasound longissimus muscle depth (ULMD) respectively was moderate. The prediction of lean meat proportion using UBFT, ULMD and ULMA gave an R2 which varied from 0·35 to 0·79. Real-time ultrasound is a tool that could potentially be used to predict the composition of pig carcasses before slaughter particularly if measurements can be taken with a higher degree of accuracy than at present.

The effect of partial replacement of poly- (PUFA) with monounsaturated (MUFA) fatty acids in pig diets on fatty acid composition of subcutaneous and intramuscular fat and on fat and lean firmness was studied. No effect of dietary fat was observed on total saturated fatty acid concentration in any of the backfat layers or intramuscular lipid fractions. No significant effect of dietary fat was observed for the MUFA concentration in the outer layer, but a marked effect was evident for the inner layer (P < 0·001). A linear effect of dietary MUFA was observed for MUFA (P < 0·001) and PUFA (P < 0·001) in polar lipids. No significant effect of dietary treatment was observed on total concentration of n-3 fatty acids in any lipid location but a marked effect was observed for total n-6 fatty acid concentration. The response of pig fatty acid n-6 concentration was different depending on the lipid location. The neutral lipid fraction showed significantly lower n-6/n-3 fatty acid ratio than the subcutaneous fat. Intramuscular polar lipids showed no significant response of n-6/n-3 ratio. A linear effect of dietary MUFA concentration was observed on the melting point on the inner backfat layer (MP = 34·4 (s.e. 2·51) + 0·15 (s.e. 0·07) ✕ dietary MUFA (g/kg dry matter) (R2 = 0·24, P < 0·05)), indicating that the partial substitution of dietary PUFA by MUFA produced a fat of higher consistency. No response of the melting point of the outer layer to dietary treatment was observed. A marked effect of dietary fat was shown for backfat hardness (P < 0·001), gumminess (P < 0·001) and chewiness (P < 0·001). No effect of dietary fat was observed on the rheological properties of longissimus lumborum muscle.

Polyamines (putrescine, spermidine and spermine) are required for optimal growth in all cells, and are essential for cell proliferation and growth of cultured wool follicles, with an optimal concentration of spermidine required for the fibre elongation. The effects of a local supply of exogenous spermidine on the rate of cell division in the wool follicles, the length growth rate and diameter of fibres were therefore examined in Merino lambs. Three groups of eight lambs (40 kg) were given food at 1·2 ✕ maintenance. Spermidine was injected intradermally into a small patch (3 ✕ 3 cm) on the left flank three times per day for 7 days at one of three concentrations: 1·38, 2·75 or 4·58 џmol in 0·8 ml volume. The same volume of saline was injected into the contralateral side as a control. The concentration of spermidine in the skin patch 3 h after injection on day 7 increased by proportionately 018, 0·33 or 0·41 (P < 0001) respectively. The rates of cell division in the follicle bulb 3 h after the spermidine injection were proportionately 0104, 0184 and 0·283 higher compared with the contralateral side (P = 0078 overall) for the low, medium and high doses of spermidine respectively and differed between the three doses (P < 005). The fibre length growth rate, as measured using autoradiography, was proportionately 0099, 0117 and 0156 higher than that of the contralateral side (P < 0001 overall) for the low, medium and high doses of spermidine respectively, but differences between doses were not significant (P > 005). Spermidine injection did not result in a significant change in fibre diameter during the treatment period. The ratio of fibre length growth rate to fibre diameter was increased by the injection of spermidine (P < 0001). The results suggest that injecting extra spermidine into the skin altered spermidine homeostasis in the skin, stimulated cell proliferation and resulted in increased fibre growth.

The objective of this study was to examine the effect of breed, parity and body fatness on the lipolytic response of dairy cows. The lipolytic response was estimated as the plasma non-esterified fatty acid (NEFA) response to an adrenergic challenge. Four challenges per lactation were carried out on 124 Danish Holsteins, 101 Danish Red and 82 Jerseys through consecutive lactations. Within breed, there were two genetic lines. Cows were equally distributed across two feeding treatments, a normal and a low energy total mixed ration. Diet composition was constant throughout lactation. The lipolytic response was significantly affected by breed, parity and stage of lactation. Lipolytic response was greater in early lactation than other stages in lactation (P 0·001). The larger breeds had a higher lipolytic response than Jerseys (P 0·05), and showed an increase in lipolytic response between first and second parity (P 0·05), but not between second and third lactation. Lipolytic response in Jerseys was not significantly affected by parity. No line or feeding treatment effects were observed on the lipolytic response. Ultrasound measurement of the area of subcutaneous backfat was used to estimate effect of body fatness on the lipolytic response. There was an increase in lipolytic response with increasing body fatness (P 0·05) in mid lactation and the dry period. The slope of this was not affected by breed or parity. It was concluded that the lipolytic response of dairy cows, and by implication the responsiveness of the lipid reserves, varies according to breed, parity and physiological state.

Male beef calves in northern Australia are generally castrated under 6 months of age as an aid to management of animal behaviour and for the purpose of producing sufficiently fat carcasses at slaughter. It is also common for beef producers to administer hormone growth promotants, such as oestradiol, to increase the growth rates of steers at pasture. This experiment tested the hypothesis that delaying castration by 9 months would produce an increase in growth rate for the period while the cattle are retained as bulls without compromising management of animal behaviour. Bulls of three genotypes were castrated at 7 months or 16 months of age and half were treated with oestradiol after castration. Body weight (BW) and serum insulin-like growth factor-1 concentrations (IGF-1) were measured and behaviour was observed before and after the 16 month castration. At both 7 and 16 months of age, surgical castration of bulls caused no animal welfare problems. BW gain was affected by genotype with Bos taurus types having a lower BW gain than Bos indicus and F1-cross cattle. IGF-1 was similarly affected by genotype. Oestradiol treatment increased growth of the steers (early castrates) during the 9 months between castration times compared with non-implanted steers and bulls. Oestradiol implanted steers had similar BW gain from the late castration to slaughter, regardless of age at castration, which was greater than non-implanted early castrates which, in turn, was greater than the late castrates. Similar differences were observed for IGF-1 concentrations. Behaviour was not affected by genotype, oestradiol treatment or age of castration but this may have been an artefact of the design where all treatment groups were grazed together. Although delayed castration resulted in no behavioural or management problems, it did not produce a commercially useful increase in growth rate.

A total of 77 heifers (3⁄4 Charolais crossbred) completed a study which examined the effects of parity number on growth, changes in size of the carcass, carcass composition and meat quality. The experiment had a factorial design based on the factors: parity and level of finish. The parities were: 0 (maiden), 1, 3 and 5. At each parity animals were slaughtered at medium (EU fat class 3) and high (EU fat class 4H) levels of finish. All data were analysed by analysis of variance using individual animal observations, and linear, quadratic and asymptotic trends were explored. Where appropriate, regression equations were derived using individual animal values to describe the relationships between key parameters and the parity status of the finished animal. Animals calved at turn-out to grass in spring (April/May) and the cows were housed at weaning in mid October (mean lactation length of 163 days) and all pregnant animals were given a diet of grass silage without concentrate supplementation during the winter period. The medium level of finish animals were slaughtered 24 days after commencement of the breeding programme for parity 0 or at the end of lactation for the remaining parities, except for parity 1 animals which had a short finishing period. For the high level of finish treatment, parity 0 heifers had a longer finishing period, while all bred animals had a post-weaning finishing period. The high finish animals were finished on a diet of grass silage and concentrates. Birth weights of calves increased until the fourth parity, while weaning weights increased linearly until the fifth parity. Mean daily milk yield increased until the third lactation. Live weight, carcass weight and weights of saleable beef, separable lean and separable fat all followed asymptotic patterns of rapid initial increase and then tended to plateau with increase in parity. The asymptote values for live weight and carcass weight were 723·0 and 383·2 kg respectively. Statistically significant asymptotic relationships with parity number were obtained for live weight and various tissue weights. Nominal mature weight was assumed to be 0·99 of the asymptote and nominal mature weights for live weight, carcass weight, saleable beef, separable lean and separable fat were attained at parity (age, years) 4/5 (6·1), 3/4 (5·3), 4/5 (6·2), 3/4 (4·7) and 1/2 (2·7) respectively. The proportion of high-priced joints declined with increase in parity (linear trend P 0·01) thus indicating a reduction in relative growth of the main muscle groups of the hind limb. Shear value measurements on cooked muscle from the maiden and first parity animals indicated very tender meat, but tenderness declined with increase in parity (asymptotic trend P 0·001). Taking animals to the higher level of finish effected increases in carcass weight and separable fat in the carcass of 55·1 kg (P 0·001) and 72 g/kg (P 0·001) respectively, while separable lean declined by 53 g/kg (P 0·001). Cooked muscle from the high finish animals was less tender than from the medium finish animals (P 0·05). It was concluded that slaughtering cows at the third parity would enable a self replacing closed herd to be operated, while obtaining 0·97 of the potential maximum output of saleable beef from the cow, but there may be some compromise in the tenderness of the meat for some consumers by the third parity.

The effect of tail docking on metabolizable energy requirements and carcass characteristics was studied using 80 weaned entire Awassi male lambs. Docking was performed within 3 days of birth and lambs were weaned at 90 days old. Docked and undocked lambs were randomly allocated to four groups, individually penned and offered different amounts of a pelleted concentrate diet. The pelleted diet was estimated to contain 11·8 MJ of metabolizable energy (ME) and 182 g of crude protein (CP) per kg dry matter (DM). Lambs on the high levels of intake were slaughtered at a target weight of approximately 45 kg. Other lambs were maintained on the diet for 149 days before being slaughtered. The right sides of all carcasses were cut into standardized commercial cuts then dissected into muscle, fat and bone. The soft tissue was pooled and analysed for DM, C P, ash and fat. Prediction of live-weight gain (LWG) and empty body gain for a given ME intake (MEI) was made using the growth and MEI data. MEI was expressed as MJ per kg metabolic body weight (M 0·75) per day. Tail docking had no effect (P > 0·05) on lamb growth from birth to weaning. During the post-weaning growth period, LWG and empty body gain were significantly higher (P < 0·05) for undocked lambs than docked lambs, at feeding levels between 0·31 and 0·52 MJ/kg M 0·75 per day and similar (P > 0·05) at high levels of intakes (between 0·74 and 1·1 MJ/ kg M 0·75 per day). Hot and cold carcass weights were similar (P > 0·05) for the two groups. Differences in empty body weight and fleece-free empty body weight were significant (P < 0·05) only for the 0·443 to 0·522 MJ/kg M 0·75 per day level of ME intake. Predicted ME requirements were higher for docked lambs for an estimated LWG between 0 and 100 g/day and lower for higher LWG (125 to 225 g/day). Docking had no effect (P > 0·05) on food conversion efficiency (FCE). Carcasses from docked lambs had significantly lower (P < 0·001) internal plus tail fat. Pooled soft tissue excluding tail fat, for the undocked lambs contained significantly more (P < 0·01) protein, less (P < 0·001) fat, higher (P < 0·01) moisture and similar (P > 0·05) ash content.

The effect of melatonin treatment on fur maturation period and hair follicle cycle in 4-month-old male and female chinchillas, kept under conditions of natural photoperiod, was studied. The animals were treated with continuous-release implants of melatonin (18 mg, group M, no. = 56), while no treatment was given to the control (group C, no. = 69). The effect on hair follicle activity cycle under conditions of normal hair growth (no. = 8) and after defleecing (no. = 8) and on number of hair fibres per follicle bundle (no. = 27) were measured by taking skin samples for histological examination once a month. The age at fur priming was reduced by 31 days (P < 0001) in the melatonin-treated chinchillas. When moulting began during the short-day period, the fur reached maturity 13 days (P < 005) sooner than when the moult began during the long-day period. Melatonin administration proved to be effective in these two periods. Melatonin treatment led to hair follicle activity decreasing at a faster rate, and the differences between treated and control groups from day 60 were significant (P < 005). The primary and secondary hair follicles reached the telogen phase 30 days earlier. Due to melatonin administration more fibres per follicle bundle were observed on the matured pelt (P < 005). At 4 months of age, following the removal of hair by defleecing, the growth of the first adult hair was studied without the presence of young-age hairs. No influence of defleecing as opposed to normal hair development on age at fur maturation or on the number of fibres per hair follicle bundle was observed. Within groups M and C the number of fibres per hair follicle bundle proved to be independent of age at first fur priming. No substantial differences between the groups were observed with respect to either body weight or pelt length at the time of pelting. According to these results, melatonin administration is effective in shortening the coat maturation period in growing chinchillas and causing corresponding changes in the hair follicle cycle.

The present experiment was designed to evaluate the effect of different time spans of ad libitum feeding of pigs prior to slaughter after a period of restricted feeding on performance and texture characteristics of the meat. Te n litters of five pigs (Duroc ✕ Landrace ✕ Large White crosses) were allocated to five feeding treatments (AA, R28A42, R43A27, R52A18 and R60A10) at the age of 70 days. AA-pigs were given ad libitum a concentrate diet from day 70 to slaughter at day 140 (approx. 100 kg live weight). R28A42, R43A27, R52A18 and R60A10 pigs were given food at a restricted level (0·6 of ad libitum) for 28, 43, 52 and 60 days, respectively, followed by ad libitum feeding for 42, 27, 18 and 10 days, respectively, until slaughter at day 140. All pigs that had been given food at a restricted level for a period (R28A42, R43A27, R52A18 and R60A10) showed a compensatory growth response in the subsequent ad libitum period. However, only pigs on ad libitum for a minimum of 27 days prior to slaughter (R28A42 and R43A27) had carcass weights and muscle mass similar to that of the control pigs (AA) at slaughter. The restricted feeding increased meat proportion, whereas the feeding strategies had no effect on technological meat quality traits (pH24, drip loss and CIE-colour traits: L*, a* and b*). During compensatory growth, protein turn-over was increased and positively related to the length of the ad libitum period as indicated by the concentration of elongation factor-2 (eEF-2) (P < 0·10), the activity of µ-calpain (P < 0·01) and the myofibrillar fragmentation index (MFI) 1 day post mortem in m. longissimus dorsi (P < 0·08) and the solubility of collagen (P < 0·01). Although not significant, the shear force at day 1 followed the same pattern of improvement as the MFI. The concentration of eEF-2 increased at a faster rate following transition to ad libitum feeding than did the activity of µ-calpain. This suggests that muscle protein synthesis increases at a faster rate after change to ad libitum feeding and reaches the same level as in the control pigs (AA) before muscle protein degradation. This time lag between the increase in protein synthesis and degradation could explain the compensatory growth response and it also suggests that in order to use the compensatory growth mechanism to improve tenderness, the optimal time of slaughter may not coincide with the period of highest growth rates, but may occur at a later stage, when muscle protein degradation is maximal. For pigs slaughtered at 100 kg live weight, we expect muscle protein degradation to be maximal some time beyond 42 days of ad libitum feeding prior to slaughter.

A basal diet was formulated to meet the nutrient requirements of growing rabbits. Another diet was formulated by substituting 152 g/kg of the basal diet with sunflower hulls (SH diet). One hundred and sixty-eight weaned 30-day-old rabbits were given these diets and finishing performance was recorded. Eighty animals were used to study the effect of SH inclusion on caecal fermentation traits at two ages (5 and 35 days after weaning) and disaccharidase activity in the small intestine at 35 days after weaning. Inclusion of SH in the diet reduced growth rate by proportionately 0·056 in the first 2 weeks after weaning (P 0 ×001), but had no effect from 14 to 65 days after weaning. Accordingly, daily gain was lower by a factor of 0·035 over the whole finishing period (P 0×01). There was no effect of treatment on food intake during the 14 days after weaning, but SH inclusion tended to increase it from this time onwards ( +0·026; P = 0 ×06) and over the whole finishing period ( + 0·018; P = 0 ×09). This effect was parallel to a 0·09 proportional decrease in the weight of caecal contents (P 0 ×01) observed in animals of 2 kg live weight. Food efficiency was lower by a factor of 0·05 (P 0×001) in all the periods considered when SH was included in the diet. Mortality rate (6%) was not affected by treatment nor was caecal pH or caecal concentrations of volatile fatty acids and ammonia nitrogen either at 5 days (5×75, 72×7 mmol/l and 16×6 mmol/l, respectively) or at 35 days after weaning (5×70, 74×3 mmol/l and 9 ×7 5 mmol/l, respectively). Inclusion of SH increased sucrase specific activity at the ileum by a factor of 0·47 (P 0×01) but had no effect on maltase specific activity at the jejunum or ileum or on sucrase specific activity at the jejunum. In conclusion, SH included at moderate levels (150 g/kg) in the diet reduced accumulation of digesta in the caecum, which increased voluntary food intake but impaired growth rate and food efficiency. Inclusion of SH did not affect caecal fermentation or mortality.

This study examined the effects of glutamine and nucleotides on growth, intestinal villous height and immune responses of weaned pigs. Eighty weaned pigs (Landrace ✕ Yorkshire ✕ Duroc) were randomly assigned to five treatments, including a control diet and a 2 (glutamine 1·0 and 1·5%) by 2 (nucleotides 500 and 1000 p.p.m.) factorial design. There were no differences among the five treatments in weight gain from weeks 0 to 4 and 0 to 8 of the experiment. However, the food intake of treatment 3 (glutamine 1·0% and nucleotides 1000 p. p. m. ) for weeks 4 to 8 was higher (P < 0·05) than that of the control group. Intestinal villous height, and serum immunoglobulin-G concentration 2 h post lipopolysaccharide injection, were higher (P < 0·05) for pigs administered treatment 3 than for controls. Furthermore, foot and mouth disease (FMD) neutralizing antibody titres were also higher (P < 0·05) than the control group for pigs given treatment 3 when measured 3 weeks following vaccination with FMD antigen. These observations suggest that a combination of 10% of glutamine and 1000 p. p. m. of nucleotides in the diet could improve food intake and intestinal villous height and promote the immune responses and FMD antibody titres of weaned pigs.

The aim of this study was to assess the effect of weaning weight and post-weaning diet on the performance of weaned pigs. In experiment 1, 30 litters with more than 10 pigs born alive per litter were selected. At 11 days of age, pigs of average weight for the litter were removed from 15 litters so that eight pigs remained per sow. These litters were given access to creep food (16·5 MJ digestible energy (DE) per kg and 18·7 g/kg lysine). The remaining litters were left complete and were not given creep food. Pigs were weaned at 28 days of age and pairs of pigs (a male and a female littermate of similar weight) were formed from each litter (no. = 54 pairs). Pairs were blocked on the basis of litter origin and weight and assigned at random to one of the following treatments: (1) 10 kg starter diet (16·1 MJ DE per kg and 17·4 g/kg lysine) followed by link diet (15·3 MJ DE per kg and 15·0 g/kg lysine) to 27 days (high dietary regimen; HDR); or (2) 4 kg starter diet, 10 kg link diet and weaner diet to 27 days (low dietary regimen; LDR). Thereafter pigs were given common diets to slaughter at about 95·6 kg live weight. On experiment 2, four pigs (two light and two heavy) were taken from each of 32 litters (no. = 128 pigs; age = 22 days), blocked on sex, litter origin, and weaning weight and within weight category individually assigned at random to two dietary treatments: (1) high density diet (16·1 MJ DE per kg and 17·4 g/kg lysine); and (2) low density diet (15·1 MJ DE per kg and 15·7 g/kg lysine). The duration of the experiment was 26 days. In experiment 1, reducing litter size and creep feeding increased weaning weight by 0·6 kg (P 0·05). This weight advantage at weaning was lost by day 14 post weaning (P > 0·05). From day 0 to day 27 post weaning daily gain was 472 and 427 g/day (s.e.12·8; P 0·05) and food conversion efficiency was 1·26 and 1·36 g/g (s.e. 0·026; P 0·05) for HDR and LDR, respectively. In experiment 2, weaning weight was 7·1 and 5·8 kg (s.e. 0·08; P 0·01) and pig weight at day 26 post weaning was 17·5 and 15·4 kg (s.e.0·23; P 0·01) for heavy and light weight categories, respectively. In the period from day 0 to 26, food intake was 440 and 396 g/day (s.e. 8·0; P 0·01) and daily gain was 389 and 355 g/day (s.e. 8·0; P < i 0·01) for heavy and light weight categories, respectively. Weaning weight was found to be a good determinant of weight at day 26 when terms for litter origin were included (R2 = 0·67; P 0·001 for the high density diet and R2 = 0·77; P 0·001 for the low density diet). It is concluded that weaning weight can be increased by pre-weaning management but that this weight advantage is lost in the early post-weaning period. Where weaning weight was naturally higher the weight advantage was still evident at day 26 post weaning.