Book contents
- Frontmatter
- Contents
- List of Contributors
- Foreword by Daniel R. Salomon
- Foreword by Robin Marks
- Foreword by Kathy Schwab
- Preface
- Acknowledgments
- SECTION ONE TRANSPLANT DERMATOLOGY: AN EVOLVING DYNAMIC FIELD
- Section Two Transplant Medicine and Dermatology
- Section Three Pathogenic Factors in Transplant Dermatology
- Section Four Cutaneous Effects of Immunosuppressive Medications
- Section Five Infectious Diseases of the Skin in Transplant Dermatology
- Section Six Benign and Inflammatory Skin Diseases in Transplant Dermatology
- 15 The Effects of Transplantation on Preexisting Dermatoses
- 16 Porokeratosis in Organ Transplant Recipients
- 17 Benign Cutaneous Neoplasms in Organ Transplant Recipients
- 18 Anogenital Cutaneous Disease in Organ Transplant Recipients
- 19 Cutaneous Graft versus Host Disease after Solid Organ Transplantation
- Section Seven Cutaneous Oncology in Transplant Dermatology
- Section Eight Special Scenarios in Transplant Cutaneous Oncology
- Section Nine Educational, Organizational, and Research Efforts in Transplant Dermatology
- Index
18 - Anogenital Cutaneous Disease in Organ Transplant Recipients
from Section Six - Benign and Inflammatory Skin Diseases in Transplant Dermatology
Published online by Cambridge University Press: 18 January 2010
- Frontmatter
- Contents
- List of Contributors
- Foreword by Daniel R. Salomon
- Foreword by Robin Marks
- Foreword by Kathy Schwab
- Preface
- Acknowledgments
- SECTION ONE TRANSPLANT DERMATOLOGY: AN EVOLVING DYNAMIC FIELD
- Section Two Transplant Medicine and Dermatology
- Section Three Pathogenic Factors in Transplant Dermatology
- Section Four Cutaneous Effects of Immunosuppressive Medications
- Section Five Infectious Diseases of the Skin in Transplant Dermatology
- Section Six Benign and Inflammatory Skin Diseases in Transplant Dermatology
- 15 The Effects of Transplantation on Preexisting Dermatoses
- 16 Porokeratosis in Organ Transplant Recipients
- 17 Benign Cutaneous Neoplasms in Organ Transplant Recipients
- 18 Anogenital Cutaneous Disease in Organ Transplant Recipients
- 19 Cutaneous Graft versus Host Disease after Solid Organ Transplantation
- Section Seven Cutaneous Oncology in Transplant Dermatology
- Section Eight Special Scenarios in Transplant Cutaneous Oncology
- Section Nine Educational, Organizational, and Research Efforts in Transplant Dermatology
- Index
Summary
BACKGROUND
The anogenital skin of organ transplant recipients (OTR) is commonly affected by a variety of inflammatory, infective, and premalignant conditions. Inflammatory dermatoses including lichen sclerosus and lichen planus are not increased in incidence, but carry an increased risk of malignancy. As a result, nonspecific symptoms such as itching and soreness require careful examination of the skin, combined with appropriate samples for microscopy and culture. Biopsy of clinically suspicious lesions should be undertaken early and repeated if a definitive diagnosis cannot be made or if an appropriate response to therapy is not encountered. Female transplant recipients are at higher risk of developing anogenital carcinoma than male transplant recipients. Anogenital diseases seen more frequently or with increased clinical significance in OTR include those conditions listed in Table 18.1. All are associated with human papillomavirus (HPV) infection.
CONDYLOMATA ACUMINATA
(GENITAL VIRAL WARTS)
Genital warts are a common infection caused by HPV with an increased incidence in OTR. Clinical and virological features of anogenital HPV-related lesions in transplant recipients suggest they may represent a marker for profound immunosuppression rather than the more common association with sexual partners and sexual practices. A study of 1002 OTR revealed anogenital warts in 2.1% (21/1002) of patients. Ninety-five percent (20/21) had multifocal disease involving the vulva (8/10), anus (5/10), and cervix (3/10).
- Type
- Chapter
- Information
- Skin Disease in Organ Transplantation , pp. 128 - 130Publisher: Cambridge University PressPrint publication year: 2008